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| 1 | 皮质下小血管病诊断的共识声明显示文摘血管性认知损害是用于描述一组涉及大血管和小血管的散发性和遗传性异质性疾病的诊断术语。皮质下小血管病可导致腔隙性梗死和进行性白质损害。被称为宾斯旺格病(Binswanger's disease, BD)的进行性白质损害患者构成了从单纯血管性疾病到合并神经变性病变的疾病谱。BD患者是一个相对同质性的亚组,存在缺氧缺血、腔隙性梗死和炎症,它们协同作用破坏血脑屏障和髓鞘。通过临床、脑脊液、神经心理学和影像学检查获得的多模式疾病标记物能促进该亚组患者的鉴别。本共识声明确定了一系列基于基础病理学改变的潜在生物学标记物,这将有助于诊断以及将来协作性治疗试验的患者选择。 | Gary A Rosenberg Anders Wallin Joanna M Wardlaw Hugh S Markus Joan Montaner Leslie Wolfson Costantino Iadecola Berislav V Zlokovic Anne Joutel Martin Dichgans Marco Duering Reinhold Schmidt Amos D Korczyn Lea T Grinberg Helena C Chui Vladimir Hachinski 王训师 张劼 陈涵丰 俞娅美 徐子奇 罗本燕 | 2016 | 国际脑血管病杂志2016，24，6： | 18 |
| 2 | Accuracy of clinical diagnosis of idiopathic Parkinson's disease:a clinicopathologic study of 100 cases显示文摘 | Hughes A J Daniel SE Kilford L | 1992 | J Neurol Neurosurg Psychiatry1992，55，3： | 10 |
| 3 | Three-dimensional perfused human in vitro model of nonalcoholic fatty liver disease显示文摘AIM To develop a human in vitro model of non-alcoholic fatty liver disease(NAFLD), utilising primary hepatocytes cultured in a three-dimensional(3D) perfused platform. METHODS Fat and lean culture media were developed to directly investigate the effects of fat loading on primary hepatocytes cultured in a 3D perfused culture system. Oil Red O staining was used to measure fat loading in the hepatocytes and the consumption of free fatty acids(FFA) from culture medium was monitored. Hepatic functions, gene expression profiles and adipokine release were compared for cells cultured in fat and lean conditions. To determine if fat loading in the system could be modulated hepatocytes were treated with known anti-steatotic compounds. RESULTS Hepatocytes cultured in fat medium were found to accumulate three times more fat than lean cells and fat uptake was continuous over a 14-d culture. Fat loading of hepatocytes did not cause any hepatotoxicity and significantly increased albumin production. Numerous adipokines were expressed by fatty cells and genes associated with NAFLD and liver disease were upregulated including: Insulin-like growth factorbinding protein 1, fatty acid-binding protein 3 and CYP7A1. The metabolic activity of hepatocytes cultured in fatty conditions was found to be impaired and the activities of CYP3A4 and CYP2C9 were significantlyreduced, similar to observations made in NAFLD patients. The utility of the model for drug screening was demonstrated by measuring the effects of known antisteatotic compounds. Hepatocytes, cultured under fatty conditions and treated with metformin, had a reduced cellular fat content compared to untreated controls and consumed less FFA from cell culture medium.CONCLUSION The 3D in vitro NAFLD model recapitulates many features of clinical NAFLD and is an ideal tool for analysing the efficacy of anti-steatotic compounds. | Tomasz Kostrzewski Terri Cornforth Sophie A Snow Larissa Ouro-Gnao Cliff Rowe Emma M Large David J Hughes | 2017 | World Journal of Gastroenterology2017，23，2： | 6 |
| 4 | Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density显示文摘 | W.S Simonet D.L Lacey C.R Dunstan M Kelley M.-S Chang R Lüthy H.Q Nguyen S Wooden L Bennett T Boone G Shimamoto M DeRose R Elliott A Colombero H.-L Tan G Trail J Sullivan E Davy N Bucay L Renshaw-Gegg T.M Hughes D Hill W Pattison P Campbell S Sander G Van | 1997 | Cell1997，，2： | 6 |
| 5 | 全科医生工作困难和压力应对能力及复原力:一项定性研究显示文摘背景'新自由主义'工作策略、工作环境艰苦、英国医疗服务体系(NHS)重组及工作量的增加,造成全科医生职业倦怠及数量短缺,诸如此类的报道越来越多。目的本文旨在探讨全科医生工作上的困难和压力以及其应对策略,尤其是最近NHS要求改变工作环境给全科医生造成的影响。设计与场所本研究为定性研究。研究数据来自两个讨论组的访谈及7个'一对一'电话访谈资料。方法采用方便抽样方法选择研究对象。对研究对象进行半结构化讨论组访谈及'一对一'电话访谈,调查当前英国全科医生的执业情况。对访谈数据进行主题分析。结果共22例全科医生参与研究,其中15例参与讨论组讨论,7例参与电话采访。受访者谈到全科医生正承受着前所未有的强大压力,这种压力与工作环境有关,因为工作环境使得其觉得应该做个'好'医生。许多研究报道了全职全科医生压力太大:工作压力引起情绪改变,导致睡眠不良,焦虑增加,与亲人之间关系紧张。有些人尝试通过减少工作量来改善这种状况。工作环境的变化使得全科医生几乎没有时间采取措施来提高复原力以做到工作与生活之间平衡良好以及更好地与同事相处。尽管有些全科医生能更有效地应对压力,但是其也承认,自己已经尽了最大努力来应对工作压力。结论 NHS诸多因素造成了全科医生在感情生活及工作压力上的明显改变。为促进全科医生提供有效的医疗服务,其复原力的构建应不仅局限于改善全科医生个人情况,还应包括系统地解决其工作上的困难与压力。 | CHESHIRE A RIDGE D HUGHES J 本刊编辑部 | 2017 | 中国全科医学2017，20，21： | 3 |
| 6 | Suppression of experimental autoimmune myasthenia gravis in IL-10 gene-disrupted mice is associteed with reduced B ceils and serum cytotoxicity on mouse cell line expressing AehR显示文摘 | Poussin M A Goluszko E Hughes T K | 2000 | J Neuroimmunol2000，111，： | 2 |
| 7 | The relations among environmental disclosure, environmental performance, and economic performance: a simultaneous equations approach显示文摘 | Sulaiman A Al-Tuwaijri Theodore E Christensen K.E Hughes | 2003 | Accounting, Organizations and Society2003，，5： | 2 |
| 8 | ST2可能并非心血管事件、心力衰竭和死亡有用的预测因子显示文摘研究人员假设可溶性ST2(soluble ST2,sST2)水平可识别出心血管疾病(cardiovascular disease,CVD)风险较高的人群,应将其纳入风险预测计算指标。ST2是炎症性细胞因子白细胞介素33的受体。sST2水平增加与急性心肌梗死患者和一般人群的心力衰竭及死亡相关。方法:研究人员测定FINRISK97前瞻性研究人群队列中的8444名男性和女性(25-74岁)的高敏sST2水平,应用Cox比例风险模型评估在15年的随访中,sST2对致命性或非致命性心力衰竭、CVD(冠状动脉性心脏病和脑卒中)、糖尿病和死亡情况的预测能力。研究者获取10年绝对风险识别和重新分类的统计数据, | 赵狄 叶鹏 Hughes MF Appelbaum S Havulinna AS Jagodzinski A Zeller T2 Kee F Blankenberg S Salomaa V | 2014 | 中华高血压杂志2014，22，8： | 2 |
| 9 | Esophageal Subepithelial Fibrosis in Children With Eosinophilic Esophagitis显示文摘 | Mirna Chehade Hugh A Sampson Raffaella A Morotti Margret S Magid | 2007 | Journal of Pediatric Gastroenterology and Nutrition2007，，3： | 2 |
| 10 | Hepatitis delta virus显示文摘 | Sarah A Hughes Heiner Wedemeyer Phillip M Harrison | 2011 | The Lancet2011，，9785： | 2 |
| 11 | Computational of tailing-edge noise due to turbulent flow over an airfoil 显示文摘 | OBERAI A RONALDKIN F HUGHS T | 2002 | AIAA Journal2002，40，5： | 1 |
| 12 | Finite element modeling of blood flow in arteries 显示文摘 | Thomas J R Hughes Zarins C K | 1998 | Computer Methods in Applied Mechanics and Engineering1998，158，： | 1 |
| 13 | Occupational exp- osure to pesticides and risk of non-hodgkln' s lymphoma显示文摘 | FRITSCHI L BENKE G HUGHES A M | 2005 | Am J Epidemiol2005，162，9： | 1 |
| 14 | Changes in limestone sorbent morphology during CaO-CaCO3 looping at pilot scale显示文摘 | Hughes R W Macchi A Lu D Y | 2009 | Chemical Engineering & Technology2009，32，3： | 1 |
| 15 | Isogeometricanalysis:CAD,finite elements,NURBS,exact geometry andmesh refinement显示文摘 | Hughes T J R Cottrell J A Bazilevs Y | 2005 | Computer Methods in AppliedMechanics and Engineering2005，194，41： | 1 |
| 16 | The molecular biology of plantacclimation to low temperature显示文摘 | Hughes M A Durm M A | 1996 | Journal of ExperimentalBotany1996，47，： | 1 |
| 17 | Genetic immunization of chimpanzees chronically infected with the hepatitis B virus, using a recombinant retroviral vector encoding the hepatitis B virus core antigen 显示文摘 | Sallberg M Hughes J Javadian A | 1998 | Hum Gene Ther1998，9，： | 1 |
| 18 | A three-node Mindlin plate element with improved transverse shear显示文摘 | Tessler A Hughes T Jr | 1985 | Computer Methods in Applied Mechanics and Engineering1985，50，： | 1 |
| 19 | E mpiricial Assessment of the Impact of Audit Quality on Valuation of New Issues显示文摘 | Feltham G A J S Hughes D A Simunic | 1991 | Journal of Accounting and Economics1991，，： | 1 |
| 20 | Reverse transcriptase motify in the catalytic subunit of telomerase显示文摘 | Lingner J Hughes TR Shevchenko A | 1997 | Science1997，276，： | 1 |
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