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| 1 | Stroke and depression: A bidirectional link显示文摘A number of studies have assessed the influence of depression on the risk of cardiovascular disease. A growing literature indicates a link between depression and cerebrovascular events, although the direction of this association remains unclear. Numerous data have emerged suggesting an association between depressive symptoms and subsequent risk of stroke, thus leading to the hypothesis that a direct causality between depression and stroke exists. Notwithstanding, how depression may act as a risk factor for stroke is still unclear. Depression might be linked to stroke via neuroendocrine and inflammation effects, through correlation with major comorbidities such as hypertensionand diabetes or by intervention of lifestyle behavioral mediators. Finally, antidepressant medications have recently drawn attention for a possible association with increased risk of stroke, although such findings remain uncertain. Depression has been also established as an important consequence after stroke, exerting a significant adverse impact on the course of motor recovery, social functioning and, overall, on quality of life. Post stroke depression occurs in nearly one third of stroke cases, but the exact mechanism leading to depression after stroke is still incompletely understood. In this article, we will review contemporary epidemiologic studies, discuss potential mechanisms and specific aspects of the complex relation between depression and stroke. | Elisabetta Del Zotto Paolo Costa Andrea Morotti Loris Poli Valeria de Giuli Alessia Giossi Irene Volonghi Antonio Callea Alessandro Padovani Alessandro Pezzini | 2014 | World Journal of Meta-Analysis2014，2，3： | 2 |
| 2 | The genomes of medicinal skullcaps reveal the polyphyletic origins of clerodane diterpene biosynthesis in the family Lamiaceae显示文摘The presence of anticancer clerodane diterpenoids is a chemotaxonomic marker for the traditional Chinese medicinal plant Scutellaria barbata,although the molecular mechanisms behind clerodane biosynthesis are unknown.Here,we report a high-quality assembly of the 414.98 Mb genome of S.barbata into 13 pseudochromosomes.Using phylogenomic and biochemical data,we mapped the plastidial metabolism of kaurene(gibberellins),abietane,and clerodane diterpenes in three species of the family Lamiaceae(Scutellaria barbata,Scutellaria baicalensis,and Salvia splendens),facilitating the identification of genes involved in the biosynthesis of the clerodanes,kolavenol,and isokolavenol.We show that clerodane biosynthesis evolved through recruitment and neofunctionalization of genes from gibberellin and abietane metabolism.Despite the assumed monophyletic origin of clerodane biosynthesis,which is widespread in species of the Lamiaceae,our data show distinct evolutionary lineages and suggest polyphyletic origins of clerodane biosynthesis in the family Lamiaceae.Our study not only provides significant insights into the evolution of clerodane biosynthetic pathways in the mint family,Lamiaceae,but also will facilitate the production of anticancer clerodanes through future metabolic engineering efforts. | Haixiu Li Song Wu Ruoxi Lin Yiren Xiao Ana Luisa Malaco Morotti Ya Wang Meytal Galilee Haowen Qin Tao Huang Yong Zhao Xun Zhou Jun Yang Qing Zhao Angelos K.Kanellis Cathie Martin Evangelos C.Tatsis | 2023 | Molecular Plant2023，16，3： | 2 |
| 3 | Esophageal Subepithelial Fibrosis in Children With Eosinophilic Esophagitis显示文摘 | Mirna Chehade Hugh A Sampson Raffaella A Morotti Margret S Magid | 2007 | Journal of Pediatric Gastroenterology and Nutrition2007，，3： | 2 |
| 4 | Collision tumours in children:a review of the litereture and presention of a rare Case of mesoblastic nephroma and neuroblastoma in an infant显示文摘 | Morotti RA shiels WE | 2000 | Pediatr surg2000，35，： | 1 |
| 5 | PML targeting eradicates quiescent leukaemia-initiating cells显示文摘 | Ito K Bernardi R Morotti A | 2008 | Nature2008，453，7198： | 1 |
| 6 | Collision tumors in children:a review of the literature and presentation of a rare case of mesoblastie nephroma and neuroblastoma in an infant 显示文摘 | Vegunta RK Morotti RA SlaMs WE | 2000 | J Pediatr Surg2000，35，9： | 1 |
| 7 | Congenital cystic adenomatoid malformation of the lung: evaluation of the cellulatr components显示文摘 | Morotti RA Cangiarella J Gutierrez MC | 1999 | Hum Pathology1999，30，6： | 1 |
| 8 | Pemetrexed disodi- um in ovarian cancer treatment 显示文摘 | Morotti M Valenzano Menada M | 2012 | Expert ()pin lnvestig Drugs2012，，： | 1 |
| 9 | Expression of thyroid transcription factor - 1 in congenital cystic adenomatoid malformation of the lung 显示文摘 | Morotti RA GutierrezMC Askin F | 2000 | Pediatr Dev Pathol2000，3，5： | 1 |
| 10 | PML targeting eradicates quiescent leukaemia-initiating cells显示文摘 | Ito K Bernardi R Morotti A | 2008 | Nature2008，453，7198： | 1 |
| 11 | Activation of NF-kappa B is essential for hepatocyte growth factor-mediated proliferation and tubulogenesis显示文摘 | Muller M Morotti A Ponzetto C | 2002 | Mol Cell Biol2002，22，4： | 1 |
| 12 | Breast cancer with synchronous massive metastasis in the uterine cervix:a case report and review of the literature显示文摘 | Bogliolo S Morotti M Valenzano Menada M | 2010 | Arch Gynecol Obstet2010，281，： | 1 |
| 13 | PML targetingeradicates quiescent leukaemia- initiating cells显示文摘 | ITO K BERNARDI R MOROTTI A | 2008 | Nature2008，453，7198： | 1 |
| 14 | Kinase-inhibitor-insensitive Cancer Stem Cells in Chronic Myeloid Leukemia 显示文摘 | Morotti A Panuzzo C Fava C | 2013 | Expert Opin Biol TH2013，14，3： | 1 |
| 15 | Expression of thyroid transcription factor-1 in congenital cystic adenomatoid malformation of the lung显示文摘 | GUTIERREZ M C ASKIN F | 2000 | Pediatr Dev Pathol2000，3，： | 1 |
| 16 | Tumor hypoxia induces nuclear paraspeckle formation through HIF-2a dependent transcriptional activation of NEAT1 leading to cancer cell survival 显示文摘 | Choudhry H Albukhari A Morotti M | 2015 | Oncogene2015，34，34： | 1 |
| 17 | K252a inhibits the oncogenic properties of Met, the HGF receptor显示文摘 | MOROTTI A MILA S ACCORNERO P | 2002 | Oncogene2002，21，32： | 1 |
| 18 | Pediatric inflammatory myofibroblastic tumor with late metastasis to the lung:case report and review of the literature显示文摘 | Morotti R A Legman M D Kerkar N | | 0，，2： | 1 |
| 19 | Ca2+current facilitation is Ca MKII-dependent and has arrhythmogenic consequences显示文摘 | Donald M Morotti S | 2014 | Front Pharmacol2014，5，： | 1 |
| 20 | Expression of thyroid transcription factor-1,surfactant proteins,type Ⅰ cell-associated antigen,and Clara cell secretory protein in pulmonary hypoplasia显示文摘 | Zhou H Morotti RA Profitt SA | 2001 | Pediatr Dev Pathol2001，4，4： | 1 |
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