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| 1 | Prevention of esophageal strictures after endoscopic submucosal dissection显示文摘Endoscopic mucosal resection(EMR) and endoscopic submucosal dissection(ESD) have recently been accepted as less invasive methods for treating patients with early esophageal cancers such as squamous cell carcinoma and dysplasia of Barrett's esophagus.However,the large defects in the esophageal mucosa often cause severe esophageal strictures,which dramatically reduce the patient's quality of life.Although preventive endoscopic balloon dilatation can reduce dysphagia and the frequency of dilatation,other approaches are necessary to prevent esophageal strictures after ESD.This review describes several strategies for preventing esophageal strictures after ESD,with a particular focus on anti-inflammatory and tissue engineering approaches.The local injection of triamcinolone acetonide and other systemic steroid therapies are frequently used to prevent esophageal strictures after ESD.Tissue engineering approaches for preventing esophageal strictures have recently been applied in basic research studies.Scaffolds with temporary stents have been applied in five cases,and this technique has been shown to be safe and is anticipated to prevent esophageal strictures.Fabricated autologous oral mucosal epithelial cell sheets to cover the defective mucosa similarly to how commercially available skin products fabricated from epidermal cells are used for skin defects or in cases of intractable ulcers.Fabricated autologous oralmucosal-epithelial cell sheets have already been shown to be safe. | Shinichiro Kobayashi Nobuo Kanai Takeshi Ohki Ryo Takagi Naoyuki Yamaguchi Hajime Isomoto Yoshiyuki Kasai Takahiro Hosoi Kazuhiko Nakao Susumu Eguchi Masakazu Yamamoto Masayuki Yamato Teruo Okano | 2014 | World Journal of Gastroenterology2014，20，41： | 12 |
| 2 | Cell sheet technology for regeneration of esophageal mucosa显示文摘The progress of tissue-engineering technology has realized development of new therapies to treat various disorders by using cultured cells. Cell-and tissue-based therapies have been successfully applied to human patients, and several tissue-engineered products have been approved by the regulatory agencies and are commercially available. In the review article, we describe our experience of development and clinical application of cell sheet-based regenerative medicine.Endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) have been shown to be useful for removal of gastrointestinal neoplasms with less invasiveness compared with open surgery, especially in esophageal surgery. However, postoperative inflammation and stenosis are major complications observed after intensive mucosal resection. Therefore, we have developed novel regenerative medicine to prevent such complications and promote wound healing of esophageal mucosa after EMR or ESD. Transplantable oral mucosal epithelial cell sheets were fabricated from patients' own oral mucosa. Immediately after EMR or ESD, fabricated autologous cell sheets were endoscopically transplanted to the ulcer sites. We performed a preclinical study with a canine model. In human clinical settings, cell culture and cell sheet fabrication were performed in clean rooms according to good manufacturing practice guidelines, and pharmaceutical drugs were used as supplements to culture medium in place of research regents used in animal study. We believe that cell-based regenerative medicine would be useful to improve quality of life of patients after EMR or ESD. | Ryo Takagi Masayuki Yamato Nobuo Kanai Daisuke Murakami Makoto Kondo Takaaki Ishii Takeshi Ohki Hideo Namiki Masakazu Yamamoto Teruo Okano | 2012 | World Journal of Gastroenterology2012，18，37： | 9 |
| 3 | Periodontal regeneration with multi-layered periodontal ligament-derived cell sheets in a canine model显示文摘 | Takanori Iwata Masayuki Yamato Hiroaki Tsuchioka Ryo Takagi Shigeki Mukobata Kaoru Washio Teruo Okano Isao Ishikawa | 2009 | Biomaterials2009，，14： | 1 |
| 4 | A Study on Accuracy of Fixed Point Arithmetic FDTD Method 显示文摘 | Yamaguchi Ryo Suzuki Hidetoshi Takagi Yuta Uebayashi Shinji | 2006 | IEIC Technical Report (S0913-5685)2006，106，40： | 1 |
| 5 | Usefulness of magnetic resonance imaging for diagnosing deep anorectal abscesses显示文摘 | Ryo Maruyama Tsuyoshi Noguchi Masahiro Takano Koichi Takagi Norikazu Morita Ryuichi Kikuchi Yuzo Uchida | 2000 | Diseases of the Colon & Rectum2000，，： | 1 |
| 6 | Fluid–structure Interaction Modeling of Aneurysmal Conditions with High and Normal Blood Pressures显示文摘 | Ryo Torii Marie Oshima Toshio Kobayashi Kiyoshi Takagi Tayfun E. Tezduyar | 2006 | Computational Mechanics (-)2006，，4： | 1 |
| 7 | Prevention of Esophageal Stricture After Endoscopic Submucosal Dissection Using Tissue-Engineered Cell Sheets显示文摘 | Takeshi Ohki Masayuki Yamato Masaho Ota Ryo Takagi Daisuke Murakami Makoto Kondo Ryo Sasaki Hideo Namiki Teruo Okano Masakazu Yamamoto | 2012 | Gastroenterology2012，，3： | 1 |
| 8 | Molecular Dissection of Premalignant Colorectal Lesions Reveals Early Onset of the CpG Island Methylator Phenotype显示文摘 | Eiichiro Yamamoto Hiromu Suzuki Hiro-o Yamano Reo Maruyama Masanori Nojima Seiko Kamimae Takeshi Sawada Masami Ashida Kenjiro Yoshikawa Tomoaki Kimura Ryo Takagi Taku Harada Ryo Suzuki Akiko Sato Masahiro Kai Yasushi Sasaki Takashi Tokino Tamotsu Sugai Ko | 2012 | The American Journal of Pathology2012，，5： | 1 |
| 9 | LOH analysis of free DNA in the plasma of patients with mucosal malignant melanoma in the head and neck显示文摘 | Ryo Takagi Daisuke Nakamoto Jun-etsu Mizoe Hirohiko Tsujii | 2007 | International Journal of Clinical Oncology2007，，3： | 1 |
| 10 | In situ observation of the phase transformation kinetics of bismuth during shock release显示文摘A time-resolved x-ray diffraction technique is employed to monitor the structural transformation of laser-shocked bismuth.Results reveal a retarded transformation from the shock-induced Bi-Ⅴphase to a metastable Bi-Ⅳphase during the shock release,instead of the thermodynamically stable Bi-Ⅲphase.The emergence of the metastable Bi-Ⅳphase is understood by the competitive interplay between two transformation pathways towards the Bi-Ⅳand Bi-Ⅲ,respectively.The former is more rapid than the latter because the Bi-Ⅴto B-Ⅳtransformation is driven by interaction between the closest atoms while the Bi-Ⅴto B-Ⅲtransformation requires interaction between the second-closest atoms.The nucleation time for the Bi-Ⅴto Bi-Ⅳtransformation is determined to be 5.1±0.9 ns according to a classical nucleation model.This observation demonstrates the importance of the formation of the transient metastable phases,which can change the phase transformation pathway in a dynamic process. | 李江涛 王倩男 徐亮 柳雷 张航 Sota Takagi Kouhei Ichiyanagi Ryo Fukaya Shunsuke Nozawa 胡建波 | 2024 | Chinese Physics B2024，33，4： | 0 |
| 11 | 回眸高速铁路10年的发展显示文摘本文介绍了自世界上首条高速铁路日本东海道干线之后,世界高速铁路发展状况,提出了今后高速铁路发展的前景。文章还总结了铁路私有化和运输市场竞争的状况,以及目前正在进行的有关研究。作者对磁悬浮是否成为今后发展的趋势提出了自己的看法。 | Ryo Takagi 宋文伟 | 2005 | 西铁科技2005，，4： | 0 |
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