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| 1 | Allele-aware chromosome-level genome assembly of Artemisia annua reveals the correlation between ADS expansion and artemisinin yield显示文摘Artemisia annua is the major natural source of artemisinin,an anti-malarial medicine commonly used worldwide.Here,we present chromosome-level haploid maps for two A.annua strains with different artemisinin contents to explore the relationships between genomic organization and artemisinin production.High-fidelity sequencing,optical mapping,and chromatin conformation capture sequencing were used to assemble the heterogeneous and repetitive genome and resolve the haplotypes of A.annua.Approximately 5o,ooo genes were annotated for each haplotype genome,and a triplication event that occurred approximately 58.12million years ago was examined for the first time in this species.A total of 3,903,467-5,193,414 variants(SNPs,indels,and structural variants)were identified in the 1.5-Gb genome during pairwise comparison between haplotypes,consistent with the high heterozygosity of this species.Genomic analyses revealed a correlation between artemisinin concents and the copy number of amorpha-4,11-dienes ynthasegenes.This correlation was further confirmed by resequencing of 36A.annua samples with varied artemisinin contents.Circular consensus sequencing of transcripts facilitated the detection of paralog expression.Collectively,our study provides chromosome-level allele-aware genome assemblies for two A.annua strains and new insights into the biosynthesis of artemisinin and its regulation,which will contribute to conquering malaria worldwide. | Baosheng Liao Xiaofeng Shen Li Xiang Shuai Guo Shiyu Chen Ying Meng Yu Liang Dandan Ding Junqi Bai Dong Zhang Tomasz Czechowski Yi Li Hui Yao Tingyu Mai Caroline Howard Chao Sun Haitao Liu Jiushi Liu Jin Pei Jihai Gao Jigang Wang Xiaohui Qiu Zhihai Huang Hongyi Li Ling Yuan Jianhe Wei lan Graham Jiang Xu Boli Zhang Shilin Chen | 2022 | Molecular Plant2022，15，8： | 9 |
| 2 | Enhancing the competitiveness and sustainability of social enterprises in Hong Kong: A three-dimensional analysis显示文摘Running a social enterprise(SE) is more difficult than running a small or medium-sized enterprise because SEs have to achieve both economic sustainability as business enterprises and their social mission for the benefit of society.After a few years of operation, many SEs fail or struggle for survival. In this study, we examine some of the factors that affect an SE’s profitability, financial management, and business planning and management. Based on in-depth interviews with 22 social enterprises in Hong Kong, we find that SEs with the dual investment objectives of social mission and financial return are more sustainable and competitive than SEs with social impact as their sole objective. Furthermore, SEs managed by non-owner managers have better financial planning and performance than those managed by owner managers. In addition, SEs with an oversight/advisory committee are more competitive and have better management practices than those without such a committee. Our findings have policy implications for government, SEs, funding bodies, and non-profit organizations to enhance and promote the development of the social enterprise sector. | Sidney Leung Phyllis Mo Howard Ling Yanto Chandra So Sum Ho | 2019 | China Journal of Accounting Research2019，，2： | 1 |
| 3 | Serum vascular endothelial growth factor and Doppler blood flow velocities in in vitro fertilization: relevance to ovarian hyperstimulation syndrome and polycystic ovaries显示文摘 | Rina Agrawal Gerard Conway Povilas Sladkevicius Seang Ling Tan Lawrence Engmann Nadia Payne Jinan Bekir Stuart Campbell Howard Jacobs | 1998 | Fertility and Sterility1998，，4： | 1 |
| 4 | Garlic-derived S-allylmercaptocysteine is a novel in vivo antimetastatic agent for androgen-independent prostate cancer 显示文摘 | HOWARD E W LING M T CHUA C W | 2007 | Clin Cancer Res2007，13，6： | 1 |
| 5 | Protective immune responses to the 42-kilodalton (kDa) region of plasmodium yoelii merozoite surface protein 1 are induced by the C-Terminal 19-kDa region but not by the adjacent 33-kDa region显示文摘 | Ahlborg N Ling IT Howard W | 2002 | Infect Immun2002，70，： | 1 |
| 6 | Treatment planning and delivery of intensity-modulated radiation therapy for primary nasopharynx cancer显示文摘 | Margie A Hunt Michael J Zelefsky Suzanne Wolden Chen-Shou Chui Thomas LoSasso Kenneth Rosenzweig Lanceford Chong Spiridon V Spirou Lisa Fromme Moira Lumley Howard A Amols Clifton C Ling Steven A Leibel | 2001 | International Journal of Radiation Oncology Biology Physics2001，，3： | 1 |
| 7 | Protective immune responses to the 42-kilodalton region of Plasmodium yoelii merozoite surface protein 1 are induced by the C-terminal 19-kDa region but not by the adjacent 33-kDa region显示文摘 | Ahlborg N Ling IT Howard W | 2002 | Infect Immun2002，70，： | 1 |
| 8 | CO: A Chemical Ontology for Identification of Functional Groups and Semantic Comparison of Small Molecules显示文摘 | Feldman Howard J Dumontier M Ling Susan | 2005 | FEBS Lett2005，，21： | 1 |
| 9 | Molecular evidence for species-level distinctions in clouded leopards显示文摘 | Buckley-Beason VA Johnson WE Nash WG Stanyon R Menninger JC Driscoll CA Howard J Bush M Page JE Roelke ME Stone G Martelli PP Wen C Ling L Duraisingam RK Lam PV O'Brien SJ | | 0，，： | 1 |
| 10 | Will California Proposition 37 Affect Genetically Modified Food Labeling Policy in the United States显示文摘 | Howard G. Ling Joseph P. Lakatos | 2013 | China-USA Business Review2013，12，6： | 0 |
| 11 | Interferon-related secretome from direct interaction between immune cells and tumor cells is required for upregulation of PD-L1 in tumor cells显示文摘 | Yuan-Qin Yang Wen-Jie Dong Xiao-Fei Yin Yan-Ni XU Yu Yang Jiao-Jiao Wang Su-Jing Yuan Jing Xiao Jonathan Howard DeLong Liang Chu Hai-Neng Xu Xiu- Mei Zhou Ru-Wei Wang Ling Fang Xin-Yuan Liu Kang-Jian Zhang | 2016 | Protein & Cell2016，7，7： | 0 |
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