|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Hypertriglyceridemia-induced pancreatitis: A case-based review显示文摘Hypertriglyceridemia is an established cause of pancreatitis. In a case-based approach, we present a review of hypertriglyceridemia and how it can cause pancreatitis. We outline how to investigate and manage such patients. A 35 year old man presented to the emergency department with abdominal pain and biochemical evidence of acute pancreatitis. There was no history of alcohol consumption and biliary imaging was normal. The only relevant past medical history was that of mild hyperlipidemia, treated with diet alone. Physical exam revealed epigastric tenderness, right lateral rectus palsy, lipemia retinalis, bitemporal hemianopsia and a delay in the relaxation phase of his ankle reflexes. Subsequent laboratory investigation revealed marked hypertriglyceridemia and panhypopituarism. An enhanced CT scan of the head revealed a large suprasellar mass impinging on the optic chiasm and hypothalamus. The patient was treated supportively; thyroid replacement and lipid lowering agents were started. He underwent a successful resection of a craniopharyngioma. Post- operatively, the patient did well on hormone replacement therapy. He has had no further attacks of pancreatitis. This case highlights many of the factors involved in the regulation of triglyceride metabolism. We review the common causes of hypertriglyceridemia and the proposed mechanisms resulting in pancreatitis. The incidence and management of hypertriglyceridemia- induced pancreatitis are also discussed. | S Ian Gan Alun L Edwards Christopher J Symonds Paul L Beck | 2006 | World Journal of Gastroenterology2006，12，44： | 35 |
| 2 | 卒中一级预防指南 美国心脏协会/美国卒中协会为医疗卫生专业人员制定的指南美国神经病学学会肯定本指南作为神经科医生继续教育工具的价值显示文摘背景和目的本指南对各种已确定和新出现的卒中危险因素的证据进行概述,以提供降低首次卒中风险的循证推荐。方法写作组成员由委员会主席根据每位成员先前在相关课题领域中的工作提名,并经美国心脏协会(American HeartAssociation,AHA)卒中委员会科学声明监督委员会批准。写作组采用系统文献回顾的方法(涵盖时间为2006年上一次回顾发表到2009年4月),参考先前已发表的指南、个人文件和专家意见来总结现有证据,并指出现有知识的差距;如果合适,则根据标准的AHA标准做出推荐。写作组全体成员均有机会对推荐进行评论并审核这份声明的最终文本。在AHA科学咨询和协调委员会考察和批准之前,本指南已南卒中委员会领导层和AIIA科学声明督察委员会进行过广泛的同行评议。结果对评价个体首次卒巾风险的流程图进行了评价。根据干预的町能性(不可于预、可于预或潜在可干预)和证据的强度(证据充分或证据不太充分),对首次卒中的危险因素或风险标记物进行分类。不可干预危险因素包括年龄、性别、低出生体质量、人种/种族和遗传倾向。证据充分的叮干预危险因素包括高血压、吸烟、糖尿病、心房颤动和某些其他心脏病、血脂异常、颈动脉狭窄、镰状细胞病、绝经后激素治疗、不良饮食习惯、体力活动过少以及肥胖和体脂分布。证据不太充分或潜在的可干预危险因素包括代谢综合征、酗酒、药物滥用、口服避孕药、睡眠呼吸障碍、偏头痛、高同型半胱氨酸血症、脂蛋白(a)升高、高凝状态、炎症和感染。对用阿司匹林进行卒中一级预防的资料进行了回顾。结论多方面的证据可用于确定能增高首次卒中风险的多种具体因素并提供降低这种风险的策略。 | Larry B. Goldstein Cheryl D. Bushnell Robert J. Adams Lawrence J. Appel Lynne T. Braun Seemant Chaturvedi Mark A. Creager Antonio Culebras Robert H. Eckel Robert G. Hart Judith A. Hinchey Virginia J. Howard Edward C. Jauch Steven R. Levine James F. Meschia Wesley S. Moore J.V. (Ian) Nixon Thomas A. Pearson 张霞(译) 尤寿江(译) 陈孝东(译) 卢涛声(译) 石际俊(译) 曹勇军(译) 徐兴顺(译) | 2010 | 国际脑血管病杂志2010，18，12： | 12 |
| 3 | Anti-tumour necrosis factor agent and liver injury:literature review,recommendations for management显示文摘Abnormalities in liver function tests,including transient and self-limiting hypertransaminasemia,cholestatic disease and hepatitis,can develop during treatment with anti-tumour-necrosis-factor(TNF)therapy.The optimal management of liver injury related to antiTNF therapy is still a matter of debate.Although some authors recommend discontinuing treatment in case of both a rise of alanine aminotransferase more than5 times the upper limit of normal,or the occurrence of jaundice,there are no standard guidelines for the management of anti-TNF-related liver injury.Bibliographical searches were performed in Pub Med,using the following key words:inflammatory bowel disease(IBD);TNF inhibitors;hypertransaminasemia;drugrelated liver injury;infliximab.According to published data,elevation of transaminases in patients with IBD treated with anti-TNF is a common finding,but resolution appears to be the usual outcome.Anti-TNF agents seem to be safe with a low risk of causing severe drugrelated liver injury.According to our centre experience,we found that hypertransaminasemia was a common,mainly self-limiting finding in our IBD cohort and was not correlated to infliximab treatment on both univariate and multivariate analyses.An algorithm for the management of liver impairment occurring during antiTNF treatment is also proposed and this highlights the need of a multidisciplinary approach and suggests liver biopsy as a key-point in the management decision in case of severe rise of transaminases.However,hepatic injury is generally self-limiting and drug withdrawal seems to be an exception. | Roberta Elisa Rossi Ioanna Parisi Edward John Despott Andrew Kenneth Burroughs James O'Beirne Dario Conte Mark Ian Hamilton Charles Daniel Murray | 2014 | World Journal of Gastroenterology2014，20，46： | 7 |
| 4 | Percutaneous transhepatic cholangioscopy and lithotripsy in treating difficult biliary ductal stones: Two case reports显示文摘BACKGROUND Endoscopic retrograde cholangiopancreatography(ERCP) is preferred for managing biliary obstruction in patients with bilio-enteric anastomotic strictures(BEAS) and calculi. In patients whose duodenal anatomy is altered following upper gastrointestinal(UGI) tract surgery, ERCP is technically challenging because the biliary tree becomes difficult to access by per-oral endoscopy.Advanced endoscopic therapies like balloon-enteroscopy or rendevous-ERCP may be considered but are not always feasible. Biliary sepsis and comorbidities may also make these patients poor candidates for surgical management of their biliary obstruction.CASE SUMMARY We present two 70-year-old caucasian patients admitted as emergencies with obstructive cholangitis. Both patients had BEAS associated with calculi that were predominantly extrahepatic in Patient 1 and intrahepatic in Patient 2. Both patients were unsuitable for conventional ERCP due to surgically-altered UGl anatomy. Emergency biliary drainage was by percutaneous transhepatic cholangiography(PTC) in both cases and after 6-weeks' maturation, PTC tracts were dilated to perform percutaneous transhepatic cholangioscopy and lithotripsy(PTCSL) for duct clearance. BEAS were firstly dilated fluoroscopically,and then biliary stones were flushed into the small bowel or basket-retrieved under visualization provided by the percutaneously-inserted video cholangioscope. Lithotripsy was used to fragment impacted calculi, also under visualization by video cholangioscopy. Satisfactory duct clearance was achieved in Patient 1 after one PTCSL procedure, but Patient 2 required a further procedure to clear persisting intrahepatic calculi. Ultimately both patients had successful stone clearance confirmed by check cholangiograms.CONCLUSION PTCSL offers a pragmatic, feasible and safe method for biliary tract clearance when neither ERCP nor surgical exploration is suitable. | Edward Alabraba Simon Travis Ian Beckingham | 2019 | World Journal of Gastrointestinal Endoscopy2019，11，4： | 6 |
| 5 | Development of a 100 J,10 Hz laser for compression experiments at the High Energy Density instrument at the European XFEL显示文摘In this paper we review the design and development of a 100 J, 10 Hz nanosecond pulsed laser, codenamed DiPOLE100 X,being built at the Central Laser Facility(CLF). This 1 kW average power diode-pumped solid-state laser(DPSSL) is based on a master oscillator power amplifier(MOPA) design, which includes two cryogenic gas cooled amplifier stages based on DiPOLE multi-slab ceramic Yb:YAG amplifier technology developed at the CLF. The laser will produce pulses between 2 and 15 ns in duration with precise, arbitrarily selectable shapes, at pulse repetition rates up to 10 Hz, allowing real-time shape optimization for compression experiments. Once completed, the laser will be delivered to the European X-ray Free Electron Laser(XFEL) facility in Germany as a UK-funded contribution in kind, where it will be used to study extreme states of matter at the High Energy Density(HED) instrument. | Paul Mason Saumyabrata Banerjee Jodie Smith Thomas Butcher Jonathan Phillips Hauke Hoppner Dominik Moller Klaus Ertel Mariastefania De Vido Ian Hollingham ANDrew Norton Stephanie Tomlinson Tinesimba Zata Jorge Suarez Merchan Chris Hooker Mike Tyldesley Toma Toncian Cristina HernANDez-Gomez Chris Edwards John Collier | 2018 | High Power Laser Science and Engineering2018，6，4： | 4 |
| 6 | Developing Wheat for Improved Yield and Adaptation Under a Changing Climate: Optimization of a Few Key Genes显示文摘世界上雨养无灌溉条件下种植的小麦常常受到干旱的影响。针对未来气候的模拟预测显示,除非采用适当的品种,否则温度上升和降雨模式的联合作用将加剧这种干旱情况,并可能造成小麦大幅度减产。由于物候基因的多样性,小麦具有广泛的适应性。小麦物候学提供了一个根据目标环境中可用水改变作物的发育阶段从而提高抗旱性。本文综述了春化(Vrn)、光周期(Ppd)和矮秆(Rht)基因等小麦物候学研究的最新进展。在不同气候条件下Vrn和Ppd基因的等位基因、单倍型和拷贝数有不同的反应,因而不仅可以改变发育阶段,而且可以改良产量。与模式植物拟南芥(Arabidopsis thaliana)相比,还有更多尚未发现的小麦物候基因,在目标环境中量化其效应将有助于通过育种提高小麦的耐旱性。因此,通过配置适当的物候基因、Rht基因和其他耐旱性相关的重要生理性状的组合,可以在水资源有限的环境中使产量最大化。 | M.A.N. Nazim Ud Dowl Ian Edwards Graham O'Hara Shahidul Islam Wujun Ma | 2018 | Engineering2018，4，4： | 3 |
| 7 | Utility of liver biopsy in predicting clinical outcomes after percutaneous angioplasty for hepatic venous obstruction in liver transplant patients显示文摘AIM: To determine utility of transplant liver biopsy in evaluating efficacy of percutaneous transluminal angioplasty(PTA) for hepatic venous obstruction(HVOO). METHODS: Adult liver transplant patients treated with PTA for HVOO(2003-2013) at a single institution were reviewed for pre/post-PTA imaging findings, manometry(gradient with right atrium), presence of HVOO on prePTA and post-PTA early and late biopsy(EB and LB, < or > 60 d after PTA), and clinical outcome, defined as good(no clinical issues, non-HVOO-related death) or poor(surgical correction, recurrent HVOO, or HVOOrelated death). RESULTS: Fifteen patients meeting inclusion criteria underwent 21 PTA, 658 ± 1293 d after transplant.In procedures with pre-PTA biopsy(n = 19), no difference was seen between pre-PTA gradient in 13/19 procedures with HVOO on biopsy and 6/19 procedures without HVOO(8 ± 2.4 mm Hg vs 6.8 ± 4.3 mm Hg; P = 0.35). Post-PTA, 10/21 livers had EB(29 ± 21 d) and 9/21 livers had LB(153 ± 81 d). On clinical follow-up(392 ± 773 d), HVOO on LB resulted in poor outcomes and absence of HVOO on LB resulted good outcomes. Patients with HVOO on EB(3/7 good, 4/7 poor) and no HVOO on EB(2/3 good, 1/3 poor) had mixed outcomes. CONCLUSION: Negative liver biopsy greater than 60 d after PTA accurately identifies patients with good clinical outcomes. | Ammar Sarwar Edward Ahn Ian Brennan Olga R Brook Salomao Faintuch Raza Malik Khalid Khwaja Muneeb Ahmed | 2015 | World Journal of Hepatology2015，7，14： | 2 |
| 8 | A practical synthesis of a COX-2 specific inhibitor 显示文摘 | Ian W D Jean-Francois M Edward G | 2000 | J Org Chem2000，65，： | 1 |
| 9 | Efficacy of atrial antitachycardia pacing using the Medtronic AT500 pacemaker in patients with congenital heart disease显示文摘 | Elizabeth A. Stephenson David Casavant Joann Tuzi Mark E. Alexander Ian Law Gerald Serwer Margaret Strieper Edward P. Walsh Charles I. Berul | 2003 | The American Journal of Cardiology2003，，7： | 1 |
| 10 | 'Idiopathic' Cranial Hypertrophic Pachymeningitis Responsive to Antituberculous Therapy: Case Report显示文摘 | Ian F. Parney Edward S. Johnson Peter B.R. Allen | 1997 | Neurosurgery1997，，4： | 1 |
| 11 | Natural infection of guinea pigs exposed to patients with highly drug-resistant tuberculosis显示文摘 | Ashwin S. Dharmadhikari Randall J. Basaraba Martie L. Van Der Walt Karin Weyer Matsie Mphahlele Kobus Venter Paul A. Jensen Melvin W. First Sydney Parsons David N. McMurray Ian M. Orme Edward A. Nardell | 2011 | Tuberculosis2011，，： | 1 |
| 12 | Purification and characterisation of a family of glutathione transferases with roles in herbicide detoxification in soybean ( Glycine max L.); selective enhancement by herbicides and herbicide safeners显示文摘 | Christopher J. Andrews Ian Cummins Mark Skipsey Nicholas M. Grundy Ian Jepson Jane Townson Robert Edwards | 2005 | Pesticide Biochemistry and Physiology2005，，3： | 1 |
| 13 | Western body mass indices need not compromise outcomes after modified D2 gastrectomy for carcinoma显示文摘 | Jonathan D. Barry Guy R.J.C. Blackshaw Paul Edwards Wyn G. Lewis Paula Murphy Ilias Hodzovic Ian W. Thompson Miles C. Allison | 2003 | Gastric Cancer2003，，2： | 1 |
| 14 | Cell-Type Specific Gene Expression Signature in Liver Underlies Response to Interferon Therapy in Chronic Hepatitis C Infection显示文摘 | Limin Chen Ivan Borozan Jing Sun Maha Guindi Sandra Fischer Jordan Feld Nitasha Anand Jenny Heathcote Aled M. Edwards Ian D. McGilvray | 2010 | Gastroenterology2010，，3： | 1 |
| 15 | Conservative Management of Patients with Cerebrospinal Fluid Shunt Infections显示文摘 | Erwin M. Brown Richard J. Edwards Ian K. Pople | 2006 | Neurosurgery2006，，4： | 1 |
| 16 | Western body mass indices need not compromise outcomes after modified D2 gastrectomy for carcinoma显示文摘 | Jonathan D. Barry Guy R.J.C. Blackshaw Paul Edwards Wyn G. Lewis Paula Murphy Ilias Hodzovic Ian W. Thompson Miles C. Allison | 2003 | Gastric Cancer2003，，2： | 1 |
| 17 | Detection of large numbers of novel sequences in the metatranscriptomes of complex marine microbial communities显示文摘 | Gilbert Jack A Field Dawn Huang Ying Edwards Rob Li Weizhong Gilna Paul Joint Ian | 2008 | Plos One2008，3，8： | 1 |
| 18 | Hepatic Gene Expression Discriminates Responders and Nonresponders in Treatment of Chronic Hepatitis C Viral Infection显示文摘 | Limin Chen Ivan Borozan Jordan Feld Jing Sun Laura-Lee Tannis Catalina Coltescu Jenny Heathcote Aled M. Edwards Ian D. McGilvray | 2005 | Gastroenterology2005，，5： | 1 |
| 19 | 一个基于深度学习的眼病和肺炎两大类疾病的AI诊断系统显示文摘文章简介本研究开发了一个基于深度学习框架能诊断致盲性视网膜疾病的人工智能(AI)诊断工具。而且,该AI诊断工具还可用于诊断小儿肺炎。这是一项将AI应用于医疗领域的重磅研究成果,有望高精确诊断多种可治疗性疾病。在眼科治疗中,视网膜OCT(光学相干断层扫描)成像技术是最常用的诊断技术之一。 | Daniel S.Kermany Michael Goldbaum Wenjia Cai Carolina C.S.Valentim Huiying Liang Sally L.Baxter Alex McKeown Ge Yang Xiaokang Wu Fangbing Yan Justin Dong Made K.Prasadha Jacqueline Pei Magdalene Y.L.Ting Jie Zhu Christina Li Sierra Hewett Jason Dong Ian Ziyar Alexander Shi Runze Zhang Rui Hou William Shi Xin Fu Yaou Duan Viet A.N. Huu Cindy Wen Edward D. Zhang Charlotte L. Zhang Oulan Li Xiaobo Wang Michael A. Singer Xiaodong Sun Jie Xu Ali Tafreshi M. Anthony Lewis Huimin Xia 张康 | 2019 | 科学新闻2019，0，2： | 1 |
| 20 | Shake table testing and numerical simulation of a utility‐scale wind turbine including operational effects显示文摘 | Ian Prowell Ahmed Elgamal Chia‐Ming Uang J. Enrique Luco Harold Romanowitz Edward Duggan | 2014 | Wind Energ2014，，7： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员