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| 1 | 42,573 cases of hepatectomy in China: a multicenter retrospective investigation显示文摘Hepatectomy is currently routinely performed in most hospitals in China. China owns the largest population of liver diseases and the biggest number of liver resection cases. A nationwide multicenter retrospective investigation involving 112 hospitals was performed, and focused on liver resection for patients with hepatocellular carcinoma(HCC). 42,573 cases of hepatectomy were enrolled, and 18,275 valid cases of liver resection for HCC patients were selected for statistical analysis. The epidemiology of HCC, distribution of hepatectomy, postoperative complications and prognosis were finally analyzed. In the 18,275 HCC patients,81% had hepatitis B virus infection and 10% had hepatitis C virus infection. 38% of the HCC patients had normal Alphafetoprotein(AFP) level, and other 35% had an AFP level lower than 400 ng mL^(-1). In the study period, 97% of the hepatectomy for HCC were treated with open surgery, and 23.81% had vascular exclusion techniques. The operation time was(191.7±105.6) min,the blood loss was(546.0±562.8) m L, and blood transfusion was(543.0±1,035.2) m L. The median survival for HCC patients was 631 days, with 1-, 3-, and 5-year overall survival of 73.2%, 28.8% and 19.6%, respectively. Liver cirrhosis, multiple nodules,tumor thrombosis and high AFP level were risk factors that affect postoperative survival. | Binhao Zhang Bixiang Zhang Zhiwei Zhang Zhiyong Huang Yifa Chen Minshan Chen Ping Bie Baogang Peng Liqun Wu Zhiming Wang Bo Li Jia Fan Lunxiu Qin Ping Chen Jingfeng Liu Zhe Tang Jun Niu Xinmin Yin Deyu Li Songqing He Bin Jiang Yilei Mao Weiping Zhou Xiaoping Chen | 2018 | Science China(Life Sciences)2018，61，6： | 39 |
| 2 | cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions显示文摘癌症房间被知道经历新陈代谢的 reprogramming 然而,支撑幸存和快速的增长 oncogenic 损害怎么在各种各样的强调条件下面协调新陈代谢的开关,尚待充分被阐明。这里,我们显示出葡萄糖或夫酸安的那剥夺,为癌症房间的二主要营养来源,被伴随由的戏剧性地激活的丝氨酸生合成小径(SSP ) 提高了 cMyc 表示。我们进一步鉴别那 cMyc 刺激了 SSP 激活由 transcriptionally 多重 SSP 酶的 upregulating 表示。而且,我们证明 cMyc 便于的 SSP 激活导致了提高的谷胱甘肽(GSH ) 生产,房间周期前进和 nucleic 酸合成,它在剥夺营养素的条件下面特别为房间幸存和增长是必要的。我们进一步揭开了那 phosphoserine 磷酸酶( PSPH ), SSP 小径的最后的限制率的酶,在 vitro 并且在 vivo 为 驾驶cMyc 的癌症前进是批评的,并且重要地, PSPH 的异常表示高度在 hepatocellular 与死亡被相关癌( HCC )病人,一般来说建议在这 调整cMyc 的酶,或 SSP 激活之间的一种潜在的原因的关系,并且癌症开发。一起拿,我们的结果表明 cMyc 的那异常表情导致提高的 SSP 激活,新陈代谢的开关的必要部分,在剥夺营养素的条件下面便于癌症前进。 | Linchong Sun Libing Song Qianfen Wan Gongwei Wu Xinghua Li Yinghui Wang Jin Wang Zhaoji Liu Xiuying Zhong Xiaoping He Shengqi Shen Xin Pan Ailing Li Yulan Wang Ping Gao Huiru Tang Huafeng Zhang | 2015 | Cell Research2015，25，4： | 33 |
| 3 | 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers显示文摘象 5-methylcytosine (5mC ) 和 5-hydroxymethylcytosine (5hmC ) 那样的 DNA 修正是知道在哺乳动物影响全球基因表示的 epigenetic 标记。在人的染色体,与基因表示的靠近的关联和高化学的稳定性给他们的流行,这些 DNA epigenetic 标记能为癌症用作理想的 biomarkers 诊断。利用一种高度敏感、选择的化学标记技术,我们这里报导在传播没有房间的 DNA ( cfDNA )并且在从最近与 colorectal 诊断的 260 个病人的一个队收集的配对的肿瘤和邻近的纸巾的 genomic DNA ( gDNA )的 5hmC 的染色体宽的介绍,胃,胰腺,从 90 个健康个人的肝或甲状腺癌症和正常纸巾。5hmC 主要在与开的染色质和容许的 histone 修正重合的 transcriptionally 活跃的区域被散布。柔韧的联系癌症的 5hmC 签名在 cfDNA 被识别为特定的癌症类型是特征的。传播 cfDNA 的 5hmC 底 biomarkers colorectal 和胃的癌症是高度预兆的并且比常规 biomarkers 优异并且比得上从织物活体检视的 5hmC biomarkers。因此,这新策略能从血样品的分析为癌症的诊断和预后导致有效、最低限度地侵略的方法的发展。 | Wenshuai Li Xu Zhang Xingyu Lu Lei You Yanqun Song Zhongguang Luo Jun Zhang Ji Nie Wanwei Zheng Diannan Xu Yaping Wang Yuanqiang Dong Shulin Yu Jun Hong Jianping Shi Hankun Hao Fen Luo Luchun Hua Peng Wang Xiaoping Qian Fang Yuan Lianhuan Wei Ming Cui Taiping Zhang Quan Liao Menghua Dai Ziwen Liu Ge Chen Katherine Meckel Sarbani Adhikari Guifang Jia Marc B Bissonnette Xinxiang Zhang Yupei Zhao Wei Zhang Chuan He Jie Liu | 2017 | Cell Research2017，27，10： | 30 |
| 4 | Genetic analysis and gene mapping of a dominant presenescing leaf gene PSL3 in rice (Oryza sativa L.)显示文摘Leaf senescence as an active process is essential for plant survival and reproduction.However,premature senility is harmful to agricultural production.In this study,a rice mutant,named as psl3 (presescing leaf 3) isolated from EMS-treated Jinhui 10,displays obvious premature senility features both in morphological and physiological level.Genetic analysis showed that mutant trait was controlled by a single dominant gene (PSL3),which was located on rice chromosome 7 between SSR marker c7sr1 and InDel marker ID10 with an interval of 53.5 kb.The result may be useful for the isolation of the PSL3 gene. | FANG LiKui LI YunFeng GONG XiaoPing SANG XianChun LING YingHua WANG XiaoWen CONG YunFei HE GuangHua | 2010 | Chinese Science Bulletin2010，55，23： | 20 |
| 5 | TRPV1 activation improves exercise endurance and energy metabolism through PGC-1α upregulation in mice显示文摘 | Zhidan Luo Liqun Ma Zhigang Zhao Hongbo He Dachun Yang Xiaoli Feng Shuangtao Ma Xiaoping Chen Tianqi Zhu Tingbing Cao Daoyan Liu Bernd Nilius Yu Huang Zhencheng Yan Zhiming Zhu | 2012 | Cell Research2012，22，3： | 18 |
| 6 | RGF1 INSENSITIVE 1 to 5, a group of LRR receptor-like kinases, are essential for the perception of root meristem growth factor I in Arabidopsis thaliana显示文摘RGF1,分泌的肽荷尔蒙,戏在 Arabidopsis 在根分裂组织开发给角色调音。以前的研究显示功能的 RGF1 需要是在由 tyrosylprotein sulfotransferase 的酷氨酸残余的 sulfated 并且 RGF1 主要经由二个下游的抄写因素调整根分裂组织活动,过多 1 (PLT1 ) 并且 PLT2。然而,细胞外的 RGF1 怎么被一个植物房间察觉,是不清楚的。用基因途径,我们发现了充满白氨酸的重复的 clade 像受体的 kinases,指定了为 RGF1 感觉迟钝 1 (RGI1 ) 到 RGI5,用作 RGF1 的受体。二独立 rgi1 rgi2 rgi3 rgi4 rgi5 五倍的异种与分裂组织的一种小尺寸显示一致的短主要的根显型。四倍的异种显示出的 rgi1 rgi2 rgi3 rgi4 到 RGF1 的显著地减少的敏感,和五倍的异种对 RGF1 完全感觉迟钝。PLT1 和 PLT2 的表示在五倍的异种是几乎无法发现的。一个 RGI2 倡导者极大地在五倍的异种驾驶的 PLT2 的宫外的表示救了它的根分裂组织缺点。RGI 之一, RGI1,随后详细生物化学地被分析。在 vitro 点弄污和下拉,分析显示 RGI1 能身体上与 RGF1 交往。RGF1 的外长的申请能快速并且同时导致 RGI1 的 phosphorylation 和 ubiquitination,显示 RGI1 能察觉并且 transduce RGF1 肽信号。然而,激活的 RGI1 多半很快被翻。这些结果表明那 RGI,充当 RGF1 的受体,在在 Arabidopsis thaliana 的 RGF1-PLT-mediated 根分裂组织开发的戏必需品角色。 | Yang Ou Xiaoting Lu Quaner Zi Qingqing Xun Jingjie Zhang Yujun Wu Hongyong Shi Zhuoyun Wei Baolin Zhao Xiaoyue Zhang Kai He Xiaoping Gou Chuanyou Li Jia Li | 2016 | Cell Research2016，26，6： | 18 |
| 7 | What Happened in the Trans-North China Orogen in the Period 2560-1850 Ma?显示文摘Trans 北方中国造山带(TNCO ) 是东方、西方的块沿着混合了形成一个协调 NorthChina 古地台(NCC ) 的一条 Paleoproterozic continent-continentcollisional 带。最近地质,结构,有在东方块的西方的边缘下面的海洋的岩石圈的东方指导俯冲的 geochemical 和 theorogen 沿着东方块的西方的边缘是大陆人边缘或日本类型弧的同位素的数据表演,由旧海洋与西方的块被分开,。在 2550-2520 妈, deepsubduction 引起了媒介降低的外壳的部分融化,生产被侵入进形成 granitoid plutons 在的外壳的上面的层次的丰富的 granitoid 岩浆低 --tomedium 等级花岗石绿岩岩层。在 2530-2520 妈,海洋的岩石圈的俯冲引起了披风楔的部分融化,它在弧在下地壳和普遍 mafic 和次要的 felsic 火山作用在 mafic 岩浆的 plating 下面导致了,形成绿岩集合的部分。普遍 mafic 驾驶到 felsic 火山作用的扩展在造山带导致了发展 ofback 弧或 intra 弧盆。在 2520-2475 妈,俯冲引起了形成大量 tonalitic-trondhjemitic-granodioritic (TTG ) 的下地壳的进一步偏爱的融化岩浆酌。背弧盆的在这时候后面的进一步的扩展,阵发性的 granitoidmagmatism 发生了,导致 2360 妈,的炮兵阵地~ 2 250 妈 2110-21760 妈和~ 2 在造山带的 050 Magranites。当代的火山沉积的岩石在背弧 orintra 弧盆发展了。在 2150-1920 妈,造山带经历了几前紧张的事件,一条海洋的山脉的可能到期的 tosubduction,导致是的 mafic 女同性恋的炮兵阵地随后变形了到角闪岩和媒介 -- 到高压的 mafic granulites。在 1880-1820 妈,在东方、西方的块之间的海洋被俯冲完全消费,并且关门海洋导致了 continent-arc-continent 碰撞,它引起了大规模推进和等斜褶皱并且搬运了一些岩石进更低的外壳的层次或上地幔形成 granulites 或 eclogites 。山峰变态被 exhumation/uplift 跟随,导致在岩石中的不对称褶皱和 symplectic 质地的普遍开发。 | Guochun ZHAO LIU Shuwen Min SUN LI Sanzhong Simon WILDE Xiaoping XIA Jian ZHANG Yanhong HE | 2006 | Acta Geologica Sinica(English Edition)2006，80，6： | 16 |
| 8 | U-Pb Zircon Dating of the Granitic Conglomerates of the Hutuo Group:Affinities to the Wutai Granitoids and Significance to the Tectonic Evolution of the Trans-North China Orogen显示文摘与在中间的最好、古典的剖面图 Trans 北方 ChinaOrogen 分割的邻近的 Fuping 和 Hengshan Complexesrepresents 联系的 Wutai 建筑群,通常划分了成东方、西方的块。Unconformably overlying Wutai andFuping 建筑群 Hutuo 组在这个区域被看作最年轻的岩石地层单位并且为解释前寒武纪的历史以及 theTrans 北方中国造山带的全面进化重要。在这个组的沉积岩的起源的知识的缺乏妨碍了 depositional 和构造意义的理解。LA-ICP-MS 被使用为花岗石的卵石获得 U-Pb 锆石年龄, Hutuo 组的最低岩石层位学的岩石,它,与结合了以前的岩石层位学, geochronological,结构、变形的数据,在沉积起源和这个区域的构造进化上提供新限制。Hutuo 的顺序从更低的底砾岩 andvolcaniclastic 岩石(Doucun 亚群) 向上组织范围,通过碎屑沉积物,板岩,白云石和云石(Dongye 亚群) ,到在顶(Guojiazhai 亚群) 的沙岩和集团企业。从在 Doucun 亚群底砾岩保存的花岗石的卵石的锆石给加权的mean~( 207 )在 2517 妈和 2566 妈之间的Pb/~( 206 ) Pb 年龄,它与为迟了的 ArcheanWutai Granitoids 的那些一样,显示卵石从 Wutai 花岗石的侵入( 2566-2515 妈)被导出。基于新数据和以前的研究,与在 Hutuo 组为 volcanics 获得的 2087 ±9 妈的火的锆石结晶化年龄结合了, Hutuo 组在在东方块的西方的边缘下面在西方的块的东方指导俯冲期间在 theWutai 弧后面发展了的subduction相关的制动火箭弧低岬盆环境被扔。这盆经历了长寿沉积并且最后在~ 1 期间关上了导致了北方中国古地台的最后的合并的 850 妈 collisional 事件。 | Jian ZHANG Guochun ZHAO LI Sanzhong Min SUN LIU Shuwen Xiaoping XIA Yanhong HE | 2006 | Acta Geologica Sinica(English Edition)2006，80，6： | 15 |
| 9 | Genome-Wide Expression Pattern Analyses of the Arabidopsis Leucine-Rich Repeat Receptor-Like Kinases显示文摘像受体的蛋白质 kinases (RLK ) 是在房间房间和房间环境通讯起关键作用的 transmembrane 蛋白质的一个大组。基于细胞外的领域结构, RLK 被分类进超过 21 个亚科,充满白氨酸的重复 RLK (LRR-RLKs ) 在象 Arabidopsis 和米饭那样的植物在之中属于最大的亚科。在 Arabidopsis,有近似 223LRR-RLKs,但是哪个中的仅仅大约 60 个机能上地迄今为止被描述了。为了系统地在调整调查 LRR-RLKs 的 theroles,种生长,开发,和压力改编,我们产生了 promoter::GUS 为在 Arabidopsis 的所有 223 LRR-RLK 基因的转基因的植物并且在各种各样的发展舞台分析了他们的详细表达式模式。Theresults 提供 forfunctionally 阐明的珍贵资源这个大、必要的发信号的蛋白质亚科。 | Yunzhe Wu Qingqing Xun Yi Guo Jinghua Zhang Kaili Cheng Tao Shi Kai He Suiwen Hou Xiaoping Gou Jia Li | 2016 | Molecular Plant2016，9，2： | 13 |
| 10 | U-Pb Age and Hf Isotope Study of Detrital Zircons from the Wanzi Supracrustals:Constraints on the Tectonic Setting and Evolution of the Fuping Complex,Trans-North China Orogen显示文摘在 Trans 北方中国造山带的中间的片断定位了, FupingComplex 在理解北方 ChinaCraton (NCC ) 的进化历史被看作一个批评区域。建筑群由各种各样的高级、多样地使变形的岩石组成,包括灰色的片麻岩,基本 granulite,角闪岩,有细密纹理的片麻岩和大理石,变形了到上面的角闪岩或 granulite 外形。它能被划分成四个岩石单位:Fuping TTG 片麻岩, Longquanguan augen, Wanzi 在上 crustals,和 Nanying 花岗石的片麻岩。从 FupingComplex 的 Wanzi 在上 crustals 的大约 200 由岩屑形成的锆石的 U-Pb 年龄和 Hfisotope 作文被分析了。边界给的变形锆石上的数据 1.82-1.84 Ga 变老,相应于 NCC 的最后的合并事件为在~ 2 .10 和~ 2 .51 Ga 的火的锆石核心产量二年龄人口的数据,与在第 2.5a 2.9 Ga 之间散布的一些继承年龄。这些结果建议 Wanzi 在上 crustals 从 Fuping TTGgneisses (~ 2 .5 Ga ) 和 Nanying 花岗石的片麻岩(2.0-2.1 Ga ) 被导出并且在 2.10 and1.84 Ga 之间扔了。有~ 2 .51 Ga 年龄的所有锆石有起始的ε _(Hf ) 从 +1.4 珍视到 +10.9 的 positive,建议在通过从披风的少年材料的增加的~ 2 .5 Ga 的一个重要外壳的生长事件。为由岩屑形成的锆石的 Hf 同位素数据进一步暗示 2.8 Ga 岩石是在下地壳的重要部件,它与从为东方块的 Nd 同位素数据的一个建议一致。 2.10 Ga 人口的锆石有起始的ε_( Hf ) -4.9 to+6.1 的价值,作为在 2.1 Ga.These 结果与次要的少年材料贡献外壳的再融化混合解释了为西方的块从那是不同的,支持 Fuping 建筑群是在在东方块的西方的边缘的构造活跃环境的 emplaced 。 | Xiaoping XIA Min SUN Guochun ZHAO WU Fuyuan XU Ping Jian ZHANG Yanhong HE ZHANG Jiheng | 2006 | Acta Geologica Sinica(English Edition)2006，80，6： | 12 |
| 11 | Three-dimensional Reconstruction of Geological Solids Based on Section Topology Reasoning显示文摘以便解决动态重建和三维的地质的固体的本地更新问题,推理的拓扑学被用于三维的地质的建模。这能在实现 3D 推进相应的节自动化的水平由构造的地质的稳固的动态重建并且在 3D 上在拓扑学上推理弯了表面。这个方法成功地在南京城市里被使用了地质的建模和当模特儿的 Zijin 金矿。结果证明这个方法适应共面的节和非共面的节数据,并且改进 3D 的效率地质的建模。 | HE Zhenwen WU Chonglong TIAN Yiping MAO Xiaoping | 2008 | Geo-Spatial Information Science2008，11，3： | 12 |
| 12 | Spinal Cord Stimulation Frequency Influences the Hemodynamic Response in Patients with Disorders of Consciousness显示文摘Spinal cord stimulation(SCS) is a promising technique for treating disorders of consciousness(DOCs).However, differences in the spatio-temporal responsiveness of the brain under varied SCS parameters remain unclear. In this pilot study, functional near-infrared spectroscopy was used to measure the hemodynamic responses of 10 DOC patients to different SCS frequencies(5 Hz, 10 Hz, 50 Hz, 70 Hz, and 100 Hz). In the prefrontal cortex, a key area in consciousness circuits, we found significantly increased hemodynamic responses at 70 Hz and 100 Hz, and significantly different hemodynamic responses between 50 Hz and 70 Hz/100 Hz. In addition, the functional connectivity between prefrontal and occipital areas was significantly improved with SCS at 70 Hz. These results demonstrated that SCS modulates the hemodynamic responses and long-range connectivity in a frequency-specific manner(with 70 Hz apparently better), perhaps by improving the cerebral blood volume and information transmission through the reticular formation-thalamus-cortex pathway. | Juanning Si Yuanyuan Dang Yujin Zhang Yaxin Li Wenyue Zhang Yi Yang Yue Cui Xiaoping Lou Jianghong He Tianzi Jiang | 2018 | Neuroscience Bulletin2018，34，4： | 10 |
| 13 | Holocene aeolian stratigraphic sequences in the eastern portion of the desert belt(sand seas and sandy lands) in northern China and their palaeoenvironmental implications显示文摘This paper presents the environmental history and its responses to palaeoclimatic changes since the start of the Holocene in the eastern portion of the desert belt(sand seas and sandy lands) in northern China by comparing the aeolian sandpalaeosol sequences and their palaeoclimatic proxies. The optically stimulated luminescence(OSL) ages of the aeolian sandpalaeosol sedimentary sequences and a series of palaeoenvironmental proxies show that:(1) The large-scale dune landscape currently in the Kubuqi Sand Sea was formed during the Holocene in general;and the palaeosol was generally developed during the period of 4–2 ka, indicating conditions favorable for vegetation growth, soil development, and organic carbon accumulation due to increased precipitation or effective moisture and weakened aeolian activities;the large-scale expansion of dunes in the recent 2 ka is closely linked to human activities. The variable discharge of the Yellow River with diversions for irrigation may have resulted in a more consistent supply of aeolian particles for dune field expansion.(2) The dune landscape of the Hunshandake Sandy Land was likely formed around 12 ka, and before this, the western part of the Hunshandake Sandy Land would have been covered by a single large lake;it was obviously wetter than today in the sandy land during the period of 9.6–3 ka and the palaeosols were developed at the same time. But the aeolian activities have not been completely dormant in this long-lasting wetter epoch;because the Holocene wetter period was likely time-transgressive across the region.(3) The palaeosol of the Hulunbuir Sandy Land began to develop as early as 14.5 ka, probably continuing until the last 2 ka. The palaeosol development of various dune fields in the eastern portion of the desert belt(sand seas and sandy lands) in northern China is spatially heterogeneous, and even the palaeosol development time in different locations within each sandy land is inconsistent. During the middle Holocene(especially the 7.5–3.5 ka), all the sandy lands were stabilized in general and the intensity of aeolian activities was significantly weakened. The number of palaeoenvironmental records in the eastern portion of the desert belt(sand seas and sandy lands) in northern China has increased rapidly in the past decade, but the amount of published data still does not match the vast extent of the dune fields. It does require much more in-depth palaeoenvironmental studies for a full understanding of the relationship between aeolian activities and climate change in northern China. | Xiaoping YANG Peng LIANG Deguo ZHANG Hongwei LI Patrick RIOUAL Xulong WANG Bing XU Zhibang MA Qianqian LIU Xiaozong REN Fangen HU Yuxin HE Gang RAO Ninghua CHEN | 2019 | Science China Earth Sciences2019，62，8： | 10 |
| 14 | SERK Receptor-like Kinases Control Division Patterns of Vascular Precursors and Ground Tissue Stem Cells during Embryo Development in Arabidopsis显示文摘During embryo development, the vascular precursors and ground tissue stem cells divide to renew them-selves and produce the vascular tissue, endodermal cells, and cortical cells. However, the molecular mech-anisms regulating division of these stem cells have remained largely elusive. In this study, we show that loss of function of SOMATIC EMBRYOGENESIS RECEPTOR-UKE KINASE (SERK) genes results in aberrant em-bryo development. Fewer cortical, endodermal, and vascular cells are generated in the embryos of serk1 serk2bak1 triple mutants. WUSCHEL-RELATED HOMBOBOX5 (WOXS) is ectopically expressed in vascular cells of serkl serk2 bak1 embryos. The first transverse division of vascular precursors in mid-globular em-bryos and second asymmetric division of ground tissue stem cells in early-heart embryos are abnormally altered to a longitudinal division. The embryo defects can be partially rescued by constitutively activated mitogen-activated protein kinase (MAPK) kinase kinase YODA (YDA) and MAPK kinase MKK5. Taken together, our results reveal that SERK-mediated signals regulate division patterns of vascular precursors and ground tissue stem cells, likely via the YDA-MKK4/5 cascade, during embryo development. | Huiqiang Li Zeping Cai Xiaojuan Wang Meizhen Li Yanwei Cui Nan Cui Fei Yang Mingsong Zhu Junxiang Zhao Wenbin Du Kai He Jing Yi Frans E.Tax Suiwen Hou Jia Li Xiaoping Gou | 2019 | Molecular Plant2019，12，7： | 7 |
| 15 | The ignored emission of volatile organic compounds from iron ore sinter process显示文摘Iron ore sintering is a major source of gaseous and particulate pollutants emission in iron smelt plant. The aim of present study is to characterize the volatile organic compounds(VOCs) emission profiles from iron ore sintering process. Both sinter pot test and sinter simulation experiment were conducted and compared. Out results showed that sinter process produced large quantity of VOCs together with NOxand SO_2. VOCs and NO were produced simultaneously in sinter pot test from 3 to 24 min after ignition, flowed by SO_2 production from 15 min to the end of sintering. Total VOCs(TVOC) concentration in sinter flue gas was affected by the coal and coke ratio in sinter raw material. The maximum TVOC concentration was 34.5 ppm when using 100% coal as fuel. Sinter simulation experiments found that the number of VOCs species and their concentrations were found by sinter temperature. The largest VOCs species varieties were obtained at 500 °C. Benzene, toluene,xylene and ethylbenzene were major VOCs in sinter flue gas based on the results from both simulation test and sinter pot. It thus demonstrated that in addition to NO_x, SO_2 and metal oxide particles, sinter flue gas also contained significant amount of VOCs whose environmental impact cannot be ignored. Based on our work, it is timely needed to establish a new VOC emission standard for sinter flue gas and develop advanced techniques to simultaneously eliminate multi-pollutants in iron ore sinter process. | Juexiu Li Xiaoping He Bing Pei Xianwei Li Diwen Ying Yalin Wang Jinping Jia | 2019 | Journal of Environmental Sciences2019，31，3： | 7 |
| 16 | Molecular epidemiology demonstrates that imported and local strains circulated during the 2014 dengue outbreak in Guangzhou, China显示文摘The dengue virus(DENV) is a vital global public health issue. The 2014 dengue epidemic in Guangzhou, China, caused approximately 40,000 cases of infection and five deaths. We carried out a comprehensive investigation aimed at identifying the transmission sources in this dengue epidemic. To analyze the phylogenetics of the 2014 dengue strains, the envelope(E) gene sequences from 17 viral strains isolated from 168 dengue patient serum samples were sequenced and a phylogenetic tree was reconstructed. All 17 strains were serotype Ⅰ strains, including 8genotype Ⅰ and 9 genotype V strains. Additionally, 6 genotype Ⅰ strains that were probably introduced to China from Thailand before 2009 were widely transmitted in the 2013 and 2014 epidemics, and they continued to circulate until 2015, with one affinis strain being found in Singapore. The other 2 genotype Ⅰ strains were introduced from the Malaya Peninsula in 2014. The transmission source of the 9 genotype Ⅴ strains was from Malaysia in 2014. DENVs of different serotypes and genotypes co-circulated in the 2014 dengue outbreak in Guangzhou. Moreover, not only had DENV been imported to Guangzhou, but it had also been gradually exported, as the viruses exhibited an enzootic transmission cycle in Guangzhou. | Geng Li Pan Pan Qiuyan He Xiujuan Kong Kailang Wu Wei Zhang Yuntao Liu Huiting Huang Jianbo Liu Zhongde Zhang De Wu Xiaoping Lai Xiaohong Liu Jianguo Wu | 2017 | Virologica Sinica2017，32，1： | 7 |
| 17 | Cross-cultural adaption and psychometric properties of the Chinese version of the Diabetes Behavior Rating Scale: a pilot study显示文摘Self-care behavior plays a major role in diabetic management. However, in China, a satisfactory instrument has not yet been developed to evaluate the compliance of self-care behavior for young patients with type 1 diabetes mellitus(T1 DM). The Diabetes Behavior Rating Scale(DBRS) has a potential to be the first mature instrument. The purpose of this study is to cross-culturally adapt the DBRS, and preliminarily evaluate its psychometric properties. The instrument translation included translation, back translation and culture adaptation. Psychometric properties were assessed in a sample of 116 young patients with T1 DM adapting insulin injection therapy. The Chinese version of the DBRS was divided to four subscales. Cronbach's α for the total scale was 0.92. The mean inter-item and item-total correlations were 0.35 and 0.54 respectively. Test-retest reliability showed good temporal stability(r=0.81, P=0.001). Negative correlations were found between DBRS scores with the Diabetes Distress Scale scores(r=.0.32, P=0.003) and hemoglobin A1 c(HbA1 c) levels(r=.0.36, P=0.002). Higher DBRS scores correlated with better glycemic control. The Chinese insulin injection therapy version of the DBRS is well translated and culturally adapted. It shows good overall reliability and validity and appears to be a valuable tool for assessing the diabetic self-care behaviors for young patients with T1 DM. | Jing Zhu Jingjing Xu Yang Chen Yong Gu Li Ji Yufeng Zhou Min Zhu Hsiang-Ting Hsu Xiaoping Huang Cuiping Yuan Yun Shi Dan Yan Lili Xie Shuang Chen Tao Yang Wei He | 2018 | Science China(Life Sciences)2018，61，3： | 6 |
| 18 | An antiretroviral regimen containing 6 months of stavudine followed by long-term zidovudine for first-fine HIV therapy is optimal in resource-limited settings: a prospective, multicenter study in China显示文摘 | Li Taisheng Guo Fuping Li Yijia Zhang Chengda Han Yang Lye Wei He Yun Lu Hongzhou Xie Jing Huang Aiqiong Li Yanling Tang Xiaoping Wang Hui Zhang Tong Gao Guiju Lei Junkang Zhang Xiaoying Wu Xinhua Sun Yongtao Bai Jinsong Luo Ling Wang Huanlmg | 2014 | Chinese Medical Journal2014，，1： | 6 |
| 19 | Novel Resonant Accelerometer with Micro Leverage Fabricated by MEMS Technology显示文摘For the purpose of improving the precision of the inertial guidance system,it is necessary to enhance the accuracy of the accelerometer.Combining the micro-fabrication processes with resonant sensor technology,a high-resolution inertial-grade novel micro resonant accelerometer is studied.Based on the detecting theory of the resonant sensors,the accelerometer is designed,fabricated,and tested.The accelerometer consists of one proofmass,two micro leverages and two double-ended-tuning-fork (DETF) resonators.The sensing principle of this accelerometer is based on that the natural frequency of the DETF resonator shifts with its axial load which is caused by inertial force.The push-pull configuration of the DETF is for temperature compensation.The two-stage micro leverage mechanisms are employed to amplify the force and increase the sensitivity of the accelerometer.The micro leverage and the resonator are modeled for static analysis and nonlinear modal analysis via theory method and finite element method (FEM),respectively.The geometrical parameters of them are optimized.The amplification factor of the leverage is 102,and the sensitivity of the resonator on theory is about 62 Hz/g.The samples of the accelerometer are fabricated with deep reactive ion etching (DRIE) technology which can get a high-aspect ratio structure for contributing a greater sensing-capacitance.The measuring results of the samples by scanning electron microscopy (SEM) show that the process is feasible,because of the complete structure,the sound combs and micro leverages,and the acceptable errors.The frequency of the resonator and the sensitivity of the accelerometer are tested via printed circuit board (PCB),respectively.The result of the test shows that the frequency of the push-resonator is about 54 530 Hz and the sensitivity of the accelerometer is about 55 Hz/g.The amplification factor of the leverage is calculated more accurately because the coupling of the two stages leverage is considered during derivation of the analysis formula.In addition,the novel differential structure of the accelerometer can greatly improve the sensitivity of the accelerometers. | HE Gaofa TANG Yike ZHOU Chuande HE Xiaoping WU Ying | 2011 | Chinese Journal of Mechanical Engineering2011，24，3： | 5 |
| 20 | Rearrangement and expression of the immunoglobulin μ-chain gene in human myeloid cells显示文摘 | Jing Huang Xiaoping Sun Xiaoting Gong Zhiqiao He Lei Chen Xiaoyan Qiu C Cameron Yin | 2014 | Cellular & Molecular Immunology2014，11，1： | 5 |
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