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| 1 | Combined TACE and PEI for palliative treatment of unresectable hepatocellular carcinoma显示文摘瞄准:估计是否 transarterial chemoembolization 的联合的有效性(不作声) 并且在 unresectable 肝细胞癌(HCC ) 的治疗的经皮的乙醇注射(PEI ) 是优异的独自不作声使随机化的控制试用是 performed.METHODS:长期的幸存率和住院的持续时间上的联合治疗的效果在 52 以前未经治疗的 HCC 被评估,随机分配了到 TACE-PEI (27 磅) 或独自不作声(25 磅) 。结果:TACE 组的累积幸存率在 6 瞬间是 75.8% , 62.9% 在 12 瞬间,并且 18.0% 分别地在 24 瞬间并且 TACE-PEI 组织 76.9% , 61.5% ,和 38.7% 。在两个组的全面幸存的比较统计上不出现了有效差量。关于有 HCC 的病人, Okuda 上演我(n = 26 ) , TACE-PEI 组的中部的幸存显著地更长(>24 瞬间,还没在学习时期到达的 median ) 与 TACE 组相比(18.4 瞬间[范围 11.6-21.7 瞬间] ;P = 0.04 ) 。TACE-PEI 为死亡把相对风险归结为 0.4 (95%CI 0.15-0.96 ) 独自与接待了的病人相比不作声。在有 HCC Okuda 阶段 II 或 III 的病人的中部的幸存是在 TACE 组的 5.0 瞬间(1.7 瞬间不定义) 与 10.4 相比,在 TACE-PEI 的瞬间组织。结论:联合 TACE-PEI 改进了生存时间与相比独自不作声。我们的学习在 HCC Okuda 舞台揭示了统计上重要的改进幸存我。副作用是次要的,联合治疗没更加延长住院的持续时间。 | Gerhild Becker Tarik Soezgen Manfred Olschewski Joerg Laubenberger Hubert Erich Blum Hans-Peter Allgaier | 2005 | World Journal of Gastroenterology2005，11，39： | 32 |
| 2 | Hepatocellular carcinoma: Therapy and prevention显示文摘Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide. The major etiologies and risk factors for the development of HCC are well defined and some of the multiple steps involved in hepatocarcinogenesis have been elucidated in recent years. Despite these scientific advances and the implementation of measures for the early detection of HCC in patients at risk, patient survival has not improved during the last three decades. This is due to the advanced stage of the disease at the time of clinical presentation and limited therapeutic options. The therapeutic options fall into five main categories: surgical interventions including tumor resection and liver transplantation, percutaneous interventions including ethanol injection and radiofrequency thermal ablation, transarterial interventions including embolization and chemoembolization, radiation therapy and drugs as well as gene and immune therapies. These therapeutic strategies have been evaluated in part in randomized controlled clinical trials that are the basis for therapeutic recommendations. Though surgery, percutaneous and transarterial interventions are effective in patients with limited disease (1-3 lesions, <5 cm in diameter) and compensated underlying liver disease (cirrhosis Child A), at the time of diagnosis more than 80% patients present with multicentric HCC and advanced liver disease or comorbidities that restrict the therapeutic measures to best supportive care. In order to reduce the morbidity and mortality of HCC, early diagnosis and the development of novel systemic therapies for advanced disease, including drugs, gene and immune therapies as well as primary HCC prevention are of paramount importance. Furthermore, secondary HCC prevention after successful therapeutic interventions needs to be improved in order to make an impact on the survival of patients with HCC. New technologies, including gene expression profiling and proteomic analyses, should allow to further elucidate the molecular events underlying HCC development and to identify novel diagnostic markers as well as therapeutic and preventive targets. | Hubert E Blum | 2005 | World Journal of Gastroenterology2005，11，47： | 27 |
| 3 | Surgical management of esophagogastric junction tumors显示文摘 | Burkhard HA von Rahden Hubert J Stein J Rüdiger Siewert | 2006 | World Journal of Gastroenterology2006，12，41： | 18 |
| 4 | EGFR and HER2 expression in advanced biliary tract cancer显示文摘AIM:To analyze the pathogenetic role and potential clinical usefulness of the epidermal growth factor receptor(EGFR)and the human epidermal growth factor receptor 2(HER2)in patients with advanced biliary tract cancer(BTC). METHODS:EGFR and HER2 expression was studied in biopsy samples from 124 patients(51%women; median age 64.8 years),with advanced BTC diagnosed between 1997 and 2004.Five micrometers sections of paraffin embedded tissue were examined by standard, FDA approved immunohistochemistry.Tumors with scores of 2+or 3+for HER2 expression on immunochemistry were additionally tested for HER2 gene amplification by fluorescence in situ hybridisation(FISH).RESULTS:34/124 patients(27.4%)had gallbladder cancer,47(37.9%)had intrahepatic BTC and 43(34.7%)had extrahepatic or perihilar BTC.EGFR expression was examined in a subset of 56 samples. EGFR expression was absent in 22/56 tumors(39.3%). Of the remaining samples expression was scored as 1+in 12(21.5%),2+in 13(23.2%)and 3+in 9(16%), respectively.HER2 expression was as follows:score 0 73/124(58.8%),score 1+27/124(21.8%),score 2+ 21/124(17%)and score 3+4/124(3.2%).HER2 gene amplification was present in 6/124,resulting in an overall amplification rate of 5%. CONCLUSION:Our data suggest that routine testing and therapeutic targeting of HER2 does not seem to be useful in patients with BTC,while targeting EGFR may be promising. | Jan Harder Oliver Waiz Florian Otto Michael Geissler Manfred Olschewski Brigitte Weinhold Hubert E Blum Annette Schmitt-Graeff Oliver G Opitz | 2009 | World Journal of Gastroenterology2009，15，36： | 18 |
| 5 | Interaction of hepatitis C virus envelope glycoprotein E2 with the large extracellular loop of tupaia CD81显示文摘AIM: To further analyze the interaction of tupaia CD81 with hepatitis C virus (HCV) envelope protein E2. METHODS: A tupaia CD81 large extracellular loop (CD81 LEL), which binds to HCV E2 protein, was cloned and expressed as a GST-fusion protein, and interaction of HCV E2 protein with a tupaia CD81 LEL was evaluated by enzyme-linked immunosorbent assay (EIA). RESULTS: Although tupaia and human CD81 LEL differed in 6 amino acid changes, tupaia CD81 LEL was strongly recognized by anti-CD81 antibodies against human CD81 LEL conformation-dependent epitopes. Investigating LEL CD81-E2 interactions by EIA, we demonstrated that binding of tupaia CD81 LEL GST fusion protein to recombinant HCV E2 protein was markedly reduced compared to binding of human CD81 LEL GST fusion protein to recombinant HCV E2 protein. CONCLUSION: These data suggest that the structural differences in-between the tupaia and human CD81 may alter the interaction of the large extracellular loop with HCV envelope glycoprotein E2. These findings may be important for the understanding of the mechanisms of binding and entry of HCV to PTHs. | Zhan-Fei Tian Hong Shen Xi-Hua Fu Yi-Chun Chen Hubert E Blum Thomas F Baumert Xi-Ping Zhao | 2009 | World Journal of Gastroenterology2009，15，2： | 16 |
| 6 | Neurotherapeutic potential of erythropoietin after ischemic injury of the central nervous system显示文摘Erythropoietin (EPO) is one of the most successful biopharmaceuticals in history and is used for treating anemia of different origins. However, it became clear that EPO could also work in a neuroprotective, antiapoptotic, antioxidative, angiogenetic and neurotropic way. It causes stimulation of cells to delay cell apoptosis, especially in the central nervous system. In rodent models of focal cerebral ischemia, EPO showed an impressive reduction of infarct size by 30% and improvement of neurobehavioral outcome by nearly 40%. A large animal model dealing with ischemia and reperfusion of the spinal cord showed that EPO could reduce the risk of spinal cord injury significantly. In addition, some clinical studies tested whether EPO works in real live clinical settings. One of the most promising studies showed the innocuousness and improvements in follow-up, outcome scales and in infarct size, of EPO-use in humans suffering from ischemic stroke. Another study ended unfortunately in a negative outcome and an increased overall death rate in the EPO group. The most possible reason was the involvement of patients undergoing simultaneously systemic thrombolysis with recombinant tissue plasminogen activator. An experimental study on rats demonstrated that administration of EPO might exacerbate tissue plasminogen activator-induced brain hemorrhage without reducing the ischemic brain damage. This case shows clearly how useful animal models can be to check negative side effects of a treatment before going into clinical trials. Other groups looked in human trials at the effects of EPO on the outcome after ischemic stroke, relation to circulating endothelial progerdtor cells, aneurysmal subarachnoid hemorrhage, traumatic brain injury, hemoglobin transfusion thresholds and elective first-time coronary artery bypass surgery. Most of the results were pos-让ive, but are based mostly on small group sizes. However, some of the most neglected facts when focusing on experimental setups of ischemia of the central nervous system are issues like age and comorbidities. It might be extremely worthy to consider these points for future projects, because EPO might influence all these factors. | Florian Simon Nicolaos Floros Wiebke Ibing Hubert Schelzig Artis Knapsis | 2019 | Neural Regeneration Research2019，14，8： | 15 |
| 7 | 透视科学中的探究及工程与技术中的问题解决——以实践、跨学科概念、核心概念的视角显示文摘科学,工程、技术不仅渗透在现代生活的每个方面,而且它们对现在及未来社会中最紧迫的挑战起着关键性作用。 | Hubert Dyasi Derek Bell 刘润林 | 2017 | 中国科技教育2017，0，1： | 14 |
| 8 | 肿瘤细胞的进行性增殖和Bip/GRP78的合成显示文摘目的 探讨肿瘤细胞生长和Bip/GRP78合成的关系。方法 利用体外肿瘤细胞培养 ,离子交换色谱、SDS PAGE、特异性酶、化学降解和质谱分析等手段 ,检查生长在指数生长期、汇合期及汇合后期MCF 7、MDA MB 2 31两种人乳腺癌细胞Bip/GRP78的合成情况 ,并与正常人乳腺上皮细胞进行比较。结果 在两种肿瘤细胞进行性生长增殖过程中 ,Bip/GRP78呈赖生长状态、赖细胞密度和赖恶性程度性暴发性合成。结论 肿瘤细胞在生长增殖过程中 ,能通过赖生长状态、赖细胞密度和赖恶性程度性地合成Bip/GRP78来维持其内环境的稳定 ,构筑自身防御机制。因为大量的研究业已证实Bip/GRP78能降低细胞毒性T细胞对瘤细胞的杀伤力、促成肿瘤的生成和抗药性产生、防止肿瘤细胞凋亡等 ,因此有针对性地破坏肿瘤细胞Bip/GRP78合成 ,可为肿瘤的治疗提供一个新方法。 | 蒋志文 LeBourhis Xuefen Hubert Hondermarck | 2002 | 中国药理学通报2002，18，1： | 13 |
| 9 | Effects of Taxotere on invasive potential and multidrug resistance phenotype in pancreatic carcinoma cell line SUIT-2显示文摘INTRODUCTIONDevelopment of drug-resistance to chemotherapyand subsequent metastasis of tumor are primarilyresponsible for treatment failure and the death fromcancer. There have been many previous studies onthe relationship between expression of multidrugresistance (MDR) phenotype P-glycoprotein (P-gp)and the malignant properties of tumors, but theresults are often conflicting[1-8]. The difference intumor types or MDR phenotype induced by specificagents might account for this discrepancy. Taxotere(TXT), a member of the family of taxanes, hasantitumor activity through its effect of promotingthe polymerization of tubulin[9,10]. | Edgar Staren Takeshi Iwamura Hubert Appert John Howard | 2001 | World Journal of Gastroenterology2001，7，1： | 12 |
| 10 | 多功能土地利用 应对未来景观福利和服务需要显示文摘该书是2005年在爱沙尼亚塔图市(Tartu)举行的未来景观网络国际研讨会的论文集,大会主题是“多功能土地利用:应对未来景观福利和服务需要”。传统的土地利用重视土地的生产能力,这种生产能力是同产品产量密切相关的,在对土地的改造中,为了方便运输和管理,大面积种植一种粮食,往往将不同景观特征同质化, | Ulo Mander Katharina Helming Hubert Wiggering 龚剑明(博士) | 2007 | 国外科技新书评介2007，，12： | 11 |
| 11 | Hepatitis C virus infection and apoptosis显示文摘Apoptosis is central for the control and elimination of viral infections. In chronic hepatitis C virus (HCV) infection, enhanced hepatocyte apoptosis and upregulation of the death inducing ligands CD95/Fas, TRAIL and TNFα occur. Nevertheless, HCV infection persists in the majority of patients. The impact of apoptosis in chronic HCV infection is not well understood. It may be harmful by triggering liver fibrosis, or essential in interferon (IFN) induced HCV elimination. For virtually all HCV proteins, pro- and anti-apoptotic effects have been described, especially for the core and NS5A protein. To date, it is not known which HCV protein affects apoptosis in vivo and whether the infectious virions act pro- or anti- apoptotic. With the availability of an infectious tissue culture system, we now can address pathophysiologically relevant issues. This review focuses on the effect of HCV infection and different HCV proteins on apoptosis and of the corresponding signaling cascades. | Richard Fischer Thomas Baumert Hubert E Blum | 2007 | World Journal of Gastroenterology2007，13，36： | 10 |
| 12 | Role of environmental pollution in irritable bowel syndrome显示文摘Irritable bowel syndrome(IBS),with the prevalence of 10%-20 % of the population has become an emerging problem worldwide. IBS is a functional gastrointestinal(GI) disorder characterized by abdominal pain or discomfort and altered bowel habits. The etiology of IBS contains genetic,psychological,and immunological factors,and has not been fully elucidated; of note,recent studies also point at environmental pollution and its role in the development of functional GI diseases. In this review we focus on several environmental factors,such as bacterial contamination,air pollution,radiation and even stress as potential triggers of IBS. We discuss associated disturbances in homeostasis,such as changes in intestinal microbiome and related pathophysiological mechanisms. Based on the effect of environmental factors on the GI tract,we also propose novel targets in IBS treatment. | Mateusz Marynowski Aleksandra Likońska Hubert Zatorski Jakub Fichna | 2015 | World Journal of Gastroenterology2015，21，40： | 10 |
| 13 | Cerebral processing of auditory stimuli in patients with irritable bowel syndrome显示文摘瞄准:用大脑决定功能的磁性的回声成像(fMRI ) 非内脏的刺激的服的处理是否在急躁的肠症候群(IBS ) 被改变病人与健康题目相比。围绕针的内脏躯体集中机制,并且识别心理因素的可能的影响,我们使用了听觉的刺激刺激在他们的感情的质量不同。方法:在 8 个 IBS 病人和 8 控制, fMRI 大小用不同感情的质量(钟声,讨厌的偷看(2000 Hz ) ,中立的词,和感情的词的愉快的声音) 的 4 听觉的刺激的一个块图案被执行。坡度回响 T2 * 加权的顺序被用于功能的扫描。统计地图用一般线性模型被构造。结果:到感情的听觉的刺激,,相对控制的 IBS 病人在感情的处理区域的一个更大的变化与更强壮的释放反应了反应模式,在控制不同,没在令人烦恼或愉快的声音之间区分。到中立听觉的刺激,由对比,仅仅 IBS 病人与大重要激活反应了。结论:到在感情的处理刺激的区域的听觉的刺激的改变的服的反应模式建议在 IBS 的改变的感觉处理不能为内脏的感觉是特定的,但是可能在感情的敏感和感情方面的反应反映概括变化,可能与经常在 IBS 病人发现的心理 comorbidity 联系了。 | Viola Andresen Alexander Poellinger Chedwa Tsrouya Dominik Bach Albrecht Stroh Annette Foerschler Petra Georgiewa Marco Schmidtmann Ivo R van der Voort Peter Kobelt Claus Zimmer Bertram Wiedenmann Burghard F Klapp Hubert Monnikes | 2006 | World Journal of Gastroenterology2006，12，11： | 8 |
| 14 | Two-phase air-water flows: Scale effects in physical modeling显示文摘Physical modeling represents probably the oldest design tool in hydraulic engineering together with analytical approaches. In free surface flows, the similitude based upon a Froude similarity allows for a correct representation of the dominant forces, namely gravity and inertia. As a result fluid flow properties such as the capillary forces and the viscous forces might be incorrectly reproduced, affecting the air entrainment and transport capacity of a high-speed model flow. Small physical models operating under a Froude similitude systematically underestimate the air entrainment rate and air-water interfacial properties. To limit scale effects, minimal values of Reynolds or Weber number have to be respected. The present article summarizes the physical background of such limitations and their combination in terms of the Morton number. Based upon a literature review, the existing limits are presented and discussed, resulting in a series of more conservative recommendations in terms of air concentration scaling. For other air-water flow parameters, the selection of the criteria to assess scale effects is critical because some parameters(e.g., bubble sizes, turbulent scales) can be affected by scale effects, even in relatively large laboratory models. | PFISTER Michael CHANSON Hubert | 2014 | Journal of Hydrodynamics2014，26，2： | 7 |
| 15 | 浅论基于机器人手术辅助培训系统的“初、中、高”级培训体系显示文摘随着机器人手术在全球范围内迅猛发展,微创外科逐渐由普通腹腔镜时代过渡到机器人手术时代。由于对操作模式的不熟悉,大部分的副损伤和手术并发症发生在术者学习曲线的初段。患者的生命安全和手术者的职业安全凸显了手术机器人培训工作的重要性。 | 杨琨 张林 王行环 Jacques HUBERT | 2016 | 中华医学杂志2016，96，18： | 6 |
| 16 | 建立广州生物库进行慢性重大疾病研究概述显示文摘目的报告《建立广州生物库进行慢性重大疾病研究》过去十年的研究进展和今后十年的研究展望。方法选择≥50岁的30 518名有广州市户籍的居民,收集其个人背景资料、职业接触、居住和生活环境与习惯、营养摄入及个人与家族史等详细资料,并作体格检查,血生化检验、尿柯铁宁及心电图、X线胸片与肺功能检测等,同时储存其白细胞与血浆在-196℃液态氮库内使其永生化;定期重复体检随访及电话随访并建立亚队列进行基因、生活方式与职业环境等因素对慢性重大疾病影响的研究。计数资料采用χ2检验,计量资料符合正态分布的采用t检验,不符合正态分布的采用秩和检验,以双侧P<0.05为差异有统计学意义。结果 (1)建立液态氮生物库、条码识别技术与Fico11-Pague分离细胞室及分子流行病学研究室的管理系统;(2)分三个阶段收集30 518名研究对象建立生物库中老年队列;(3)基线资料分析表明,'三高'凸显,男女血压高值分别为24.0%和17.8%,高血压患病率分别为45.3%和41.3%,χ2值为39.89,P<0.001;血糖高值和糖尿病患者男性分别为11.1%和12.0%,略高于女性的9.9%和12.6%,χ2值分别为9.00和2.04,P=0.191和0.293,差异无统计学意义;而高脂血症更为明显,检出率则女性明显高于男性;(4)中央型肥胖、超重和全身性肥胖以及代谢综合征也呈现女性高于男性;短期记忆受损则男性为13.9%,稍高于女性的12.7%,χ2值为8.05,P=0.005;(5)发现不良的生活方式如吸烟、二手烟、饮酒、缺乏体力活动、不良睡眠状态及打鼾对健康的影响,经历不同社会经济环境(生命历程)成长发育对健康的影响,研究已发表论文80多篇;(6)第一次重复体检和电话随访已于2012年12月结束,除606名研究对象因户口迁出或身份证有误无法确定外,成功随访率达98.0%,已知1 801例死亡,随访资料仍在处理和分析中。结论既往十年《广州生物库中老年队列研究》项目已建立标准化的研究平台及完成第一次重复体检与电话随访,未来十年将继续重复体检为主的纵向随访及建立亚队列进行基因、职业与环境因素及生活方式对慢性重大疾病影响的研究,不断向深度和广度发展。 | 江朝强 林大庆 郑家强 刘斌 张维森 靳雅丽 徐琳 Kin Bong Hubert Lam Graham Neil Thomas Peymane Adap 朱彤 梁卓伟 | 2013 | 中国预防医学杂志2013，14，11： | 6 |
| 17 | 次氯酸钙饼剂在饮用水消毒中应用显示文摘针对我国村镇供水工程对消毒技术的需求,采用消毒效果可靠、设备管理简单的次氯酸钙消毒。次氯酸钙消毒由次氯酸钙复配饼剂以及自动化加药器构成。针对次氯酸钙消毒进行了实验室模拟水厂试验,试验结果表明在管道流量为9m3/h时,投加药量为0.3~0.5L/h即可达到国家饮用水卫生标准对出厂水消毒剂余氯要求的限值0.3mg/L,且有效氯浓度稳定、衰减慢。在模拟水厂试验的基础上,将次氯酸钙消毒设施投入水厂实际应用,以廊坊广阳区万庄南水厂为例,探讨次氯酸钙消毒设施的实际运行效果以及最佳运行工况。实际应用表明次氯酸钙消毒效果可靠,设备简单方便,无需设备维护,运行费用低,吨水处理成本约0.012 5元。因此,次氯酸钙饼状消毒剂配备专用自动化加药器在村镇供水工程中具有较大的推广价值。 | 李连香 孙瑞刚 王智勇 田克军 王桂娟 Gordon Dong Hubert Huang | 2012 | 中国农村水利水电2012，，11： | 5 |
| 18 | Combination Therapy With Infliximab and Azathioprine Is Superior to Monotherapy With Either Agent in Ulcerative Colitis显示文摘 | Remo Panaccione Subrata Ghosh Stephen Middleton Juan R. Márquez Boyd B. Scott Laurence Flint Hubert JF. van Hoogstraten Annie C. Chen Hanzhe Zheng Silvio Danese Paul Rutgeerts | 2013 | Gastroenterology2013，，： | 5 |
| 19 | Physical modelling and scale effects of air-water flows on stepped spillways显示文摘During the last three decades, the introduction of new construction materials (e.g. RCC (Roller Compacted Concrete), strengthened gabions) has increased the interest for stepped channels and spillways. However stepped chute hydraulics is not simple, because of different flow regimes and importantly because of very-strong interactions between entrained air and turbu- lence. In this study, new air-water flow measurements were conducted in two large-size stepped chute facilities with two step heights in each facility to study experimental distortion caused by scale effects and the soundness of result extrapolation to pro- totypes. Experimental data included distributions of air concentration, air-water flow velocity, bubble frequency, bubble chord length and air-water flow turbulence intensity. For a Froude similitude, the results implied that scale effects were observed in both facilities, although the geometric scaling ratio was only Lr=2 in each case. The selection of the criterion for scale effects is a critical issue. For example, major differences (i.e. scale effects) were observed in terms of bubble chord sizes and turbulence levels al- though little scale effects were seen in terms of void fraction and velocity distributions. Overall the findings emphasize that physical modelling of stepped chutes based upon a Froude similitude is more sensitive to scale effects than classical smooth-invert chute studies, and this is consistent with basic dimensional analysis developed herein. | CHANSON Hubert GONZALEZ Carlos A. | 2005 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2005，6，3： | 5 |
| 20 | 从多利到波来:用体细胞核转移克隆显示文摘绵羊多利(Dolly)是第一只从成年动物成熟体细胞克隆出来的哺乳动物,这一研究一方面向基础生物发生学原则提出了挑战;另一方面为生殖生物学、医学以及制药学等的基础研究和应用开创了全新的前景。因此,用体细胞核转移克隆的技术具有巨大潜在意义。同时,它也提出了伦理问题,不仅在专业领域,而且在社会上引起广泛的讨论。 | Darius Moradpour Hubert E.Blum 郝连杰 | 1999 | 德国医学1999，16，6： | 5 |
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