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| 1 | Long Term Culture of Human Kidney Proximal Tubule Epithelial Cells Maintains Lineage Functions and Serves as an Ex vivo Model for Coronavirus Associated Kidney Injury显示文摘The mechanism of how SARS-CoV-2 causes severe multi-organ failure is largely unknown. Acute kidney injury(AKI) is one of the frequent organ damage in severe COVID-19 patients. Previous studies have shown that human renal tubule cells could be the potential host cells targeted by SARS-CoV-2. Traditional cancer cell lines or immortalized cell lines are genetically and phenotypically different from host cells. Animal models are widely used, but often fail to reflect a physiological and pathogenic status because of species tropisms. There is an unmet need for normal human epithelial cells for disease modeling. In this study, we successfully established long term cultures of normal human kidney proximal tubule epithelial cells(KPTECs) in 2 D and 3 D culture systems using conditional reprogramming(CR) and organoids techniques.These cells had the ability to differentiate and repair DNA damage, and showed no transforming property. Importantly, the CR KPTECs maintained lineage function with expression of specific transporters(SLC34 A3 and cubilin). They also expressed angiotensin-converting enzyme 2(ACE2), a receptor for SARS-CoV and SARS-CoV-2. In contrast, cancer cell line did not express endogenous SLC34 A3, cubilin and ACE2. Very interestingly, ACE2 expression was around twofold higher in 3 D organoids culture compared to that in 2 D CR culture condition. Pseudovirion assays demonstrated that SARS-CoV spike(S) protein was able to enter CR cells with luciferase reporter. This integrated 2 D CR and 3 D organoid cultures provide a physiological ex vivo model to study kidney functions, innate immune response of kidney cells to viruses, and a novel platform for drug discovery and safety evaluation. | Siyu Xia Ming Wu Si Chen Tao Zhang Lina Ye Jun Liu Hui Li | 2020 | Virologica Sinica2020，35，3： | 3 |
| 2 | Removal of roosters alters the domestic phenotype and microbial and genetic profile of hens显示文摘Hens are raised apart from roosters in modern poultry production, a substantial change from their natural social structure. We compared productivity, injuries, behavior, physiology, microbiome and transcriptome of hens housed with(R+) or without(R–)roosters to quantify the effects of this change in social structure. Hens were raised free-range from 70 to 280 days when 30 birds per treatment were assigned to battery cages until Day 315(R+C vs. R–C), while 30 birds per treatment remained in free-range pens(R+F vs. R–F). Response to a novel environment and object, behavioral time budgets, cecum microbiome, blood composition and transcriptomic sequencing of thigh muscle and spleen were analyzed. Hens housed without roosters showed better survival, consumed less food, produced more eggs and had better feed conversion. R+F hens clustered around the rooster and were less mobile in the novel environment and object tests. R+F hens displayed the richest microbiome, and the presence of roosters resulted in differentially expressed genes related to muscle development, cellular processes, environmental information processing and immune function. Removing roosters from housed hens intensified desirable characteristics favored by domestication probably operating by deprivation of mating behavior and reduced fear, along with altered microbial and genetic function. | Hai Xiang Siyu Chen Hui Zhang Xu Zhu Dan Wang Huagui Liu Jikun Wang Tao Yin Langqing Liu Minghua Kong Jian Zhang Hua Li Simon Turner Xingbo Zhao | 2021 | Science China(Life Sciences)2021，64，11： | 2 |
| 3 | High-density lipoprotein nitration and chlorination catalyzed by myeloperoxidase impair its effect of promoting endothelial repair显示文摘 | Bing Pan Baoqi Yu Hui Ren Belinda Willard Ling Pan Lingyun Zu Xiaoli Shen Yijing Ma Xiuli Li Chenguang Niu Jinge Kong Siyu Kang Y. Eugene Chen Subramaniam Pennathur Lemin Zheng | 2013 | Free Radical Biology and Medicine2013，，： | 1 |
| 4 | Dynamic changes of renal cortical blood perfusion before and after percutaneous transluminal renal artery stenting in patients with severe atherosclerotic renal artery stenosis显示文摘Background:This study aims to observe the dynamic changes of renal artery(RA)disease and cortical blood perfusion(CBP)evaluated by contrast-enhanced ultrasound(CEUS)after percutaneous transluminal renal artery stenting(PTRAS)in patients with severe atherosclerotic renal artery stenosis(ARAS)and to analyze the relationship between CBP and prognosis.Methods:This was a single-center retrospective cohort study.A total of 98 patients with unilateral severe ARAS after successful PTRAS in Beijing Hospital from September 2017 to September 2020 were included.According to renal glomerular filtration rate(GFR)detected by radionuclide imaging at 12 months after PTRAS,all patients were divided into the poor prognosis group(n=21,GFR decreased by≥20%compared with baseline)and the control group(n=77,GFR decreased by<20%or improved compared with baseline).Renal artery stenosis was diagnosed by digital subtraction angiography,and renal CBP was evaluated by CEUS using TomTec Imaging Systems(Germany)before PTRAS,at 6 months and 12 months after discharge.The receiver operating characteristic(ROC)curve with area under the curve(AUC)was used to analyze the predictive value of CBP parameters,including area under ascending curve(AUC1),area under the descending curve(AUC2),rising time(RT),time to peak intensity(TTP),maximum intensity(IMAX),and mean transit time(MTT)for poor prognosis.Results:Among the 98 patients,there were 52 males(53.1%),aged 55–74 years old,with an average age of 62.1±8.7 years,and an average artery stenosis of 82.3±12.9%.The poor prognosis group was associated with significantly increased incidence of diabetes(76.2%vs.41.6%),and lower levels of GFR of the stenotic kidney(21.8 mL/min vs.25.0 mL/min)and total GFR(57.6 mL/min vs.63.7 mL/min)(all P<0.05),compared with the control group(P<0.05).In addition,the rate of RA restenosis was significantly higher in the poor prognosis group than in the control group(9.5%vs.0,χ^(2)=9.462,P=0.002).Compared with the control group,the poor prognosis group was associated with significantly decreased baseline AUC1 and AUC2,and extended duration of TTP and MTT(P<0.05).At 6 months and 12 months of follow-up,patients in the control group were associated with markedly increased AUC1,AUC2,and IMAX,and shorter duration of RT and MTT(P<0.05).The ROC curve showed that the predictive values of AUC1,AUC2,RT,TTP,IMAX,and MTT for poor prognosis were 0.812(95%CI:0.698–0.945),0.752(95%CI:0.591–0.957),0.724(95%CI:0.569–0.961),0.720(95%CI:0.522–0.993),0.693(95%CI:0.507–0.947),and 0.786(95%CI:0.631–0.979),respectively.Conclusions:Preoperative renal CBP in severe ARAS patients with poor prognosis is significantly reduced,and does not show significant improvement after stent treatment over the first year of follow-up.The parameter AUC1 may be a good predictor for renal dysfunction after PTRAS in severe ARAS patients.Trial Registration:ChiCTR.org.cn,ChiCTR1800016252. | Na Ma Yan Li Siyu Wang Mengpu Li Yongjun Li Hu Ai Hui Zhu Yang Wang Fajin Guo Junhong Ren | 2022 | Chinese Medical Journal2022，，13： | 1 |
| 5 | Cross-sectional rainfall observation on the central-western Tibetan Plateau in the warm season:System design and preliminary results显示文摘The central and western Tibetan Plateau(CWTP)is characterized by harsh environment and strong interactions among the spheres of earth as well as significant changes in climate and water cycles over the past four decades.The lack of precipitation observations is a bottleneck for the study of land surface processes in this region.Over the past six years,we have designed and established two observation transects across the south-north and the west-east in this region to obtain hourly rainfall data during the warm season(May-September).The south-north transect extends from Yadong Valley on the southern slope of the Himalayas to Shuanghu County in the hinterland of the plateau,with a total of 31stations;the west-east transect extends from Shiquanhe in the west to Naqu in the central TP,with a total of 22 stations.The observation dataset has been applied to clarify the spatiotemporal characteristics of precipitation in the CWTP,to evaluate the quality of typical gridded precipitation products,to support the development of regional climate models,and to reveal the processes of summertime lake-air interactions.The observation dataset has been released in the National Tibetan Plateau Data Center. | Kun YANG Yingying CHEN Lazhu Changhui ZHAN Xiaoyan LING Xu ZHOU Yaozhi JIANG Xiangnan YAO Hui LU Xiaogang MA Lin OUYANG Weihao PAN Yanghang REN Changkun SHAO Jiaxin TIAN Yan WANG Hua YANG Siyu YUE Ke ZHANG Dingchi ZHAO Long ZHAO Jianhong ZHOU Mijun ZOU | 2023 | Science China Earth Sciences2023，66，5： | 0 |
| 6 | Feasibility and physics potential of detecting ^(8)B solar neutrinos at JUNO显示文摘The Jiangmen Underground Neutrino Observatory(JUNO)features a 20 kt multi-purpose underground liquid scintillator sphere as its main detector.Some of JUNO's features make it an excellent location for^8B solar neutrino measurements,such as its low-energy threshold,high energy resolution compared with water Cherenkov detectors,and much larger target mass compared with previous liquid scintillator detectors.In this paper,we present a comprehensive assessment of JUNO's potential for detecting^8B solar neutrinos via the neutrino-electron elastic scattering process.A reduced 2 MeV threshold for the recoil electron energy is found to be achievable,assuming that the intrinsic radioactive background^(238)U and^(232)Th in the liquid scintillator can be controlled to 10^(-17)g/g.With ten years of data acquisition,approximately 60,000 signal and 30,000 background events are expected.This large sample will enable an examination of the distortion of the recoil electron spectrum that is dominated by the neutrino flavor transformation in the dense solar matter,which will shed new light on the inconsistency between the measured electron spectra and the predictions of the standard three-flavor neutrino oscillation framework.IfDelta m^(2)_(21)=4.8times10^(-5);(7.5times10^(-5))eV^(2),JUNO can provide evidence of neutrino oscillation in the Earth at approximately the 3sigma(2sigma)level by measuring the non-zero signal rate variation with respect to the solar zenith angle.Moreover,JUNO can simultaneously measureDelta m^2_(21)using^8B solar neutrinos to a precision of 20% or better,depending on the central value,and to sub-percent precision using reactor antineutrinos.A comparison of these two measurements from the same detector will help understand the current mild inconsistency between the value of Delta m^2_(21)reported by solar neutrino experiments and the KamLAND experiment. | Angel Abusleme Thomas Adam Shakeel Ahmad Sebastiano Aiello Muhammad Akram Nawab Ali Fengpeng An Guangpeng An Qi An Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde Marcondes de André Didier Auguste Andrej Babic Wander Baldini Andrea Barresi Eric Baussan Marco Bellato Antonio Bergnoli Enrico Bernieri David Biare Thilo Birkenfeld Sylvie Blin David Blum Simon Blyth Anastasia Bolshakova Mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Max Buesken Mario Buscemi Jose Busto Ilya Butorov Anatael Cabrera Hao Cai Xiao Cai Yanke Cai Zhiyan Cai Antonio Cammi Agustin Campeny Chuanya Cao Guofu Cao Jun Cao Rossella Caruso Cédric Cerna Jinfan Chang Yun Chang Pingping Chen Po-An Chen Shaomin Chen Shenjian Chen Xurong Chen Yi-Wen Chen Yixue Chen Yu Chen Zhang Chen Jie Cheng Yaping Cheng Alexander Chepurnov Davide Chiesa Pietro Chimenti Artem Chukanov Anna Chuvashova Gérard Claverie Catia Clementi Barbara Clerbaux Selma Conforti Di Lorenzo Daniele Corti Salvatore Costa Flavio Dal Corso Christophe De La Taille Jiawei Deng Zhi Deng Ziyan Deng Wilfried Depnering Marco Diaz Xuefeng Ding Yayun Ding Bayu Dirgantara Sergey Dmitrievsky Tadeas Dohnal Georgy Donchenko Jianmeng Dong Damien Dornic Evgeny Doroshkevich Marcos Dracos Frédéric Druillole Shuxian Du Stefano Dusini Martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri Lukas Fajt Donghua Fan Lei Fan Can Fang Jian Fang Marco Fargetta Anna Fatkina Dmitry Fedoseev Vladko Fekete Li-Cheng Feng Qichun Feng Richard Ford Andrey Formozov Amélie Fournier Haonan Gan Feng Gao Alberto Garfagnini Alexandre Göttel Christoph Genster Marco Giammarchi Agnese Giaz Nunzio Giudice Franco Giuliani Maxim Gonchar Guanghua Gong Hui Gong Oleg Gorchakov Yuri Gornushkin Marco Grassi Christian Grewing Maxim Gromov Vasily Gromov Minghao Gu Xiaofei Gu Yu Gu Mengyun Guan Nunzio Guardone Maria Gul Cong Guo Jingyuan Guo Wanlei Guo Xinheng Guo Yuhang Guo Paul Hackspacher Caren Hagner Ran Han Yang Han Miao He Wei He Tobias Heinz Patrick Hellmuth Yuekun Heng Rafael Herrera Daojin Hong YuenKeung Hor Shaojing Hou Yee Hsiung Bei-Zhen Hu Hang Hu Jianrun Hu Jun Hu Shouyang Hu Tao Hu Zhuojun Hu Chunhao Huang Guihong Huang Hanxiong Huang Qinhua Huang Wenhao Huang Xingtao Huang Yongbo Huang Jiaqi Hui Wenju Huo Cédric Huss Safeer Hussain Antonio Insolia Ara Ioannisian Daniel Ioannisyan Roberto Isocrate Kuo-Lun Jen Xiaolu Ji Xingzhao Ji Huihui Jia Junji Jia Siyu Jian Di Jiang Xiaoshan Jiang Ruyi Jin Xiaoping Jing Cécile Jollet Jari Joutsenvaara Sirichok Jungthawan Leonidas Kalousis Philipp Kampmann Li Kang Michael Karagounis Narine Kazarian Amir Khan Waseem Khan Khanchai Khosonthongkee Patrick Kinz Denis Korablev Konstantin Kouzakov Alexey Krasnoperov Svetlana Krokhaleva Zinovy Krumshteyn Andre Kruth Nikolay Kutovskiy Pasi Kuusiniemi Tobias Lachenmaier Cecilia Landini Sébastien Leblanc Frederic Lefevre Liping Lei Ruiting Lei Rupert Leitner Jason Leung Demin Li Fei Li Fule Li Haitao Li Huiling Li Jiaqi Li Jin Li Kaijie Li Mengzhao Li Nan Li Nan Li Qingjiang Li Ruhui Li Shanfeng Li Shuaijie Li Tao Li Weidong Li Weiguo Li Xiaomei Li Xiaonan Li Xinglong Li Yi Li Yufeng Li Zhibing Li Ziyuan Li Hao Liang Hao Liang Jingjing Liang Jiajun Liao Daniel Liebau Ayut Limphirat Sukit Limpijumnong Guey-Lin Lin Shengxin Lin Tao Lin Jiajie Ling Ivano Lippi Fang Liu Haidong Liu Hongbang Liu Hongjuan Liu Hongtao Liu Hu Liu Hui Liu Jianglai Liu Jinchang Liu Min Liu Qian Liu Qin Liu Runxuan Liu Shuangyu Liu Shubin Liu Shulin Liu Xiaowei Liu Yan Liu Alexey Lokhov Paolo Lombardi Claudio Lombardo Kai Loo Chuan Lu Haoqi Lu Jingbin Lu Junguang Lu Shuxiang Lu Xiaoxu Lu Bayarto Lubsandorzhiev Sultim Lubsandorzhiev Livia Ludhova Fengjiao Luo Guang Luo Pengwei Luo Shu Luo Wuming Luo Vladimir Lyashuk Qiumei Ma Si Ma Xiaoyan Ma Xubo Ma Jihane Maalmi Yury Malyshkin Fabio Mantovani Francesco Manzali Xin Mao Yajun Mao Stefano MMari Filippo Marini Sadia Marium Cristina Martellini Gisele Martin-Chassard Agnese Martini Davit Mayilyan Axel Müller Ints Mednieks Yue Meng Anselmo Meregaglia Emanuela Meroni David Meyhöfer Mauro Mezzetto Jonathan Miller Lino Miramonti Salvatore Monforte Paolo Montini Michele Montuschi Nikolay Morozov Pavithra Muralidharan Massimiliano Nastasi Dmitry VNaumov Elena Naumova Igor Nemchenok Alexey Nikolaev Feipeng Ning Zhe Ning Hiroshi Nunokawa Lothar Oberauer Juan Pedro Ochoa-Ricoux Alexander Olshevskiy Domizia Orestano Fausto Ortica Hsiao-Ru Pan Alessandro Paoloni Nina Parkalian Sergio Parmeggiano Teerapat Payupol Yatian Pei Nicomede Pelliccia Anguo Peng Haiping Peng Frédéric Perrot Pierre-Alexandre Petitjean Fabrizio Petrucci Luis Felipe Piñeres Rico Oliver Pilarczyk Artyom Popov Pascal Poussot Wathan Pratumwan Ezio Previtali Fazhi Qi Ming Qi Sen Qian Xiaohui Qian Hao Qiao Zhonghua Qin Shoukang Qiu Muhammad Rajput Gioacchino Ranucci Neill Raper Alessandra Re Henning Rebber Abdel Rebii Bin Ren Jie Ren Taras Rezinko Barbara Ricci Markus Robens Mathieu Roche Narongkiat Rodphai Aldo Romani Bedřich Roskovec Christian Roth Xiangdong Ruan Xichao Ruan Saroj Rujirawat Arseniy Rybnikov Andrey Sadovsky Paolo Saggese Giuseppe Salamanna Simone Sanfilippo Anut Sangka Nuanwan Sanguansak Utane Sawangwit Julia Sawatzki Fatma Sawy Michaela Schever Jacky Schuler Cédric Schwab Konstantin Schweizer Dmitry Selivanov Alexandr Selyunin Andrea Serafini Giulio Settanta Mariangela Settimo Muhammad Shahzad Vladislav Sharov Gang Shi Jingyan Shi Yongjiu Shi Vitaly Shutov Andrey Sidorenkov FedorŠimkovic Chiara Sirignano Jaruchit Siripak Monica Sisti Maciej Slupecki Mikhail Smirnov Oleg Smirnov Thiago Sogo-Bezerra Julanan Songwadhana Boonrucksar Soonthornthum Albert Sotnikov Ondrej Sramek Warintorn Sreethawong Achim Stahl Luca Stanco Konstantin Stankevich DušanŠtefánik Hans Steiger Jochen Steinmann Tobias Sterr Matthias Raphael Stock Virginia Strati Alexander Studenikin Gongxing Sun Shifeng Sun Xilei Sun Yongjie Sun Yongzhao Sun Narumon Suwonjandee Michal Szelezniak Jian Tang Qiang Tang Quan Tang Xiao Tang Alexander Tietzsch Igor Tkachev Tomas Tmej Konstantin Treskov Andrea Triossi Giancarlo Troni Wladyslaw Trzaska Cristina Tuve Stefan van Waasen Johannes van den Boom Guillaume Vanroyen Nikolaos Vassilopoulos Vadim Vedin Giuseppe Verde Maxim Vialkov Benoit Viaud Cristina Volpe Vit Vorobel Lucia Votano Pablo Walker Caishen Wang Chung-Hsiang Wang En Wang Guoli Wang Jian Wang Jun Wang Kunyu Wang Lu Wang Meifen Wang Meng Wang Ruiguang Wang Siguang Wang Wei Wang Wenshuai Wang Xi Wang Xiangyue Wang Yangfu Wang Yaoguang Wang Yi Wang Yifang Wang Yuanqing Wang Yuman Wang Zhe Wang Zheng Wang Zhimin Wang Zongyi Wang Apimook Watcharangkool Lianghong Wei Wei Wei Yadong Wei Liangjian Wen Christopher Wiebusch Steven Chan-Fai Wong Bjoern Wonsak Diru Wu Fangliang Wu Qun Wu Wenjie Wu Zhi Wu Michael Wurm Jacques Wurtz Christian Wysotzki Yufei Xi Dongmei Xia Yuguang Xie Zhangquan Xie Zhizhong Xing Benda Xu Donglian Xu Fanrong Xu Jilei Xu Jing Xu Meihang Xu Yin Xu Yu Xu Baojun Yan Xiongbo Yan Yupeng Yan Anbo Yang Changgen Yang Huan Yang Jie Yang Lei Yang Xiaoyu Yang Yifan Yang Haifeng Yao Zafar Yasin Jiaxuan Ye Mei Ye Ugur Yegin Frédéric Yermia Peihuai Yi Xiangwei Yin Zhengyun You Boxiang Yu Chiye Yu Chunxu Yu Hongzhao Yu Miao Yu Xianghui Yu Zeyuan Yu Chengzhuo Yuan Ying Yuan Zhenxiong Yuan Ziyi Yuan Baobiao Yue Noman Zafar Andre Zambanini Pan Zeng Shan Zeng Tingxuan Zeng Yuda Zeng Liang Zhan Feiyang Zhang Guoqing Zhang Haiqiong Zhang Honghao Zhang Jiawen Zhang Jie Zhang Jingbo Zhang Peng Zhang Qingmin Zhang Shiqi Zhang Tao Zhang Xiaomei Zhang Xuantong Zhang Yan Zhang Yinhong Zhang Yiyu Zhang Yongpeng Zhang Yuanyuan Zhang Yumei Zhang Zhenyu Zhang Zhijian Zhang Fengyi Zhao Jie Zhao Rong Zhao Shujun Zhao Tianchi Zhao Dongqin Zheng Hua Zheng Minshan Zheng Yangheng Zheng Weirong Zhong Jing Zhou Li Zhou Nan Zhou Shun Zhou Xiang Zhou Jiang Zhu Kejun Zhu Honglin Zhuang Liang Zong Jiaheng Zou | 2021 | Chinese Physics C2021，45，2： | 0 |
| 7 | A review of membrane distillation enhancement via thermal management and molecular transport through nanomaterial-based membranes显示文摘Low-energy,high-efficiency desalination techniques are important because of the critical water-energy nexus.In particular,membrane distillation has great potential to harness low-grade and renewable energy sources.Composite membranes using micro-and nanomaterials have new capabilities and characteristics.This review focuses on the most recent developments and potential capabilities in membrane distillation systems from the perspective of nanomaterial enhancements,thermal management,and water transport.Self-heating nanomaterial membrane distillations using permeable composite membranes with significant photothermal or Joule-heating conversion capabilities enable macroscale thermal management and mitigate temperature polarization effects.Modifying the membrane structure and its interaction with water can accelerate water transport and evaporation,improving distillation at the microscopic level.This is expected to provide directions for the fabrication and manipulation of novel micro-and nanocomposite membranes for distillation processes at various levels,and enhance their applications. | HUANG Jian HE YuRong HUI SiYu WANG MingHao TANG TianQi | 2023 | Science China(Technological Sciences)2023，66，6： | 0 |
| 8 | Interface engineering of Fe-Sn-Co sulfide/oxyhydroxide heterostructural electrocatalyst for synergistic water splitting显示文摘To realize large-scale hydrogen production by electrolysis of water,it is essential to develop non-precious metal catalysts for oxygen evolution reaction(OER)and hydrogen evolution reaction(HER).Here,we fabricate Sn-,Fe-,and Co-based sulfide/oxyhydroxide heterostructural catalyst on nickel foam(FeSnCo_(0.2)S_(x)O_(y)/NF)by solvothermal method.The FeSnCo_(0.2)S_(x)O_(y)/NF requires low overpotentials of 48 and 186 mV at 10 mA·cm^(-2),respectively,for HER and OER.When it is assembled into an electrolytic cell as a bifunctional electrocatalyst,it only needs 1.54 V to reach 10 mA·cm^(-2),far better than IrO_(2)||Pt/C electrolyzer.The formation of sulfide/hydroxide heterostructural interfaces improves the electron transfer and reduces the reaction energy barrier,thus promoting the electrocatalytic processes. | Siyu Chen Ting Zhang Jingyi Han Hui Qi Shihui Jiao Changmin Hou Jingqi Guan | 2024 | Nano Research Energy2024，3，2： | 0 |
| 9 | REEP1 Preserves Motor Function in SOD1^(G93A) Mice by Improving Mitochondrial Function via Interaction with NDUFA4显示文摘A decline in the activities of oxidative phosphorylation(OXPHOS)complexes has been consistently reported in amyotrophic lateral sclerosis(ALS)patients and animal models of ALS,although the underlying molecular mechanisms are still elusive.Here,we report that receptor expression enhancing protein 1(REEP1)acts as an important regulator of complex IV assembly,which is pivotal to preserving motor neurons in SOD1^(G93A) mice.We found the expression of REEP1 was greatly reduced in transgenic SOD1^(G93A) mice with ALS.Moreover,forced expression of REEP1 in the spinal cord extended the lifespan,decelerated symptom progression,and improved the motor performance of SOD1^(G93A) mice.The neuromuscular synaptic loss,gliosis,and even motor neuron loss in SOD1^(G93A) mice were alleviated by increased REEP1 through augmentation of mitochondrial function.Mechanistically,REEP1 associates with NDUFA4,and plays an important role in preserving the integrity of mitochondrial complex IV.Our findings offer insights into the pathogenic mechanism of REEP1 deficiency in neurodegenerative diseases and suggest a new therapeutic target for ALS. | Siyue Qin Pan You Hui Yu Bo Su | 2023 | Neuroscience Bulletin2023，39，6： | 0 |
| 10 | Surface reconstruction and structural transformation of twodimensional Ni-Fe MOFs for oxygen evolution in seawater media显示文摘As a four-electron transfer reaction,oxygen evolution reaction(OER)is limited by large overpotential and slow kinetics.Here,we in-situ synthesized two-dimensional(2D)Ni-Fe metal-organic framework nanosheets on nickel foam(NixFe-TPA/NF,TPA=terephthalic acid)for oxygen evolution in alkaline and alkaline seawater electrolytes.In 1 M KOH,Ni3Fe-TPA/NF shows a low overpotential(η10)of 189 mV at 10 mA·cm^(-2) and an ultra-low overpotential of only 260 mV at 500 mA·cm^(-2).In alkaline seawater,Ni3Fe-TPA/NF still provides impressive OER performance,with anη10 of 265 mV.In-situ Raman characterization results show that the phase transition occurs during the OER,and Ni3FeOOH with more oxygen vacancies is in-situ formed,reducing the OER energy barrier.Density functional theory(DFT)reveals that the synergy between Ni and Fe reduces the energy barrier and accelerates the rate-determining step.In addition,the ultra-thin 2D sheet structure and the close combination of Ni3FeOOH and highly conductive NF support ensure the high catalytic OER activity.Therefore,the surface reconstruction and structural modification strategy can be used to design and prepare high-performance OER electrocatalysts for energy-related applications. | Liyuan Xiao Xue Bai Jingyi Han Tianmi Tang Siyu Chen Hui Qi Changmin Hou Fuquan Bai Zhenlu Wang Jingqi Guan | 2024 | Nano Research2024，17，4： | 0 |
| 11 | Saturation evaluation of microporous low resistivity carbonate oil pays in Rub Al Khali Basin in the Middle East显示文摘To solve the problem that it is difficult to identify carbonate low resistivity pays(LRPs) by conventional logging methods in the Rub Al Khali Basin, the Middle East, the variation of fluid distribution and rock conductivity during displacement were analyzed by displacement resistivity experiments simulating the process of reservoir formation and production, together with the data from thin sections, mercury injection and nuclear magnetic resonance experiments. In combination with geological understandings, the genetic mechanisms of LRPs were revealed, then the saturation interpretation model was selected, the variation laws and distribution range of the model parameters were defined, and finally an updated comprehensive saturation interpretation technique for the LRPs has been proposed. In the study area, the LRPs have resistivity values of less than 1 Ω·m, similar to or even slightly lower than that of the water layers. Geological research reveals that the LRPs were developed in low-energy depositional environment and their reservoir spaces are controlled by micro-scale pore throats, with an average radius of less than 0.7 μm, so they are typical microporous LRPs. Different from LRPs of sandstone and mudstone, they have less tortuous conductive paths than conventional reservoirs, and thus lower resistivity value under the same saturation. Archie’s formula is applicable to the saturation interpretation of LRPs with a cementation index value of 1.77-1.93 and a saturation index value of 1.82-2.03 that are 0.2-0.4 lower than conventional reservoirs respectively. By using interpretation parameters determined by classification statistics of petrophysical groups(PGs), oil saturations of the LRPs were calculated at bout 30%-50%,15% higher than the results by conventional methods, and basically consistent with the data of Dean Stark, RST, oil testing and production. The 15 wells of oil testing and production proved that the coincidence rate of saturation interpretation is over 90%and the feasibility of this method has been further verified. | WANG Yongjun SUN Yuanhui YANG Siyu WU Shuhong LIU Hui TONG Min LYU Hengyu | 2022 | Petroleum Exploration and Development2022，49，1： | 0 |
| 12 | Sb_(2)Se_(3) film with grain size over 10μm toward X-ray detection显示文摘Direct X-ray detectors are considered as competitive next-generation X-ray detectors because of their high spatial resolution,high sensitivity,and simple device configuration.However,their potential is largely limited by the imperfections of traditional materials,such as the low crystallization temperature of α-Se and the low atomic numbers of α-Si and α-Se.Here,we report the Sb_(2)Se_(3) X-ray thin-film detector with a p-n junction structure,which exhibited a sensitivity of 106.3 μC/(Gyair·cm^(2))and response time of<2.5 ms.This decent performance and the various advantages of Sb_(2)Se_(3),such as the average atomic number of 40.8 and μτ product(μ is the mobility,and τ is the carrier lifetime)of 1.29×1O^(-5) cm^(2)/V,indicate its potential for application in X-ray detection. | Chong WANG Xinyuan DU Siyu WANG Hui DENG Chao CHEN Guangda NIU Jincong PANG Kanghua LI Shuaicheng LU Xuetian LIN Haisheng SONG Jiang TANG | 2021 | Frontiers of Optoelectronics2021，14，3： | 0 |
| 13 | Development of Rural Tourism in Liaoning Province from the Perspective of Types显示文摘With the vigorous development of the tourism industry,the types of tourism become rich and diverse,and the development models have their own characteristics.At present,rural tourism has become a hot spot in the development of tourism,and it is also a driver of rural revitalization.However,its development type and development model are not mature yet,and there are still some fundamental problems in the process of development.Based on the development status of rural tourism in Liaoning Province,an in-depth survey was carried out on the types and development models of rural tourism in Liaoning Province,and its basic types and development models are clarified,to explore the deep-rooted problems existing in the development of rural tourism in Liaoning Province.Besides,the development models adopted in different regions of China were compared to find the universally applicable rules for the development of rural tourism.Finally,according to the distribution of rural tourism resources,the development direction was clearly defined,supporting policy recommendations were proposed,including adjusting and upgrading the existing types and development models,and implementing development strategies in a targeted manner to promote the sustainable development of rural tourism in Liaoning Province. | Siyu WANG Liang ZHAO Na SAI Yaning HUI | 2021 | Asian Agricultural Research2021，13，9： | 0 |
| 14 | Distribution characteristics of delta reservoirs reshaped by bottom currents:A case study from the second member of the Yinggehai Formation in the DF1-1 gas field,Yinggehai Basin,South China Sea显示文摘The Dongfang1-1 gas field(DF1-1)in the Yinggehai Basin is currently the largest offshore self-developed gas field in China and is rich in oil and gas resources.The second member of the Pliocene Yinggehai Formation(YGHF)is the main gas-producing formation and is composed of various sedimentary types;however,a clear understanding of the sedimentary types and development patterns is lacking.Here,typical lithofacies,logging facies and seismic facies types and characteristics of the YGHF are identified based on high-precision 3D seismic data combined with drilling,logging,analysis and testing data.Based on 3D seismic interpretation and attribute analysis,the origin of high-amplitude reflections is clarified,and the main types and evolution characteristics of sedimentary facies are identified.Taking gas formation upper II(IIU)as an example,the plane distribution of the delta front and bottom current channel is determined;finally,a comprehensive sedimentary model of the YGHF second member is established.This second member is a shallowly buried“bright spot”gas reservoir with weak compaction.The velocity of sandstone is slightly lower than that of mudstone,and the reflection has medium amplitude when there is no gas.The velocity of sandstone decreases considerably after gas accumulation,resulting in an increase in the wave impedance difference and high-amplitude(bright spot)reflection between sandstone and mudstone;the range of high amplitudes is consistent with that of gas-bearing traps.The distribution of gas reservoirs is obviously controlled by dome-shaped diapir structural traps,and diapir faults are channels through which natural gas from underlying Miocene source rocks can enter traps.The study area is a delta front deposit developed on a shallow sea shelf.The lithologies of the reservoir are mainly composed of very fine sand and coarse silt,and a variety of sedimentary structural types reflect a shallow sea delta environment;upward thickening funnel type,strong toothed bell type and toothed funnel type logging facies are developed.In total,4 stages of delta front sand bodies(corresponding to progradational reflection seismic facies)derived from the Red River and Blue River in Vietnam have developed in the second member of the YGHF;these sand bodies are dated to 1.5 Ma and correspond to four gas formations.During sedimentation,many bottom current channels(corresponding to channel fill seismic facies)formed,which interacted with the superposed progradational reflections.When the provenance supply was strong in the northwest,the area was dominated by a large set of delta front deposits.In the period of relative sea level rise,surface bottom currents parallel to the coastline were dominant,and undercutting erosion was obvious,forming multistage superimposed erosion troughs.Three large bottom current channels that developed in the late sedimentary period of gas formation IIU are the most typical. | Shuo Chen Renhai Pu Huiqiong Li Hongjun Qu Tianyu Ji Siyu Su Yunwen Guan Hui Zhang | 2022 | Acta Oceanologica Sinica2022，41，9： | 0 |
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