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| 1 | A Short Amino-Terminal Part of Arabidopsis Phytochrome A Induces Constitutive Photomorphogenic Response显示文摘Phytochrome A (phyA ) 是在 Arabidopsis thaliana 察觉到的 far-red 光的主导的光敏电阻器。phyA 在发信号的变白的幼苗,和导致光的 phyA 的细胞质在高水平积累被一个复杂规章的网络调停。这包括光 -- 并且进在 vivo 的原子核的本国的 phyA 的 FHY1/FHL 蛋白质依赖者 translocation。phyA (PHYA406 ) 的短 N 终端碎片对 phenocopy 足够,这也被显示出在 vitro 的这个高度调整的细胞的过程。为了测试这 N 终端的生物活动,在 planta phyA 碎裂,我们生产了表示 PHYA406YFP 的转基因的 phyA-201 植物(黄荧光灯蛋白质) DD, PHYA406YFPDDNLS (原子本地化信号) ,和 PHYA406YFPDDNES (原子出口信号) 熔化蛋白质。这里,我们报导 PHYA406YFPDD 被进口进原子核,而 PHYA406YFPDDNLS 和 PHYA406YFPDDNES 显示期望的组成的本地化模式,这进程部分是轻依赖者的。我们的结果证明这些截断的 phyA 蛋白质是轻马厩的,当局部性时,他们在他们的原子核,和两个都不触发组成的象 photomorphogenic 一样回答导致合适的 phyA 发信号。我们证明在 vitro 并且在 vivo PHYA406, Pfr 和 Pr 绑 COP1, photomorphogenesis 的一个一般抑压者,并且在原子身体与它共同本地化。因此,我们断定在 planta,截断的 PHYA406 蛋白质以一种光无关的方式在原子核使 COP1 失去活性。 | Andra's Viczia'n E'va Ada'm Iris Wolf Ja'nos Bindics Stefan Kircher Marc Heijde Roman Ulm Eberhard Scha'fer Ferenc Nagy | 2012 | Molecular Plant2012，5，3： | 2 |
| 2 | Cerebral magnetic resonance imaging in quiescent Crohn's disease patients with fatigue显示文摘AIM To evaluate brain involvement in quiescent Crohn's disease (CD) patients with fatigue using quantitative magnetic resonance imaging(MRI).METHODS Multiple MRI techniques were used to assess cerebral changes in 20 quiescent CD patients with fatigue(defined with at least 6 points out of an 11-point numeric rating scale compared with 17 healthy age and gender matched controls without fatigue. Furthermore, mental status was assessed by cognitive functioning, based on the neuropsychological inventory including the different domains global cognitive functioning, memory and executive functioning and in addition mood and quality of life scores. Cognitive functioning and mood status were correlated with MRI findings in the both study groups.RESULTS Reduced glutamate + glutamine (Glx = Glu + Gln) concentrations (P = 0.02) and ratios to total creatine(P = 0.02) were found in CD patients compared with controls. Significant increased Cerebral Blood Flow(P = 0.05) was found in CD patients (53.08 ± 6.14 mL/100 g/min) compared with controls (47.60 ± 8.62 mL/100 g/min). CD patients encountered significantly more depressive symptoms (P < 0.001). Cognitive functioning scores related to memory (P = 0.007) and executive functioning (P = 0.02) were lower in CD patients and both scores showed correlation with depression and anxiety. No correlation was found subcortical volumes between CD patients and controls in the T1-weighted analysis. In addition, no correlation was found between mental status and MRI findings.CONCLUSION This work shows evidence for perfusion, neurochemical and mental differences in the brain of CD patients with fatigue compared with healthy controls. | Sanne van Erp Ece Ercan Perla Breedveld Lianne Brakenhoff Eidrees Ghariq Sophie Schmid Matthias van Osch Mark van Buchem Bart Emmer Jeroen van der Grond Ron Wolterbeek Daniel Hommes Herma Fidder Nic van der Wee Tom Huizinga Désirée van der Heijde Huub Middelkoop Itamar Ronen Andrea van der Meulen-de Jong | 2017 | World Journal of Gastroenterology2017，23，6： | 2 |
| 3 | Comparison of etanereept and methotrexate, alone and combined, in the treatment of rheumatoid arthritis 显示文摘 | van der Heijde D Klareskog L Rodriguez-Valverde V | 2006 | Arthrtis Rheum2006，54，4： | 1 |
| 4 | Nonsteroidal anti-inflammatory drugs reduce radiographic progression in patients with ankylosing spondylitis:a randomized clinical trial显示文摘 | Wanders A Heijde D Landewe R | 2005 | Arthritis Rheum2005，，： | 1 |
| 5 | Efficacy and safety of adallmumab in patients with non-radiographic axial spondyloarthritis: results of a randomised placebo-controlled trial (ABILITY-1) 显示文摘 | SIEPER J VAN DER HEIJDE D DOUGADOS M | 2012 | Ann Rheum Dis2012，，： | 1 |
| 6 | Relative val- ue of erythrocyte sedimentation rate and C-reactive proteili in as-sessment of disease activity in ankylosing spondylitis显示文摘 | Spoorenberg A van der Heijde D de Klerk E | 1999 | J Rheu matol1999，26，： | 1 |
| 7 | Recombinant human tumor necrosis factor receptor (etanercept) for treating ankylosing spondylitis: a randomized, controlled trial 显示文摘 | Davis J C Van Der Heijde D Braun J | 2003 | Arthritis Rheum2003，48，11： | 1 |
| 8 | HLA-B27 positive patients differ from HLA-B27 negative patients in clinical presentation and imaging: results from the DESIH cohort of patients with recent onset axial spondyloarthritis显示文摘 | Chung HY Machado P van der Heijde D | 2011 | Ann Rheum Dis2011，70，11： | 1 |
| 9 | Recombinant human tumor necrosis factor receptor (etanercept)for treating ankylosing spondylitis:a randomized,controlled trial显示文摘 | Van Der Heijde D Braun J | 2003 | Arthritis Rheum2003，48，： | 1 |
| 10 | Recombinant human tumor necrosis factor receptor (etanercept) for treating ankylosing spondylitis:a randomized,controlled trial显示文摘 | Davis JC Jr Van Der Heijde D Braun J | 2003 | Arthritis Rheum2003，48，11： | 1 |
| 11 | Efficacy and safety of infliximab in patients with ankylosing spondylitis re- sults of a randomized, placebo - controlled trial(ASSERT) 显示文摘 | Vander Heijde D Dijkmans B Geusens P | 2005 | Arthritis Rheum2005，52，2： | 1 |
| 12 | TheAssessment of SpondyloArthritis International Societyclassification criteria for peripheral spondyloarthritis and forspondyloarthritis in general显示文摘 | Rudwaleit M van der Heijde D LandewéR | 2011 | Ann Rheum Dis2011，70，1： | 1 |
| 13 | Infliximab and methotrexate in the treatment of rheumatoid arthritis显示文摘 | Lipsky P E Van der Heijde D M St clair E W | 2000 | N Eng J Med2000，343，： | 1 |
| 14 | How to diagnose axial spondyloarthritis early显示文摘 | Rudwaleit M van der Heijde D Khan MA | 2004 | Ann Rheum Dis2004，63，5： | 1 |
| 15 | Higher disease activity leads to more structural damage in the spine in ankylosing spondylitis: 12-year longitudinal data from the OASIS cohort显示文摘 | RAMIRO S VAN DER HEIJDE D VAN TUBERGEN A | 2014 | Annals of the Rheumatic Diseases2014，73，8： | 1 |
| 16 | Radiographic imaging: the 'gold standard' for assessment of disease progression in rheumatoid arthritis显示文摘 | van der Heijde DM | 2000 | Rheumatology (Oxford)2000，39，11： | 1 |
| 17 | UV-B photoreeeptor-mediated sig- nalling in plants显示文摘 | Heijde M Ulm R | 2012 | Trends in Plant Science2012，17，4： | 1 |
| 18 | 2010 Update of the international ASAS recommendations for the use of anti-TNF agents in patients with axial spondyloarthritis显示文摘 | Van der Heijde D Sieper J Maksymowyeh WP | 2011 | Ann Rheum Dis2011，70，6： | 1 |
| 19 | Joint erosiond and patients with early rheumatoid arthritis显示文摘 | Van der Heijde DM | 1995 | Br J Rheumatol1995，34，： | 1 |
| 20 | Disease remission and sustained halting of radiographic progression with combination etanercept and methotrexate in patients with rheumatoid arthritis 显示文摘 | van der Heijde D Klareskog L Landewe R | 2007 | Arthritis Rheum2007，56，： | 1 |
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