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| 1 | Combination Therapy With Infliximab and Azathioprine Is Superior to Monotherapy With Either Agent in Ulcerative Colitis显示文摘 | Remo Panaccione Subrata Ghosh Stephen Middleton Juan R. Márquez Boyd B. Scott Laurence Flint Hubert JF. van Hoogstraten Annie C. Chen Hanzhe Zheng Silvio Danese Paul Rutgeerts | 2013 | Gastroenterology2013，，： | 5 |
| 2 | Influence of irritable bowel syndrome on treatment outcome in gastroesophageal reflux disease显示文摘AIM: To investigate the influence of irritable bowel syndrome (IBS)-like symptoms on treatment outcomes with pantoprazole in gastroesophageal reflux disease (GERD) in a real life setting. METHODS: For this prospective, open-label, multinational, multicentre study, 1888 patients assessed by the investigators as suffering from GERD were recruited. The patients were additionally classified as with or without IBS-like symptoms at baseline. They were treated with pantoprazole 40 mg once daily and completed the Reflux Questionnaire (ReQuest) short version daily. Response rates and symptom scores were compared after 4 and 8 wk of treatment for subgroups defined by the subclasses of GERD [erosive(ERD) and non-erosive reflux disease (NERD)] and the presence of IBS-like symptoms. RESULTS: IBS-like symptoms were more prevalent in NERD than in ERD (18.3% vs 12.7%, P = 0.0015). Response rates after 4 and/or 8 wk of treatment were lower in patients with IBS-like symptoms than in patients without IBS-like symptoms in both ERD (Week 4: P < 0.0001, Week 8: P < 0.0339) and NERD (Week 8: P = 0.0088). At baseline, ReQuest 'lower abdominal com- plaints' symptom scores were highest in NERD patients with IBS-like symptoms. Additionally, these patients had the strongest symptom improvement after treatment compared with all other subgroups. CONCLUSION: IBS-like symptoms influence treatment outcome and symptom burden in GERD and should be considered in management. Proton pump inhibitors can improve IBS-like symptoms, particularly in NERD. | Hubert Mnnikes Robert C Heading Holger Schmitt Hubert Doerfler | 2011 | World Journal of Gastroenterology2011，17，27： | 4 |
| 3 | Megacolon in adulthood after surgical treatment of Hirschsprung's disease in early childhood显示文摘Hirschsprung's disease (HD) is a disorder associated with congenital malformation of the enteric nervous system with segmental aganglionosis. Prevailing therapy includes a resection of the affected part of the bowel. However, patients often do not obtain complete functional improvement after surgical treatment. We present the case of a 25-year-old woman who had surgical treatment of HD in early childhood. After that procedure she had clinical features of constipation for years in the end,passing of stool once a week, requiring laxatives and enemas. We diagnosed an incomplete resection of the aganglionic bowel via rectal biopsy and resected the remaining aganglionic segment. Two months after surgery the patient's bowel function improved to a frequency of 1-4 stools per day. We conclude that regular follow-up is required to identify HD patients with persistent alterations of bowel function after surgery. In patients presenting with constipation, recognition of a remaining aganglionic segment or other alterations of the enteric nervous system should be aimed at in an early stage. | Christoph R.Werner Gisela Stoltenburg-Didinger Henning Weidemann Christoph Benckert Marco Schmidtmann Ivo R.van der Voort Viola Andresen Burghard F.Klapp Peter Neuhaus Bertram Wiedenmann Hubert Mnnikes | 2005 | World Journal of Gastroenterology2005，11，36： | 3 |
| 4 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 5 | Initial experience with successful totally robotic laparoscopic cystoprostatectomy and ileal conduit construction in tet-raplegic patients:report of two cases显示文摘 | Hubert J Chammas M Larre S | 2006 | Journal of Endocrinology2006，，02： | 2 |
| 6 | Structure of the angiotensin I-converting enzyme gene显示文摘 | Hubert C Houot A M Corvol P | 1991 | J Bio Chem1991，266，15： | 1 |
| 7 | Transforming growth factor-betal-mediated Slug and Snail transcription factor up-regulation reduces the density of Langerhans cells in epithelial metaplasia by affecting E-cadherin ex-pression 显示文摘 | Hefts M Hubert P Kholod N | 2008 | Am J Pathol2008，，172： | 1 |
| 8 | First pharmacokinetic-pharmacodynamic study in humans with a selective 5-HT4 receptor agonist显示文摘 | Appel S Kumle A Hubert M | 1997 | Clin Pharmacol1997，37，3： | 1 |
| 9 | Expulsion of dummy transmitters by rainbow trout 显示文摘 | Chisholm I M Hubert W A | 1985 | Trans Am Fish Soc1985，114，： | 1 |
| 10 | Determination and on-line clean-up of (fluoro)quinolones in bovine milk using column-switching liquidchromatography fluorescence detection显示文摘 | Clare Ho Della W M Sin Hubert P 0 Tang | 2004 | Journal ofChromatography A2004，1061，： | 1 |
| 11 | Obesity as an inde- pendent risk factor for cardiovascular disease: a 26-year follow-up of participants in the Framingham Heart Study 显示文摘 | Hubert HB Feinleib M McNamara PM | 1983 | Circulation1983，67，5： | 1 |
| 12 | Effects of plyometric training on maximal power output and jumping ability显示文摘 | HUBERT M TOMASZ S | | 0，，01： | 1 |
| 13 | Half-wavelength power transmis- sion lines显示文摘 | Hubert G J Gent M R | 1965 | IEEE Trans on Power Apparatus and Sys- tems1965，84，10： | 1 |
| 14 | Two-Phase Simulations of Micro Heat Pipes显示文摘 | Rahmat M Hubert P | 2010 | Computers & Fluids2010，39，3： | 1 |
| 15 | Preclinical efficacy and safety of rVIII-SingleChain (CSL627), a novel recombinant single-chain factor VIII显示文摘 | Sabine B. Zollner Elmar Raquet Jochen Müller-Cohrs Hubert J. Metzner Thomas Weimer Ingo Pragst Gerhard Dickneite Stefan Schulte | 2013 | Thrombosis Research2013，，： | 1 |
| 16 | A scheduling system for the steelmaking-continuous casting process:a case study from the steel-making industry 显示文摘 | Hubert M Wolfgang H Wemer S | 2009 | International Journal of Production Research2009，47，15： | 1 |
| 17 | Efficacy of ketogenic diet in severe refractory status epilepticus initiating fever in- duced refractory epileptic encephalopathy in school age chil- dren(FIRES)显示文摘 | Nabbout R Mazzuca M Hubert P | 2010 | Epilepsia2010，51，20： | 1 |
| 18 | Identification and characterization of PDZ-1,a N-ERMAD specific interaction partner of the Echinococcus multilocularis ERM protein Elp显示文摘 | Hubert K Zavala-Gongora R Frosch M | | 0，，01： | 1 |
| 19 | Randomised comparison of combined step-down prednisolone, methotrexate and sulphasalazine with sulphasalazine alone in early rheumatoid arthritis显示文摘 | Maarten Boers Arco C Verhoeven Harry M Markusse Mart AFJ van de Laar Rene Westhovens J Christiaan van Denderen Derkjen van Zeben Ben AC Dijkmans Andre J Peeters Piet Jacobs Hans R van den Brink Hubert JA Schouten Désirée MFM van der Heijde Annelies Boonen | 1997 | The Lancet1997，，9074： | 1 |
| 20 | Robust methods for partial least squares regression显示文摘 | Hubert M Branden K V | 2003 | Journal of Chemometrics2003，17，： | 1 |
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