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1Black hairy tongue syndrome显示文摘Black hairy tongue(BHT) is a benign medical condition characterized by elongated filiform lingual papillae with typical carpet-like appearance of the dorsum of the tongue. Its prevalence varies geographically, typically ranging from 0.6% to 11.3%. Known predisposing factors include smoking, excessive coffee/black tea consumption, poor oral hygiene, trigeminal neuralgia, general debilitation, xerostomia, and medication use. Clinical presentation varies but is typically asymptomatic, although aesthetic concerns are common. Differential diagnosis includes pseudo-BHT, acanthosis nigricans, oral hairy leukoplakia, pigmented fungiform papillae of the tongue, and congenital melanocytic/melanotic nevi/macules. Clinical diagnosis relies on visual observation, detailed history taking, and occasionally microscopic evaluation. Treatment involves identification and discontinuation of the offending agent, modifications of chronic predisposing factors, patient's re-assurance to the benign nature of the condition, and maintenance of adequate oral hygiene with gentle debridement to promote desquamation. Complications of BHT(burning mouth syndrome, halitosis, nausea, gagging, dysgeusia) typically respond to therapy. Prognosis is excellent with treatment of underlying medical conditions. BHT remains an important medical condition which may result in additional burden on the patient and health care system and requires appropriate prevention, recognition and treatment.Grigoriy E Gurvits Amy Tan 2014World Journal of Gastroenterology2014,20,31:12
2Burning mouth syndrome显示文摘Burning mouth syndrome is a debilitating medical condition affecting nearly 1.3 million of Americans.Its common features include a burning painful sensation in the mouth,often associated with dysgeusia and xerostomia,despite normal salivation.Classically, symptoms are better in the morning,worsen during the day and typically subside at night.Its etiology is largely multifactorial,and associated medical conditions may include gastrointestinal,urogenital,psychiatric,neurologic and metabolic disorders,as well as drug reactions.BMS has clear predisposition to peri-/post menopausal females.Its pathophysiology has not been fully elucidated and involves peripheral and central neuropathic pathways.Clinical diagnosis relies on careful history taking,physical examination and laboratory analysis.Treatment is often tedious and is aimed at correction of underlying medical conditions,supportive therapy,and behavioral feedback.Drug therapy with alpha lipoic acid,clonazepam,capsaicin,and antidepressants may provide symptom relief.Psychotherapy may be helpful.Short term follow up data is promising,however,long term prognosis with treatment is lacking.BMS remains an important medical condition which often places a recognizable burden on the patient and health care system and requires appropriate recognition and treatment.Grigoriy E Gurvits Amy Tan 2013World Journal of Gastroenterology2013,19,5:7
3Bleeding with the artificial heart: Gastrointestinal hemorrhage in CF-LVAD patients显示文摘Continuous-flow left ventricular assist devices(CF-LVADs)have significantly improved outcomes for patients with end-stage heart failure when used as a bridge to cardiac transplantation or,more recently,as destination therapy.However,its implantations carries a risk of complications including infection,device malfunction,arrhythmias,right ventricular failure,thromboembolic disease,postoperative and nonsurgical bleeding.A significant number of left ventricular assist devices(LVAD)recipients may experience recurrent gastrointestinal hemorrhage,mainly due to combination of antiplatelet and vitamin K antagonist therapy,activation of fibrinolytic pathway,acquired von Willebrand factor deficiency,and tendency to develop small intestinal angiodysplasias due to increased rotary speed of the pump.Gastrointestinal bleeding in LVAD patients remains a source of increased morbidity including the need for blood transfusions,extended hospital stays,multiple readmissions,and overall mortality.Management of gastrointestinal bleeding in LVAD patients involves multidisciplinary approach in stabilizing the patients,addressing risk factors and performing structured endoluminal evaluation with focus on upper gastrointestinal tract including jejunum to find and eradicate culprit lesion.Medical and procedural intervention is largely successful and universal bleeding cessation occurs in transplanted patients.Grigoriy E Gurvits Elena Fradkov 2017World Journal of Gastroenterology2017,23,22:4
4Black esophagus: Acute esophageal necrosis syndrome显示文摘Acute esophageal necrosis (AEN), commonly referred to as 'black esophagus', is a rare clinical entity arising from a combination of ischemic insult seen in hemodynamic compromise and low-flow states, corrosive injury from gastric contents in the setting of esophago-gastroparesis and gastric outlet obstruction, and decreased function of mucosal barrier systems and reparative mechanisms present in malnourished and debilitated physical states. AEN may arise in the setting of multiorgan dysfunction, hypoperfusion, vasculopathy, sepsis, diabetic ketoacidosis, alcohol intoxication, gastric volvulus, traumatic transection of the thoracic aorta, thromboembolic phenomena, and malignancy. Clinical presentation is remarkable for upper gastrointestinal bleeding. Notable symptoms may include epigastric/abdominal pain, vomiting, dysphagia, fever, nausea, and syncope. Associated laboratory f indings may reflect anemia and leukocytosis. The hallmark of this syndrome is the development of diffuse circumferential black mucosal discoloration in the distal esophagus that may extend proximally to involve variable length of the organ. Classic 'black esophagus' abruptly stops at the gastroesophageal junction. Biopsy is recommended but not required for the diagnosis. Histologically, necrotic debris, absence of viable squamous epithelium, and necrosis of esophageal mucosa, with possible involvement of submucosa and muscularis propria, are present. Classif ication of the disease spectrumis best described by a staging system. Treatment is directed at correcting coexisting clinical conditions, restoring hemodynamic stability, nil-per-os restriction, supportive red blood cell transfusion, and intravenous acid suppression with proton pump inhibitors. Complications include perforation with mediastinal infection/abscess, esophageal stricture and stenosis, superinfection, and death. A high mortality of 32% seen in the setting of AEN syndrome is usually related to the underlying medical co-morbidities and diseases.Grigoriy E Gurvits 2010World Journal of Gastroenterology2010,16,26:4
5Video capsule endoscopy and CT enterography in diagnosing adult hypertrophic pyloric stenosis显示文摘Primary adult hypertrophic pyloric stenosis is a rare but important cause of gastric outlet obstruction that may be misdiagnosed as idiopathic gastroparesis.Clinically,patients present with early satiety,abdominal fullness,nausea,epigastric discomfort and eructation.Permanent gastric retention of a video capsule endoscope is diagnostic in differentiating between the two diseases,in the absence of an organic gastric outlet obstruction.This case presents the longest video capsule retention in the medical literature to date.It is also the first case report of adult hypertrophic pyloric stenosis diagnosed with video capsule endoscopy or a computed tomography scan.Finally,an unusual'plugging'of the gastric outlet with free floating capsule has an augmented effect on disease physiology and on patient’s symptoms.Grigoriy E Gurvits Amy Tan Dmitri Volkov 2013World Journal of Gastroenterology2013,19,37:3
6Enterolithiasis显示文摘Enterolithiasis or formation of gastrointestinal concretions is an uncommon medical condition that develops in the setting of intestinal stasis in the presence of the intestinal diverticula,surgical enteroanastomoses,blind pouches,afferent loops,incarcerated hernias,small intestinal tumors,intestinal kinking from intra-abdominal adhesions,and stenosing or stricturing Crohn’s disease and intestinal tuberculosis.Enterolithiasis is classified into primary and secondary types.Its prevalence ranges from 0.3%to 10%in selected populations.Proximal primary enteroliths are composed of choleic acid salts and distal enteroliths are calcified.Clinical presentation includes abdominal pains,distention,nausea,and vomiting of occasionally sudden but often fluctuating subacute nature which occurs as a result of the enterolith tumbling through the bowel lumen.Thorough history and physical exam coupled with radiologic imaging helps establish a diagnosis in a patient at risk.Complications include bowel obstruction,direct pressure injury to the intestinal mucosa,intestinal gangrene,intussusceptions,afferent loop syndrome,diverticulitis,iron deficiency anemia,gastrointestinal hemorrhage,and perforation.Mortality of primary enterolithiasis may reach 3%and secondary enterolithiasis 8%.Risk factors include poorly conditioned patients with significant obstruction and delay in diagnosis.Treatment relies on timely recognition of the disease and endoscopic or surgical intervention.With advents in new technology,improved outcome is expected for patients with enterolithiasis.Grigoriy E Gurvits Gloria Lan 2014World Journal of Gastroenterology2014,20,47:2
7Mobile robot localization using landmarks显示文摘Betke M Gurvits L 1997IEEE Transactions on Robotics and Automation1997,13,2:1
8On the stability of switched positive linear systems显示文摘GURVITS L SHORTEN R MASON O 2007IEEE Trans on Automatic Control2007,52,6:1
9Magnetic resonance imaging study of hippocampal volume in chronic, combat- elated post traumatic stress disorder 显示文摘Gurvits TV Shenton ME 1996Biopsyehiatry1996,40,:1
10Mobile Robot Localization Using Landmarks显示文摘M Betke L Gurvits 1999IEEE Trans on Robot Automat1999,13,:1
11Attitude control of a space platform/manipulator system using internal motion显示文摘FERNANDES C GURVITS L LI Z 1994The Inter Jour- nat of Robotics Research1994,13,4:1
12Cognitive impairment in amyotrophic Lateral Sclerosis;Ecidence from neuropsychological investigation and event-related potentials显示文摘Hanagasi HA Gurvit IH Ermutle 2002Brain ResCogn Brain Res2002,12,2:1
13Pain is common in Parkinson's disease显示文摘Hanagasi HA Akat S Gurvit H 2011Clinical Neurol and Neurosurg2011,113,:1
14Mobile robot localization using landmarks显示文摘BETKE M GURVITS L 1997IEEE Transactions on Robot Automat1997,13,2:1
15Burning mouth syndrome 显示文摘Gurvits GE Tan A 2013World J Gastroentero12013,19,5:1
16Air under the right diaphragm: eolonoseopy in the setting of Chilaiditi syndrome 显示文摘Grigoriy E Gurvits MD Nancy Lau MD 2009Gastrointest Endosc2009,69,3:1
17The effects of rasagiline on cog- nitive deficits in Parkinson's diseasepatients without dementia: A ran- domized, double-blind, placebo-con- trolled, muhicenter study 显示文摘Hanagasi HA Gurvit H Unsalan P 2011Mov Disord2011,16,10:1
18Magnetic resonance imaging study of hippocampal volume in chronic,combat-related posttraumatic stress disorder显示文摘Gurvits TV Shenton ME Hokama H 0,,11:1
19Magnetic resonance imaging study of hippocampal volume in chronic,combat-related posttraumatic stress disorder显示文摘Gurvits TV Shenton ME Hokama H 1996Biol Psychiatry1996,40,11:1
20Pain is common in Parkinson's disease显示文摘Hanagasi HA Akat S Gurvit H 2011Clin Neurol Neurosur2011,113,:1
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