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| 1 | role of the normal gut microbiota显示文摘Relation between the gut microbiota and human health is being increasingly recognised. It is now well established that a healthy gut flora is largely responsible for overall health of the host. The normal human gut microbiota comprises of two major phyla, namely Bacteroidetes and Firmicutes. Though the gut microbiota in an infant appears haphazard, it starts resembling the adult flora by the age of 3 years. Nevertheless, there exist temporal and spatial variations in the microbial distribution from esophagus to the rectum all along the individual's life span. Developments in genome sequencing technologies and bioinformatics have now enabled scientists to study these microorganisms and their function and microbehost interactions in an elaborate manner both in health and disease. The normal gut microbiota imparts specific function in host nutrient metabolism, xenobiotic and drug metabolism, maintenance of structural integrity of the gut mucosal barrier, immunomodulation, and protection against pathogens. Several factors play a role in shaping the normal gut microbiota. They include(1) the mode of delivery(vaginal or caesarean);(2) diet during infancy(breast milk or formula feeds) and adulthood(vegan based or meat based); and(3) use of antibiotics or antibiotic like molecules that are derived from the environment or the gut commensal community. A major concern of antibiotic use is the long-term alteration of the normal healthy gut microbiota and horizontal transfer of resistance genes that could result in reservoir of organisms with a multidrug resistant gene pool. | Sai Manasa Jandhyala Rupjyoti Talukdar Chivkula Subramanyam Harish Vuyyuru Mitnala Sasikala D Nageshwar Reddy | 2015 | World Journal of Gastroenterology2015，21，29： | 187 |
| 2 | Effect of Commiphora mukul gum resin on hepatic marker enzymes,lipid peroxidation and antioxidants status in pancreas and heart of streptozotocin induced diabetic rats显示文摘Objective:To study the antioxidant efficacy of Commiphora mukul(C.mukul) gum resin ethanolic extract in streptozotocin(STZ) induced diabetic rats.Methods:The male Wistar albino rats were randomly divided into four groups of eight animals each:Control group(C),CM-treated control group(C_+CMEE),Diabetic control group(D),CM- treated diabetic group(D_+CMEE).Diabetes was induced by intraperitoneal injection of STZ(55 mg/kg/ bwt).After being confirmed the diabetic rats were treated with C.mukul gum resin ethanolic extract(CMEE) for 60 days.The biochemical estimations like antioxidant,oxidative stress marker enzymes and hepatic marker enzymes of tissues were performed.Results:The diabetic rats showed increased level of enzymatic activities aspartate aminotransaminase(AST),alanine aminotransaminase(ALT) in liver and kidney and oxidative markers like lipid peroxidation(LPO) and protein oxidation(PO) in pancreas and heart. Antioxidant enzyme activities were significantly decreased in the pancreas and heart compared to control group.Administration of CMEE(200 mg/kg bw) to diabetic rats for 60 days significantly reversed the above parameters towards normalcy.Conclusions:In conclusion,our data indicate the preventive role of C.mukul against STZ-induced diabetic oxidative stress;hence this plant could be used as an adjuvant therapy for the prevention and/or management of diabetes and aggravated antioxidant status. | Ramesh B Karuna R Sreenivasa Reddy S Haritha K Sai Mangala D Sasi Bhusana Rao B Saralakumari D | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，11： | 3 |
| 3 | MicroRNAs play an embryessential role in the development of cardiac hypertrophy显示文摘 | Sayed D Hong C Chen IY | 2007 | Circ Res2007，100，3： | 1 |
| 4 | Hepatic complications of antituberculosis therapy revisited显示文摘 | Cohen C D Sayed A R Kirsch R E | 1983 | S Afr Med J1983，63，： | 1 |
| 5 | Traveling- wave -based fault- location scheme for multiend- aged underground cable system显示文摘 | GILANY M G IBRAHIM D K SAYED E | 2007 | IEEE Transactions on Power Delivery2007，22，1： | 1 |
| 6 | MicroRNA with a macrofunction 显示文摘 | Rane S Sayed D Abdellatif M | 2007 | Cell Cycle2007，6，15： | 1 |
| 7 | MicroRNAs play an essential role in the development of cardiac hypertrophy显示文摘 | SAYED D HONG C CHEN I Y | 2007 | Circ Res2007，100，3： | 1 |
| 8 | MicroRNA-21targets Sprouty2and promotes cellular outgrowths显示文摘 | Sayed D Rane S Lypowy J | 2008 | Mol Biol Cell2008，19，8： | 1 |
| 9 | MicroRNAs in Development and Dis-ease显示文摘 | Sayed D Abdellatif M | 2011 | Physiol Rev2011，91，3： | 1 |
| 10 | MicroRNA-21 is a down- stream effector of AKT that mediates its antiapoptotic ef- fects via suppression ofFas ligand显示文摘 | Sayed D He M Hong C eta1 | 2010 | J Biol Chem2010，285，20： | 1 |
| 11 | Effects of DUT mismatch on the noise figure characterization:a comparative analysis of two Y-factor techniques显示文摘 | Collantes J M POLLARD R D SAYED M | | 0，，06： | 1 |
| 12 | MieroRNAs in development and disease显示文摘 | Sayed D Abdellatif M | 2011 | PhysiolRev2011，91，3： | 1 |
| 13 | Serological survey ofToxoplasma gondii in schizophrenia patients referred to Psychi-atric Hospital,Sari City,Iran显示文摘 | Ahmad D Mehdi S Sayed HH | 2010 | Trop Biomed2010，27，3： | 1 |
| 14 | Temporary and persistent poverty among ethnic minorities and majority in rural China显示文摘 | Gustafsson B Sai D | 2009 | Review of Income and Wealth2009，55，1： | 1 |
| 15 | Downregulation of miR-1 9 9 a derepresses hypoxia-inducible factor-1 alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes显示文摘 | RANE S HE M SAYED D | 2009 | Circ Res2009，104，7： | 1 |
| 16 | Downregulation of miR-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes显示文摘 | Rane S He M Sayed D | 2009 | Circ Res2009，104，7： | 1 |
| 17 | Variations in ^7Be concentrations in the atmosphere of Kuwait during the period 1994 to 1998 显示文摘 | Al-Azmi D Sayed A M Yatim H A | 2001 | Appl Radiat Isot2001，55，3： | 1 |
| 18 | MicroRNAs in development and disease 显示文摘 | Sayed D Abdellatif M | 2011 | Physiol Rev2011，91，3： | 1 |
| 19 | Villages where China's ethnic minorities live显示文摘 | Gustafsson B Sai D | 2009 | China Economic Review2009，20，2： | 1 |
| 20 | An antagonism between the AKT and beta-adrenergic signaling pathways mediatedthrough their reciprocal effects on miR-199a-5p 显示文摘 | Rane S He M Sayed D | 2010 | CEL- LULAR SIGNALLING2010，22，7： | 1 |
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