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| 1 | Cell sheet technology for regeneration of esophageal mucosa显示文摘The progress of tissue-engineering technology has realized development of new therapies to treat various disorders by using cultured cells. Cell-and tissue-based therapies have been successfully applied to human patients, and several tissue-engineered products have been approved by the regulatory agencies and are commercially available. In the review article, we describe our experience of development and clinical application of cell sheet-based regenerative medicine.Endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) have been shown to be useful for removal of gastrointestinal neoplasms with less invasiveness compared with open surgery, especially in esophageal surgery. However, postoperative inflammation and stenosis are major complications observed after intensive mucosal resection. Therefore, we have developed novel regenerative medicine to prevent such complications and promote wound healing of esophageal mucosa after EMR or ESD. Transplantable oral mucosal epithelial cell sheets were fabricated from patients' own oral mucosa. Immediately after EMR or ESD, fabricated autologous cell sheets were endoscopically transplanted to the ulcer sites. We performed a preclinical study with a canine model. In human clinical settings, cell culture and cell sheet fabrication were performed in clean rooms according to good manufacturing practice guidelines, and pharmaceutical drugs were used as supplements to culture medium in place of research regents used in animal study. We believe that cell-based regenerative medicine would be useful to improve quality of life of patients after EMR or ESD. | Ryo Takagi Masayuki Yamato Nobuo Kanai Daisuke Murakami Makoto Kondo Takaaki Ishii Takeshi Ohki Hideo Namiki Masakazu Yamamoto Teruo Okano | 2012 | World Journal of Gastroenterology2012，18，37： | 9 |
| 2 | Genetic analysis and molecular characterisation of laboratory and field mutants of Botryotinia fuckeliana ( Botrytis cinerea ) resistant to QoI fungicides显示文摘 | Rita M De Miccolis Angelini Caterina Rotolo Mario Masiello Stefania Pollastro Hideo Ishii Francesco Faretra | 2012 | Pest Manag Sci2012，，9： | 1 |
| 3 | Interval priorities in AHP by interval regression analysis显示文摘 | Sugihaa Kazutomi Ishii Hiroaki Tanaka Hideo | 2004 | European Journal of Operational Research2004，158，3： | 1 |
| 4 | Studies on self-learning autonomous vehicles (Part 1): Following control using neuro-controller显示文摘 | Kazunobu ISHII Hideo TERAO Noboru NOGUCHI | 1994 | Journal of the Japanese Society of Agricultural Machinery1994，56，4： | 1 |
| 5 | Optimal control of agricultural vehicles by neural network (Part 2): Optimal schedule of working route by genetic algorithms 显示文摘 | Noboru Noguchi Kazunobu Ishii Hideo Terao | 1994 | Journal of the Japanese Society of Agricultural Machinery1994，56，2： | 1 |
| 6 | Gene expression of bone morphogenic protein 8B in the primary site,peripheral blood and bone marrow of patients with gastric cancer显示文摘 | Kosuke Mima Takeo Fukagawa Junji Kurashige Yuki Takano Ryutaro Uchi Hiroki Ueo Tae Matsumura Masahisa Ishibashi Genta Sawada Yusuke Takahashi Sayuri Akiyoshi Hidetoshi Eguchi Tomoya Sudo Keishi Sugimachi Masayuki Watanabe Hideshi Ishii Masaki Mori Hideo B | 2013 | Oncology Letters2013，，2： | 1 |
| 7 | Noradrenaline systems in the hypothalamus, amygdala and locus coeruleus are involved in the provocation of anxiety: basic studies显示文摘 | Masatoshi Tanaka Masami Yoshida Hiroyuki Emoto Hideo Ishii | 2000 | European Journal of Pharmacology2000，，1： | 1 |
| 8 | An Investigation of Thermal Conductivity of Silicon as a Function of Isotope Concentration by Molecular Dynamics 显示文摘 | Atsushi Murakawa Hideo Ishii | 2004 | Journal of Crystal Growth2004，267，： | 1 |
| 9 | A new tourniquet system that determines pressures in synchrony with systolic blood pressure in knee surgery显示文摘 | Yoshinori Ishii Hideo Noguchi Mitsuhiro Takeda To-ichi Higashihara | 2009 | Knee Surgery Sports Traumatology Arthroscopy2009，，1： | 1 |
| 10 | Large-scale DNA polymorphism study of Oryza sativa and O. rufipogon reveals the origin and divergence of Asian rice显示文摘 | Sujay Rakshit Arunita Rakshit Hideo Matsumura Yoshihiro Takahashi Yoshitaka Hasegawa Akiko Ito Takashige Ishii Naohiko T. Miyashita Ryohei Terauchi | 2007 | Theoretical and Applied Genetics2007，，4： | 1 |
| 11 | Proteomics approach for investigating the disease resistance using cucumber as model plant显示文摘 | SALIGRAMA A DEEPAK JUNKO SHIBATO HIDEO ISHII | 2008 | American Journal of Biochemistry and Biotechnology2008，4，3： | 1 |
| 12 | High precision calibration method of intrinsic parameters for fish-eye camera显示文摘 | Hideki Komagata Ikuo Ishii Hideo Makino | 2009 | Proc of SPIE2009，7432，： | 1 |
| 13 | The Association Between Plaque Characterization by CT Angiography and Post-Procedural Myocardial Infarction in Patients With Elective Stent Implantation显示文摘 | Tadayuki Uetani Tetsuya Amano Ayako Kunimura Soichiro Kumagai Hirohiko Ando Kiminobu Yokoi Tomohiro Yoshida Bunichi Kato Masataka Kato Nobuyuki Marui Michio Nanki Tatsuaki Matsubara Hideki Ishii Hideo Izawa Toyoaki Murohara | 2010 | JACC: Cardiovascular Imaging2010，，1： | 1 |
| 14 | Genetic analysis and PCR-based identification of major Fusarium species causing head blight on wheat in Japan显示文摘 | Chung Wen-hsin Ishii Hideo Nishimura Kumiko Ohshima Michiyo Iwama Toshitaka Yoshimatsu Hideaki | 2008 | Journal of General Plant Pathology : JGPP2008，，5： | 1 |
| 15 | Pressure stimulates proliferation and DNA synthesis in rat intestinal epithelial cells显示文摘 | Masahiko Hirokawa Soichiro Miura Takeharu Shigematsu Hideo Yoshida Ryota Hokari Hajime Higuchi Iwao Kurose Hiroyuki Kimura Hidetsugu Saito Toshio Nakaki Hiromasa Ishii | 1997 | Life Sciences1997，，7： | 1 |
| 16 | Interval priorities in AHP by interval regression analysis显示文摘 | Kazutomi Sugihara Hiroaki Ishii Hideo Tanaka | 2004 | European Journal of Operational Research2004，，158： | 1 |
| 17 | Loading of Mechanical Pressure Activates Mitogen-Activated Protein Kinase and Early Immediate Gene in Intestinal Epithelial Cells显示文摘 | Masahiko Hirokawa Soichiro Miura Hiroshi Kishikawa Hideo Yoshida Hiromasa Nakamizo Hajime Higuchi Ruri C. Nakatsumi Hidekazu Suzuki Hidetsugu Saito Hiromasa Ishii | 2001 | Digestive Diseases and Sciences2001，，9： | 1 |
| 18 | Absence of platelet-activating factor receptor protects mice from osteoporosis following ovariectomy显示文摘 | Hisako HikUi Satoshi Ishii Hideo Shindou | 2004 | J Clin Invest2004，114，： | 1 |
| 19 | Antagonism between acibenzolar- S -methyl-induced systemic acquired resistance and jasmonic acid-induced systemic acquired susceptibility to Colletotrichum orbiculare infection in cucumber显示文摘 | Chunlin Liu Ying Ruan Zongjun Lin Ran Wei Qi Peng Chunyun Guan Hideo Ishii | 2008 | Physiological and Molecular Plant Pathology2008，，4： | 1 |
| 20 | Changes of body balance before and after total knee arthroplasty in patients who suffered from bilateral knee osteoarthritis显示文摘 | Yoshinori Ishii Hideo Noguchi Mitsuhiro Takeda Junko Sato Yoshihiro Kishimoto Shin-Ichi Toyabe | 2013 | Journal of Orthopaedic Science2013，，5： | 1 |
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