|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Changes in hippocampal connectivity in the early stages of Alzheimer's disease: evidence from resting state fMRI显示文摘 | Wang L Zang Y He Y Liang M Zhang X Tian L Wu T Jiang T Li K | 2006 | 中国生物学文摘2006，20，10： | 84 |
| 2 | FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis显示文摘 | Xu Zhao Ying Yang Bao-Fa Sun Yue Shi Xin Yang Wen Xiao Ya-Juan Hao Xiao-Li Ping Yu-Sheng Chen Wen-Jia Wang Kang-Xuan Jin Xing Wang Chun-Min Huang Yu Fu Xiao-Meng Ge Shu-Hui Song Hyun Seok Jeong Hiroyuki Yanagisawa Yamei Niu Gui-Fang Jia Wei Wu Wei-Min Tong Akimitsu Okamoto Chuan He Jannie M Rendtlew Danielsen Xiu-Jie Wang Yun-Gui Yang | 2014 | Cell Research2014，24，12： | 109 |
| 3 | 帕博利珠单抗单用或与放疗联用治疗转移性非小细胞肺癌:两个随机试验的汇总分析显示文摘背景放疗可以提高整个机体对免疫治疗的应答。在Ⅱ期PEMBRO-RT研究和Ⅰ/Ⅱ期MDACC研究中,患有转移性非小细胞肺癌(NSCLC)的患者被随机分配入组,接受免疫治疗(帕博利珠单抗)+放疗联合疗法,或免疫治疗单一疗法。当上述2个研究单独分析时,联合疗法组显示出潜在获益。由于每个研究的样本量较小,缓解率和结局并未显示出统计学意义,然而却有显著的临床获益。因此,本研究进行汇总分析,来判断放疗是否会改善转移性NSCLC患者的免疫治疗应答。方法PEMBRO-RT和MDACC研究纳入标准:患者年龄≥18岁,患有转移性NSCLC,且有≥1处未经放疗照射的病灶,以便进行射野外应答监测。PEMBRO-RT研究纳入曾接受过化疗患者,MDACC研究纳入曾接受过治疗或新诊断患者。2个研究中的患者均未接受过免疫治疗。在PEMBRO-RT研究中患者被等比例随机分配入组,并根据吸烟状态进行分层(分为<10年组和≥10年组)。MDACC研究的患者根据放疗计划可行性被等比例随机分配入2个受试组。由于联合治疗组的干预本质,每个研究中的放疗均不适用盲法。在2个研究中,不论是否进行放疗,均静脉滴入帕博利珠单抗(每3周200 mg)。在PEMBRO-RT研究中,在放疗(24 Gy 3次分割照射)结束后1周给予第1剂帕博利珠单抗。在MDACC研究中,在第1次放疗(50 Gy 4次分割照射或45 Gy 15次分割照射)同时给予帕博利珠单抗。仅检测未经照射病灶的应答。本研究的终点为最佳射野外(远隔)应答率(ARR)、最佳射野外疾病控制率(ACR)、12周时ARR、12周时ACR、无进展生存期(PFS)和总生存期(OS)。2个研究的意向治疗(ITT)人群均纳入分析。PEMBRO-RT研究(NCT02492568)和MDACC研究(NCT02444741)均在ClinicalTrials.gov上注册。发现纳入148例患者,76例接受帕博利珠单抗治疗,72例接受帕博利珠单抗+放疗治疗。所有患者随访时间中位数为33个月[四分位距(IQR):32.4~33.6]。148例患者中124例(84%)组织学特征为非鳞癌,111例(75%)患者曾经接受过化疗。组间没有基线特征差异,包括PD-L1表达状态和转移灶体积。最常见的照射部位为肺转移灶(39%,28/72)、胸腔内淋巴结(21%,15/72)和非原发灶(17%,12/72)。帕博利珠单抗组和联合治疗组的最佳ARR分别为19.7%(15/76)和41.7%(30/72),OR=2.96,95%CI:1.42~6.20,P=0.0039;最佳ACR分别为43.4%(33/76)和65.3%(47/72),OR=2.51,95%CI:1.28~4.91,P=0.0071;PFS中位数分别为4.4(IQR:2.9~5.9)和9.0个月(IQR:6.8~11.2),HR=0.67,95%CI:0.45~0.99,P=0.045;OS中位数分别为8.7(IQR:6.4~11.0)和19.2个月(IQR:14.6~23.8),OR=0.67,95%CI:0.54~0.84,P=0.0004。在汇总分析中没有发现新的安全问题。解读帕博利珠单抗免疫疗法+放疗显著提高转移性NSCLC患者的应答和改善治疗结局。这些结果需要在三期临床试验中进行验证。 | 陈大卫(翻译) 于金明(校对) Willemijn S M E Theelen Vivek Verma Brian P Hobbs Heike M U Peulen Joachim G J V Aerts Idris Bahce Anna Larissa N Niemeijer Joe Y Chang Patricia M de Groot Quynh-Nhu Nguyen Nathan I Comeaux George R Simon Ferdinandos Skoulidis Steven H Lin Kewen He Roshal Patel John Heymach Paul Baas James W Welsh | 2021 | 中华肿瘤防治杂志2021，28，24： | 49 |
| 4 | The Late Mesozoic Orogenic Processes of Mongolia-Okhotsk Orogen: Evidence from Field Investigations into Deformation of the Mohe Area, NE China显示文摘Based on field investigation in 1999, two deformational domains with d ifferent dynamics have been distinguished from the Jurassic geological outcrops in the Mohe area of NE China, i.e. northern ductile and southern plastic-brittl e ones. Their deformational features are stated in this paper. And then, three st ages of structural deformation of the area relative to the late Mesozoic orogeni c processes of Mongolian-Okhotsk orogen are reconstructed as follows, (1) south w ards thrusting in the middle-late Jurassic, (2) eastwards thrusting and strike -s lipping parallel to the orogen in the late Jurassic, and (3) southeastwards thru sting in the early Cretaceous. | Li Jinyi, He Zhengjun, Mo Shenguo and (Institute of Geology, CAGS, Beijing 100037, China) Zheng Qingdao (Heilongjiang Bureau of Exploration and Exploitation of Geology and M ineral Resources, Ha’erbin 150036, China) | 1999 | Global Geology1999，4，2： | 26 |
| 5 | Unusual life-threatening Rosai-Dorfman disease of the trachea. role of NF-kappa B显示文摘 | Zhou, LF Chen, LA Zhu, QA Wang, C Xu, H Cui, XF Jiang, LF He, Ski Huang, M Yin, KS | 2010 | 南京医科大学学报(自然科学版)2010，30，11： | 21 |
| 6 | The modulation of co-stimulatory molecules by circulating exosomes in primary biliary cirrhosis显示文摘Exosomes 是 endocytic 起源的 nanoparticles,由由他们调制 cell-to-cell 通讯的能力的优点正在吸引增加的注意的无数房间人口藏匿了。他们也在许多免疫学的问题正在吸引注意,包括 autoimmunity 和,特别地调整 cytokine 和 chemokine 激活的他们的能力。主要胆汁的肝硬化(PBC ) 被认为一个模型自体免疫疾病,它对胆汁的上皮的房间有高度集中的细胞毒素的回答。我们与 PBC 和 30 健康控制(HC ) 从 29 个病人从血浆孤立 exosomes,并且用一个前 vivo 系统在 mononuclear 房间人口在 co-stimulatory 分子表示和 cytokine 生产上学习了这些 exosomes 的效果。我们也与 HC exosomes 相比在 PBC 识别了 microRNA (miRNA ) 人口。我们此处报导尽管 exosomes 不改变 cytokine 生产,他们显著地确实在介绍抗原的人口上改变 co-stimulatory 分子表示。进一步,我们在 CD14 + 单核白血球上表明了那 CD86 起来调整的表情,而在 CD11c + 上起来调整的 CD40 由从有 PBC 的病人的 exosomes 的树枝状的房间。另外,有在有 PBC 的病人的传播 exosomes 的 miRNA 表示的差别。这些数据基于 co-stimulatory 分子玩的观察有重要重要性在 T 房间激活的规定的一个微分角色。我们的观察显示从 PBC 的异常 exosomes 有选择地在介绍抗原的房间的不同子集导致 co-stimulatory 分子的表示。这些改变可以在自体免疫的肝疾病的致病包含。 | Takashi Tomiyama Guo-Xiang Yang Ming Zhao Weici Zhang Hajime Tanaka Jing Wang Patrick SC Leung Kazuiclli Okazaki Xiao-Song He Qianjin Lu Ross L Coppel Christopher L Bowlus M Eric Gershwin | 2017 | Cellular & Molecular Immunology2017，14，3： | 18 |
| 7 | Management of borderline and locally advanced pancreatic cancer:Where do we stand?显示文摘Many patients with pancreas cancer present with locally advanced pancreatic cancer(LAPC).The principle tools used for diagnosis and staging of LAPC include endoscopic ultrasound,axial imaging with computed tomography and magnetic resonance imaging,and diagnostic laparoscopy.The definition of resectability has historically been vague,as there is considerable debate and controversy as to the definition of LAPC.For the patient with LAPC,there is some level of involvement of the surrounding vascular structures,which include the superior mesenteric artery,celiac axis,hepatic artery,superior mesenteric vein,or portal vein.When feasible,most surgeons would recommend possible surgical resection for patients with borderline LAPC,with the goal of an R0 resection.For initially unresectable LAPC,neoadjuvant should be strongly considered.Specifically,these patients should be offered neoadjuvant therapy,and the tumor should be assessed for possible response and eventual resection.The efficacy of neoadjuvant therapy with this approach as a bridge to potential curative resection is broad,ranging from 3%-79%.The different modalities of neoadjuvant therapy include sin-gle or multi-agent chemotherapy combined with radiation,chemotherapy alone,and chemotherapy followed by chemotherapy with radiation.This review focuses on patients with LAPC and addresses recent advances and controversies in the field. | Jin He Andrew J Page Matthew Weiss Christopher L Wolfgang Joseph M Herman Timothy M Pawlik | 2014 | World Journal of Gastroenterology2014，20，9： | 11 |
| 8 | 煤灰沉积的传热过程模型及其数值研究显示文摘计算流体力学(CFD)方法的应用在锅炉设计或燃烧设备的改造过程中有着十分重要的作用.本文研究了实际燃烧过程中普遍存在的煤灰沉积现象对数值计算结果的影响,提出了描述煤灰沉积的新型传热模型,比较了新模型采用前后数值计算结果与实测数据的差异,从而验证了该模型的合理性,提高了对炉内积灰、结渣过程数值描述的精度. | 徐明厚 郑楚光 HE X G AZEVEDO J L T CARVALHO M G | 2002 | 工程热物理学报2002，23，1： | 10 |
| 9 | Effect of nitrogen fertilization on yield, N content, and nitrogen fixation of alfalfa and smooth bromegrass grown alone or in mixture in greenhouse pots显示文摘Planting grass and legume mixtures on improved grasslands has the potential advantage of realizing both higher yields and lower environmental pollution by optimizing the balance between applied N fertilizer and the natural process of legume biological nitrogen fixation. However, the optimal level of N fertilization for grass-legume mixtures, to obtain the highest yield, quality, and contribution of N2 fixation, varies with species. A greenhouse pot experiment was conducted to study the temporal dynamics of N2 fixation of alfalfa(Medicago sativa L.) grown alone and in mixture with smooth bromegrass(Bromus inermis Leyss.) in response to the addition of fertilizer N. Three levels of N(0, 75, and 150 kg ha–1) were examined using 15N-labeled urea to evaluate N2 fixation via the 15 N isotope dilution method. Treatments were designated N0(0.001 g per pot), N75(1.07 g per pot) and N150(2.14 g per pot). Alfalfa grown alone did not benefit from the addition of fertilizer N; dry matter was not significantly increased. In contrast, dry weight and N content of smooth bromegrass grown alone was increased significantly by N application. When grown as a mixture, smooth bromegrass biomass was increased significantly by N application, resulted in a decrease in alfalfa biomass. In addition, individual alfalfa plant dry weight(shoots+roots) was significantly lower in the mixture than when grown alone at all N levels. Smooth bromegrass shoot and root dry weight were significantly higher when grown with alfalfa than when grown alone, regardless of N application level. When grown alone, alfalfa's N2 fixation was reduced with N fertilization(R2=0.9376, P=0.0057). When grown in a mixture with smooth bromegrass, with 75 kg ha–1 of N fertilizer, the percentage of atmospheric N2 fixation contribution to total N in alfalfa(%Ndfa) had a maximum of 84.07 and 83.05% in the 2nd and 3rd harvests, respectively. Total 3-harvest %Ndfa was higher when alfalfa was grown in a mixture than when grown alone(shoots: |t|=3.39, P=0.0096; root: |t|=3.57, P=0.0073). We believe this was due to smooth bromegrass being better able to absorb available soil N(due to its fibrous root system), resulting inlower soil N availability and allowing alfalfa to develop an effective N2 fixing symbiosis prior to the 1st harvest. Once soil N levels were depleted, alfalfa was able to fix N2, resulting in the majority of its tissue N being derived from biological nitrogen fixation(BNF) in the 2nd and 3rd harvests. When grown in a mixture, with added N, alfalfa established an effective symbiosis earlier than when grown alone; in monoculture BNF did not contribute a significant portion of plant N in the N75 and N150 treatments, whereas in the mixture, BNF contributed 17.90 and 16.28% for these treatments respectively. Alfalfa has a higher BNF efficiency when grown in a mixture, initiating BNF earlier, and having higher N2 fixation due to less inhibition by soil-available N. For the greatest N-use-efficiency and sustainable production, grass-legume mixtures are recommended for improving grasslands, using a moderate amount of N fertilizer(75 kg N ha–1) to provide optimum benefits. | XIE Kai-yun LI Xiang-lin HE Feng ZHANG Ying-jun WAN Li-qiang David B Hannaway WANG Dong QIN Yan Gamal M A Fadul | 2015 | Journal of Integrative Agriculture2015，14，9： | 5 |
| 10 | Numerical and safety considerations about the Daguangbao landslide induced by the 2008 Wenchuan earthquake显示文摘The 2008 Wenchuan earthquake resulted in a large number of fatalities and caused significant economic losses.Thousands of landslides,many of which are very large,were triggered by the earthquake.A majority of catastrophic landslides were distributed along the central Longmenshan fault system,at the eastern margin of the Tibetan Plateau.Some of the landslides resulted in sudden damming of rivers causing flooding,which in turn induced secondary sliding disasters.Among the most significant landslides,the Daguangbao landslide was the largest in volume with the maximum thickness.For this,a numerical model of the Daguangbao landslide,using the material point method(MPM),was developed to simulate the interaction of the seismic loads imposed on the slope.The numerical results then are compared with the post-earthquake profile.As a consequence of the landslide,a nearly vertical head scarp with a maximum height of about 700 m was generated.This is considered as a high risk situation that requires constant monitoring and evaluation.Finally,we propose a methodology based on Bayesian networks(BNs)to manage the risk associated with the stability of the rockwall at the Daguangbao landslide site. | Manchao He L.Ribeiro e Sousa AndréMüller Eurípedes Vargas Jr. R.L.Sousa C.Sousa Oliveira Weili Gong | 2019 | Journal of Rock Mechanics and Geotechnical Engineering2019，11，5： | 4 |
| 11 | Assessing crop water stress of winter wheat by thermography under different irrigation regimes in North China Plain显示文摘Thermal imaging can be used as an indicator of water stress due to the closure of stomatal aperture.In this paper,we analyzed the robustness and sensitivity of thermography of winter wheat in the North China Plain.The seasonal and diurnal variations of Crop Water Stress Index(CWSI)were evaluated.Five treatments were applied by means of irrigation,with plots receiving 100%of ETo(DI),50%(D50),16%(D16)and no irrigation(NI).A high correlation was found between stomatal conductance(gs)and CWSI,depending on the phenological stage of the crop with R2=0.44 at pre-heading stage and R2=0.77 at post-heading stage.In addition,a high correlation between yield and CWSI at different growth stages indicates that thermography can predict yield.Hourly measurements of canopy temperature were taken to study the effect of the time of day on image acquisition and it was found that midday was the most appropriate time.These results should assist in designing precision irrigation scheduling for setting the threshold values. | Shamaila Zia Du Wenyong Wolfram Spreer Klaus Spohrer He Xiongkui Joachim Müller | 2012 | International Journal of Agricultural and Biological Engineering2012，5，3： | 4 |
| 12 | Improving Densification and Mechanical Properties of FeAl/TiC Composites by Addition of Ni显示文摘FeAl/TiC composites were fabricated by hot pressing blended elemental powders. The effects of Ni-doping on thedensification and mechanical properties of the composites were studied. Results show that the density of the com-posites decreases with the content of TiC increasing, and the addition of Ni significantly improves the densificationprocess by enhancing mass transfer in the bonding phase. The mechanical properties of the composites are closelyrelated with their porosity. Besides increasing the density of the composites, the addition of Ni improves the mechan-ical properties by other three effects: solution-strengthening the bonding phase, strengthening the FeAl-TiC interfaceand increasing ductile fracture in FeAl phase. | Yong LIU, Fengxiao LIU, Baiyun HUANG, Kechao ZHOU, Yuehui HE and Zhihong TANGNational Key Lab for P/M, Central South University, Changsha 410083, China | 2003 | Journal of Materials Science & Technology2003，19，1： | 4 |
| 13 | Utilization of Thermal Infrared Image for Inversion of Winter Wheat Yield and Biomass显示文摘The present paper utilizes thermal infrared image for inversion of winter wheat yield and biomass with different technology of irrigation(drip irrigation,sprinkler irrigation,flood irrigation).It is the first time that thermal infrared image is used for predicting the winter wheat yield and biomass.The temperature of crop and background was measured by thermal infrared image.It is necessary to get the crop background separation index(CBSIL,CBSIH),which can be used for distinguishing the crop value from the image.CBSIL and CBSIH(the temperature when the leaves are wet adequately;the temperature when the stomata of leaf is closed completely) are the threshold values.The temperature of crop ranged from CBSIL to CBSIH.Then the ICWSI was calculated based on relevant theoretical method.The value of stomata leaf has strong negative correlation with ICWSI proving the reliable value of ICWSI.In order to construct the high accuracy simulation model,the samples were divided into two parts.One was used for constructing the simulation model,the other for checking the accuracy of the model.Such result of the model was concluded as:(1) As for the simulation model of soil moisture,the correlation coefficient(R2) is larger than 0.887 6,the average of relative error(Er) ranges from 13.33% to 16.88%;(2) As for the simulation model of winter wheat yield,drip irrigation(0.887 6,16.89%,-0.12),sprinkler irrigation(0.970 0,14.85%,-0.12),flood irrigation(0.969 0,18.87%,0.18),with the values of R2,Er and CRM listed in the parentheses followed by the individual term.(3) As for winter wheat biomass,drip irrigation(0.980 0,13.70%,0.13),sprinkler irrigation(0.95,13.15%,-0.14),flood irrigation(0.970 0,14.48%,-0.13),and the values in the parentheses are demonstrated the same as above.Both the CRM and Er are shown to be very low values,which points to the accuracy and reliability of the model investigated.The accuracy of model is high and reliable.The results indicated that thermal infrared image can be used potentially for inversion of winter wheat yield and biomass. | DU Wen-yong ZHANG Lu-da HU Zhen-fang Shamaila Z ZENG Ai-jun SONG Jian-li LIU Ya-jia Wolfram S Joachim M HE Xiong-kui | 2011 | 光谱学与光谱分析2011，31，6： | 3 |
| 14 | Adaptive immunity in the liver显示文摘 | Zongwen Shuai Miranda WY Leung Xiaosong He Weici Zhang Guoxiang Yang Patrick SC Leung M Eric Gershwin | 2016 | Cellular & Molecular Immunology2016，13，3： | 3 |
| 15 | Changes in hippocampal connectivity in the early stages of Alzheimer's disease: evidence from resting state fMRI显示文摘 | Wang L Zang Y He Y Liang M Zhang X Tian L Wu T Jiang T Li K | 2006 | 中国生物学文摘2006，20，8： | 3 |
| 16 | Does Financial Intermediation Development Increase Per Capita Income in Rural China?显示文摘这篇论文调查金融中间人的影响(或银行) 用为在 1993 和 2006 之间的选择的年的中国数据集的村庄级的人均的收入上的开发。从一个随机的效果回归模型的实验结果显示当金融调解发展,农村村庄里的那项吝啬的人均的收入跟随一条转换 U 字形的路径。用一条分享的 quantile 回归途径,然而,我们发现农村村庄里的那项中部的人均的收入跟随一条积极线性路径,而非一条转换 U 字形的路径,当金融调解发展。金融中间人开发的积极线性效果被观察在更低并且有条件的人均的收入分发的高端。这建议在中国的金融调解的开发可能没在低收入或高收入的农村村庄里有统计上重要的微分效果。 | Suwen Pan Roderick M Xiurong He | 2009 | China & World Economy2009，17，4： | 3 |
| 17 | Non-invasive water status detection in grapevine(Vitis vinifera L.)by thermography显示文摘Grapevines are preferentially grown under mild to moderate water stress conditions to achieve the best compromise between wine quality and quantity.Water status detection for advanced irrigation scheduling is frequently done by predawn leaf water potential(ΨPD)or leaf stomata conductance(gL)measurements.However,these measurements are time and labor consuming.Therefore,the use of infrared thermography(IRT)opens up the possibility to study large population of leaves and to give an overview on the stomatal variation and their dynamics.In the present study IRT was used to identify water stress of potted grapevines.In order to define the sensitivity of IRT measurements to water stress,the IRT-based water status information were compared with simultaneously measuredΨPD and gL data.Correlations between IRT-based CWSI data on the one hand and gL andΨPD on the other showed the potential of IRT for water stress detection.However,the CWSI calculation procedure is laborious and the sensitivity of CWSI for water stress detection still needs to be improved.Therefore,further improvements are necessary in order to apply remote IRT-based systems for irrigation scheduling in the field. | Shamaila Zia Klaus Spohrer Nikolaus Merkt Du Wenyong Xiongkui He Joachim Müller | 2009 | International Journal of Agricultural and Biological Engineering2009，2，4： | 3 |
| 18 | Subepicardial endothelial cells invade the embryonic ventricle wall to form coronary arteries显示文摘冠的动脉把血流动带到心肌肉。理解冠的动脉的发展程序提供卓见进冠的动脉疾病的治疗。多重来源被描述了为包括 proepicardium,湾穴 venosus (SV ) ,和心内膜贡献冠的动脉。然而,冠的容器的发展起源仍然在强烈学习下面。我们为学习冠的开发生产了一个新基因工具,一只 AplnCreER 老鼠在开发冠的容器明确地衬里 recombinase,它表示可诱导的 Cre。冠的开发和 AplnCreER 命运跟踪的预定正式就职的定量分析证明 subepicardial endothelial 房间(EC ) 的子孙两个都入侵紧缩的心肌层形成冠的动脉并且在表面上留下生产静脉。我们发现这些 subepicardial EC 是 intramyocardial 的主要来源在发展中的心的冠的容器。在 vitro 将生物的活组织移植于培养基中培养,试金显示这些 subepicardial EC 的多数从 SV 和中庭的心内膜,然而并非从室的心内膜产生。Apln 积极的房间的同种细胞的分析显示单个 subepicardial EC 同等地作出贡献到冠的动脉和静脉。一起,这些数据建议 subepicardial EC 是 intramyocardial 的主要来源在室的冠的动脉墙,和那冠的动脉和静脉在发展中的心有普通起源。 | Xueying Tian Tianyuan Hu Hui Zhang Lingjuan He Xiuzhen Huang Qiaozhen Liu Wei Yu Liang He Zhongzhou Yang Zhen Zhang Tao P Zhong Xiao Yang Zhen Yang Yan Yan Antonio Baldini Yunfu Sun Jie Lu Robert J Schwartz Sylvia M Evans Adriana C Gittenberger-de Groot Kristy Red-Horse Bin Zhou | 2013 | Cell Research2013，23，9： | 3 |
| 19 | Importance of integrating nanotechnology with pharmacology and physiology for innovative drug delivery and therapy - an illustration with, firsthand examples显示文摘纳米技术在药交货广泛地被使用了改进各种各样的疾病的治疗学的结果。巨大的努力在与他们的生物命运和函数的关系集中于 nanoparticles 的物理化学的性质的新奇 nanoparticles 和描述的开发。然而在这些基于纳米技术的药交货系统的设计和评估,交付的药的药理学并且(patho-) 主人的生理学收到了更少的注意。在这评论,我们讨论集成于使纳米技术能的药交货系统和治疗的设计的重要药理学机制,生理的特征,和病理学的因素。第一手的例子被举由利用 1 为癌症治疗说明如此的综合设计策略的原则和优点)到克服的multidrug抵抗的癌症的药药和 drug-nanomaterial 联合的细胞内部的 synergistic 相互作用, 2 )循环系统到的血流动方向为肺转移最大化药交货到肿瘤 neovasculature 和房间 overexpressing integrin 受体, 3 )装饰 nanocarriers 和 t 的内长的脂蛋白关于在糖尿病管理的申请,一个使纳米技术能的靠近环的胰岛素交货系统被设计在生理地相关的时间规模和葡萄糖层次提供动态胰岛素版本。和另外的研究结果,这些例子建议药理学的相互影响的那利用,(patho-) 生理学和纳米技术是一条灵巧的途径与高效率和翻译潜力开发创新的药交货系统和治疗。 | Rui Xue ZHANG Jason LI Tian ZHANG Mohammad A AMINI Chunsheng HE Brian LU Taksim AHMED HoYin LIP Andrew M RAUTH Xiao Yu WU | 2018 | Acta Pharmacologica Sinica2018，39，5： | 3 |
| 20 | Monitoring physiological responses to water stress in two maize varieties by infrared thermography显示文摘Water stress is one of the main causes of yield reductions in crops,especially in arid and semi-arid regions where the water supply is limited.Plant water status is frequently assessed by pre-dawn leaf water potential(ΨPD)or leaf stomata conductance(gL)measurements,in support of advanced irrigation scheduling.However,both methods are time and labour consuming.A non-invasive approach to water status detection is the use of infrared thermography(IRT).This experiment was conducted in a greenhouse on two potted maize varieties under irrigated and non-irrigated conditions,and the measurements began when the crop had reached its twelve leaf stage.In order to establish the IRT measurements for detecting the water status of maize,an IRT-based crop water stress index(CWSI)was calculated and compared with simultaneously measuredΨPD and gL data.Good correlations were found between CWSI and gL data(r2=0.71&0.81),as well between CWSI andΨPD data(r2=0.53&0.81).These results highlight the appropriateness of infrared thermal imagery to detect and differentiate between the crop water statuses of different genotypes. | Shamaila Zia Klaus Sophrer Du Wenyong Wolfram Spreer Giuseppe Romano He Xiongkui Joachim Müller | 2011 | International Journal of Agricultural and Biological Engineering2011，4，3： | 3 |
您所在的机构暂未开通此部分的功能，请联系管理员