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| 1 | Distribution of pericellular matrix molecules in the temporomandibular joint and their chondroprotective effects against inflammation显示文摘The objectives of this study were to(1) determine the distribution and synthesis of pericellular matrix(PCM) molecules(collagen VI, collagen IV and laminin) in rat temporomandibular joint(TMJ) and(2) investigate the effects of PCM molecules on chondrocytes against inflammation in osteoarthritis. Four zones(fibrous, proliferating, mature and hypertrophic) of condylar cartilage and three bands(anterior, intermediate and posterior) of disc were analysed by immunohistochemistry for the presence of PCM molecules in rat TMJs. Isolated chondrocytes were pre-treated with PCM molecules before being subjected to interleukin(IL)-1β treatment to stimulate inflammation. The responses of the chondrocytes were analysed using gene expression, nitric oxide release and matrix metalloproteinase(MMP)-13 production measures. Histomorphometric analyses revealed that the highest areal deposition of collagen VI(67.4%), collagen IV(45.7%) and laminin(52.4%) was in the proliferating zone of TMJ condylar cartilage. No significant difference in the distribution of PCM molecules was noted among the three bands of the TMJ disc. All three PCM molecules were expressed intracellularly by chondrocytes cultured in the monolayer. Among the PCM molecules, pre-treatment with collagen VI enhanced cellular proliferation, ameliorated IL-1β-induced MMP-3, MMP-9, MMP-13 and inducible nitric oxide synthase gene expression, and attenuated the downregulation of cartilage matrix genes, including collagen I, aggrecan and cartilage oligomeric matrix protein(COMP). Concurrently, collagen VI pretreatment inhibited nitric oxide and MMP-13 production. Our study demonstrates for the first time the distribution and role of PCM molecules, particularly collagen VI, in the protection of chondrocytes against inflammation. | Wern Cui Chu Shipin Zhang Timothy J Sng Yu Jie Ong Wen-Li Tan Vivien Y Ang Casper B Foldager Wei Seong Toh | 2017 | International Journal of Oral Science2017，9，1： | 5 |
| 2 | Prevent bile duct injury by indocyanine green guide fluorescent imaging during laparoscopic cholecystectomy in liver transplantation recipient显示文摘Cholecystolithiasis with acute cholecystitis is a rare,late biliary complication occurring in liver transplantation(LT)recipients who received the liver graft with preserved donor’s gallbladder.Although laparoscopic cholecystectomy(LC)is not contraindicated after upper abdominal surgery,misunderstanding of the biliary anatomy due to inflammatory phenomena or severe adhesion might increase the risk of bile duct injury(BDI)(1). | Chee-Chien Yong Shih-Min Yin Yi-Ping Sng Chao-Long Chen | 2020 | Hepatobiliary Surgery and Nutrition2020，9，6： | 2 |
| 3 | Vesicle and tubular microstructure formation from synthetic sugar-linked amphiphiles evidence of vesicle formation from single-chain amphiphilcs bearing a disaccharide headgroup显示文摘 | Bhattacharya S Acharya SNG | 2000 | Langmuir2000，16，1： | 1 |
| 4 | IMP-4 and OXA beta-lacta-mases in Aeinetobaeter baumannii from Singapore显示文摘 | Koh TH Sng LH W ang GC | 2007 | J Antimi- crob Chemother2007，59，4： | 1 |
| 5 | The relationship between body mass index and physical activity levels in relation to bone mineral density in premenopausal and postmenopausal women 显示文摘 | Wee J Sng BY Shen L | 2013 | Arch Osteoporos2013，8，： | 1 |
| 6 | IMP-4 and OXA beta-lactamases in Acinetobacter baumannii from Singapore显示文摘 | Koh TH Sng LH Wang GC | 2007 | J Antimicrob Chemother2007，59，4： | 1 |
| 7 | Closed-loop double-vasopressor automated system vs manual bolus vasopressor to treat hypotension during spinal anaesthesia for caesarean section: a randomised controlled trial显示文摘 | Sng BL Tan HS Sia AT | 2014 | Anaesthesia2014，69，1： | 1 |
| 8 | The prevalence of BRCA1 mutations in Chinese patients with early onset breast cancer and affected relatives显示文摘 | Sng JH Chang J Feroze F | 2000 | Br J Cancer2000，82，3： | 1 |
| 9 | Radial Error Propagation Issues in Self-Servo Track Writing Technology显示文摘 | Ye Haibei Sng Vincent Du Chunling | 2002 | IEEE Trans on Magnetics2002，38，5： | 1 |
| 10 | Surgical treatment of angle-closure glaucoma显示文摘 | Chew P Sng C Aquino MC | 2012 | Dev Ophthalmol2012，50，： | 1 |
| 11 | Histone modifications in kainate-induced status epilepticus显示文摘 | Sng JC Taniura H Yoneda Y | 2006 | Eur J Neurosci2006，23，5： | 1 |
| 12 | Condensing osteitis of the medial clavicle-an intermediate-term follow-up 显示文摘 | Sng KK Chart BK Chakrabarti A J | 2004 | Ann Acad Med Singapore2004，4，： | 1 |
| 13 | In-situ derivatisation of degradation products of chemical warfare agents in water by solid phase microextraction and gas chromatographic mass spectromteric analysis显示文摘 | Mui Tiang Sng Wei Fang Ng | 1999 | J Chromatogr A1999，823，： | 1 |
| 14 | Production Coal and DryBiomass a Technology Review From 1950 to 2009 显示文摘 | Kopyscinski of Synthetic J Schildhauer Natural Gas T J Biollaz (SNG) From S | 2010 | Fuel2010，89，17： | 1 |
| 15 | A eomparison between remifentaniland meperidinetor labor analgesia: a systematic review 显示文摘 | Leong WL Sng BL Sia AT | 2011 | Anesth Analg2011，113，4： | 1 |
| 16 | Fractal analysis of the retinal vasculature and chronic kidneydisease 显示文摘 | SNG C C SABANAYAGAM C Lamoureux EL | 2010 | Nephrol Dial Transplant2010，25，7： | 1 |
| 17 | Analysis of series compensation and DC-Link voltage controls of a transformerless self-charging dynamic voltage restorer显示文摘 | Sng E K K Choi S S Vilathgamuwa D M | 2004 | IEEE Transactions on Power Delivery2004，19，3： | 1 |
| 18 | IMP-4 and OXA β-lactamases in Acinetoacter baumannii from Singapore显示文摘 | Koh TH Sng LH Wang GC | 2007 | J Antimicrob Chemother2007，59，4： | 1 |
| 19 | IMP-4 and OXA beta -lactamases in Acinetobacterbaumannii from Smgapore显示文摘 | KohTH Sng LH W ang GC | 2007 | J Antimicrob Chmother2007，59，4： | 1 |
| 20 | Mechanism and management of angle closure in uveitis显示文摘 | Sng C C A Barton K | 2015 | Current opinion in ophthalmology2015，26，2： | 1 |
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