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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | Diagnostic performance of contrast-enhanced ultrasound and enhanced magnetic resonance for breast nodules显示文摘In the current study, we sought to evaluate the diagnostic efficacies of conventional ultrasound(US), contrastenhanced US(CEUS), combined US and CEUS and magnetic resonance imaging(MRI) in detecting focal solid breast lesions. Totally 117 patients with 120 BI-RADS category 4A-5 breast lesions were evaluated by conventional US and CEUS, and MRI, respectively. SonoVue was used as contrast agent in CEUS and injected as an intravenous bolus; nodule scan was performed 4 minutes after bolus injection. A specific sonographic quantification software was used to obtain color-coded maps of perfusion parameters for the investigated lesion, namely the time-intensity curve.The pattern of contrast enhancement and related indexes regarding the time-intensity curve were used to describe the lesions, comparatively with pathological results. Histopathologic examination revealed 46 benign and 74 malignant lesions. Sensitivity, specificity, and accuracy of US in detecting malignant breast lesions were 90.14%, 95.92%, and 92.52%, respectively. Meanwhile, CE-MRI showed sensitivity, specificity, and accuracy of 88.73%, 95.92%, and91.67%, respectively. The area under the ROC curve for combined US and CEUS in discriminating benign from malignant breast lesions was 0.936, while that of MRI was 0.923, with no significant difference between them, as well as among groups. The time-intensity curve of malignant hypervascular fibroadenoma and papillary lesions mostly showed a fast-in/fast-out pattern, with no good correlation between them(kappa <0.20). In conclusion, the combined use of conventional US and CEUS displays good agreement with MRI in differentiating benign from malignant breast lesions. | Cuiying Li Haiyan Gong Lijun Ling Liwen Du Tong Su Shui Wang Jie Wang | 2018 | The Journal of Biomedical Research2018，32，3： | 27 |
| 3 | Beneficial effects of Houttuynia cordata polysaccharides on “two-hit” acute lung injury and endotoxic fever in rats associated with anti-complementary activities显示文摘Houttuynia cordata Thunb. is a traditional herb used for clearing heat and eliminating toxins,and has also been used for the treatment of severe acute respiratory syndrome(SARS). In vitro, the crude H. cordata polysaccharides(CHCP) exhibited potent anti-complementary activity through both the classical and alternative pathways by acting on components C3 and C4 of the complement system without interfering with the coagulation system. This study was to investigate the preventive effects of CHCP on acute lung injury(ALI) induced by hemorrhagic shock plus lipopolysaccharide(LPS) instillation(two-hit)and LPS-induced fever in rats. CHCP significantly attenuated pulmonary injury in the 'two-hit' ALI model by reducing pulmonary edema and protein exudation in bronchoalveolar lavage fluid(BALF). In addition, it reduced the deposit of complement activation products in the lung and improved oxidantantioxidant imbalance. Moreover, CHCP administration inhibited fever in rats, reduced the number of leukocytes and restored serum complement levels. The inhibition on the inappropriate activation of complement system by CHCP may play an important role in its beneficial effects on inflammatory diseases. The anti-complementary polysaccharides are likely to be among the key substances for the heatclearing function of H. cordata. | Yan Lu Yun Jiang Lijun Ling Yunyi Zhang Hong Li Daofeng Chen | 2018 | Acta Pharmaceutica Sinica B2018，8，2： | 18 |
| 4 | Echinacoside Protects Against MPP+-Induced Neuronal Apoptosis via ROS/ATF3/CHOP Pathway Regulation显示文摘Echinacoside(ECH) is protective in a mouse model of Parkinson's disease(PD) induced by 1-methyl-4-phenylpyridinium ion(MPP^+). To investigate the mechanisms involved, SH-SY5Y neuroblastoma cells were treated with MPP^+or a combination of MPP^+and ECH,and the expression of ATF3(activating transcription factor3), CHOP(C/EBP-homologous protein), SCNA(synuclein alpha), and GDNF(glial cell line-derived neurotrophic factor) was assessed. The results showed that ECH significantly improved cell survival by inhibiting the generation of MPP^+-induced reactive oxygen species(ROS). In addition, ECH suppressed the ROS and MPP^+-induced expression of apoptotic genes(ATF3, CHOP, and SCNA). ECH markedly decreased the MPP^+-induced caspase-3 activity in a dose-dependent manner. ATF3-knockdown also decreased the CHOP and cleaved caspase-3 levels and inhibited the apoptosis induced by MPP^+.Interestingly, ECH partially restored the GDNF expression that was down-regulated by MPP^+. ECH also improved dopaminergic neuron survival during MPP^+treatment and protected these neurons against the apoptosis induced by MPTP. Taken together, these data suggest that the ROS/ATF3/CHOP pathway plays a critical role in mechanisms by which ECH protects against MPP^+-induced apoptosis in PD. | Qing Zhao Xiaoyan Yang Dingfang Cai Ling Ye Yuqing Hou Lijun Zhang Jiwei Cheng Yuan Shen Kaizhe Wang Yu Bai | 2016 | Neuroscience Bulletin2016，32，4： | 14 |
| 5 | Urban expansion in China and its effect on cultivated land before and after initiating'Reform and Open Policy'显示文摘Urbanization in China has expanded at an unprecedented speed since the declaration of 'Reform and Open Policy'and presented many challenges. Unbalanced regional development, appearance of super megacities and concomitant problems,and conflicts between urbanization and cultivated land protection are three critical problems that Chinese urbanization has to face. To develop new plans for foreseeable future urbanization in China, it is critical to understand the evolving history of cities across China. This study maps urban expansion of 60 typical Chinese cities based on large amount of remote sensing data and the labor-intensive image interpretation method, in order to understand the history of urban expansion from the 1970 s to 2013.Results showed that area of cities expanded 5.23 times compared to their area in the 1970 s. Urban expansion in China accelerated three times(1988–1996, 1999–2006, and 2009–2011) and decelerated three times(1997–1998, 2007–2008, and 2012–2013) over the 40 years. The urban area of South China expanded most significantly 9.42 times, while the urban area in Northeast China expanded only 2.37 times. The disparity among different administrative ranks of cities was even greater than(3.81 times) the differences among different regions. Super megacities have been continuously expanding at a fast rate(8.60-fold), and have not shown obvious signs of slowing down. The proportion of cultivated land among the land sources for urban expansion decreased to a small extent in the 1990 s, but cultivated land continues to be the major land source for urban expansion. Effective future urbanization needs controlling the expansion scale of large cities and reasonably developing medium and small cities, as well as balancing regional development. | ZHANG ZengXiang WEN QingKe LIU Fang ZHAO XiaoLi LIU Bin XU JinYong YI Ling HU ShunGuang WANG Xiao ZUO LiJun LI Na LI MinMin SHI LiFeng ZENG Tian JU HongRun | 2016 | Science China Earth Sciences2016，59，10： | 12 |
| 6 | Subduction tectonics vs.plume tectonics——Discussion on driving forces for plate motion显示文摘Plate tectonics describes the horizontal motions of lithospheric plates,the Earths outer shell,and interactions among them across the Earths surface.Since the establishment of the theory of plate tectonics about half a century ago,considerable debates have remained regarding the driving forces for plate motion.The early'Bottom up'view,i.e.,the convecting mantledriven mechanism,states that mantle plumes originating from the core-mantle boundary act at the base of plates,accelerating continental breakup and driving plate motion.Toward the present,however,the'Top down'idea is more widely accepted,according to which the negative buoyancy of oceanic plates is the dominant driving force for plate motion,and the subducting slabs control surface tectonics and mantle convection.In this regard,plate tectonics is also known as subduction tectonics.'Top down'tectonics has received wide supports from numerous geological and geophysical observations.On the other hand,recent studies indicate that the acceleration/deceleration of individual plates over the million-year timescale may reflect the effects of mantle plumes.It is also suggested that surface uplift and subsidence within stable cratonic areas are correlated with plumerelated magmatic activities over the hundred-million-year timescale.On the global scale,the cyclical supercontinent assembly and breakup seem to be coupled with superplume activities during the past two billion years.These correlations over various spatial and temporal scales indicate the close relationship and intensive interactions between plate tectonics and plume tectonics throughout the history of the Earth and the considerable influence of plumes on plate motion.Indeed,we can acquire a comprehensive understanding of the driving forces for plate motion and operation mechanism of the Earth's dynamic system only through joint analyses and integrated studies on plate tectonics and plume tectonics. | Ling CHEN Xu WANG Xiaofeng LIANG Bo WAN Lijun LIU | 2020 | Science China Earth Sciences2020，63，3： | 10 |
| 7 | Spatial and temporal variations of coastlines in northern China (2000-2012)显示文摘This study examined the spatial distribution of the continent coastline in northern China using remote sensing and GIS techniques,and calculated the fractal dimension of the coastline by box-counting method,with a time span from 2000 to 2012.Moreover,we analyzed the characteristics of spatial-temporal changes in the coastline's length and fractal dimension,the relationship between the length change and fractal dimension change,and the driving forces of coastline changes in northern China.During the research period,the coastline of the study area increased by 637.95 km,at a rate of 53.16 km per year.On the regional level,the most significant change in coastline length was observed in Tianjin and Hebei.Temporally,the northern China coastline grew faster after 2008.The most dramatic growth was found between 2010 and 2011,with an increasing rate of 2.49% per year.The fractal dimension of the coastline in northern China was increasing during the research period,and the most dramatic increase occurred in Bohai Rim.There is a strong-positive linear relationship between the historical coastline length and fractal dimension(the correlation coefficient was 0.9962).Through statistical analysis of a large number of local coastline changes,it can be found that the increase(or decrease) of local coastline length will,in most cases,lead to the increase(or decrease) of the whole coastline fractal dimension.Civil-coastal engineering construction was the most important factor driving the coastline change in northern China.Port construction,fisheries facilities and salt factories were the top three construction activities.Compared to human activities,the influence of natural processes such as estuarine deposit and erosion were relatively small. | XU Jinyong ZHANG Zengxiang ZHAO Xiaoli WEN Qingke ZUO Lijun WANG Xiao YI Ling | 2014 | Journal of Geographical Sciences2014，24，1： | 10 |
| 8 | IL-37b suppresses T cell priming by modulating dendritic cell maturation and cytokine production via dampening ERK/NF-κB/S6K signalings显示文摘Interleukin 37b (IL-37b ) 在压制有免疫力的回答起一个关键作用,部分由 modulating 树枝状的房间(DC ) 的功能。然而,精确机制大部分仍然是未知的。这里,我们在回答由 DC 导致了的 DC 成熟和 T 房间上调查了 IL-37b 的效果,并且探索了深奥发信号的小径。它被发现那 IL-37b 下面调整在 vitro 的 DC 上的 co-stimulatory 分子 CD80 和 CD86 的表情。同时,支持 inflammatory cytokines 的表情例如 TNF-6, 和 IL-6,被压制,当时 T 房间的表示禁止的 cytokine TGF- 在 IL-37b-treated DC 被增加。另外, T 房间上的 DC 的激活效果被 IL-37b 损害。我们进一步表明细胞外的调整单人赛的 kinase (英皇家空军之阶级最低之兵) ,原子 factor-B (NF-B ) ,和表明小径的 mTOR-S6K 涉及 IL-37b 导致的 DC 的抑制。这被化学禁止者的同样镇压的效果在 DC 在 IL-6 和 TNF- 的表情上对 NF-B,英皇家空军之阶级最低之兵,和 S6K 证实。在结论,这些结果证明 IL-37b 由在英皇家空军之阶级最低之兵, NF-B,和基于 S6K 的禁止的发信号小径包含在 T 房间 priming 压制了 DC 成熟和 immunostimulatory 能力。 | Wantong Wu Weiqiang Wang Yun Wang Wenwen Li Gang Yu Zhonglong Li Chunmin Fang Yue Shen Zhina Sun Ling Han Juan Yu Lijun Fang Song Chen Kui Dong Zhongchao Han Hanzhi Liu Yuechen Luo Xiaoming Feng | 2015 | Acta Biochimica et Biophysica Sinica2015，47，8： | 8 |
| 9 | Urban Expansion in China Based on Remote Sensing Technology:A Review显示文摘Urban areas and its evolution are important anthropogenic indicators and human ecological footprints, and play decisive roles in environmental change analysis, global geo-conditional monitoring, and sustainable development. China has the highest rate of urban expansion and has emerged as an urban expansion hotspot worldwide. In this paper, the progress of studies on Chinese urban expansion based on remote sensing technology are summarized and analyzed from the aspects of urban area definition, remotely sensed imagery applied in urban expansion, monitoring methods of urban expansion, and urban expansion applications. Existing issues and future directions of Chinese urban expansion are discussed and proposed. Results indicate that: 1) The fusion of multi-source remotely sensed imagery is imperative to meet the needs of urban expansion with various monitoring terms and frequencies on different scales and dimensions. 2) To guarantee the classification accuracy and efficiency and describe urban expansion and its influences on local land use simultaneously, the combination of visual interpretation and automatic classification is the tendency of future monitoring methods of urban areas. 3) Urban expansion data have become the prerequisite for recognizing the urban development process, excavating its driving forces, simulating and predicting the future development directions, and also is conducive to revealing and explaining urban ecological and environmental issues. 4) In the past decades, Chinese scholars have promoted the application of remote sensing technology in the urban expansion field, with data construction, methods and models developing from the quotation stage to improvement and innovation stage; however, an independent and consistent urban expansion data on the national scale with long-term and high-frequency(such as annual monitoring) monitoring is still lacking. | ZHANG Zengxiang LIU Fang ZHAO Xiaoli WANG Xiao SHI Lifeng XU Jinyong YU Sisi WEN Qingke ZUO Lijun YI Ling HU Shunguang LIU Bin | 2018 | Chinese Geographical Science2018，28，5： | 6 |
| 10 | Integrated genomic analysis identifies deregulated JAK/STAT-MYC-biosynthesis axis in aggressive NK-cell leukemia显示文摘好攻击的 NK 房间白血病(ANKL ) 是在从亚洲的人之中是更流行的 NK 房间瘤的一种稀罕形式并且中央并且南美洲。病人们通常在天以内死到月,甚至在收到迅速的治疗学的管理以后。这里,我们由集成整个染色体执行了 ANKL 的第一全面研究, transcriptome 并且定序指向,象功能的试金一样的 cytokine 数组。在 JAK-STAT 小径的变化在 48% 被识别(14/29 ) ANKL 病人,当细胞外的 STAT3 激发器 IL10 被 56 褶层的一般水准提高时(P < 0.0001 ) 在检查的所有病人的血浆。另外的经常变异的基因包括的 TP53 (34%) , TET2 (28%) , CREBBP (21%) 和 MLL2 (21%) 。耐心的 NK 白血病房间在多重新陈代谢的小径显示出 STAT3 phosphorylation, MYC 表示和 transcriptional 活动的突出的激活。机能上地, STAT3 激活和 MYC 表示为 ANKL 房间的增长和幸存是批评的。发信号的 STAT 调整了发信号的 MYC 抄写节目,和两 STAT, MYC 抄写被要求维持核苷酸合成和 glycolysis 的激活。一起, JAK-STAT 小径在 ANKL 为 genomic 改变和 IL10 刺激代表一个主要目标。这最新发现的 JAK/STAT-MYC-biosynthesis 轴可以在对待白血病的这种子类型为新奇治疗学的策略的发展提供机会。 | Liang Huang Dan Liu Na Wang Shaoping Ling Yuting Tang Jun Wu Lingtong Hao Hui Luo Xuelian Hu Lingshuang Sheng Lijun Zhu Di Wang Yi Luo Zhen Shang Min Xiao Xia Mao Kuangguo Zhou Lihua Cao Lili Dong Xinchang Zheng Pinpin Sui Jianlin He Shanlan Mo Jin Yan Qilin Ao Lugui Qiu Hongsheng Zhou Qifa Liu Hongyu Zhang Jianyong Li Jie Jin Li Fu Weili Zhao Jieping Chen Xin Du Guoliang Qing Hudan Liu Xin Liu Gang Huang Ding Ma Jianfeng Zhou Qian-fei Wang | 2018 | Cell Research2018，28，2： | 5 |
| 11 | Microwave ablation of primary breast cancer inhibits metastatic progression in model mice via activation of natural killer cells显示文摘Surgery is essential for controlling the symptoms and complications of stage IV breast cancer.However,locoregional treatment of primary tumors often results in distant progression,including lung metastasis,the most common type of visceral metastasis.As a minimally invasive thermal therapy,microwave ablation(MWA)has been attempted in the treatment of breast cancer,but the innate immune response after MWA has not yet been reported.Using two murine models of stage IV breast cancer,we found that MWA of primary breast cancer inhibited the progression of lung metastasis and improved survival.NK cells were activated after MWA of the primary tumor and exhibited enhanced cytotoxic functions,and the cytotoxic pathways of NK cells were activated.Depletion experiments showed that NK cells but not CD4+or CD8+T cells played a pivotal role in prolonging survival.Then,we found that compared with surgery or control treatment,MWA of the primary tumor induced completely different NK-cell-related cytokine profiles.Macrophages were activated after MWA of the primary tumor and produced IL-15 that activated NK cells to inhibit the progression of metastasis.In addition,MWA of human breast cancer stimulated an autologous NK-cell response.These results demonstrate that MWA of the primary tumor in metastatic breast cancer inhibits metastatic progression via the macrophage/IL-15/NK-cell axis.MWA of the primary tumor may be a promising treatment strategy for de novo stage IV breast cancer,although further substantiation is essential for clinical testing. | Muxin Yu Hong Pan Nan Che Li Li Cong Wang Yue Wang Ge Ma Mengjia Qian Jiawei Liu Mingjie Zheng Hui Xie Lijun Ling Yi Zhao Xiaoxiang Guan Qiang Ding Wenbin Zhou Shui Wang | 2021 | Cellular & Molecular Immunology2021，18，9： | 5 |
| 12 | Extraction of Basic Trends of Urban Expansion in China over Past 40 Years from Satellite Images显示文摘If urban sprawl is to be avoided in China in the next ten years, it is not only crucial to understand the overall history, current status, and future trends of urban expansion there, but also these differences, and this is presently lacking. In this study, remotely sensed images with approximately 30 m spatial resolution were used to quantitatively assess the spatial and temporal patterns of urban expansion of 60 Chinese cities(1973–2013). Urban-expansion-process curves of the cities studied were drawn using annual expansion area as an indicator. Curve similarity analysis generated four basic process modes of urban expansion in China. These included cities that: 1) peaked around 2004 and then decelerated; 2) peaked around 2010 and then decelerated; 3) showed sustained acceleration, and 4) showed continued deceleration. Four basic process modes represented cities under different levels of development stage. Geographic location was found to be the most related characteristic to urban expansion process. Regional development policies at the national level in each region also showed highly temporal consistency with fluctuation characteristics of urban expansion process. Urban characteristic such as population size and administrative level were not found to be significantly related to urban expansion-process modes. Understanding the basic process-mode categories well is extremely important for future regional-balance planning and development of macroeconomic policies. | WEN Qingke ZHANG Zengxiang SHI Lifeng ZHAO Xiaoli LIU Fang XU Jinyong YI Ling LIU Bin WANG Xiao ZUO Lijun HU Shunguang LI Na LI Minmin | 2016 | Chinese Geographical Science2016，26，2： | 4 |
| 13 | City Size Distribution and Its Spatiotemporal Evolution in China显示文摘Based on the National Land Use/Cover Database of China(NLUD-C) in the end of the 1980s(the 1980s,hereafter), 1995, 2000, 2005, and 2010, 665 cities were selected to study the size distribution and its changes of urban lands in China. In this study, the spatiotemporal evolutions of urban land size distribution as well as the influence of administrative-level on these cities were explored by combining urban spatial positions and administrative-levels. Results indicate that: 1) City size distribution using urban lands was more practical and reasonable than using non-agricultural population. 2) In the 1980s, cities with ascending urban land rank were centralized in Eastern China, specially the Changjiang(Yangtze) River Delta, the Zhujiang(Pearl) River Delta, and Beijing-Tianjin-Hebei region. Cities in Central, Western, and Northeast China mainly indicated descending urban land rank. 3) The transfer of national development focus resulted in cities with ascending urban land rank becoming evenly distributed nationwide; however, this trend was slightly centralized around Chengdu, Chongqing, and Wuhan in different periods. 4) During the 1980s to 2010, the proportion of cities with ascending urban land rank in provincial capitals, municipalities, and special administrative regions(high-level cities, hereafter) was consistently higher than those in prefecture- and county-level cities except for 2005–2010. The ranks of the majority of the prefecture- and county-level cities were mainly descending, supported by ascending; the proportion of cities with unchanged rank is small. This study breaks through the bottleneck of traditional research in the area of city size distribution by examining urban land replacing the non-agricultural population. The current study also provides scientific explanation for the healthy and reasonable development of urban land as well as the coordinated development of population urbanization and land urbanization. | SHI Lifeng ZHANG Zengxiang LIU Fang ZHAO Xiaoli WANG Xiao LIU Bin HU Shunguang WEN Qingke ZUO Lijun YI Ling XU Jinyong | 2016 | Chinese Geographical Science2016，26，6： | 4 |
| 14 | Application of regional citrate anticoagulation in patients at high risk of bleeding during intermittent hemodialysis:a prospective multicenter randomized controlled trial显示文摘Objective:Safe and effective anticoagulation is essential for hemodialysis patients who are at high risk of bleeding.The purpose of this trial is to evaluate the effectiveness and safety of two-stage regional citrate anticoagulation(RCA)combined with sequential anticoagulation and standard calcium-containing dialysate in intermittent hemodialysis(IHD)treatment.Methods:Patients at high risk of bleeding who underwent IHD from September 2019 to May 2021 were prospectively enrolled in 13 blood purification centers of nephrology departments,and were randomly divided into RCA group and saline flushing group.In the RCA group,0.04 g/mL sodium citrate was infused from the start of the dialysis line during blood draining and at the venous expansion chamber.The sodium citrate was stopped after 3 h of dialysis,which was changed to sequential dialysis without anticoagulant.The hazard ratios for coagulation were according to baseline.Results:A total of 159 patients and 208 sessions were enrolled,including RCA group(80 patients,110 sessions)and saline flushing group(79 patients,98 sessions).The incidence of severe coagulation events of extracorporeal circulation in the RCA group was significantly lower than that in the saline flushing group(3.64%vs.20.41%,P<0.001).The survival time of the filter pipeline in the RCA group was significantly longer than that in the saline flushing group((238.34±9.33)min vs.(221.73±34.10)min,P<0.001).The urea clearance index(Kt/V)in the RCA group was similar to that in the saline flushing group with no statistically significant difference(1.12±0.34 vs.1.08±0.34,P=0.41).Conclusions:Compared with saline flushing,the two-stage RCA combined with a sequential anticoagulation strategy significantly reduced extracorporeal circulation clotting events and prolonged the dialysis time without serious adverse events. | Xiaoyan TANG Dezheng CHEN Ling ZHANG Ping FU Yanxia CHEN Zhou XIAO Xiangcheng XIAO Weisheng PENG Li CHENG Yanmin ZHANG Hongbo LI Kehui LI Bizhen GOU Xin WU Qian YU Lijun JIAN Zaizhi ZHU Yu WEN Cheng LIU Hen XUE Hongyu ZHANG Xin HE Bin YAN Liping ZHONG Bin HUANG Mingying MAO | 2022 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022，23，11： | 4 |
| 15 | Numerical Simulation of Stress and Deformation for a Duplex Stainless Steel Impeller during Casting and Heat Treatment Processes显示文摘一面大规模、薄墙有复杂几何学的双不锈钢 impeller 在扔期间严重地并且 unpredictably 被使变形,热处理过程为最后的部分导致了维的失败。在这篇论文, impeller 的失真在扔和热处理期间是 calculated.A 广告软件, Experto-ViewCast,被用来在扔和热处理过程期间模仿短暂的热转移,团结和机械行为。为质量,精力和机械平衡管理微分方程的联合集合被有限控制体积和有限元素 method.A thermoelastic-visco-plastic 变阻器解决逻辑模型被用来计算扔的抑制收缩。在每次增加, a coupling of 热转移和力学被执行。有模型预言的试验性的大小的比较显示出好同意。从片的关键点的计算排水量,合适的反的排水量决心提供扔模式的最佳并且为片的两张脸完成一件制服和合理用机器制造津贴。 | Lugui CHEN Yong LING Xiuhong KANG Lijun XIA Dianzhong LI | 2008 | Journal of Materials Science & Technology2008，24，3： | 4 |
| 16 | Effect of Chaihu Shugan decoction on gastric smooth muscle cell apoptosis in rats with functional dyspepsia显示文摘Objective:To investigate the effect of Chaihu Shugan decoction(CSD)on gastric smooth muscle cells(GSMCs)apoptosis in rats with functional dyspepsia(FD).Methods:48Sprague-Dawley(SD)rats were randomly assigned into six groups:a normal control group,a model group,apositive control(domperidone)group and low-,middle-and high-dose CSD groups.A rat model of FD was established by constantly squeezing their tails.The rats were administered CSD(0.16g/mL,0.32g/mL,0.64g/mL)or domperidone(0.3 g/L)via intragastric gavage for four weeks.The gastric emptying rate was detected at 4 weeks post-administration.Apoptosis of GSMCs was determined by terminal deoxynucleotidyl transferase dUTP nick end labeling(TUNEL)staining and the mitochondrial morphology was observed by transmission electron microscopy.The expression of Bcl-2and Bax was measured by immunohistochemistry.Results:FD resulted in marked reduction of gastric emptying rate,severe gastric tissue damage and mitochondria injury,but were reversed by CSD treatment(P<0.05).The apoptosis-induced protein Bax was markedly down-regulated by CSD,whereas the expression of the anti-apoptotic Bcl-2 protein was notably increased(P<0.05).Furthermore,CSD could protect the FD rats against GSMCs apoptosis manifested by a decreased in TUNEL-positive cells(P<0.05).Conclusion:CSD could alleviate GSMCs apoptosis in FD rats,possibly by the modulation of Bcl-2 and Bax expression,and the suppression of mitochondria injury. | Xinchao Shangguan Jianghong Ling Jing Deng Lijun Zeng Yuqin Zhang Tianyi Xie Yujiao Wang | 2017 | 广西医科大学学报2017，34，4： | 3 |
| 17 | HSP70L1-mediated intracellular priming of dendritic cell vaccination induces more potent CTL response against cancer显示文摘Heat-shock protein(HSP)-based immunotherapy is established on its adjuvant effects when applied via an extracellular approach to pulse and activate dendritic cells(DCs).Our previous studies indicate that DCs pulsed with recombinant fusion proteins of antigenic fragment and HSP70-like protein 1(HSP70L1)are potent in stimulating antigen-specific Th1 responses.We herein evaluated the cytotoxic T cell(CTL)response by an intracellular approach of priming DCs with transfection of recombinant adenovirus-expressing the fusion gene of the 576–699 fragment of carcinoembryonic antigen(CEA)and HSP70L1.As compared with DCs pulsed with extracellular fusion protein,the DCs transfected with recombinant adenovirus expressing the fusion gene displayed equivalent mature phenotypes but less inflammatory appearance.However,the transfected DCs were superior to the pulsed DCs in inducing CEA-specific CTLs.Consistently,immunization of HLA-A2.1/H-2Kb transgene mice with the transfected DCs could induce more quantities of HLA-A2.1-restricted CEA-specific CTLs,protecting nude mice more significantly from human CEA-expressing colon tumor challenge when adoptively transferred.Mechanistic investigation indicated that intracellular expression of the fusion protein empowered the transfected DCs by activation of STAT1 possibly via inducing IFN-βand ERK pathways.Therefore,the more potent ability to induce anti-CEA CTL responses enables the DCs,which transfected with recombinant adenovirus expressing the fusion gene of antigenic CEA fragment and Th1 adjuvant,as an alternative promising approach for the immunotherapy of CEA-positive tumors. | Shuxun Liu Lin Yi Ma Ling Jinxia Jiang Lijun Song Juan Liu Xuetao Cao | 2018 | Cellular & Molecular Immunology2018，15，2： | 2 |
| 18 | Urban Expansion of China from the 1970s to 2020 Based on Remote Sensing Technology显示文摘Based on Remote Sensing (RS) and Geographical Information System (GIS) technology,urban expansion of 75 cities in China from the 1970s to 2020 was reconstructed by visual-interpretation method,which described the growing process of urban lands and its influences on local land use structures synchronously.By employing annual expansion area per city and urban expansion density,spatial-temporal characteristics and macro patterns of urban expansion were analyzed from the aspects of regional-distributions,administrative-levels and population-sizes comprehensively.Results indicate that:1) urban expansion in China was universal,distinct,persistent,periodic and fluctuating.In the past five decades,urban lands of 75 monitored cities in China expanded dramatically from 3606.26 km2 to 30 521.13 km2.2) Though urban expansion presented significant differences from the aspects of regional distribution,administrative levels,and population sizes,it exhibited a deceleration trend in the 13th Five-Year Plan among all kinds of cities.3) Cultivated lands were the first land resource for urban expansion,and 55.17% of newly-expanded urban lands appeared by encroaching this land use type.China’s urban expansion has caused sustained pressure on cultivated land protection,especially in super megacities,and the contradiction between urban expansion and cultivated land protection will always exist.4) The compactness of urban lands in China increased before 1987 and reduced in the next three decades,which was consistent with the implementation of major policies and the deployment of national strategies,and is expected to become compact with a stopping declining or even rebounding after the 13th Five-Year Plan. | LIU Fang ZHANG Zengxiang ZHAO Xiaoli LIU Bin WANG Xiao YI Ling ZUO Lijun XU Jinyong HU Shunguang SUN Feifei WANG Yafei | 2021 | Chinese Geographical Science2021，31，5： | 2 |
| 19 | Effect of naloxone on level of plasma beta-endorphin in neonates with severe asphyxia显示文摘BACKGROUND: β-endorphin is the most actively endogenous substance of cerebral endorphin. When combined with opiate receptor specially,it manifests a strong morphine-like activity and can decrease sensitivity of central nervous system to carbon dioxide so as to inhibit breath. OBJECTIVE: To observe the changes of content of plasma β-endorphin in neonates with severe asphyxia after naloxone treatment in a large dosage. DESIGN: Randomized controlled observation. SETTINGS: Department of Pediatrics,Shenzhen Shajing People's Hospital; Center of Pediatrics,Guangzhou Zhujiang Hospital. PARTICIPANTS: A total of 97 neonates with severe asphyxia including 57 boys and 40 girls were selected from Neonatal Intensive Care Unit,Department of Pediatrics,Shenzhen Shajing People's Hospital from January 2004 to November 2005. Their gestational age was (38±3) weeks,body mass was (3.2±1.7) kg,and hospitalization duration was (2.8±2.3) hours. All neonates met the diagnostic criteria of with severe asphyxia and all their parents provided the confirmed consent. METHODS: All neonates were treated with inspired oxygen,sedation,stopping terror,decreasing cranial pressure,maintaining a well blood perfusion and normal level of blood glucose (about 5.0 mmol/L). After hospitalization,0.1 mg/(kg·d) naloxone hydrochloride (Beijing Sihuan Pharmaceutical Technology Co.,Ltd.; certification: H10900021; bullet preparation; 0.4 mg/ampoule) was intravenously dribbled into neonates for 4–6 hours,14 days in total. 2 mL blood was collected from radial artery in neonates at the beginning of hospitalization and at 3 days after naloxone treatment,put in aprotinin-pre-cool tube,mixed evenly,and centrifuged at hypothermia. Plasma was maintained in refrigerator at –70 ℃. The kit was provided by Neurobiology Department of Shanghai Second Military Medical University of Chinese PLA. Concentration of plasma β-endorphin was measured by using radio-immunity assay.All data were expressed as Mean± SD and results were compared with paired t test. MAIN OUTCOME MEASURE: Concentration of plasma β-endorphin. RESULTS: All 97 neonates were involved in the final analysis. Concentration of plasma β-endorphin in neonates with severe asphyxia was lower after treatment as compared with that before treatment,and there was significant difference (t =10.31,P < 0.01). CONCLUSION: Naloxone can decrease level of plasma β-endorphin in neonates with severe asphyxia. | Yinghong Wang Ling Xu Lijun Xue Yi Xiao Yangjun Liu Lingyan Huang | 2007 | Neural Regeneration Research2007，2，10： | 1 |
| 20 | Gum Chewing Slightly Enhances Early Recovery from Postoperative Ileus after Cesarean Section: Results of a Prospective, Randomized, Controlled Trial显示文摘 | Hongkai Shang Yang Yang Xiaowen Tong Lijun Zhang Aiming Fang Ling Hong | 2010 | Amer J Perinatol2010，，05： | 1 |
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