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| 1 | The predictive value of triglyceride-glucose index for in-hospital and one-year mortality in elderly non-diabetic patients with ST-segment elevation myocardial infarction显示文摘BACKGROUND Triglyceride-glucose(TyG)index,a reliable marker of insulin resistance,was associated with cardiovascular morbidity and mortality.This study aimed to evaluate the predictive value of TyG index for mortality in elderly non-diabetic pa-tients with ST-segment elevation myocardial infarction(STEMI).METHODS In total,430 non-diabetic patients aged over 65 years with STEMI were consecutively included.The TyG index was calculated by using the following formula:TyG index=ln(fasting triglyceride×fasting glucose/2).The 5-item modified frailty index score was utilized to determine comorbidities.Patients were divided into three groups based on TyG index tertiles.RESULTS Patients included into high TyG index tertile were male and had higher body mass index,glucose,triglyceride,low-density lipoprotein cholesterol,5-item modified frailty index and GRACE risk score;and had low systolic blood pressure,estim-ated glomerular filtration rate and left ventricular ejection fraction.A one-unit increase in TyG index was associated with 3.03 ex-tra cases per 1000 person-day for in-hospital mortality and 0.29 extra cases per 1000 person-day for long-term mortality.There was a non-linear relationship between TyG index and the risk of mortality with an increased risk above 8.5 for TyG index.Kaplan-Meier survival curves revealed that patients in high TyG index tertile had higher in-hospital and long-term mortality rates than those in low TyG index tertile.CONCLUSIONS This was the first study to demonstrate that the TyG index could predict in-hospital and long-term mortality in elderly non-diabetic STEMI patients. | FaysalŞaylık TufanÇınar Murat Selçuk İbrahim Halil Tanboğa | 2022 | Journal of Geriatric Cardiology2022，19，8： | 3 |
| 2 | Oncogenic fingerprint of epidermal growth factor receptor pathway and emerging epidermal growth factor receptor blockade resistance in colorectal cancer显示文摘Epidermal growth factor receptor(EGFR) has been an attractive target for treatment of epithelial cancers, including colorectal cancer(CRC). Evidence from clinical trials indicates that cetuximab and panitumumab(antiEGFR monoclonal antibodies) have clinical activity in patients with metastatic CRC. The discovery of intrinsic EGFR blockade resistance in Kirsten RAS(KRAS)-mutant patients led to the restriction of anti-EGFR antibodies to KRAS wild-type patients by Food and Drug Administration and European Medicine Agency. Studies have since focused on the evaluation of biomarkers to identify appropriate patient populations that may benefit from EGFR blockade. Accumulating evidence suggests that patients with mutations in EGFR downstream signaling pathways including KRAS, BRAF, PIK3CA and PTEN could be intrinsically resistant to EGFR blockade. Recent whole genome studies also suggest that dynamic alterations in signaling pathways downstream of EGFR leads to distinct oncogenic signatures and subclones which might have some impact on emerging resistance in KRAS wild-type patients. While anti-EGFR monoclonal antibodies have a clear potential in the management of a subset of patients with metastatic CRC, further studies are warranted to uncover exact mechanisms related to acquired resistance to EGFR blockade. | Zain A Sobani Ashwin Sawant Mikram Jafri Amit Keith Correa Ibrahim Halil Sahin | 2016 | World Journal of Clinical Oncology2016，7，5： | 3 |
| 3 | A longterm experiment to study the role of mulches in the physiology and macro-nutrition of strawberry grown under water stress显示文摘 | Halil K A D Cengiz K B David H C | 2001 | Australian Journal of Agricul- tural Research2001，52，9： | 1 |
| 4 | Stripping/flocculation/membrane bioreactor/reverse osmosis treatment of municipal landfill leachate 显示文摘 | Halil Hasar Sezahat A Unsal Ubeyde Ipek | 2009 | Joumal of Hazardous Materials2009，171，13： | 1 |
| 5 | First trimester markers for the prediction of pre-eclampsia in women with a-priori high risk显示文摘 | halil A Cowans NJ Spencer K otal | 2010 | Uitrasound Obstet Gynecol2010，35，67： | 1 |
| 6 | Dynamic analysis and seismic performance of reinforced concrete minarets显示文摘 | HALIL S RAMAZAN A ADEM D | 2008 | Engineering Structures2008，30，8： | 1 |
| 7 | Primary omentitis as a cause of acute abdomen显示文摘 | Fatih A Muzaffer C Halil D | 2000 | J Pediatric Surgery2000，35，9： | 1 |
| 8 | Decolorization of synthetic dyes by white rot fungi, involving laccase enzyme in the process 显示文摘 | Emrah A Erkurt Ali Unyayar Halil Kumbur | 2007 | Process Biochemistry2007，42，： | 1 |
| 9 | The influ- ence of water deficit onvegetative growth, phys- iology, fruit yield and quality in eggplants显示文摘 | Halil K Cengiz K Ismail T A S | 2001 | J Plant Physiol2001，27，34： | 1 |
| 10 | Advanced Age Is Associated with Endothelial Dysfunction in Healthy Elderly Subjects显示文摘 | Yavuz B B Yavuz B Sener Dede D Cankurtaran M Halil M Ulger Z Nazli N Kabakci G Aytemir K Tokgozoglu L Oto A Ariogul S | 2008 | Gerontology2008，，3： | 1 |
| 11 | Strippin^flocculation/ membrane bioreactor/reverse osmosis treatment of municipal landfill leachate显示文摘 | Halil Hasar Sezahat A Unsal Ubeyde Ipek | 2009 | Journal of Hazardous Materials>2009，171，3： | 1 |
| 12 | Conventional chiller performances simulation and field data显示文摘 | Halil G | 1994 | International Journal of Energy Research1994，18，3： | 1 |
| 13 | Cognitive impairment in amyotrophic lateral sclerosis: evidence from neuropsychological investigation and event-related potentials显示文摘 | Hasmet A Hanagasi I.Hakan Gurvit Numan Ermutlu Gulustu Kaptanoglu Sacit Karamursel Halil A Idrisoglu Murat Emre Tamer Demiralp | 2002 | Cognitive Brain Research2002，，2： | 1 |
| 14 | Superiority of oral phototherapy combination in the treatment of neonatal hyperbilimbincmaia 显示文摘 | Suat C Halil C Sadik A | 1993 | Pediattics1993，9，1： | 1 |
| 15 | First trime- ster maternal serum placental protein 13 for the predicttion of preeelampsia in women with a priorhigh risk显示文摘 | Halil A Cowans N J Spencer K | 2009 | Prenat Diagn2009，29，8： | 1 |
| 16 | Peroral CT enterography with lactulose solution:preliminary observations显示文摘 | Halil A Omer E Mustafa K | | 0，，： | 1 |
| 17 | Determina- tion of Ultra Trace Arsenic Species in Water Sam- ples by Hydride Generation Atomic Absorption Spectrometry After Cloud Point Extraction 显示文摘 | Halil I U Mehmet A Songfil U | 2011 | Analytica Chimica Acta2011，703，： | 1 |
| 18 | Neutrophil activation, protein oxidation and ceruloplasmin levels in children with Henoch-Sch?nlein purpura显示文摘 | Ayd?n Ece Selvi Kelek?i A?k?n Hekimo?lu Halil Kocamaz Hasan Bal?k ?lyas Yolba? ?zcan Erel | 2007 | Pediatric Nephrology2007，，8： | 1 |
| 19 | A rare case of Aeromonas hydrophila catheter related sepsis in a patient with chronic kidney disease receiving steroids and dialysis: a case report and review of Aeromonas infections in chronic kidney disease patients显示文摘 | Halil M A | 2013 | Case Rep Nephrol2013，2013，73： | 1 |
| 20 | Evaluation of the Longus Colli Muscle in Relation to Stellate Ganglion Block显示文摘 | Ye?im Ate? Ibrahim Asik Enver ?zgencil Halil ?brahim A?ar Banu Ya?murlu ?brahim Tekdemir | 2009 | Regional Anesthesia and Pain Medicine2009，，3： | 1 |
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