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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Real-time PCR diagnosis of Schistosoma japonicum in low transmission areas of China显示文摘Background:Schistosomiasis in the People’s Republic of China(PRC)can be traced back to antiquity.In the past 60 years,the Chinese government has made great efforts to control this persistent disease with elimination slated by 2020 through the implementation of a comprehensive control strategy.This strategy aims to reduce the role of bovines and humans as sources of infection as a pre-requisite for elimination through transmission interruption.The goal of elimination will be achievable only by the implementation of a sustainable surveillance and control system,with sensitive diagnosis a key feature so that the true disease burden is not underestimated.Currently used diagnostics lack the necessary sensitivity to accurately determine the prevalence of Schistosoma japonicum infection in areas with low infection intensities.It is of critical importance to find and treat people and to identify animals with low-level infections if the National Control Programme for China is to achieve schistosomiasis elimination.Methods:We evaluated a real-time polymerase chain reaction(qPCR)assay using 633 human stool samples collected from five villages in Hunan,Anhui,Hubei,and Jiangxi provinces,and 182 bovine(70 cattle and 112 buffalo)stool samples obtained from four villages in Hunan,Anhui,and Jiangxi provinces in the PRC.All stool samples were subjected to the miracidium hatching test(MHT,a diagnostic procedure used in the National Schistosomiasis Control Programme)and the qPCR assay.Samples positive by MHT were subjected to either the Kato-Katz technique for humans,or the formalin-ethyl acetate sedimentation-digestion(FEA-SD)procedure for bovines,to determine infection intensities.Results:The qPCR assay exhibited a high level of sensitivity in the detection of S.japonicum infections.With both the human and bovine samples,a significantly higher prevalence was determined using the qPCR assay(11.06%humans,24.73%bovines)than with the MHT(0.93%humans,7.69%bovines).The animal contamination index(calculated using data obtained with the qPCR technique)for all positive bovines was 27618000 eggs per day,indicating a considerable amount of environmental egg contamination that would be underestimated using less sensitive diagnostic procedures.Conclusions:The qPCR assay we have evaluated will be applicable as a future field diagnostic and surveillance tool in low-transmission zones where schistosomiasis elimination is targeted and for monitoring post-intervention areas to verify that elimination has been maintained. | Pei He Catherine A.Gordon Gail M.Williams Yuesheng Li Yuanyuan Wang Junjian Hu Darren J.Gray Allen G.Ross Donald Harn Donald P.McManus | 2018 | Infectious Diseases of Poverty2018，7，1： | 7 |
| 3 | Seed Zone Properties and Crop Performance as Affected by Three No-Till Seeders for Permanent Raised Beds in Arid Northwest China显示文摘The no-till seeders of various soil opener configurations have been shown to produce various soil physical responses in relation to soil and climate conditions, thus affecting crop performance in permanent raised beds (PRB) systems. This is particularly important in arid Northwest China where large volumes of residue are retained on the soil surface after harvest. In Zhangye, Gansu Province, China, a field trial assessed the effects of three typical (powered-chopper, powered-cutter and powered-disc) PRB no-till seeders and one traditional seeder on soil disturbance, residue cover index, bulk density, fuel consumption, plant growth, and subsequent yield. In general, seedbed conditions and crop performance for PRB no- till seeders seeded plots were better than for traditional seeded plots. In PRB cropping system, the powered-chopper seeder decreased mean soil disturbance and increased residue cover index compared to powered-disc and -cutter seeders. However, the results indicated that soil bulk density was 2.3-4.8% higher, soil temperature was 0.2-0.6℃ lower, and spring wheat emergence was 3.2-4.7% less. This was attributed to greater levels of residue cover and firmer seedbeds. Spring maize and wheat performance in the powered-cutter and -disc treatments was better (non-significant) than powered-chopper treatment. So powered disc no-till seeder, which generally provided the best planting condition and the highest yield, appeared to be the suitable seeder in heavy residue cover conditions. Considering the precision requirements for soil disturbance and residue cover, the powered strip-chopping no-till seeder could be a suitable option for PRB cropping system in Northwest China. Although these results are preliminary, they are still valuable for the design and selection of no-till seeders for PRB cropping systems in arid Northwest China. | HE Jin LI Hong-wen Allen David McHugh WANG Qing-jie LI Hui Rabi Gautam Rasaily Khokan Kumer Sarker | 2012 | Journal of Integrative Agriculture2012，11，10： | 5 |
| 4 | Design and experiment of anti-vibrating and anti-wrapping rotary components for subsoiler cum rotary tiller显示文摘The commonly used subsoiling cum rotary tiller machine(SRT)in Northern China is a combination of subsoiler and horizontal rotary tiller,however backfilling of the subsoiling slot,excessive vibration and plant residue wrapping on rotary components has been rarely considered.Therefore,the rotary components and assembly were redesigned to address these issues and to an SRT fitted with IT225 short curve rotary blades behind the V-shape subsoiling slots and IIT245 long curve rotary blades between the tines.Long and short blades were fitted on a rotor in a double helix,with optimal spiral angles of 65° and 90°,and phase angle of 147°and 180°,respectively.Compared with the commonly used SRT(CSRT),the additional anti-wrapping cutting blades in the circumferential and axial direction of ASRT could remove hanging residue on the blade holders,wrapping on the rotor and formation of an isolation layer.Moreover,the cutting edge curve of anti-wrapping cutting blades was an exponential curve.Field tests demonstrated that the redesigned SRT with anti-vibrating and anti-wrapping rotary components(ASRT)had was a significant advancement over the CSRT.Moreover,the working depth of rotary tillage was more stable,while other observations confirmed that backfilling of the subsoiling slot was also improved. | Kan Zheng Allen D.McHugh Hongwen Li Qingjie Wang Caiyun Lu Hongnan Hu Wenzheng Liu Zhiqiang Zhang Peng Liu Jin He | 2019 | International Journal of Agricultural and Biological Engineering2019，12，4： | 4 |
| 5 | Gait analysis methods for rodent models of osteoarthritis 显示文摘 | Jacobs BY Kloefkorn HE Allen KD | 2014 | Curt Pain Headache Rep2014，18，456： | 1 |
| 6 | Marine ecoregions of the world:a bioregionalization of coastal and shelf areas显示文摘 | Spalding MD Fox HE Allen GR Davidson N Ferdafia ZA Finlayson M Halpern BS Jorge MA Lombana AL Lourie SA Martin KD Manus EC Molnar J Recchia CA Robertson J | | 0，，： | 1 |
| 7 | Characterization of isolated fractions of dissolved organic matter from natural waters and a wastewater effluent显示文摘 | Ma H Allen HE Yin Y | 2001 | Wat Res2001，35，4： | 1 |
| 8 | Solid-solution Par- titioning of metals in contaminated soils:dependence on pH, total metal burden,and organic matter显示文摘 | S SAUVE W HENDERSHOT HE ALLEN | 2000 | Environmental Science & Technology2000，，34： | 1 |
| 9 | Over-expression of the Arabidopsis 14-3-3 protein GF14λ in cotton leads to a 'stay-green' phenotype and improves stress tolerance under moderate drought conditions 显示文摘 | Yan J Q He C X Wang J Mao Z H Scott A Holaday Randy D Allen Zhang H | 2004 | Plant Cell Physiol2004，45，8： | 1 |
| 10 | Seroprevalence of antibody-mediated, complement-dependent opsonophagocytic activity against Neisseria meningitidis serogroup B in England 显示文摘 | Humphries HE Brookes C Allen L | 2015 | Clin Vaccine Immunol2015，22，5： | 1 |
| 11 | A study of the distributional characteristics of FMR1 transcript levels in 238 individuals显示文摘 | ALLEN EG HE W YADAV SHAH M | 2004 | Hum Genet2004，114，5： | 1 |
| 12 | Solid-solution parti- tioning of metals in contaminated soils: Dependence on pH, total metal burden, and organic matter显示文摘 | Sauv6 S Hendershot W Allen HE | 2000 | Environmental Science & Technology2000，34，7： | 1 |
| 13 | Overexpression of the Arabidopsis 14-3-3 protein GF14 lambda in cotton leads to a 'stay-green” phenotype and improves stress tolerance under moderate drought conditions显示文摘 | Yan J He C Wang J Mao Z Holaday S A Allen g D Zhang H | | 0，，： | 1 |
| 14 | Determinants of Anterior Chamber Depth: The Singapore Chinese Eye Study显示文摘 | Chelvin C. Sng Li-Lian Foo Ching-Yu Cheng John C. Allen Mingguang He Gita Krishnaswamy Monisha E. Nongpiur David S. Friedman Tien Y. Wong Tin Aung | 2012 | Ophthalmology2012，，6： | 1 |
| 15 | James CD CDK4 amplification is an alternative mechanism top16 gene homozygous deletionin gliomas cell lines显示文摘 | He J Allen JR collins VP | 1994 | Cancer Res1994，54，22： | 1 |
| 16 | Characterization of copper complexation with natural dissolved organic matter (DOM)-link to acidic moieties of DOM and competition by Ca and Mg显示文摘 | Allen HE | 2002 | Water Research2002，36，： | 1 |
| 17 | Vascular pathogenesis of transverse limb reduction defects显示文摘 | Hoyme HE Jones KL Van Allen ML | 1982 | J Pediatr1982，101，5： | 1 |
| 18 | Thermal and photooxidative behaviour of novel 4-substituted alicyclic amino-2- hydroxybenzophenone stabilizers in polypropylene and high density polyethylene films显示文摘 | Allen N S Edge M He J | 1992 | Polymer Degradation and Stability1992，38，1： | 1 |
| 19 | Modeling kinetics of Cu and Zn release from soils显示文摘 | Shi ZQ Di toro DM Allen HE | 2005 | Environmental Science and Technology2005，39，12： | 1 |
| 20 | Pelvic floor damage and childbirth : a neurophysiological study 显示文摘 | Allen HE Hosker GL Smith AR | 1990 | Br J Ohstet Gynaecul1990，97，9： | 1 |
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