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| 1 | Insight-HXMT observations of the first binary neutron star merger GW170817显示文摘Finding the electromagnetic(EM) counterpart of binary compact star merger, especially the binary neutron star(BNS) merger,is critically important for gravitational wave(GW) astronomy, cosmology and fundamental physics. On Aug. 17, 2017,Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart,GRB 170817 A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope(HE) onboard Insight-HXMT(Hard X-ray Modulation Telescope) is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart(SSS17 a/AT2017 gfo) with very large collection area(~1000 cm^2) and microsecond time resolution in 0.2-5 MeV. In addition,Insight-HXMT quickly implemented a Target of Opportunity(ToO) observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy(0.2-5 MeV) radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817 A. Meanwhile,Insight-HXMT/HE provides one of the most stringent constraints(~10^(-7) to 10^(-6) erg/cm^2/s) for both GRB170817 A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event. | TiPei Li ShaoLin Xiong ShuangNan Zhang FangJun Lu LiMing Song XueLei Cao Zhi Chang Gang Chen Li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao CongZhan Liu GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai Liang Sun Yin Tan Lian Tao WenHui Tao YouLi Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu LinLi Yan JiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang ZiLiang Zhang HaiSheng Zhao JianLing Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu ChangLin Zou | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 12 |
| 2 | Postoperative Regulatory T-Cells and Natural Killer Cells in Stage I Nonsmall Cell Lung Cancer Underwent Video-assisted Thoracoscopic Lobectomy or Thoracotomy显示文摘 | Sai Zhang Sai-Bo Pan Qing-Hua Lyu Pin Wu Guang-Ming Qin Qi Wang Zhong-Liang He Xue-Ming He Ming Wu Gang Chen | 2015 | Chinese Medical Journal2015，，11： | 10 |
| 3 | Novel DPY19L2 variants in globozoospermic patients and the overcoming this male infertility显示文摘Globozoospermia has been reported to be a rare but severe causation of male infertility,which results from the failure of acrosome biogenesis and sperm head shaping.Variants of dpy-19-like 2(DPY19L2)are highly related to globozoospermia,but related investigations have been mainly performed in patients from Western countries.Here,we performed a screening of DPY19L2 variants in a cohort of Chinese globozoospermic patients and found that five of nine patients carried DPY19L2 deletions and the other four patients contained novel DPY19L2 point mutations,as revealed by whole-exome sequencing.Patient 3(P3)contained a heterozygous variant(c.2126+5G>A),P6 contained a homozygous nonsense mutation(c.1720C>T,p.Arg574*),P8 contained compound heterozygous variants(c.H82-1184delATCf p.Leu394_Ser395deIinsPhe;c.368A>T,p.Hisl23Arg),and P9 contained a heterozygous variant(c.H82-1184delATCTTI frameshift).We also reported intracytoplasmic sperm injection(ICSI)outcomes in the related patients,finding that ICSI followed by assisted oocyte activation(AOA)with calcium ionophore achieved high rates of live births.In summary,the infertility of these patients results from DPY19L2 dysfunction and can be treated by ICSI together with AOA. | Yong-Liang Shang Fu-Xi Zhu Jie Yan Liang Chen Wen-Hao Tang Sai Xiao Wei-Ke Mo Zhi-Guo Zhang Xiao-Jin He Jie Qiao Yun-Xia Cao Wei Li | 2019 | Asian Journal of Andrology2019，21，2： | 9 |
| 4 | Oncogenic AURKA-enhanced N6-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells显示文摘RNase III DROSHA is upregulated in multiple cancers and contributes to tumor progression by hitherto unclear mechanisms.Here,we demonstrate that DROSHA interacts withβ-Catenin to transactivate STC1 in an RNA cleavage-independent manner,contributing to breast cancer stem-like cell(BCSC)properties.DROSHA mRNA stability is enhanced by N6-methyladenosine(m^(6)A)modification which is activated by AURKA in BCSCs.AURKA stabilizes METTL14 by inhibiting its ubiquitylation and degradation to promote DROSHA mRNA methylation.Moreover,binding of AURKA to DROSHA transcript further strengthens the binding of the m^(6)A reader IGF2BP2 to stabilize m^(6)A-modified DROSHA.In addition,wild-type DROSHA,but not an m^(6)A methylation-deficient mutant,enhances BCSC stemness maintenance,while inhibition of DROSHA m^(6)A modification attenuates BCSC traits.Our study unveils the AURKA-induced oncogenic m^(6)A modification as a key regulator of DROSHA in breast cancer and identifies a novel DROSHA transcriptional function in promoting the BCSC phenotype. | Fei Peng Jie Xu Bai Cui Qilan Liang Sai Zeng Bin He Hong Zou Manman Li Huan Zhao Yuting Meng Jin Chen Bing Liu Shasha Lv Peng Chu Fan An Zifeng Wang Junxiu Huang Yajing Zhan Yuwei Liao Jinxin Lu Lingzhi Xu Jin Zhang Zhaolin Su Zhiguang Li Fangjun Wang Eric W-FLam Quentin Liu | 2021 | Cell Research2021，31，3： | 9 |
| 5 | Integrin-linked kinase overexpression promotes epithelial-mesenchymal transition via nuclear factor-κB signaling in colorectal cancer cells显示文摘AIM: To investigate the effect of integrin-linked kinase(ILK) on proliferation, metastasis, and invasion of the colorectal cancer cell line SW480. METHODS: In this study, the colorectal cancer cell line SW480 was stably transfected with ILK plasmids, and small interfering RNA(si RNA) was used to knockdown expression of nuclear factor(NF)-κB/p65. Methylthiazole tetrazolium(MTT) assay was performed to measure proliferation, and the wound healing migration assay and matrigel invasion assay were used to test the metastasis and invasion ability of SW480 cells. To explore the epithelial-mesenchymal transition(EMT) process, embryonic development, and the invasion and metastasis of tumors, the protein level of E-cadherin, vimentin, snail, and slug was detected by western blot. Immunofluorescence was also used to detect E-cadherin expression. Western blot was used to determine the level of phosphorylated-inhibitor of kappa B(IκB)a, inhibitor of gamma B(IγB)a, and nuclear factor kappa B(NF-κB) expressions and toexplore the ILK signaling pathway. RESULTS: Western blot results revealed that ILK expression significantly increased when ILK was overexpressed in SW480 cells(P < 0.05). Proliferation, metastasis, and invasion ability were improved in the vector-ILK group compared to the vector group(P < 0.05). Immunofluorescence results revealed that E-cadherin fluorescence intensity decreased after ILK was overexpressed(P < 0.05). Western blot results revealed that the protein expression of E-cadherin was reduced, while vimentin, snail, and slug were upregulated when ILK was overexpressed in SW480 cells(P < 0.05). In order to determine the role of the NF-κB signaling pathway in ILK overexpression promoted EMT occurrence, we overexpressed ILK in SW480 cells and found that levels of NF-κB/p65 and cytoplasmic phosphorylated-IκBa were increased and that cytoplasmic IкBa levels were decreased compared to the control group(P < 0.05). Furthermore, NF-κB/p65 knockout revealed that E-cadherin was increased in the overexpressed ILK group. CONCLUSION: ILK overexpression improved the proliferation, metastasis, and invasion ability of SW480 cells, and this effect may be mediated by the NF-κB signaling pathway. | Hong Shen Jun-Li Ma Yan Zhang Gan-Lu Deng Yan-Ling Qu Xiao-Ling Wu Jing-Xuan He Sai Zhang Shan Zeng | 2016 | World Journal of Gastroenterology2016，22，15： | 7 |
| 6 | Study on the Non-Contact FBG Vibration Sensor and Its Application显示文摘一个非接触颤动传感器基于纤维布拉格栅栏 FBG 传感器被介绍了,并且监视旋转的柄的颤动被用来。在纸,我们描述传感器的原则并且使一些成为试验性的分析。分析结果证明传感器的敏感和线性是 1.5 pm/m, 4.11% 分别地 2 mm2.6 公里在测量以内变化。当监视旋转的柄的颤动被用来时,分析旋转的柄的颤动发信号,获得的旋转的批评速度与从旋涡水流传感器获得了那一样。它证实传感器能被用于旋转的柄系统并且为差错监视和旋转机械的诊断的颤动的非接触测量。 | Tianliang LI Yuegang TAN Zude ZHOU Li CAI Sai LIU Zhongting HE Kai ZHENG | 2015 | Photonic Sensors2015，5，2： | 6 |
| 7 | The influence of various frequency chorus waves on electron dynamics in radiation belts显示文摘Non-adiabatic behaviour induced by the chorus-electron interaction is an important contributor to the radiation belt dynamics,and largely relies on wave frequency distribution.During the geomagnetic storm on August 2,2016,upper-band,lower-band and extremely low frequency(ELF)chorus waves were simultaneously observed within one orbit period of the Van Allen Probe B.Numerical simulations are performed to investigate the electron evolution by the observed chorus with different frequencies.The results show that various frequency chorus waves have different effects on electron dynamics.For chorus in the range f≈0.3 fce–0.7 fce,energy diffusion is the dominant process in electron evolutions.For chorus in the range 0.1 fce≤f≤0.25 fce,the pitch angle diffusion tends to be comparable to energy diffusion for Ek>0.5 MeV.For ELF chorus below 0.1 fce,the pitch angle diffusion rate is much above the energy diffusion rate,leading to potential scattering losses. | HE JiaBei JIN Yu Yue XIAO FuLiang HE ZhaoGuo YANG Chang XIE YanQiong HE Qian WANG ChengZhi SHANG XiongJun LIU Si ZHOU QingHua ZHANG Sai | 2021 | Science China(Technological Sciences)2021，64，4： | 3 |
| 8 | The potential value of microRNA-4463 in the prognosis evaluation in hepatocellular carcinoma显示文摘The purpose of this study is to measure the expression of microRNA-4463 and microRNA-6087 between normal persons and patients with hepatocellular carcinoma(HCC),and to clarify the meaning of them in the prognosis evaluation in HCC.Forty-five samples from healthy people and patients,who had been diagnosed with hepatocellular carcinoma before any treatment,were collected to study respectively.Real-time PCR was used to detect the expression of miRNA-4463 and miRNA-6087 in the serum of control group and hepatocellular carcinoma patients.The expression of miR-4463 in the serum of HCC patients was significantly higher than that in control group(P<0.05),and the expression level was independent of gender,tumor size,cell types,stages,alanine aminotransferase(ALT),aspartate aminotransferase(AST),total bilirubin(TBIL)and HBsAg status(P>0.05).But there was a significant difference of different level of AFP in HCC(P<0.05),and the difference between the group of AFP lower than 400 ug/l and the control group is statistically significant(P<0.05).Besides,the survival time had showed a significant difference at the high and low expression levels(P<0.05).But the expression level of miRNA-6087 was no difference in HCC and control group.The disorder of miRNA-4463 occurred in HCC,even the AFP level doesn’t rises.What’s more,patients who get the high level of miRNA-4463 seem to have a shorter survival time.And it contributes great to the prognostic evaluation.This is the first study to illustrate the potential significance of miRNA-4463 in the prognosis in HCC. | Tian Hu Jincheng Li Chuhong Zhang Xiu lv Sai Li Sha He Hanxing Yan Yixi Tan Mingsheng Lei Meiling Wen Jianhong Zuo | 2017 | Genes & Diseases2017，4，2： | 3 |
| 9 | Multi-satellite observations on the storm-time enhancements of energetic outer zone electron fluxes driven by chorus waves显示文摘The evolution of energetic outer zone electron fluxes during the strong magnetic storm on September 28, 2002 is investigated based on the observations of SAMPEX and GOES-10 satellites. The observations of both satellites showed that energetic electron fluxes increased significantly during the storm recovery phase, and reached the maximum on October 6. The 1.5–14 MeV and 2.5–14 MeV electron fluxes observed by SAMPEX peaked around L=3.5 with values of 6×10 2 cm -2 s -1 sr -1 keV -1 and 5×10 3 cm -2 s -1 sr -1 keV -1 , which were about 10 and 8 times the pre-storm values. At the geostationary orbit, the >0.6 MeV and >2 MeV electron fluxes observed by GOES-10 showed enhancement up to 50 and 30 times. The plasma parameters and whistler-mode chorus waves in the outer radiation belt are also analyzed based on the data from Cluster C3 satellite. Cluster C3 satellite went through the outer radiation belt twice from 1 October to 4 October, and observed whistler-mode chorus waves with high intensity (10 -5 –10 -4 nT 2 Hz -1 ). Numerical calculations indicated that the observed chorus waves were in gyro-resonance with the radiation belt electrons. The current observations and calculations provide new evidence for that the gyro-resonance with chorus waves contribute significantly to the buildup of energetic outer zone electron fluxes during storms. | HE ZhaoGuo XIAO FuLiang ZONG QiuGang WANG YongFu CHEN LiangXu YUE Chao ZHANG Sai | 2011 | Science China(Technological Sciences)2011，54，8： | 3 |
| 10 | Mouse knockout models reveal largely dispensable but context-dependent functions of IncRNAs during development显示文摘 | Xue Han Sai Luo Guangdun Peng Yuyang Lu Guizhong Cui Lichao Liu Pixi Yan Yafei Yin Wei Liu Ran Wang Jiejie Zhang Shanshan Ai Zai Chang Jie Na Aibin He Naihe Jing Xiaohua Shen | 2018 | Journal of Molecular Cell Biology2018，10，2： | 3 |
| 11 | The role of hypoxia-inducible factors in tumor angiogenesis and cell metabolism显示文摘Hypoxia-inducible factor(HIF)is a main heterodimeric transcription factor that regulates the cellular adaptive response to hypoxia by stimulating the transcription of a series of hypoxia-inducible genes.HIF is frequently upregulated in solid tumors,and the overexpression of HIF can promote tumor progression or aggressiveness by blood vessel architecture and altering cellular metabolism.In this review,we focused on the pivotal role of HIF in tumor angiogenesis and energy metabolism.Furthermore,we also emphasized the possibility of HIF pathway as a potential therapeutic target in cancer. | Xiu Lv Jincheng Li Chuhong Zhang Tian Hu Sai Li Sha He Hanxing Yan Yixi Tan Mingsheng Lei Meiling Wen Jianhong Zuo | 2017 | Genes & Diseases2017，4，1： | 3 |
| 12 | Overview to the Hard X-ray Modulation Telescope (Insight-HXMT) Satellite显示文摘As China’s first X-ray astronomical satellite, the Hard X-ray Modulation Telescope (HXMT), which was dubbed as Insight-HXMT after the launch on June 15, 2017, is a wide-band(1-250 ke V) slat-collimator-based X-ray astronomy satellite with the capability of all-sky monitoring in 0.2-3 Me V. It was designed to perform pointing, scanning and gamma-ray burst(GRB)observations and, based on the Direct Demodulation Method (DDM), the image of the scanned sky region can be reconstructed.Here we give an overview of the mission and its progresses, including payload, core sciences, ground calibration/facility, ground segment, data archive, software, in-orbit performance, calibration, background model, observations and some preliminary results. | Shuang-Nan Zhang TiPei Li FangJun Lu LiMing Song YuPeng X u CongZhan Liu Yong Chen XueLei Cao QingCui Bu Zhi Chang Gang Chen Li Chen TianXiang Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong Yuan Yuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan Can Gungor ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge Ou JinLu Qu Na Sai RenCheng Shang GuoHong Shen Liang Sun Ying Tan Lian Tao YouLi Tuo Chen Wang ChunQin Wang GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BaiYang Wu BoBing Wu Mei Wu GuangCheng Xiao ShaoLin Xiong LinLi Yan JiaWei Yang Sheng Yang YanJi Yang QiBin Yi Bin Yuan AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang ShenYi Zhangs Shu Zhang Tong Zhang WanChang Zhang Wei Zhang WenZhao Zhang Yi Zhang YiFei Zhang YongJie Zhang Yue Zhang Zhao Zhang Zhi Zhang ZiLiang Zhang HaiSheng Zhao XiaoFan Zhao ShiJie Zheng JianFeng Zhou YuXuan Zhu Yue Zhu RenLin Zhuang | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，4： | 2 |
| 13 | Microwave-assisted growth and characterization of water-dispersed CdTe/CdS core-shell nanocrystals with high photoluminescence显示文摘 | HE Yao LU Hao-ting SAI Li-man LAI Wen-yong FAN Qu-li WANG Lian-hui HUANG Wei | 2006 | J Phys Chem B2006，110，13： | 1 |
| 14 | MicroRNA-21 is a down- stream effector of AKT that mediates its antiapoptotic ef- fects via suppression ofFas ligand显示文摘 | Sayed D He M Hong C eta1 | 2010 | J Biol Chem2010，285，20： | 1 |
| 15 | Host serum miR-223 is a potential new biomarker for Schistosoma japonicum infection and the response to chemotherapy显示文摘 | He X Sai X Chen C et ol | 2013 | Parasit Vectors2013，6，： | 1 |
| 16 | Experimental realization of nonadiabatic holonomic single‐qubit quantum gates with two dark paths in a trapped ion显示文摘For circuit-based quantum computation,experimental implementation of a universal set of quantum logic gates with high-fidelity and strong robustness is essential and central.Quantum gates induced by geometric phases,which depend only on global properties of the evolution paths,have built-in noise-resilience features.Here,we propose and experimentally demonstrate nonadiabatic holonomic single-qubit quantum gates on two dark paths in a trapped ^(171)γδ^(+)ion based on four-level systems with resonant drives.We confirm the implementation with measured gate fidelity through both quantum process tomography and randomized benchmarking methods.Meanwhile,we find that nontrivial holonomic two-qubit quantum gates can also be realized within current experimental technologies.Compared with previous implementations,our experiments share both the advantages of fast nonadiabatic evolution and robustness against systematic errors.Therefore,our experiments confirm a promising method for fast and robust holonomic quantum computation. | Ming-Zhong Ai Sai Li Ran He Zheng-Yuan Xue Jin-Ming Cui Yun-Feng Huang Chuan-Feng Li Guang-Can Guo | 2022 | Fundamental Research2022，2，5： | 1 |
| 17 | Downregulation of miR-1 9 9 a derepresses hypoxia-inducible factor-1 alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes显示文摘 | RANE S HE M SAYED D | 2009 | Circ Res2009，104，7： | 1 |
| 18 | Downregulation of miR-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes显示文摘 | Rane S He M Sayed D | 2009 | Circ Res2009，104，7： | 1 |
| 19 | An antagonism between the AKT and beta-adrenergic signaling pathways mediatedthrough their reciprocal effects on miR-199a-5p 显示文摘 | Rane S He M Sayed D | 2010 | CEL- LULAR SIGNALLING2010，22，7： | 1 |
| 20 | Synthesis of CdTe nanocrystals through program process of microwave irradiation显示文摘 | HE Yao LU Haoting SAI Liman | 2006 | J Phys Chem B2006，110，13： | 1 |
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