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| 1 | Retrospective cohort study Lower incidence of complications in endoscopic nasobiliary drainage for hilar cholangiocarcinoma显示文摘AIM:To identify the most effective endoscopic biliary drainage technique for patients with hilar cholangiocarcinoma.METHODS:In total,118 patients with hilar cholangiocarcinoma underwent endoscopic management[endoscopic nasobiliary drainage(ENBD)or endoscopic biliary stenting]as a temporary drainage in our institution between 2009 and 2014.We retrospectively evaluated all complications from initial endoscopic drainage to surgery or palliative treatment.The risk factors for biliary reintervention,post-endoscopic retrograde cholangiopancreatography(post-ERCP)pancreatitis,and percutaneous transhepatic biliary drainage(PTBD)were also analyzed using patient-and procedure-related characteristics.The risk factors for bilateral drainage were examined in a subgroup analysis of patients who underwent initial unilateral drainage.RESULTS:In total,137 complications were observed in92(78%)patients.Biliary reintervention was required in 83(70%)patients.ENBD was significantly associated with a low risk of biliary reintervention[odds ratio(OR)=0.26,95%CI:0.08-0.76,P=0.012].Post-ERCP pancreatitis was observed in 19(16%)patients.An absence of endoscopic sphincterotomy was significantly associated with post-ERCP pancreatitis(OR=3.46,95%CI:1.19-10.87,P=0.023).PTBD was required in 16(14%)patients,and Bismuth type III or IV cholangiocarcinoma was a significant risk factor(OR=7.88,95%CI:1.33-155.0,P=0.010).Of 102 patients with initial unilateral drainage,49(48%)required bilateral drainage.Endoscopic sphincterotomy(OR=3.24,95%CI:1.27-8.78,P=0.004)and Bismuth II,III,or IV cholangiocarcinoma(OR=34.69,95%CI:4.88-736.7,P<0.001)were significant risk factors for bilateral drainage.CONCLUSION:The endoscopic management of hilar cholangiocarcinoma is challenging.ENBD should be selected as a temporary drainage method because of its low risk of complications. | Kazumichi Kawakubo Hiroshi Kawakami Masaki Kuwatani Shin Haba Taiki Kudo Yoko A Taya Shuhei Kawahata Yoshimasa Kubota Kimitoshi Kubo Kazunori Eto Nobuyuki Ehira Hiroaki Yamato Manabu Onodera Naoya Sakamoto | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，9： | 26 |
| 2 | Stratifying the risk of lymph node metastasis in undifferentiated-type early gastric cancer显示文摘AIM:To study how lymph node metastasis(LNM) risk is stratified in undifferentiated-type early gastric cancer(undiff-EGC) dependent on combinations of risk factors.METHODS:Five hundred and sixty-seven cases with undiff-EGC undergoing gastrectomy with lymphadenectomy were examined retrospectively.Using clinicopathological factors of patient age,location,size,an endoscopic macroscopic tumor form,ulceration,depth,histology,lymphatic involvement(LI) and venous involvement(VI),LNM risk was examined and stratified by conventional statistical analysis and datamining analysis.RESULTS:LNM was positive in 44 of 567 cases(7.8%).Univariate analysis revealed > 2 cm,protrusion,submucosal(sm),mixed type,LI and VI as significant prognostic factors and > 2 cm and LI-positive were independent factors by multivariate analysis.In preoperatively evaluable factors excluding LVI,sm and > 2 cm were independent factors.According to the depth and size,cases were categorized into the low-risk group [m and ≤ 2 cm,0%(LNM incidence)],the moderaterisk group(m and > 2 cm,5.6%; and sm and ≤ 2 cm,6.0%),and the high-risk group(sm and > 2 cm,19.3%).On the other hand,LNM occurred in 1.4% in all LI-negative cases,greatly lower than 28.2% in all LI-positive cases,and LNM incidence was low in LInegative cases even in the moderate- and high-risk groups.CONCLUSION:LNM-related factors in undiff-EGC were depth and size preoperatively while those were LI and size postoperatively.Among these factors,LI was the most significantly correlated factor. | Yukiko Asakawa Masahiko Ohtaka Shinya Maekawa Mitsuharu Fukasawa Yasuhiro Nakayama Tatsuya Yamaguchi Taisuke Inoue Tomoyoshi Uetake Minoru Sakamoto Tadashi Sato Yoshihiko Kawaguchi Hideki Fujii Kunio Mochizuki Masao Hada Toshio Oyama Tomotaka Yasumura Kosaku Omata Atsushi Nishiyama Keiichi Naito Hideo Hata Yoshiaki Haba Kazuyuki Miyata Haruhisa Saitoh Yoichi Yamadera Kazuo Miura Akira Kawaoi Tohru Abe Hajime Tsunoda Yuji Honda Masayuki Kurosaki Nobuyuki Enomoto | 2015 | World Journal of Gastroenterology2015，21，9： | 8 |
| 3 | 碱法分离大米蛋白和淀粉工艺的优化及其产品功能性质研究显示文摘本文以籼米为原料,研究了碱法提取分离大米蛋白和淀粉的工艺,并对大米分离蛋白和大米淀粉的功能性质进行了研究。确定了碱法分离大米蛋白和淀粉的最佳工艺条件:氢氧化钠溶液浓度为0.075mol/L;提取时间6h;料液比1:7g/mL;温度40℃。该优化条件下可以得到纯度高于80%的大米分离蛋白,蛋白提取率为86.23%,淀粉回收率为92.12%。所得大米分离蛋白溶解性、起泡性好,乳化性能欠佳。 | HABA Pépé Francois 丁霄霖 张连富 | 2005 | 食品研究与开发2005，26，5： | 7 |
| 4 | Prospective clinical study of endoscopic ultrasound-guided choledochoduodenostomy with direct metallic stent placement using a forward-viewing echoendoscope显示文摘 | K. Hara K. Yamao S. Hijioka N. Mizuno H. Imaoka M. Tajika S. Kondo T. Tanaka S. Haba O. Takeshi Y. Nagashio T. Obayashi A. Shinagawa V. Bhatia Y. Shimizu H. Goto Y. Niwa | 2013 | Endoscopy2013，，05： | 6 |
| 5 | Immunohistochemically Detected Expression of 3 Major Genes (CDKN2A/p16, TP53, and SMAD4/DPC4) Strongly Predicts Survival in Patients With Resectable Pancreatic Cancer显示文摘 | Minoru Oshima Keiichi Okano Shinobu Muraki Reiji Haba Takashi Maeba Yasuyuki Suzuki Shinichi Yachida | 2013 | Annals of Surgery2013，，2： | 4 |
| 6 | Studies on Thermal Contraction of Crankshaft Bearings under Extreme Low Temperatures显示文摘This paper presents how the contractions of the main components of a V6 motor with low engine displacement are determined for the cold-start phase under extreme low temperature. Internal combustion engine components have complex geometries and to obtain the thermal contractions, in the research, used the method of finite element analysis. The phenomena of thermal contractions are studied for the cold-start situations at extreme low temperature, knowing that the cold-start phase of an internal combustion engine is the main factor that determines moving rotational and translational parts wear life. Checking the proper choice of clearance is particularly important, as the use of inappropriate values of it leads to rapid operation destruction of the engine group components. The results obtained for the thermal clearances of crankshaft bearings are mathematically modeled and the relations can be used for calculating the clearances. The mathematical models are also useful for implementing in different software tools. | Sever-Alexandru Haba Gheorghe Oancea | 2015 | Journal of Thermal Science2015，24，5： | 3 |
| 7 | Influence of the safety and diagnostic accuracy of preoperative endoscopic ultrasound-guided fine-needle aspiration for resectable pancreatic cancer on clinical performance显示文摘AIM:To evaluate the safety and diagnostic accuracy of endoscopic ultrasound-guided fine-needle aspiration(EUS-FNA)in a cohort of pancreatic cancer patients.METHODS:Of 213 patients with pancreatic cancer evaluated between April 2007 and August 2011,82were thought to have resectable pancreatic cancer on the basis of cross-sectional imaging findings.Of these,54 underwent EUS-FNA before surgery(FNA+group)and 28 underwent surgery without preoperative EUSFNA(FNA-group).RESULTS:All 54 lesions were visible on EUS,and all54 attempts at FNA were technically successful.The diagnostic accuracy according to cytology and histology findings was 98.1%(53/54)and 77.8%(42/54),respectively,and the total accuracy was 98.1%(53/54).One patient developed mild pancreatitis after EUS-FNA but was successfully treated by conservative therapy.No severe complications occurred after EUS-FNA.In the FNA+and FNA-groups,the median relapse-free survival(RFS)was 742 and 265 d,respectively(P=0.0099),and the median overall survival(OS)was1042 and 557 d,respectively(P=0.0071).RFS and OS were therefore not inferior in the FNA+group.These data indicate that the use of EUS-FNA did not influence RFS or OS,nor did it increase the risk of peritoneal recurrence.CONCLUSION:In patients with resectable pancreatic cancer,preoperative EUS-FNA is a safe and accurate diagnostic method. | Taiki Kudo Hiroshi Kawakami Masaki Kuwatani Kazunori Eto Shuhei Kawahata Yoko Abe Manabu Onodera Nobuyuki Ehira Hiroaki Yamato Shin Haba Kazumichi Kawakubo Naoya Sakamoto | 2014 | World Journal of Gastroenterology2014，20，13： | 2 |
| 8 | Local steroid injection into the artificial ulcer created by endoscopic submucosal dissection for gastric cancer: prevention of gastric deformity显示文摘 | H. Mori K. Rafiq H. Kobara S. Fujihara N. Nishiyama M. Kobayashi T. Himoto R. Haba M. Hagiike K. Izuishi K. Okano Y. Suzuki T. Masaki | 2012 | Endoscopy2012，，07： | 2 |
| 9 | Association of serum endoglin with metastasis in patients with colorectal, breast, and other solid tumors, and suppressive effect of chemotherapy on the serum endoglin显示文摘 | Takahashi N Kawanishi Tabata R Haba A Tabata M Haruta Y Tsai H | 2001 | Clin Cancer Res2001，7，： | 1 |
| 10 | Coverage dependent behavior of redox reaction induced structure change and mass transport at an 11-ferrocenyl-1-undecanethiol self-assembled monolayer on a gold electrode studied by an in situ IRRAS-EQCM combined system 显示文摘 | Ye S Haba T Sato Y | 1999 | Phys Chem Chem Phys1999，1，： | 1 |
| 11 | The neural net- work involved in a bimanual Tactile-tactile matching discrimi- nation cask: a functional imaging study at 3 T显示文摘 | Habas Christophe Emmanuel Alain Cabanis | 2007 | Neuroradiol- ogy2007，49，8： | 1 |
| 12 | Local expression of the serum amyloid A and formyl pepfide receptor-like 1 genes in synovial tissue is associated with matrix metalloproteinase production in patients with inflammatory arthritis显示文摘 | O'HABA R MURPHY E P WHITEHEAD A S | 2004 | Arthritis Rheum2004，50，6： | 1 |
| 13 | Morphological con- trol of catalytically active platinum nanocrystals 显示文摘 | Lee H Habas S E Kweskin S | 2006 | An- gewandte Chemie International Edition2006，45，： | 1 |
| 14 | Angiogenesis and metastasis marker of human tumors 显示文摘 | Seon BK Takahashi N Haba A | 2001 | Rinsho Byori2001，49，10： | 1 |
| 15 | Stability of leptonic self-complementarity显示文摘 | Naoyuki Haba Kunio Kaneta Ryo Takahashi | 2013 | EPL (Europhysics Letters)2013，，1： | 1 |
| 16 | Bilaeral decompression of multilevel lumbar spinal stenosis through a unilateral approach 显示文摘 | Haba K Ikeda M Soma M | 2005 | J Clin Neurosci2005，12，2： | 1 |
| 17 | Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1显示文摘 | Kato Y and He X | 2001 | Cell2001，107，7： | 1 |
| 18 | Effects of CCK-8on independent ingestion and central c-Fos-like immunoreactivity in rats on postnatal days10and11显示文摘 | Blumberg S Schroeder M Haba D | 2006 | Peptides2006，27，11： | 1 |
| 19 | Oxidative stress effect on progesterone-induced blocking factor (PIBF) binding to PIBF- receptor in lymphocytes显示文摘 | de la Haba C Palacio JR Palkovics T | 2014 | Biochim Biophys Acta2014，1838，1： | 1 |
| 20 | Volumetric and sur- face-based 3D MRI analyses of fetal isolated mild ventriculomeg aly显示文摘 | Scott JA Habas PA Rajagopalan V | 2013 | Brain Struct Funct2013，218，3： | 1 |
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