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| 1 | 皮质下小血管病诊断的共识声明显示文摘血管性认知损害是用于描述一组涉及大血管和小血管的散发性和遗传性异质性疾病的诊断术语。皮质下小血管病可导致腔隙性梗死和进行性白质损害。被称为宾斯旺格病(Binswanger's disease, BD)的进行性白质损害患者构成了从单纯血管性疾病到合并神经变性病变的疾病谱。BD患者是一个相对同质性的亚组,存在缺氧缺血、腔隙性梗死和炎症,它们协同作用破坏血脑屏障和髓鞘。通过临床、脑脊液、神经心理学和影像学检查获得的多模式疾病标记物能促进该亚组患者的鉴别。本共识声明确定了一系列基于基础病理学改变的潜在生物学标记物,这将有助于诊断以及将来协作性治疗试验的患者选择。 | Gary A Rosenberg Anders Wallin Joanna M Wardlaw Hugh S Markus Joan Montaner Leslie Wolfson Costantino Iadecola Berislav V Zlokovic Anne Joutel Martin Dichgans Marco Duering Reinhold Schmidt Amos D Korczyn Lea T Grinberg Helena C Chui Vladimir Hachinski 王训师 张劼 陈涵丰 俞娅美 徐子奇 罗本燕 | 2016 | 国际脑血管病杂志2016，24，6： | 18 |
| 2 | Genomic resources for the brown planthopper, Nilaparvata lugens: Transcriptome pyrosequencing and microarray design显示文摘棕色的 planthopper, Nilaparvata lugens 是在整个亚洲的栽培米饭的一个害虫并且用杀虫药剂或抵抗米饭变化被控制。这种开发了抵抗到杀虫药剂的许多班,遗传因子型开发了那对先前是剧毒的抵抗米饭栽培变种。昆虫使用 detoxification 酶的一间套房,包括保卫自己对的细胞色素 P450s,谷胱甘肽 S-transferases 和 carboxyl/cholinesterases 种第二等的代谢物和杀虫剂。Roche 454-FLX 站台上的 Pyrosequencing 被用来生产补充存在 Sanger 的数据集定序的一个实质的表示顺序标签(EST ) 在 GenBank 的 EST。一个总数 78 959 读与 37 392 公开地可得到的 Sanger EST 被相结合;这些集合了进 8 911 contigs 和 10 620 单条。分发的分析试验有为生物进程和分子的函数的基因本体论的唯一的基因(拖船) 建议 454 并且 Sanger EST 汇编 N 是广泛地代表性的。lugens transcriptome。planthopper transcriptome 被发现包含编码 P450s,九个编码谷胱甘肽 S-transferases 和这些的 26 编码 carboxyl/cholinesterases 和许多的 31 条拖船的褐通常认为地涉及 xenobiotics 的 detoxification。Agilent eArray 站台被用来构造为 19 000 个 unigene 序列与探针占据的 oligonucleotide microarray,包括知道编码 detoxification 酶的所有那些。在这研究开发的 genomic 资源将对学习这个庄稼害虫的社区有用并且将帮助阐明位于杀虫药剂抵抗和 planthopper 改编下面到抵抗米饭栽培变种的分子的机制。 | Chris Bass Martin Bay Hebsgaard Joseph Hughes | 2012 | Insect Science2012，19，1： | 2 |
| 3 | Global prevalence of dementia: a Delphi consensus study显示文摘 | Cleusa P Ferri Martin Prince Carol Brayne Henry Brodaty Laura Fratiglioni Mary Ganguli Kathleen Hall Kazuo Hasegawa Hugh Hendrie Yueqin Huang Anthony Jorm Colin Mathers Paulo R Menezes Elizabeth Rimmer Marcia Scazufca | 2005 | The Lancet2005，，9503： | 2 |
| 4 | Global prevalence of dementia: a Delphi consensus study显示文摘 | Cleusa P Ferri Martin Prince Carol Brayne Henry Brodaty Laura Fratiglioni Mary Ganguli Kathleen Hall Kazuo Hasegawa Hugh Hendrie Yueqin Huang Anthony Jorm Colin Mathers Paulo R Menezes Elizabeth Rimmer Marcia Scazufca | 2005 | The Lancet . 2005 (9503)2005，，9503： | 2 |
| 5 | Equidistant Fish-Eye Calibration and Rectification by Vanishing Point Extraction 显示文摘 | Ciara'n Hughes Patrick Denny Martin Glavin and Edward Jones | 2010 | IEEE Transactions on Pattern Analysis and Machine Intelligence2010，32，12： | 1 |
| 6 | Peristomal allergic contact dermatitis case report and review of the literature 显示文摘 | Martin JA Hughes TM Stone NM | 2005 | Contact Dermatitis2005，52，5： | 1 |
| 7 | Ahuman oncogene formed by the fusion of truncted tropomyosin and protein tyrosine kinase sequences 显示文摘 | Hughes SH Barbacid M | 1986 | Nature1986，319，： | 1 |
| 8 | Realizing Product- Market Advantage in High-Technology International New Ven- tures: The Mediating Role of Ambidextrous Innovation显示文摘 | Hughes M Martin S L Morgan R E | 2010 | Jour- nal of International Marketing2010，18，4： | 1 |
| 9 | Nanoscale proteinpores modified with PAMAM dendrimers 显示文摘 | Hugh Martin Helen Kinns Nick Mitchell ef al | 2007 | Jacs2007，129，： | 1 |
| 10 | TRPV1-expressing sensory fibres and IBS:links with immune function显示文摘 | Hughes P A Brierley S M Martin C M | | 0，，03： | 1 |
| 11 | No apparent association between genetic polymorphisms (-102 C>T) and (-9 T>C) in the human manganese superoxide dismutase gene and gastric cancer(1)显示文摘 | MARTIN R C LAN Q HUGHES K | 2005 | J Surg Res2005，124，1： | 1 |
| 12 | Genetic mechanismsof fetal male undermasculinization : a background to the roleof endocrine disruptors显示文摘 | Hughes IA Martin H Jaaskelainen J | 2006 | Environ Res2006，100，1： | 1 |
| 13 | A comparison of baseline and induced DNA damage in human spermatozoa from fertile and infertile men,using a modified comet assay显示文摘 | Hughes CM Lewis SE Mckelvey Martin V J | 1996 | Mol Hum Reprod1996，2，8： | 1 |
| 14 | Neurocognitive Function and Cerebral Emboli: Randomized Study of On-Pump Versus Off-Pump Coronary Artery Bypass Surgery显示文摘 | Reza Motallebzadeh J. Martin Bland Hugh S. Markus Juan Carlos Kaski Marjan Jahangiri | 2007 | The Annals of Thoracic Surgery2007，，2： | 1 |
| 15 | Topoisomerase Ⅱ-alpha expression increases with increasing Gleason score and with hormone insensitivity in prostate carcinoma显示文摘 | Hughes C Murphy A Martin C | 2006 | J Clin Pathol2006，59，7： | 1 |
| 16 | Effects of mild processing pressures on the performance of dry powder inhaler formulations for inhalation therapy (1): Budesonide and lactose显示文摘 | Steve R. Marek Martin J. Donovan Hugh D.C. Smyth | 2011 | European Journal of Pharmaceutics and Biopharmaceutics2011，，1： | 1 |
| 17 | Network modeling of multiphase flow in fractures显示文摘 | RICHARD G Hughes MARTIN J Blunt | 2001 | Advances in Water Resources2001，24，： | 1 |
| 18 | The effects of antioxidant supplementation during percoll preparation on human sperm DNA integrity显示文摘 | Hughes CM Lewis SE McKelvey- Martin VJ Thompson W | 1998 | Hum Reprod1998，13，5： | 1 |
| 19 | A comparison of Depodur,a novel,single-dose extended-release epidural morphine,with standard epidural morphine for pain relief after lower abdominal surgery显示文摘 | Gambling D Hughes T Martin G | 2005 | Anesth Analg2005，100，4： | 1 |
| 20 | Genetic Heritability of Ischemic Stroke and the Contribution of Previously Reported Candidate Gene and Genomewide Associations显示文摘 | Steve Bevan Matthew Traylor Poneh Adib-Samii Rainer Malik Nicola L. M. Paul Caroline Jackson Martin Farrall Peter M. Rothwell Cathie Sudlow Martin Dichgans Hugh S. Markus | 2012 | Stroke2012，，12： | 1 |
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