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| 1 | Early palliative care for patients with metastatic non-small-cell lung cancer显示文摘Comments This landmark article demonstrates that integration of early palliative care with standard oncologic practice shortly after diagnosis may improve quality of life,mood,and overall survival for adults with advanced non-small-cell lung cancer(NSCLC).If validated,these findings could support a paradigm shift in the care of adults with metastatic NSCLC and possibly patients with other tumor types characterized by short survival and high symptom burden. | Temel JS Greer JA Muzikansky A Gallagher ER Admane S Jackson VA Dahlin CM Blinderman CD Jacobsen J Pirl WF Billings JA Lynch TJ | 2010 | 中国肺癌杂志2010，13，9： | 165 |
| 2 | U.S. GEOLOGICAL SURVEY PROGRAMS AND INVESTIGATIONS RELATED TO SOIL AND WATER CONSERVATION显示文摘The U.S. Geological Survey has a rich tradition of collecting hydrologic data, especially for fluxes of water and suspended sediment, that provide a foundation for studies of soil and water conservation. Applied and basic research has included investigations of the effects of land use on rangelands, croplands, and forests; hazards mapping; derivation of flood and drought frequency, and other statistics related to streamflow and reservoir storage; development and application of models of rainfall-runoff relations, chemical quality, and sediment movement; and studies of the interactive processes of overland and channel flow with vegetation. Networks of streamgaging stations and (or) sampling sites within numerous drainage basins are yielding information that extends databases and enhances the ability to use those data for interpretive studies. | W. R. OSTERKAMP and J. R. GRAY Research Hydrologist, U. S. Geological Survey, 1675 W. Anklam Road, Tucson, AZ 85745 U. S. A. Hydrologist, U. S. Geological Survey, 415 National Center, Reston, VA 20192 U. S. A. | 2001 | International Journal of Sediment Research2001，16，3： | 22 |
| 3 | Potential prospects of nanomedicine for targeted therapeutics in inflammatory bowel diseases显示文摘Inflammatory bowel diseases (IBDs) such as Crohn's disease are highly debilitating. There are inconsistencies in response to and side effects in the current conventional medications, failures in adequate drug delivery, and the lack of therapeutics to offer complete remission in the presently available treatments of IBD. This suggests the need to explore beyond the horizons of conventional approaches in IBD therapeutics. This review examines the arena of the evolving IBD nanomedicine, studied so far in animal and in vitro models, before comprehensive clinical testing in humans. The investigations carried out so far in IBD models have provided substantial evidence of the nanotherapeutic approach as having the potential to overcome some of the current drawbacks to conventional IBD therapy. We analyze the pros and cons of nanotechnology in IBD therapies studied in different models, aimed at different targets and mechanisms of IBD pathogenesis, in an attempt to predict its possible impact in humans. | Madharasi VA Pichai Lynnette R Ferguson | 2012 | World Journal of Gastroenterology2012，18，23： | 19 |
| 4 | 艾灸背俞穴联合羟考酮缓释片干预癌痛临床研究显示文摘目的:观察艾灸背俞穴联合盐酸羟考酮缓释片对癌痛患者的镇痛作用。方法:采取随机对照的临床研究模型,纳入病例随机分成两组,对照组给予口服盐酸羟考酮缓释片治疗,观察组在对照组基础上给予艾灸背俞穴,两组疗程均为6 d。采用数字化评估表法(NRS)进行疼痛定量评估,以疼痛缓解率(PAR)评估疼痛改善效率,并于第7天采血清样本,检测IL-6及TNF-α水平。结果:两组治疗后各时段NRS评分均较治疗前显著下降(P均<0.05),观察组治疗后NRS评分均优于对照组(P均<0.05);两组治疗后观察组PAR优于对照组(P<0.05);两组治疗后血清TNF-α水平均较治疗前显著降低(P<0.05)且观察组优于对照组(P<0.05);对照组治疗后血清IL-6水平无明显改变(P>0.05),观察组治疗后血清IL-6水平较治疗前显著降低(P<0.05)。结论:艾灸背俞穴可对盐酸羟考酮缓释片的止痛效果有显著协同作用,初步证实该作用与炎症反应因子IL-6及TNF-α降低有关。 | 陈军 乔海法 李静 刘奇 Karataye Va Kymba | 2020 | 陕西中医2020，41，1： | 15 |
| 5 | Immunoexpression of cyclooxygenase-2 in primary gastric carcinomas and lymph node metastases显示文摘AIM: To evaluate immunoexpression of cyclooxygenase-2 (COX-2) in primary gastric carcinomas and respective lymph node metastases. METHODS: Immunohistochemistry to analyze COX-2 expression was performed on tissue microarray slices obtained from 36 specimens of gastrectomy and satellite lymph nodes from patients with gastric carcinoma. RESULTS: Immunostaining was seen in most cases, and COX-2 expression was higher in lymph node me-tastases than in corresponding primary gastric tumors of intestinal, diffuse and mixed carcinomas, with a statistically signif icant difference in the diffuse histotype (P = 0.0108). CONCLUSION: COX-2 immunoexpression occurs frequently in primary gastric carcinomas, but higher expression of this enzyme is observed in lymph node metastases of the diffuse histotype. | Paulo RC Almeida Francisco VA Ferreira Cássio C Santos Francisco D Rocha-Filho Raul RP Feitosa Esther AA Falco Belise K Cavada Roberto CP Lima-Júnior Ronaldo A Ribeiro | 2012 | World Journal of Gastroenterology2012，18，8： | 14 |
| 6 | 菱镁矿区土壤镁污染现状及机理研究进展显示文摘镁是植物生长必需的元素,其作为营养元素的报道较多,而对于土壤镁污染的报道较少。本文介绍了菱镁矿区土壤镁污染现状,根据土壤中镁的物理化学行为阐述了镁污染作用机理,综述了镁污染土壤的治理措施,探讨和分析了研究中存在的主要问题及未来研究的重点方向。 | 付莎莎 李培军 冯倩 贾宏宇 李晓军 Verkhozina VA | 2009 | 生态学杂志2009，28，3： | 10 |
| 7 | Environmental Implications of Excessive Selenium: A Review显示文摘Selenium is a naturally occurring trace element that is nutritionally required in smallamounts but it can become toxic at concentrations only twice those required. The narrow mar-gin between beneficial and harmful levels has important implications for human activities thatincrease the amount of selenium in the environment. Two of these activities, disposal of fbssilfuel wastes and agricultural irrigation of arid, seleniferous soils, have poisoned fish andwildlife, and threatened public health at several locations in the United States. Research stud-ies of these episodes have generated a data base that clearly illustrates the environmental hazardof excessive selenium. It is strongly bioaccumulated by aquatic organisms and even slight in-creases in waterborne concentrations can quickly result in toxic effects such as deformed em-bryos and reproductive failure in wildlife. The selenium data base has been very beneficial indeveloping hazard assessment procedures and establishing environmentally sound water qualitycriteria. The two faces of selenium, required nutrient and Potent toxin, make it a particularlyimportant trace element in the health of both animals and man. Because of this paradox, envi-ronmental selenium in relation to agriculture, fisheries, and wildlife wiIl continue to raise im-POrtant land and water management issues for decades to come. If these issues are dealt withusing prudence and the available environmental selenium data base, adverse irnpacts to naturalresources andspublic health can be | A. DENNIS LEMLY(United States Forest Service, Southern Research Station, Coldwater Fisheries Research Unit, Department of Fisheries and Wildlife Sciences, Virginia Tech University, Blacksburg, VA 24061-0321, USA) | 1997 | Biomedical and Environmental Sciences1997，10，4： | 10 |
| 8 | Regulatory mechanisms for abnormal expression of the human breast cancer specific gene 1 in breast cancer cells显示文摘Breast cancer-specific gene 1 (BCSG1), also referred as synuclein γ, was originally iso-lated from a human breast cancer cDNA library and the protein is mainly localized to presynaptic terminals in the nervous system. BCSG1 is not expressed in normal or benign breast lesions, but expressed at an extremely high level in the vast majority of the advanced staged breast carcinomas and ovarian carcinomas. Overexpression of BCSG1 in cancer cells led to significant increase in cell proliferation, motility and invasiveness, and metastasis. To elucidate the molecular mechanism and regulation for abnormal transcription of BCSG1, a variety of BCSG1 promoter luciferase reporters were constructed including 3′ end deleted sequences, Sp1 deleted, and activator protein-1 (AP1) domains mutated. Transient transfection assay was used to detect the transcriptional activation of BCSG1 promoters. Results showed that the Sp1 sequence in 5′-flanking region was involved in the basal transcriptional activities of BCSG1 without cell-type specificity. In comparison to pGL3-1249, the reporter activities of pGL3-1553 in BCSG1-negative MCF-7 cells and pGL3-1759 in HepG2 cells were notably decreased. Mutations at AP1 sites in BCSG1 intron 1 significantly reduced the promoter ac-tivity in all cell lines. Transcription factors, c-jun, c-fos and cyclin AMP-responsive element binding (CREB) protein, could markedly enhance the promoter activities. Thus, our results suggest that the abnormal expression of BCSG1 in breast cancer cells is likely regulated by multiple mechanisms. The 5′ flanking region of BCSG1 provides the basal transcriptional activity without cell type specificity. A critical promoter element involved in abnormal expression of BCSG1 presents in the first exon. The cell type specificity of BCSG1 transcription is probably affected through intronic cis-regulatory se-quences. AP1 domains in the first intron play an important role in control of BCSG1 transcription. | LU Aiping1, LI Qing1, LIU Jingwen2 1. Department of Pathology, Peking University School of Oncology, Beijing Cancer Hospital, Beijing 100036, China 2. VA Palo alto Health Care System, Palo Alto, California, CA 94304, USA | 2006 | Science China(Life Sciences)2006，49，4： | 8 |
| 9 | Double balloon endoscopy associated pancreatitis:A description of six cases显示文摘AIM:To perform a single-center analysis of all double balloon endoscopy (DBE) related cases of pancreatitis identified prospectively from a recorded DBE-complication database. METHODS:From November 2003 until January 2007, 603 DBE procedures were performed on 412 patients, with data on complications recorded in a database. The setting was a tertiary care center offering DBE. DBE was performed from the antegrade or retrograde route. Out-come measurements included age, gender, medication, indication, DBE-endoscope type, insertion depth, proce-dure duration, findings, interventions, post-procedural abdominal pain, and post-procedural hospitalization. RESULTS:This is the largest single-center study report-ing on post-DBE pancreatitis prospectively. Six patients (1.0%) developed post-DBE pancreatitis, all after antegrade DBE. There was no association with gender, duration of the procedure or type of endoscope. The mean age was 51.9 years (range 25-78). Four patients had severe pancreatitis. Of these, two had inflammatory signs in the body-tail region, one had pancreatitis in the tail region, and the total pancreas was involved in one. CONCLUSION:The incidence of post-DBE pancreatitis in our series is higher than previously reported. We found no relation with DBE-endoscope type. The inflammatory changes occurred in the body-tail region of the pancreas, suggesting that post-DBE pancreatitis is caused by repetitive mechanical strain on the pancreas. | Soeresh VA Jarbandhan Stijn JB van Weyenberg Willem M van der Veer Dimitri GN Heine Chris JJ Mulder Maarten AJM Jacobs | 2008 | World Journal of Gastroenterology2008，14，5： | 8 |
| 10 | Biogeochemical cycles of selenium in Antarctic water显示文摘BiogeochemicalcyclesofseleniuminAntarcticwater￥XiaWeiping(DepartmentofOceanography,OldDominionUniversity,Norfolk,VA23529,USA)... | Xia Weiping (Department of Oceanography, Old Dominion University, Norfolk,VA 23529,USA)Zhang Haishen (Second Institute of Oceanography,SOA,Hangzhou 310012,China)Tan Jianan (Institute of Geography,Chinese Academy of Sciences,Beijing 100101,China) | 1996 | Journal of Environmental Sciences1996，8，1： | 6 |
| 11 | Design of multiple anti-windup loops for multiple activations显示文摘This paper considers anti-windup design for linear systems subject to actuator saturation.Three anti-windup gains are designed for activations immediately at the occurrence actuator saturation,after the saturation has reached a certain level and in anticipation of the occurrence of saturation,respectively.The design is based on the minimization of L 2 gain from the disturbance to the controlled output of the resulting closed-loop system.Traditional anti-windup scheme involves a single anti-windup loop for immediate activation.A recent innovation is to design a single anti-windup loop for delayed or anticipatory activation,as well as to design two anti-windup gains,one for immediate activation and one for delayed activation.Our design of three anti-windup gains for three different activations is shown through simulation to lead to significant further performance improvement over the previous activation schemes. | WU XiongJun 1,2 & LIN Zongli 3,1 1 Department of Automation,Shanghai Jiao Tong University,and Key Laboratory of System Control and Information Processing,Ministry of Education of China,Shanghai 200240,China 2 No.802 Institute of Shanghai Academy of Space Flight Technology,the Eighth Academy of China Aerospace Science and Technology Corporation,Shanghai 200090,China 3 Charles L.Brown Department of Electrical and Computer Engineering,University of Virginia,P.O.Box 400743,Charlottesville,VA 22904-4743,USA | 2012 | Science China(Information Sciences)2012，55，9： | 5 |
| 12 | Residual renal function in peritoneal dialysis with failed allograft and minimum immunosuppression显示文摘Immunosuppression(IS) is often withdrawn in patients with end stage renal disease secondary to a failed renal allograft, and this can lead to an accelerated loss of residual renal function(RRF). As maintenance of RRF appears to provide a survival benefit to peritoneal dialysis(PD) patients, it is not clear whether this benefit of maintaining RRF in failed allograft patients returning to PD outweigh the risks of maintaining IS. A 49 year-old Caucasian male developed progressive allograft failure nine years after living-donor renal transplantation. Hemodialysis was initiated via tunneled dialysis catheter(TDC) and IS was gradually withdrawn. Two weeksafter IS withdrawal he developed a febrile illness, which necessitate removal of the TDC and conversion to PD. He was maintained on small dose of tacrolimus(1 mg/d) and prednisone(5 mg/d). Currently(1 year later) he is doing exceedingly well on cycler-assisted PD. Residual urine output ranges between 600-1200 m L/d. Total weekly Kt/V achieved 1.82. RRF remained well preserved in this patient with failed renal allograft with minimal immunosuppressive therapy. This strategy will need further study in well-defined cohorts of PD patients with failed allografts and residual RRF to determine efficacy and safety. | Nadear Elmahi éva Csongrádi Kenneth Kokko Jack R Lewin Jamie Davison Tibor Fülp | 2013 | World Journal of Transplantation2013，3，2： | 5 |
| 13 | OPTIMIZATION OF A WAVE CANCELLATION MULTIHULL SHIP USING CFD TOOLS显示文摘A simple CFD tool, coupled to a discrete surface representation and a gradient based optimization procedure, is applied to the design of optimal hull forms and optimal arrangement of hulls for a wave cancellation multihull ship. The CFD tool, which is used to estimate the wave drag, is based on the zeroth order slender ship approximation. The hu ll surface is represented by a triangulation, and almost every grid point on the surface can be used as a design variable. A smooth surface is obtained via a si mplified pseudo shell problem. The optimal design process consists of two steps . The optimal center and outer hull forms are determined independently in the fi rst step, where each hull forms are determined independently in the first step, where each hull keeps the same displacement as the original design while the wav e drag is minimized. The optimal outer hull arrangement is determined in the se cond step for the optimal center and outer hull forms obtained in the first step . Results indicate that the new design can achieve a large wave drag reduction i n comparison to the original design configuration. | C. Yang, R. L■hner, O. Soto (School of Computational Sciences, George Mason University Fairfax VA 22030-4444, USA) | 2002 | Journal of Hydrodynamics2002，14，1： | 5 |
| 14 | Impact of DNA polymorphisms in key DNA base excision repair proteins on cancer risk显示文摘 | Karahalil B Bohr VA Wilson DM | 2012 | EN2012，，10： | 4 |
| 15 | Phytochemical overview and medicinal importance of Coffea species from the past until now显示文摘Coffea(coffee) species are grown in almost all countries along the Equator. Many members of the genus have a large production history and an important role both in the global market and researches. Seeds(Coffeae semen) are successfully used in food, cosmetic, and pharmaceutical industries due to its caffeine and high polyphenol content. Nowadays, the three best-known coffee species are Arabic(Coffea arabica L.), Robusta(Coffea robusta L. Linden), and Liberian coffees(Coffea liberica Hier.). Even though, many records are available on coffee in scientific literature, wild coffee species like Bengal coffee(Coffea benghalensis Roxb. Ex Schult.) could offer many new opportunities and challenges for phytochemical and medical studies. In this comprehensive summary, we focused on the ethnomedicinal, phytochemical, and medical significance of coffee species up to the present. | éva Brigitta Patay Tímea Bencsik Nóra Papp | 2016 | Asian Pacific Journal of Tropical Medicine2016，9，12： | 4 |
| 16 | Alleviated mucosal and neuronal damage in a rat model of Crohn's disease显示文摘AIM:To establish a rat model suitable to investigate the repetitive relapsing inflammations(RRI)characteristic to Crohn’s disease.METHODS:Colitis was induced by 2,4,6-trinitrobenzenesulfonic acid(TNBS).RRI were mimicked by repeating administrations of TNBS.Tissue samples were taken from control,once,twice and three times treated rats from the inflamed and adjacent non-inflamed colonic segments at different timepoints during the acute intestinal inflammation.The means of the ulcerated area were measured to evaluate the macroscopic mu-cosal damage.The density of myenteric neurons was determined on whole mounts by Hu C/Hu D immunohistochemistry.Heme oxygenase-1(HO-1)expression was evaluated by molecular biological techniques.RESULTS:TNBS-treated rats displayed severe colitis,but the mortality was negligible,and an increase of body weight was characteristic throughout the experimental period.The widespread loss of myenteric neurons,and marked but transient HO-1 up-regulation were demonstrated after the first TNBS administration.After repeated doses the length of the recovery time and extent of the ulcerous colonic segments were markedly decreased,and the neuronal loss was on a smaller scale and was limited to the inflamed area.HO-1 m RNA level was notably greater than after a single dose and overexpression was sustained throughout the timepoints examined.Nevertheless,the HO-1protein up-regulation after the second TNBS treatment proved to be transient.Following the third treatment HO-1 protein expression could not be detected.CONCLUSION:Experimentally provoked RRI may exert a protective preconditioning effect against the mucosal and neuronal damage.The persistent up-regulation of HO-1 m RNA expression may correlate with this. | Petra Talapka Lajos István Nagy Alexandra Pál Marietta Zita Poles Anikó Berkó Mária Bagyánszki László Géza Puskás éva Fekete Nikolett Bódi | 2014 | World Journal of Gastroenterology2014，20，44： | 3 |
| 17 | Autoimmune pancreatitis: Functional and morphological recovery after steroid therapy显示文摘自体免疫的胰腺炎,慢性胰炎的一种最近公认的类型,不在其它地方在它的日本,而是报告是稀罕的是相对不平常的。我们在匈牙利报导自体免疫的胰腺炎的第一个外科手术前地诊断的案例,它对类固醇处理作出回应很好并且提供了这改进的 X 光线照相术、功能的证据。与周期性的腹上部的疼痛和 5-kg 重量损失的 4 月的历史介绍的 62 岁的女性。口头的葡萄糖耐量测试(OGTT ) 显示糖尿病和烘便的弹性硬蛋白酶测试的结果是反常的。Ultrasonography (美国) 和 CT 扫描表明了广泛地扩大的胰,并且内视镜后退 cholangiopancreatography (ERCP ) 有在头和尾巴的长苛评的不规则的主要的胰腺的管。自体免疫的胰腺炎被诊断。病人每天在 32 mg 氢化尼松上被开始。在 4 wk 以后, OGTT 和排泄物的弹性硬蛋白酶测试结果使正常化。重复美国和 CT 扫描揭示了 diffuse 的显著改进胰腺,在重复 ERCP 上胀大,变窄的主要的胰腺的管被看见被改善。因为 AIP 能临床上类似于 pancreatobiliary 恶意,或长期或尖锐的胰腺炎,知道这疾病和它的诊断是重要的。然而在有慢性胰炎的对比,它的症状并且词法并且实验室改变被口头的类固醇治疗完全颠倒。 | László Czakó (E|')va Hegyk(o|¨)zi Attila Pálinkás János Lonovics | 2006 | World Journal of Gastroenterology2006，12，11： | 3 |
| 18 | Studies on the Morphology of Natural Rubber/Polyacrylate Interpenetrating Polymer Networks显示文摘The interpenetrating polymer network(IPN) systems have attracted a lot of attention because of their unique two-phase structure and properties. There have been many publications concerning the IPNs in which poly (isoprene) (PIP) or polyacrylates (PAC) is formed as one of the networks.In the present study, Four serles of natural rubber(NR)/PAC IPNs were prepared and their morphologies were investigated with dynamic mechanics analysis(DMA) and transmission electron microscopy (TEM). | Llao Kalrong (Institute of Polymer Science, Zhangshan University, Guangzhou)Thomas C. Ward (Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA) | 1990 | Chemical Research in Chinese Universities1990，6，1： | 3 |
| 19 | Development and validation of a clinical scale for the diagnosis of drug-induced hepatitis显示文摘 | VA Maria RM Victorino | 1997 | Hepatology1997，，3： | 3 |
| 20 | 场依存型学习风格对语言教学的启示(英文)显示文摘学习风格是学习者在学习过程中表现出来的一种整体性的、持久的、具有个性化的认知方式。学习风格有多种类型,不同的学习者有不同的学习风格。在语言学习的表现方面,一般认为“场依存型”学习者受学习环境影响较大,喜欢与人交往,属于感性学习者。这类学习者在正规课堂学习中具有一定的优势。本文主要探讨以认知方式为基础的场依存型学习风格以及这种学习风格对今后教学工作的启示。 | 张涛 Va Neda Perkins(英文校对) | 2006 | 语文学刊(高等教育版)2006，，2： | 3 |
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