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| 1 | Anti-inflammatory activity of probiotic Bifidobacterium: Enhancement of IL-10 production in peripheral blood mononuclear cells from ulcerative colitis patients and inhibition of IL-8 secretion in HT-29 cells显示文摘AIM: To determine the anti-inflammatory activity of probiotic Bifidobacteria in Bifidobacteria-fermented milk (BFM) which is effective against active ulcerative colitis (UC) and exacerbations of UC, and to explore the immunoregulatory mechanisms. METHODS: Peripheral blood mononuclear cells (PBMNC) from UC patients or HT-29 cells were co-cultured with heat-killed probiotic bacteria or culture supernatant of Bifidobacterium breve strain Yakult (BbrY) or Bifidobacterium bifidum strain Yakult (BbiY) to estimate the amount of IL-10 or IL-8 secreted. RESULTS: Both strains of probiotic Bifidobacteria contained in the BFM induced IL-10 production in PBMNC from UC patients, though BbrY was more effective than BbiY. Conditioned medium (CM) and DNA of both strains inhibited IL-8 secretion in HT-29 cells stimulated with TNF-α, whereas no such effect was observed with heat- killed bacteria. The inhibitory effect of CM derived from BbiY was greater than that of CM derived from BbrY. DNAs of the two strains had a comparable inhibitory activity against the secretion of IL-8. CM of BbiY induced a repression of IL-8 gene expression with a higher expression of IκB-ζ mRNA 4 h after culture of HT-29 cells compared to that in the absence of CM.CONCLUSION: Probiotic Bifidobacterium strains in BFM enhance IL-10 production in PBMNC and inhibit IL-8 secretion in intestinal epithelial cells, suggesting that BFM has anti-inflammatory effects against ulcerative colitis. | Akemi Imaoka Tatsuichiro Shima Kimitoshi Kato Shigeaki Mizuno Toshiki Uehara Satoshi Matsumoto Hiromi Setoyama Taeko Hara Yoshinori Umesaki | 2008 | World Journal of Gastroenterology2008，14，16： | 37 |
| 2 | Can mosapride citrate reduce the volume of lavage solution for colonoscopy preparation?显示文摘AIM:To evaluate the possibility of reducing the volume of polyethylene glycol(PEG)-electrolyte solution using adjunctive mosapride citrate for colonoscopy preparation. METHODS:This was a single-center,prospective, randomized,investigator-blinded,non-inferiority study involving 252 patients of both sexes,aged from 20 to 80 years,scheduled for screening or diagnostic colonoscopy in our department.A total of 126 patients was randomized to receive 1.5 L PEG-electrolyte solution plus 15 mg of mosapride(1.5 L group),and 126 received 2 L PEG-electrolyte solution plus 15 mg of mosapride(2 L group).Patients completed a questionnaire on the acceptability and tolerability of the bowel preparation process.The efficacy of bowel preparation was assessed using a 5-point scale based on the Aronchick scale.The primary end point was adequate bowel preparation rates(score of excellent/good/fair) vs(poor/inadequate).Acceptability and tolerability,as well as disease detection,were secondary end points. RESULTS:A total of 244 patients was included in the analysis.There were no significant differences between the 2 L and 1.5 L groups in age,sex,body mass index, number of previous colonoscopies,and the preparation method used previously.The adequate bowel preparation rates were 88.5%in the 2 L group and 82.8%in the 1.5 L group[95%lower confidence limit(LCL)for the difference=-14.5%,non-inferiority P=0.019]in the right colon.In the left colon,the adequate bowel preparation rates were 89.3%in the 2 L group and 81.1%in the 1.5 L group(95%LCL=-17.0%,non-inferiority P=0.066).Compliance,defined as complete (100%)intake of the PEG solution,was significantly higher in the 1.5 L group than in the 2 L group(96.8% vs 85.7%,P=0.002).The proportion of abdominal distension(none/mild/moderate/severe)was significantly lower in the 1.5 L group than in the 2 L group (36/65/22/3 vs 58/48/18/2,P=0.040).Within the subgroup who had undergone colonoscopy previously, a significantly higher number of patients in the 1.5 L group than in the 2 L group felt that the current preparation was easier than the previous one(54.1%vs 28.0%,P=0.001).The disease detection rate was not significantly different between the two groups. CONCLUSION:Although the 1.5 L group had better acceptability and tolerability,15 mg of mosapride may be insufficient to compensate for a 0.5-L reduction of PEG solution. | Masahiro Tajika Yasumasa Niwa Vikram Bhatia Shinya Kondo Tsutomu Tanaka Nobumasa Mizuno Kazuo Hara Susumu Hijioka Hiroshi Imaoka Koji Komori Kenji Yamao | 2013 | World Journal of Gastroenterology2013，19，5： | 8 |
| 3 | Prospective clinical study of endoscopic ultrasound-guided choledochoduodenostomy with direct metallic stent placement using a forward-viewing echoendoscope显示文摘 | K. Hara K. Yamao S. Hijioka N. Mizuno H. Imaoka M. Tajika S. Kondo T. Tanaka S. Haba O. Takeshi Y. Nagashio T. Obayashi A. Shinagawa V. Bhatia Y. Shimizu H. Goto Y. Niwa | 2013 | Endoscopy2013，，05： | 6 |
| 4 | endoscopic ultrasonography-guided biliary drainage:Who,when,which,and how?显示文摘Both endoscopic ultrasonography(EUS)-guided choledochoduodenostomy( EUS- CDS) and EUS-guided hepaticogastrostomy(EUS-HGS) are relatively well established as alternatives to percutaneous transhepatic biliary drainage(PTBD). Both EUSCDS and EUS-HGS have high technical and clinical success rates(more than 90%) in high-volume centers. Complications for both procedures remain high at 10%-30%. Procedures performed by endoscopists who have done fewer than 20 cases sometimes result in severe or fatal complications. When learning EUSguided biliary drainage(EUS-BD), we recommend a mentor's supervision during at least the first 20 cases. For inoperable malignant lower biliary obstruction, a skillful endoscopist should perform EUS-BD before EUS-guided rendezvous technique(EUS-RV) and PTBD. We should be select EUS-BD for patients having altered anatomy from malignant tumors before balloon-enteroscope-assisted endoscopic retrograde cholangiopancreatography, EUS-RV, and PTBD. If both EUS-CDS and EUS-HGS are available, we should select EUS-CDS, according to published data. EUSBD will potentially become a first-line biliary drainage procedure in the near future. | Kazuo Hara Kenji Yamao Nobumasa Mizuno Susumu Hijioka Hiroshi Imaoka Masahiro Tajika Tutomu Tanaka Makoto Ishihara Nozomi Okuno Nobuhiro Hieda Tukasa Yoshida Yasumasa Niwa | 2016 | World Journal of Gastroenterology2016，22，3： | 4 |
| 5 | Prognostic value of K - ras mutation status and subtypes in endoscopic ultrasound-guided fine-needle aspiration specimens from patients with unresectable pancreatic cancer显示文摘 | Takeshi Ogura Kenji Yamao Kazuo Hara Nobumasa Mizuno Susumu Hijioka Hiroshi Imaoka Akira Sawaki Yasumasa Niwa Masahiro Tajika Shinya Kondo Tsutomu Tanaka Yasuhiro Shimizu Vikram Bhatia Kazuhide Higuchi Waki Hosoda Yasushi Yatabe | 2013 | Journal of Gastroenterology2013，，5： | 4 |
| 6 | Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria显示文摘 | Ivaylo I. Ivanov Koji Atarashi Nicolas Manel Eoin L. Brodie Tatsuichiro Shima Ulas Karaoz Dongguang Wei Katherine C. Goldfarb Clark A. Santee Susan V. Lynch Takeshi Tanoue Akemi Imaoka Kikuji Itoh Kiyoshi Takeda Yoshinori Umesaki Kenya Honda Dan R. Littma | 2009 | Cell2009，，3： | 3 |
| 7 | Application of sentinel node biopsy to gastric cancer surgery显示文摘 | Masahiro Hiratsuka Isao Miyashiro Osamu Ishikawa Hiroshi Furukawa Kazuyoshi Motomura Hiroaki Ohigashi Masao Kameyama Yo Sasaki Toshiyuki Kabuto Shingo Ishiguro Shingi Imaoka Hiroki Koyama | 2001 | Surgery2001，，3： | 2 |
| 8 | MR imaging of disorders associated with female infertility: use in diagnosis, treatment, and management 显示文摘 | Imaoka I Wada A MatsuoM | 2003 | RadioGraphics2003，23，6： | 1 |
| 9 | Interleukin-18 production and pulmonary function in COPD显示文摘 | Imaoka H Hoshino T Takei S | 2008 | Eur Resp ir J2008，31，2： | 1 |
| 10 | Identification of CYP2C23 expressed in rat kidney as an arachidonic acid epoxygenase显示文摘 | Imaoka S Wedlund PJ Ogawa H | 1993 | J Pharmacol Exp Ther1993，267，2： | 1 |
| 11 | *-congruences on regular *-semigroups显示文摘 | Imaoka | 1981 | Semigroup Forum1981，23，： | 1 |
| 12 | The progression of comor- bidity in IL-18 transgenic chronic obstructive pulmonary disease mice model显示文摘 | Takenaka S Kawayama T Imaoka H | 2014 | Biochem Biophys Res Commun2014，445，3： | 1 |
| 13 | Improvement of the AMSR-E algorithm for soil moisture estimation by introducing a fractional vegetation cov- erage dataset derived from MODIS data显示文摘 | Fujii Koike Imaoka | 2009 | Journal of the Remote Sensing Society of Japan2009，29，1： | 1 |
| 14 | Chaboche Nonlinear Kinematic Hardening Model显示文摘 | Imaoka S | 2008 | Memo ST108052008，，5： | 1 |
| 15 | Interleukin-18 expression,CD8+T cells,and eosinophils in lungs of nonsmokers with fatal asthma显示文摘 | Oda H Kawayama T Imaoka H | 2014 | Ann Allergy Asthma Immunol2014，112，1： | 1 |
| 16 | Three dimensional apparel CAD system 显示文摘 | Okabe H Imaoka H | 1992 | Computer Graphics1992，26，2： | 1 |
| 17 | Delayed washout of intratumor blood flow is associated with good response to intraarterial chemoembolization for liver metastasis of colorectal cancer显示文摘 | Kameyama M Imaoka S Fukuda I | 1993 | Surgery1993，114，： | 1 |
| 18 | IL- 18 induces air- way hyperresponsiveness and pulmonary inflammation via CD4 +T cell and IL- 13 显示文摘 | Sawada M Kawayama T Imaoka H | 2013 | PLoS One2013，8，54： | 1 |
| 19 | Developing an MR Imaging Strategy for Diagnosis of Ovarian Masses显示文摘 | Imaoka I Wada A Kaji Y | 2006 | Radiographics2006，26，5： | 1 |
| 20 | Immunochemotherapy in human hepatocellular carcinoma using the streptococcal agent OK- 432显示文摘 | Imaoka S Sasaki Y Ishikawa O | 1986 | J Clin Oncol1986，4，11： | 1 |
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