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| 1 | Toll-like receptor 4/nuclear factor-kappa B signaling detected in brain after early subarachnoid hemorrhage显示文摘背景发炎和免疫在 subarachnoid 出血(SAH ) 以后在早大脑损害的致病起一个重要作用。原子 factor-kappa B (NF-KB ) 为发炎和免疫调整许多基因必需品并且被像使用费的受体(TLR ) 激活。这研究试图检测在早 SAH 以后在老鼠大脑发信号的像使用费的受体 4/nuclear factor-kappa B (TLR4/NF-KB ) 的表示。老鼠被将斩首的方法和他们的大脑在血的单个注射以后在 0, 2, 4, 6, 12, 24 和 48 个小时被移开进 prechiasmatic 水塘, TLR4 的 mRNA 表示被 immunohistochemistry 并且西方的弄污被 Taqman 即时 RT-PCR,和蛋白质表示测量。肿瘤坏死 factor-alpha (TNF-) 的 NF-KB 活动和集中, interleukin-lbeta (IL-) 和 intedeukin-6 (IL-6 ) 被试金(ELISA ).Results TaqMan 即时 RT-PCR 并且西方的弄污识别了的连接酶的 immunosorbent 测量在在 mRNA 和蛋白质的 TLR4 表示的一个 biphasic 变化:一座起始的山峰(2-6 小时) 和持续举起(12-48 小时) 。染色的 Immunohistochemical 在 glial 房间和脉管的内皮细胞层主要显示出 TLR4-1ike 免疫反应的可诱导的表示。在象 NF-KB-regulated proinflammatory cytokines (TNF- , IL-1 和 IL-6 ) 的生产一样的 NF-KB 子单元 p65 的激活的一个类似的 biphasic 变化被 ELISA 检测。结论这些数据建议试验性的 SAH 导致在早大脑损害发信号的 TLR4 表示和 NF-KB 的重要起来规定。发信号的 TLR4/NF-KB 的激活可以在 SAH 以后调整煽动性的回答。 | MA Chun-xiao YIN Wei-ning CAI Bo-wen WU Jian WANG Jun-yi HE Min SUN Hong DING Jun-li YOU Chao | 2009 | Chinese Medical Journal2009，，13： | 33 |
| 2 | 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers显示文摘象 5-methylcytosine (5mC ) 和 5-hydroxymethylcytosine (5hmC ) 那样的 DNA 修正是知道在哺乳动物影响全球基因表示的 epigenetic 标记。在人的染色体,与基因表示的靠近的关联和高化学的稳定性给他们的流行,这些 DNA epigenetic 标记能为癌症用作理想的 biomarkers 诊断。利用一种高度敏感、选择的化学标记技术,我们这里报导在传播没有房间的 DNA ( cfDNA )并且在从最近与 colorectal 诊断的 260 个病人的一个队收集的配对的肿瘤和邻近的纸巾的 genomic DNA ( gDNA )的 5hmC 的染色体宽的介绍,胃,胰腺,从 90 个健康个人的肝或甲状腺癌症和正常纸巾。5hmC 主要在与开的染色质和容许的 histone 修正重合的 transcriptionally 活跃的区域被散布。柔韧的联系癌症的 5hmC 签名在 cfDNA 被识别为特定的癌症类型是特征的。传播 cfDNA 的 5hmC 底 biomarkers colorectal 和胃的癌症是高度预兆的并且比常规 biomarkers 优异并且比得上从织物活体检视的 5hmC biomarkers。因此,这新策略能从血样品的分析为癌症的诊断和预后导致有效、最低限度地侵略的方法的发展。 | Wenshuai Li Xu Zhang Xingyu Lu Lei You Yanqun Song Zhongguang Luo Jun Zhang Ji Nie Wanwei Zheng Diannan Xu Yaping Wang Yuanqiang Dong Shulin Yu Jun Hong Jianping Shi Hankun Hao Fen Luo Luchun Hua Peng Wang Xiaoping Qian Fang Yuan Lianhuan Wei Ming Cui Taiping Zhang Quan Liao Menghua Dai Ziwen Liu Ge Chen Katherine Meckel Sarbani Adhikari Guifang Jia Marc B Bissonnette Xinxiang Zhang Yupei Zhao Wei Zhang Chuan He Jie Liu | 2017 | Cell Research2017，27，10： | 30 |
| 3 | The subducted slab of Yangtze Continental block beneath the Tethyan orogen in western Yunnan显示文摘The western Yunnan area is a natural laboratory with fully developed and best preserved Tethyan orogen in the world. Seismic tomography reveals a slab-like high velocity anomaly down to 250 km beneath the western Yunnan Tethyan orogen, to its west there is a low-velocity column about 300 km wide. in the region from Lancangjiang to Mojiang an obvious low velocity in the lower crust and uppermost mantle overlies on the slab. Synthesizing the available geological and geochemical results, the present paper demonstrates that this slab-like high velocity anomaly is a part of the subducted plate of Yangtze Continental segment after the closure of Paleotethys. The collision of India and Eurasia continent starting from 50-60 MaBP might trigger thermal disturbance in the upper mantle and cause the uprising of asthenosphere, in that case the subducted Yangtze plate could be broken off, causing Cenozoic magmatic activities and underplating in the Lancangjiang-Mojiang region. | Futian Liu Jianhua Liu Dalai Zhong Jiankun He Qingyu You | 2000 | Chinese Science Bulletin2000，45，5： | 28 |
| 4 | Relationship between expression of α-fetoprotein messenger RNA and some clinical parameters of human hepatocelular carcinoma显示文摘METHODWedetectedtheexpressionofAFPinmRNAlevelintissuesamplesfrom52patientssuferingfromHCCbyRTPCRmethod.RESULTSThepositiverat... | HE Ping, TANG Zhao You, YE Sheng Long and LIU Bin Bin | 1999 | World Journal of Gastroenterology1999，5，2： | 23 |
| 5 | Special Section:SARS-CoV-2 Preliminary evidence from a multicenter prospective observational study of the safety and efficacy of chloroquine for the treatment of COVID-19显示文摘Effective therapies are urgently needed for the SARS-CoV-2 pandemic.Chloroquine has been proved to have antiviral effect against coronavirus in vitro.In this study,we aimed to assess the efficacy and safety of chloroquine with different doses in COVID-19.In this multicenter prospective observational study,we enrolled patients older than 18 years old with confirmed SARS-CoV-2 infection excluding critical cases from 12 hospitals in Guangdong and Hubei Provinces.Eligible patients received chloroquinephosphate s00 mg,orally,once(half dose)or twice(full dose)daily.Patients treated with non-chloroquine therapy were included as historical controls.The primary endpoint is the time to undetectable viral RNA.Secondary outcomes include the proportion of patients with undetectable viral RNA by day 10 and 14,hospitalization time,duration of fever,and adverse events.A total of 197 patients completed chloroquine treatment,and 176patients were included as historical controls.The median time to achieve an undetectable viral RNA was shorter in chloroquine than in non-chloroquine(absolute difference in medians-6.0 days;95%CI-6.0 to—4.0).The duration of fever is shorter in chloroquine(geometric mean ratio 0.6;95%CIO.5 to 0.8).No serious adverse events were observed in the chloroquine group.Patients treated with half dose experienced lower rate of adverse events than with full dose.Although randomized trials are needed for further evaluation,this study provides evidence for safety and efficacy of chloroquine in COVID-19 and suggests that chloroquine can be a cost-effective therapy for combating the COVID-19 pandemic. | Mingxing Huang Man Li Fei Xiao Pengfei Pang Jiabi Liang Tiantian Tang Shaoxuan Liu Binghui Chen Jingxian Shu Yingying You Yang Li Meiwen Tang Jianhui Zhou Guanmin Jiang Jingfen Xiang Wenxin Hong Songmei He Zhaoqin Wang Jianhua Feng Changqing Lin Yinong Ye Zhilong Wu Yaocai Li Bei Zhong Ruilin Sun Zhongsi Hong Jing Liu Huili Chen Xiaohua Wang Zhonghe Li Duanqing Pei Lin Tian Jinyu Xia Shanping Jiang Nanshan Zhong Hong Shan | 2020 | National Science Review2020，7，9： | 20 |
| 6 | Human umbilical cord mesenchymal stem cells derived from Wharton's jelly differentiate into insulin-producing cells in vitro显示文摘背景小岛移植是颠倒类型糖尿病的一个有效方法。然而,小岛移植被象施主小岛的有免疫力的拒绝和缺乏那样的问题妨碍。间充质的干细胞能区分进生产胰岛素的房间。然而,人的脐的绳索的潜力间充质的干细胞(huMSCs ) 到变得的生产胰岛素的房间遗体 undetermined.Methods 我们在小岛房间文化条件下面孤立并且导致有教养的 huMSCs。huMSCs 的反应在一台转换阶段对比显微镜下面被监视。染色方法的 Immunocytochemical 和 immunofluorescence 被用来测量胰岛素和 glucagon 蛋白质层次。反向的抄写聚合酶链反应(RT-PCR ) 被执行检测人的胰岛素和 PDX-1 的基因表示。染色 Dithizone 被采用在 huMSCs 决定锌内容。胰岛素分泌物也通过菸碱和 -mercaptoethanol 导致的 radioimmunoassay.Results HuMSCs 被评估或由神经原的区别, 1 基因(NeuroD1 ) transfection 逐渐地从典型地伸长的塑造成纤维细胞的房间把形态学改变了到圆房间。他们有一个趋势形成簇。Immunocytochemical 研究响应正式就职在这些房间显示出人的胰岛素和 glucagon 的积极表示。发现那 huMSCs 的 RT-PCR 实验表示了感应的列在后面的胰岛素和 PDX-1 基因, dithizone 染色了 huMSCs 的细胞质一种呈褐色的红颜色在以后感应。在导致的 huMSCs 的胰岛素分泌物显著地与控制组相比被提高(t=6.183, P0.05 ).Conclusions HuMSCs 能在 vitro 区分进生产胰岛素的房间。在糖尿病的房间代替治疗的 huMSCs 的潜在的使用需要进一步被学习。 | WANG Hong-wu LIN Li-min HE Hong-yan YOU Fang LI Wei-zhong HUANG Tian-hua MA Gui-xia MA Lian | 2011 | Chinese Medical Journal2011，，10： | 19 |
| 7 | mm Wave communications for 5G: implementation challenges and advances显示文摘The requirement of the fifth generation(5 G) wireless communication for high throughput motivates the wireless industry to use the mm Wave(millimeter wave) communications for its wide bandwidth advantage. To compensate the heavy path loss and increase the communications capacity, phased array beamforming and massive multiple-input multiple-output(MIMO) techniques are employed at both the user equipment(UE) and base stations(BS). Considering the commercial requirements, 5 G mm Wave large array systems should be implemented in an energy-and cost-efficient way with a small form factor. To address above issues and realize a reliable communications link, taking into account the particular characteristics of5 G mm Wave systems, this paper firstly examines the design challenges and trade-offs in system implementations, then some of the design strategies are summarized. At last, recent advance in RF front-end circuits and receiver sub-systems is then highlighted. | Lianming LI Dongming WANG Xiaokang NIU Yuan CHAI Linhui CHEN Long HE Xu WU Fuchun ZHENG Tiejun CUI Xiaohu YOU | 2018 | Science China(Information Sciences)2018，61，2： | 19 |
| 8 | Clinical significance of Fas antigen expression in gastric carcinoma显示文摘INTRODUCTIONInordertodeterminewhetherFasantigenplaysaroleinthegastriccarcinogenicsequence,animmunohistochemicalstudyofFasant... | LIU Hai Feng 1, LIU Wei Wen 1, FANG Dian Chun 1, LIU Feng Xian 2 and HE Guang You 2 | 1999 | World Journal of Gastroenterology1999，5，1： | 15 |
| 9 | Effect of Environmental Gradients on the Quantity and Quality of Fallen Logs in Tsuga longibracteata Forest in Tianbaoyan National Nature Reserve, Fujian Province,China显示文摘We investigated the quantity and quality of fallen logs in different Tsuga longibracteata forest communities in the Tianbaoyan National Nature Reserve. We used redundancy analysis to determine the spatial distribution of fallen logs in the different forest communities and to analyze the relationships among stand structure, topographic factors and human disturbance. The volume, covered area, mean log length and number of fallen logs differed significantly among forest types(P < 0.05), but mean diameter at breast height showed no significant difference(P > 0.05). The log volume and covered area in different forest types showed the following trend: T. longibracteata pure forest < T.longibracteata + Oligostachyum scabriflorur < T.longibracteata + hardwood < Rhododendron simiarum + T. longibracteata < T. longibracteata +Phyllostachys heterocycla pubescens. The spatial distribution patterns of logs quantity and quality indicated that log volume and covered area were strongly affected by environmental factors in the following order: human disturbance > elevation >slope position > bole height > tree height > slope aspect > density > basal area > slope gradient. The relative contribution of environmental variables on the total variance was topography(76%) >disturbance(42%) > stand structure(35%).Topography and disturbance combined explained83% of the variance. Fallen logs quantity and qualitywere negatively related to elevation and slope position,and positively associated to human disturbance. The log volume decreased from northern to southern slopes. Environmental factors had the highest impact on class I(slightly decayed), and lowest impact on class V(highly decayed). | YOU Hui-ming HE Dong-jin YOU Wei-bin LIU Jin-shan CAI Chang-tang | 2013 | Journal of Mountain Science2013，10，6： | 14 |
| 10 | Relationship between β-amyloid protein 1-42, thyroid hormone levels and the risk of cognitive impairment after ischemic stroke显示文摘BACKGROUND Post-stroke cognitive impairment(PSCI)is not only a common consequence of stroke but also an important factor for adverse prognosis of patients.Biochemical indicators such as blood lipids and blood pressure are affected by many factors,and the ability of evaluating the progress of patients with PSCI is insufficient.Therefore,it is necessary to find sensitive markers for predicting the progress of patients and avoiding PSCI.Recent studies have shown thatβ-amyloid protein 1-42(Aβ1-42)and thyroid hormone levels are closely related to PSCI,which may be the influencing factors of PSCI,but there are few related studies.AIM To investigate the relationship between serum levels of Aβand thyroid hormones in acute stage and PSCI and its predicted value.METHODS A total of 195 patients with acute cerebral infarction confirmed from June 2016 to January 2018 were enrolled in this study.Baseline data and serological indicators were recorded to assess cognitive function of patients.All patients were followed up for 1 year.Their cognitive functions were evaluated within 1 wk,3 mo,6 mo and 1 yr after stroke.At the end of follow-up,the patients were divided into PSCI and non-PSCI according to Montreal cognitive assessment score,and the relationship between biochemical indexes and the progression of PSCI was explored.RESULTS Compared with patients with non-PSCI,the levels of Aβ1-42,triiodothyronine(T3)and free thyroxin were lower in the patients with PSCI.Repeated measures analysis of variance showed that the overall content of Aβ1-42 and T3 in PSCI was also lower than that of the non-PSCI patients.Further analysis revealed that Aβ1-42(r=0.348),T3(r=0.273)and free thyroxin(r=0.214)were positively correlated with disease progression(P<0.05),suggesting that these indicators have the potential to predict disease progression and outcome.Cox regression analysis showed that Aβ1-42 and T3 were important factors of PSCI.Then stratified analysis showed that the lower the Aβ1-42 and T3,the higher risk of PSCI in patients who were aged over 70,female and illiterate.CONCLUSION Aβ1-42 and T3 have the ability to predict the progression of PSCI,which is expected to be applied clinically to reduce the incidence of PSCI and improve the quality of life of patients. | Lei Mao Xiao-Han Chen Jian-Hua Zhuang Peng Li Yi-Xin Xu Yu-Chen Zhao Yue-Jin Ma Bin He You Yin | 2020 | World Journal of Clinical Cases2020，8，1： | 13 |
| 11 | Transboundary hydrological effects of hydropower dam construction on the Lancang River显示文摘 | HE Daming FENG Yan GAN Shu Darrin Magee YOU Weihong | 2006 | Chinese Science Bulletin2006，51，B11： | 13 |
| 12 | Reversible transition between hepatocytes and liver progenitors for in vitro hepatocyte expansion显示文摘 | Wu, Han Zhou, Xu Fu, Gong-Bo He, Zhi-Ying Wu, Hong-Ping You, Pu Ashton, Charles Wang, Xin Wang, Hong-Yang Yan, He-Xin | 2017 | Cell Research2017，27，5： | 12 |
| 13 | Measuring Conflict Functions in Generalized Power Space显示文摘One of the most important open issues is that the classical conflict coefficient in D-S evidence theory (DST) cannot correctly determine the conflict degree between two pieces of evidence. This drawback greatly limits the use of DST in real application systems. Early researches mainly focused on the improvement of Dempster’s rule of combination (DRC). However, the current research shows it is very important to define new conflict coefficients to determine the conflict degree between two or more pieces of evidence. The evidential sources of information are considered in this work and the definition of a conflict measure function (CMF) is proposed for selecting some useful CMFs in the next fusion work when sources are available at each instant. Firstly, the definition and theorems of CMF are put forward. Secondly, some typical CMFs are extended and then new CMFs are put forward. Finally, experiments illustrate that the CMF based on Jousselme and its similar ones are the best suited ones. | HU Lifang GUAN Xin DENG Yong HAN Deqiang HE You | 2011 | Chinese Journal of Aeronautics2011，24，1： | 11 |
| 14 | Plumbagin inhibits cell growth and potentiates apop-tosis in human gastric cancer cells -in vitro through the NF-KB signaling pathway显示文摘 | Jing LI Lin SHEN Fu-rong LU You QIN Rui CHEN Jia LI fan LI Han-zi ZHAN Yuan-qiao HE | 2012 | Acta Pharmacologica Sinica2012，33，2： | 11 |
| 15 | Optimal allocation of multi-sensor passive localization显示文摘To improve multi-sensor passive localization precision,the optimal allocation form of multi-sensor bearing-only localization is analyzed from the perspective of the geometric dilution of precision(GDOP) of the least squares(LS) algorithm.This paper indicates that whether the target lies inside the closed region formed by the sensors or not,the optimal allocation is when each adjacent cut angle between a sensor pair is identical,and all sensors are located on the border of the circle that has the target(which is also the origin of the coordinate system) as its center.When there is no restriction on the adjacent cut angle in the above allocation,the optimal estimate of the LS algorithm in the sense of minimum variance can be acquired.When the LS algorithm achieves the optimal estimate and the sensors present the optimal allocation,the respective consistencies are analyzed.Simulation results verify the analysis of the optimal allocation form above,which can be used in multi-sensor passive localization algorithms based on sensor management. | WANG BenCai HE You WANG GuoHong XIU JianJuan | 2010 | Science China(Information Sciences)2010，53，12： | 11 |
| 16 | Admission delay is associated with worse surgical outcomes for elderly hip fracture patients:A retrospective observational study显示文摘BACKGROUND:The influence of surgical delay on mortality and morbidity has been studied extensively among elderly hip fracture patients.However,most studies only focus on the timing of surgery when patients have already been hospitalized,without considering pre-admission waiting time.Therefore,the present study aims to explore the infl uence of admission delay on surgical outcomes.METHODS:In this retrospective study,we recorded admission timing and interval from admission to surgery for included patient.Other covariates were also collected to control confounding.The primary outcome was 1-year mortality.The secondary outcomes were 1-month mortality,3-month mortality,ICU admission and postoperative pneumonia.We mainly used multivariate logistic regression to determine the effect of admission timing on postoperative outcomes.An additional survival analysis was also performed to assess the impact of admission delay on survival status in the fi rst year after operation.RESULTS:The proportion of patients hospitalized on day 0,day 1,day 2 after injury was 25.4%,54.7%and 66.3%,respectively.And 12.6%patients visited hospital one week later after injury.Mean time from admission to surgery was 5.2 days(standard deviation 2.8 days).Hospitalization at one week after injury was a risk factor for 1-year mortality(OR 1.762,95%CI 1.026–3.379,P=0.041).CONCLUSION:Admission delay of more than one week is signifi cantly associated with higher 1-year mortality.As a supplement to the current guidelines which emphasizes early surgery after admission,we also advocate early admission once patients get injured. | Wei He Yue-yang You Kai Sun Chen Xie Yue Ming Li-na Yu Feng-jiang Zhang Min Yan | 2020 | World Journal of Emergency Medicine2020，11，1： | 11 |
| 17 | Two adaptive detectors for range-spread targets in non-Gaussian clutter显示文摘This paper addresses adaptive detection of range-spread target in spherically invariant random vector clutter. Based on the nonadaptive detectors of NSDD-GLRT and SDD-GLRT, two adaptive detectors named ANSDD-GLRT and ASDD-GLRT are devised by replacing the unknown normalized clutter covariance matrix with the sample covariance matrix based on the secondary data. The formulas of detection probability and false alarm probability are deduced. Moreover, the constant false alarm rate properties of both adaptive detectors are assessed and the inffuence of mismatched steering vector on detection probability is analyzed. The experimental results show that the adaptive detectors have an acceptable loss with respect to the nonadaptive counterparts. Furthermore, the ANSDD-GLRT converges much faster than the ASDD-GLRT, however, the latter rejects the misaligned signals more effectively. Both detectors perform well for the uniformly-distributedenergy target, but degenerate for the fluctuating targets. In addition, the correlation between target scatterers results in an additional gain for low signal-to-clutter power ratio. | HE You JIAN Tao SU Feng PING DianFa | 2011 | Science China(Information Sciences)2011，54，2： | 10 |
| 18 | Dietary seaweed-derived polysaccharides improve growth performance of weaned pigs through maintaining intestinal barrier function and modulating gut microbial populations显示文摘Background:Seaweed-derived polysaccharides(SDP)represent an attractive source of prebiotic nutraceuticals for the food and animal husbandry industry.However,the mechanism by which SDP from Enteromorpha mediates pig growth are not fully understood.This study aimed to investigate how SDP supplementation influences the growth performance and intestinal health in weaned pigs.Results:In Exp.1,240 weaned pigs were randomly assigned to four dietary treatments and fed with a basal diet or a basal diet containing 200,400 or 800 mg/kg SDP,respectively,in a 21-day trial.Pigs on the 400 or 800 mg/kg SDP-supplemented group had greater ADG and lower F/G ratio than those on the control group(P<0.05).In Exp.2,20 male weaned pigs were randomly assigned to two treatments and fed with a basal diet(CON group)or a basal diet supplemented with 400 mg/kg SDP(the optimum does from Exp.1),in a 21-day trial.Pigs fed the SDP diet had greater ADG,the concentrations of serum IL-6 and TNF-αand the activities of glutathione peroxidase,superoxide dismutase and catalase(P<0.05),and lower F/G,diarrhea rate,as well as serum D-lactate concentrations and diamine oxidase activity(P<0.05).Moreover,dietary SDP supplementation enhanced secretory immunoglobulin A content,villus height and villous height:crypt depth ratio in small intestine,as well as the lactase and maltase activities in jejunum mucosa(P<0.05).SDP supplementation elevated the mRNA levels of inflammatory responserelated genes(IL-6,TNF-α,TLR4,TLR6 and MyD88),and the mRNA and protein levels of ZO-1,claudin-1 and occludin in jejunum mucosa(P<0.05).Importantly,SDP not only increased the Lactobacillus population but also reduced the Escherichia coli population in cecum(P<0.05).Furthermore,SDP increased acetic acid and butyric acid concentrations in cecum(P<0.05).Conclusions:These results not only suggest a beneficial effect of SDP on growth performance and intestinal barrier functions,but also offer potential mechanisms behind SDP-facilitated intestinal health in weaned pigs. | Tiande Zou Jin Yang Xiaobo Guo Qin He Zirui Wang Jinming You | 2021 | Journal of Animal Science and Biotechnology2021，12，3： | 10 |
| 19 | Study on the effect and mechanism of the dysfunction of CD4^+ T cells in the disease process of chronic cardiac failure显示文摘Objective: To study the effect and mechanism of the dysfunction of CD4+ T cells in the disease process of chronic cardiac failure (CHF).Methods:According to different group technologies, 100 CHF patients were divided into the following groups: ischemia group and non-ischemia group, heart function Ⅰ-Ⅱ group and heart function Ⅲ-Ⅳ group, event group and non-event group, and 50 healthy volunteers were included in the control group. Realtime PCR was used to detect transcription factors T-bet and GATA-3 of Th1 and Th2; flow cytometry was applied to determine the ratio of Th17 and Treg cells; ELISA was employed to test cytokines IFN-γ, IL-4, IL-17 and IL-10 of peripheral blood Th1, Th2, Th17 and Treg cells, respectively; ultrasonic cardiogram was used to exploit to LVEF and LVEDd; and electrochemilu minescene immunoassay was used to examine plasma BNP. The differences of all indexes of all groups were analyzed and the correlation between CD4 T cells and clinical indexes was analyzed by Pearson correlation analysis. Results: As compared to the control group, the transcription factors T-bet and GATA-3 of Th1 and Th2, the ratio of cytokines Th17 and IFN-γ, cytokines IL-17, T-bet/GATA-3, IFN-γ/IL-4, Th17 cells/Treg cells, IL-17/IL-10 of the ischemia group and non-ischemia group, heart functionⅠ-Ⅱgroup and heart function Ⅲ-Ⅳ group, event group and non-event group were all increased significantly, while their transcription factor GATA-3 of Th2, cytokines IL4, Treg cells ratio, cytokines IL10 were decreased obviously. The differences showed statistical significance (P < 0.05). The increase or decrease of the partial CD4+ T cells of the ischemia group, heart function Ⅲ-Ⅳ group and event group was more distinctly. The results of Pearson correlation analysis showed that IFN-γ and IL-17 were significantly positively correlated with LVEDd and BNP, IL-4 and IL-10 were also significantly positively correlated with LVEF, but correlated negatively with BNP, and IL-17 was negatively correlative with LVEF. Conclusions: There was a correlation between CHF and the dysfunction of CD4+ T cells showing immune activation phenomenons of deviations from the Th1/Th2 balance towards Th1 and from the Th17/Treg balance towards Th17, which was also related to the types, severity and prognosis of the disease. | Yin-Hao Cai Zi-Jian Ma Xiu-Ying Lu En-Le He Ming-Yao You | 2016 | Asian Pacific Journal of Tropical Medicine2016，9，7： | 10 |
| 20 | Assessing the Effectiveness of a Cervical Cancer Screening Program in a Hospital-based Study显示文摘This study compared HPV testing and liquid-based cytology(LCT)as performance indicators for cervical cancer screening in a hospital-based study.A total of 61,193 outpatients were screened initially by LCT.Samples with screening results showing atypical squamous cells of undetermined significance(ASC-US)or worse were referred for colposcopy,and some | YANG Yi LANG Jing He WANG You Fang CHENG Xue Mei CAI Yu Pin LI Hui ZHU Bao Li ZHANG Rui Fen | 2015 | Biomedical and Environmental Sciences2015，28，1： | 10 |
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