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| 1 | Is it possible to stop nucleos(t)ide analogue treatment in chronic hepatitis B patients?显示文摘Chronic hepatitis B(CHB) remains a challenging global health problem, with nearly one million related deaths per year. Nucleos(t)ide analogue(NA) treatment suppresses viral replication but does not provide complete cure of the hepatitis B virus(HBV) infection. The accepted endpoint for therapy is the loss of hepatitis B surface antigen(HBs Ag), but this is hardly ever achieved. Therefore, indefinite treatment is usually required. Many different studies have evaluated NA therapy discontinuation after several years of NA treatment and before HBs Ag loss. The results have indicated that the majority of patients can remain off therapy, with some even reaching HBs Ag seroconversion. Fortunately, this strategy has proved to be safe, but it is essential to consider the risk of liver damage and other comorbidities and to ensure aclose follow-up of the candidates before considering this strategy. Unanswered questions remain, namely in which patients could this strategy be effective and what is the optimal time point at which to perform it. To solve this enigma, we should keep in mind that the outcome will ultimately depend on the equilibrium between HBV and the host's immune system. Viral parameters that have been described as good predictors of response in HBe Ag(+) cases, have proven useless in HBe Ag(-) ones. Since antiviral immunity plays an essential role in the control of HBV infection, we sought to review and explain potential immunological biomarkers to predict safe NA discontinuation in both groups. | Elia Moreno-Cubero Robert T Sánchez del Arco Julia Pena-Asensio Eduardo Sanz de Villalobos Joaquín Míquel Juan Ramón Larrubia | 2018 | World Journal of Gastroenterology2018，24，17： | 5 |
| 2 | Synthesis and Device Applications of High-Density Aligned Carbon Nanotubes Using Low-Pressure Chemical Vapor Deposition and Stacked Multiple Transfer显示文摘For nanotube-based electronics to become a viable alternative to silicon technology,high-density aligned carbon nanotubes are essential.In this paper,we report the combined use of low-pressure chemical vapor deposition and stacked multiple transfer to achieve high-density aligned nanotubes.By using an optimized nanotube synthesis recipe,we have achieved high-density aligned carbon nanotubes with density as high as 30 tubes/μm.In addition,a facile stacked multiple transfer technique has been developed to further increase the nanotube density to 55 tubes/μm.Furthermore,high-performance submicron carbon nanotube field-effect transistors have been fabricated on the high-density aligned nanotubes.Before removing the metallic nanotubes by electrical breakdown,the devices exhibit on-current density of 92.4μA/μm and normalized transconductance of 13.3μS/μm.Moreover,benchmarking with the aligned carbon nanotube transistors in the literature indicates that our devices exhibit the best performance so far,which is attributed to both the increased nanotube density and scaling down of channel length.This study shows the great potential of using such high-density aligned nanotubes for high performance nanoelectronics and analog/RF applications. | Chuan Wang Koungmin Ryu Lewis Gomez De Arco Alexander Badmaev Jialu Zhang Xue Lin Yuchi Che Chongwu Zhou | 2010 | Nano Research2010，3，12： | 3 |
| 3 | Ent-untenospongin A, a New C_(21) Furanoterpene from the Indian Marine Sponge Hippospongia sp.显示文摘A new C21 furanoterpene. ent-untenospongin A (2), together with a known related compound. tetradehydrofurospongin-1 (1), has been isolated from the indian marine sponge Hippospongia sp. and its structure was determined on the basis of spectroscopic data. | Yue Wei GUO~1 Enrico TRIVELLONE (Istituto per la Chimica di Molecole di Interesse Biologico del CNR. Via Toiano 6. 80072 Arco Felice (Napoli), Italy) | 2000 | Chinese Chemical Letters2000，11，4： | 2 |
| 4 | A measurement method based on a modified version of the Chirplet transform for instantaneous frequency estimation显示文摘 | Angrisani L D' Arco M | 2002 | IEEE Trans Instruction and Measurement2002，51，4： | 1 |
| 5 | Test equipment for DAC's performance assessment: Design and characterization显示文摘 | A Baccigalupi M D' Arco A Liccardo M Vadursi | 2010 | IEEE Transactions on Instlumentation and Measurement2010，59，5： | 1 |
| 6 | Committee on Terminology and Classification显示文摘 | ARCO(Association Research Circulation Osseous) | | 0，，01： | 1 |
| 7 | Neurotransmitters and prefrontal cortex - limbic system interactions: implications for plasticity and psychiatric disorders 显示文摘 | Del Arco A Mora F | 2009 | J Neural Transm2009，116，8： | 1 |
| 8 | Association of clinic and am- bulatory blood pressure with vascular damage in the elderly: the EPICARDIAN study 显示文摘 | Blaneo F Gil P Arco CD | 2006 | Blood Press Monit2006，11，6： | 1 |
| 9 | Procalcitonin and C-reactive protein as markers of systemic inflammatory response syndrome severity in critically ill children 显示文摘 | Corsino Rey Marta Los Arcos Andr e s Concha | 2007 | Intensive Care Med2007，33，3： | 1 |
| 10 | Design of self-healing key distribution schemes显示文摘 | BLUNDO C D’ARCO P LISTO M | 2004 | Designs Codes and Cryptography2004，32，12： | 1 |
| 11 | Design of self-healing key distribution schemes 显示文摘 | BLUNDO C D' ARCO P SANTIS A | 2004 | Designs Codes and Cryptography2004，32，123： | 1 |
| 12 | Association of clinic and ambulatory blood pressure with vascular damage in the elderly:the EPICARDIAN study显示文摘 | Blanco F Gil P Arco CD | 2006 | Blood Press Monit2006，11，6： | 1 |
| 13 | Improving suspension bridge wind stability with aerodynamic appendages 显示文摘 | Del Arco D C Aparicio A C | 1999 | Journal of Structure Engineering1999，125，12： | 1 |
| 14 | Synthesis, characterization and catalytic behaviour of SAPO-11 obtained at low crystallization times and with low organic agent content显示文摘 | LOPEZ C M ESCOBAR V ARCOS M E NOBREGA L D YANEZ F GARACIA L V | 2008 | Catalysis Today2008，，： | 1 |
| 15 | Randomised comparison of combined step-down prednisolone, methotrexate and sulphasalazine with sulphasalazine alone in early rheumatoid arthritis显示文摘 | Maarten Boers Arco C Verhoeven Harry M Markusse Mart AFJ van de Laar Rene Westhovens J Christiaan van Denderen Derkjen van Zeben Ben AC Dijkmans Andre J Peeters Piet Jacobs Hans R van den Brink Hubert JA Schouten Désirée MFM van der Heijde Annelies Boonen | 1997 | The Lancet1997，，9074： | 1 |
| 16 | Association of clinic and ambulatory blood pressure with vascular damage in the elderly:the EPICARDIAN study显示文摘 | Blanco F Gil P Arco CD | 2006 | Blood Press Monit2006，，： | 1 |
| 17 | Silicon incorporation in hydroxyapatite obtained by controlled crystallization显示文摘 | Arcos D Rodriguez Carvajal J Vallet Regi M | 2004 | Chem Mater2004，16，6： | 1 |
| 18 | Fludarabine and cytarabine as continuous sequential infusion for elderly patients with acute myeloid leukemia显示文摘 | Ferrara F D'Arco AM De Simone M | 2005 | Haematologica2005，90，6： | 1 |
| 19 | Delayed upregulation of ATP P2X3receptors of trigeminal sensory neurons by calcitonin gene-related peptide显示文摘 | Fabbretti E D’Arco M Fabbro A | 2006 | J Neurosci2006，26，23： | 1 |
| 20 | Association of clinic and ambulatory blood pressure with vascular damage in the elderly:the EPICARDIAN study显示文摘 | Blanco F Gil P Arco CD | 2006 | Blood Press Monit2006，11，6： | 1 |
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