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| 1 | Alveolar echinococcosis-spreading disease challenging clinicians: A case report and literature review显示文摘Human alveolar echinococcosis (AE) is a potentially deadly disease; recent studies have shown that the endemic area of Echinococcus multilocularis , its causative agent, is larger than previously known. This disease has low prevalence and remains underreported in Europe. Emerging clinical data show that diagnostic difficulties are still common. We report on a 76-year old patient suffering from AE lesions restricted to the left lobe of the liver who underwent a curative extended left hemihepatectomy. Prior to the resection a liver biopsy under the suspicion of an atypical malignancy was performed. After the intervention he developed a pseudoaneurysm of the hepatic artery that was successfully coiled. Surprisingly, during surgery, the macroscopic appearance of the tumour revealed a growth pattern that was rather typical for cystic echinococcosis (CE), i.e. , a gross tumour composed of multiple large vesicles with several centimeters in diameter. In addition, there were neither extensive adhesions nor infiltrations of the neighboring pancreas and diaphragm as was expected from previous imaging results. The unexpected diagnosis of AE was confirmed by definite histopathology, specific polymerase chain reaction and serology results. This is a rare case of unusual macroscopic presentation of AE that posed immense diagnostic challenges and had an eventful course. To our knowledge this is the first case of an autochthonous infection in this particular geographic area of Germany, the federal state of Saxony. This report may provide new hints for an expanding area of risk for AE and emphasizes the risk of complications in the scope of diagnostic procedures and the limitations of modern radiological imaging. | Georgi Atanasov Christoph Benckert Armin Thelen Dennis Tappe Matthias Frosch Dieter Teichmann Thomas FE Barth Christian Wittekind Stefan Schubert Sven Jonas | 2013 | World Journal of Gastroenterology2013，19，26： | 14 |
| 2 | Autologous osteoblasts enhance osseointegration of porous titanium implants 显示文摘 | Frosch KH Dresing K Dresing K | 2003 | J Orthop Res2003，21，2： | 1 |
| 3 | Characterization of the genomic locus expressing the ERM-like protein of Echinococcus multilocularis 显示文摘 | Brehm K Jensen K Frosch P | 1999 | Mol Biochem Parasitol1999，100，： | 1 |
| 4 | Genome-based vaccines显示文摘 | Knaust A Frosch M | 2004 | Int J Med Microbiol2004，294，5： | 1 |
| 5 | Strategies for manufacturing 显示文摘 | FROSCH D GALLOPOULOS N | 1989 | Scientific American1989，261，3： | 1 |
| 6 | Raman spectroscopy-an innovative and versatile tool to follow the respirational activity and carbonate biomineralization of important cave bacteria显示文摘 | Keiner R Frosch T Hanf S | 2013 | Anal Chem2013，85，18： | 1 |
| 7 | Another look at cracking and crack control in reinforced concrete 显示文摘 | FROSCH R J | 1999 | ACI Structural Journal1999，96，3： | 1 |
| 8 | Strategies for manufacturing 显示文摘 | Frosch R A Gallopoulos N | 1989 | Scientific American1989，261，3： | 1 |
| 9 | The Duhring chamber,an improved technique for epicutaneous testing of irritant and allergic reactions显示文摘 | Frosch P Kligman A | 1979 | Contact Dermatitis1979，5，2： | 1 |
| 10 | A new posterolateral approach witbout fibula osteotomy for the treatment of tibial plateau fractures显示文摘 | Frosch KH Balcarek P Walde T | 2010 | J Orthop Trauma2010，24，8： | 1 |
| 11 | Outcomes and risks of operative treatement of rupture of the anterior eruciate ligament in children and adolescents 显示文摘 | Frosch KH Stengel D Brodhun T | 2010 | Arthroscopy2010，26，： | 1 |
| 12 | Identification and characterization of PDZ-1,a N-ERMAD specific interaction partner of the Echinococcus multilocularis ERM protein Elp显示文摘 | Hubert K Zavala-Gongora R Frosch M | | 0，，01： | 1 |
| 13 | Industrial ecology: adapting technology for a sustainable world显示文摘 | Frosch R A | 1995 | Environment1995，37，10： | 1 |
| 14 | Strategies for manu-facturing显示文摘 | FROSCH R A GALLOPOULOS N E | 1989 | Scientific American1989，261，3： | 1 |
| 15 | Serological differentiation between cystic and alveolar echinococcosis by use of recombinant larval antigens显示文摘 | Helbig M Frosch P Kern P Frosch M 1993 | 1993 | J Clin Microbiol1993，31，12： | 1 |
| 16 | A new posterolateral ap- proach without fibula usteotomy for the treatment of tibial plateau fractures 显示文摘 | Frosch K H Balcarek P Walde T | 2010 | J Ortbop Trauma2010，24，8： | 1 |
| 17 | Strategy of Manufacturing显示文摘 | Frosch R A Gallopoulos N E | 1989 | Scientific American1989，261，3： | 1 |
| 18 | Phagocyte specific calcium- binding S100 proteins as clinical laboratory markers of inflam- mation显示文摘 | Foell D Frosch M Sorg c | 2004 | Clin Chim Acta2004，344，12： | 1 |
| 19 | Strategies for Manufacturing 显示文摘 | Frosch R A Gallopoulos N E | 1989 | Scientific American1989，261，1： | 1 |
| 20 | Optimizing Chocolate Production through Traceability:A Review of the Influence of Farming Practices on Cocoa Bean Quality显示文摘 | Saltini R Akkerman R Frosch S | 2013 | Food Control2013，29，1： | 1 |
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