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| 1 | NF-KB in immunobiology显示文摘 | Matthew S Hayden Sankar Ghosh | 2011 | Cell Research2011，21，2： | 101 |
| 2 | PTEN-L is a novel protein phosphatase for ubiquitin dephosphorylation to inhibit PINK1-Parkin-mediated mitophagy显示文摘Mitophagy 是为损坏线粒体的特定的消除的选择 autophagy 的一种重要类型。(PINK1 )导致 PTEN 的通常认为的 kinase 蛋白质 1 催化 ubiquitin (Ub ) 的 phosphorylation 在 PINK1-Parkin-mediated mitophagy 的发作起一个关键作用。(PTEN-L ) 磷酸酶和 tensin 相当或相同的事物(PTEN ) 长是 PTEN 的最新识别的 isoform,与到它的 N 终点的 173 氨基酸的增加。这里,我们报导 PTEN-L 是经由它对 phosphorylated ubiquitin 的蛋白质磷酸酶活动的 mitophagy 的一个新奇否定管理者。我们发现 PTEN-L 在外部 mitochondrial 膜(OMM ) 本地化,而 PTEN-L 的删除支持, PTEN-L 的 overexpression 禁止, mitophagy 由各种各样的损坏线粒体的代理人导致了。机械学地, PTEN-L 能够有效地阻止 Parkin mitochondrial translocation,减少 Parkin phosphorylation,维持它的关上的不活跃的符合构造,并且禁止它的 E3 ligase 活动。更重要地, PTEN-L 在 vivo 减少 phosphorylated ubiquitin (pSer65-Ub ) 的水平,并且在 vitro,磷酸酶试金经由它的蛋白质磷酸酶活动证实那 PTEN-L dephosphorylates pSer65-Ub,独立于它的类脂化合物磷酸酶功能。一起拿,我们的调查结果为 ubiquitin 作为蛋白质磷酸酶表明 PTEN-L 的新奇功能,它抵抗在 mitophagy 正式就职和 mitophagy 的最终的抑制导致前馈控制机制的阻塞的调停 PINK1 的 ubiquitin phosphorylation。因此,理解 PTEN-L 的这新奇功能在控制 mitophagy 的分子的难题提供一关键错过片,在包括象 Parkinsons 那样的 neurodegenerative 混乱的许多重要人的疾病的一个批评过程疾病。 | Liming Wang Yik-Lam Cho Yancheng Tang Jigang Wang Jung-Eun Park Yajun Wu Chunxin Wang Yan Tong Ritu Chawla Jianbin Zhang Yin Shi Shuo Deng Guang Lu Yihua Wu Hayden Weng-Siong Tan Pornteera Pawijit Grace Gui-Yin Lim Hui-Ying Chan Jingzi Zhang Lei Fang Hanry Yu Yih-Cherng Liou Mallilankaraman Karthik Boon-Huat Bay Kah-Leong Lim Siu-Kwan Sze Celestial T. Yap Han-Ming Shen | 2018 | Cell Research2018，28，8： | 25 |
| 3 | Management of proximal humerus fractures in adults显示文摘The majority of proximal humerus fractures are lowenergy osteoporotic injuries in the elderly and their incidence is increasing in the light of an ageing population. The diversity of fracture patterns encountered renders objective classification of prognostic value challenging. Non-operative management has been associated with good functional outcomes in stable, minimally displaced and certain types of displaced fractures.Absolute indications for surgery are infrequent and comprise compound, pathological, multi-fragmentary head-splitting fractures and fracture dislocations, as well as those associated with neurovascular injury. A constantly expanding range of reconstructive and replacement options however has been extending the indications for surgical management of complex proximal humerus fractures. As a result, management decisions are becoming increasingly complicated, in an attempt to provide the best possible treatment for each indi-vidual patient, that will successfully address their specific fracture configuration, comorbidities and functional expectations. Our aim was to review the management options available for the full range of proximal humerus fractures in adults, along with their specific advantages, disadvantages and outcomes. | Leonidas Vachtsevanos Lydia Hayden Aravind S Desai Asterios Dramis | 2014 | World Journal of Orthopedics2014，5，5： | 22 |
| 4 | Endoscopy and polyps-diagnostic and therapeutic advances in management显示文摘Despite multiple efforts aimed at early detection through screening, colon cancer remains the third leading cause of cancer-related deaths in the United States, with an estimated 51000 deaths during 2013 alone. The goal remains to identify and remove benign neoplastic polyps prior to becoming invasive cancers. Polypoid lesions of the colon vary widely from hyperplastic, hamartomatous and inflammatory to neoplastic adenomatous growths. Although these lesions are all benign, they are common, with up to one-quarter of patients over 60 years old will develop pre-malignant adenomatous polyps. Colonoscopy is the most effective screening tool to detect polyps and colon cancer, although several studies have demonstrated missed polyp rates from 6%-29%, largely due to variations in polyp size. This number can be as high as 40%, even with advanced (> 1 cm) adenomas. Other factors including sub-optimal bowel preparation, experience of the endoscopist, and patient anatomical variations all affect the detection rate. Additional challenges in decision-making exist when dealing with more advanced, and typically larger, polyps that have traditionally required formal resection. In this brief review, we will explore the recent advances in polyp detection and therapeutic options. | Scott R Steele Eric K Johnson Bradley Champagne Brad Davis Sang Lee David Rivadeneira Howard Ross Dana A Hayden Justin A Maykel | 2013 | World Journal of Gastroenterology2013，19，27： | 16 |
| 5 | Exercise-induced oxidative stress:Friend or foe?显示文摘The first report demonstrating that prolonged endurance exercise promotes oxidative stress in humans was published more than 4 decades ago.Since this discovery,many ensuing investigations have corroborated the fact that muscular exercise increases the production of reactive oxygen species(ROS)and results in oxidative stress in numerous tissues including blood and skeletal muscles.Although several tissues may contribute to exercise-induced ROS production,it is predicted that muscular contractions stimulate ROS production in active muscle fibers and that skeletal muscle is a primary source of ROS production during exercise.This contraction-induced ROS generation is associated with(1)oxidant damage in several tissues(e.g.,increased protein oxidation and lipid peroxidation),(2)accelerated muscle fatigue,and(3)activation of biochemical signaling pathways that contribute to exercise-induced adaptation in the contracting muscle fibers.While our understanding of exercise and oxidative stress has advanced rapidly during the last decades,questions remain about whether exercise-induced increases in ROS production are beneficial or harmful to health.This review addresses this issue by discussing the site(s)of oxidant production during exercise and detailing the health consequences of exercise-induced ROS production. | Scott K.Powers Rafael Deminice Mustafa Ozdemir Toshinori Yoshihara Matthew P.Bomkamp Hayden Hyatt | 2020 | Journal of Sport and Health Science2020，9，5： | 13 |
| 6 | Nonselective betablocker therapy decreases intestinal permeability and serum levels of LBP and IL-6 in patients with cirrhosis显示文摘 | T. Reiberger A. Ferlitsch B.A. Payer M. Mandorfer B.B. Heinisch H. Hayden F. Lammert M. Trauner M. Peck-Radosavljevic H. Vogelsang | 2012 | Journal of Hepatology2012，，： | 5 |
| 7 | Shared Principles in NF-κB Signaling显示文摘 | Matthew S. Hayden Sankar Ghosh | 2008 | Cell2008，，3： | 4 |
| 8 | Surgical management of nonobstructive azoospermia显示文摘Nonobstructive azoospermia(NOA)is characterized by the complete absence of sperm in the ejaculate due to testicular failure.The evaluation and management of patients with NOA offer a challenge to the reproductive urologist.In the era of in vitro fertilization with intracytoplasmic sperm injection,surgical sperm extraction techniques can afford men with NOA biologic paternity.To provide a comprehensive review of surgical sperm retrieval approaches in the patient with NOA emphasizing complications,success rates and outcome optimization,a Medline search was conducted querying surgical approaches used to manage NOA.Four sperm extraction techniques are described including:testicular sperm aspiration,testicular sperm extraction,fine needle aspiration mapping and microdissection testicular sperm extraction.In addition,the roles for pre-extraction varicocelectomy and sperm cryopreservation are discussed.The management of NOA continues to evolve as newer tools become available.Several modalities of sperm acquisition exist.An understanding of their complications and success rates is fundamental to the treatment of NOA. | Bruno Camargo Tiseo Russell Paul Hayden Cigdem Tanrikut | 2015 | Asian Journal of Urology2015，2，2： | 4 |
| 9 | 感染人类的禽流感病毒A(H5N1)研究进展显示文摘 | Abdel-Nasser Abdel-Ghafar Tawee Chotpitayasunondh Zhancheng Gao Frederick G. Hayden Nguyen Duc Hien Menno D. de Jong Azim Naghdaliyev J.S. Malik Peiris Nahoko Shindo Santoso Soeroso Timothy M. Uyeki 钟晓琴(译) 王关嵩(校) | 2009 | 中华肺部疾病杂志(电子版)2009，2，1： | 4 |
| 10 | Feasibility, efficacy, and adverse effects of outpatient antibacterial prophylaxis in children with acute myeloid leukemia显示文摘 | Hiroto Inaba Aditya H. Gaur Xueyuan Cao Patricia M. Flynn Stanley B. Pounds Viswatej Avutu Lindsay N. Marszal Scott C. Howard Ching‐Hon Pui Raul C. Ribeiro Randall T. Hayden Jeffrey E. Rubnitz | 2014 | Cancer2014，，13： | 3 |
| 11 | Executive Function Deficits in Acute Stroke显示文摘 | Sandra Zinn Hayden B. Bosworth Helen M. Hoenig H. Scott Swartzwelder | 2007 | Archives of Physical Medicine and Rehabilitation2007，，2： | 2 |
| 12 | Comparison of the activities of zanamivir, oseltamivir, and RWJ-270201 against clinical isolates of influenza virus and neuraminidase inhibitor-resistant variants 显示文摘 | Gubareva L V Webster R G Hayden F G | 2001 | Antimicrob Agents Chemother2001，45，12： | 2 |
| 13 | 综述:颅脑损伤中脑灌注压的意义显示文摘众所周知,创伤性脑损伤后,低脑血流灌注(和脑灌注压(CPP)]是预后不良的重要原因。但尚不明确的是:改变脑血流抑或CPP,是否可以改善临床预后。最初的研究表明,提高CPP是有益的,脑创伤研究协会(Braill Trauma Foundation)将目标值定为70rnrnHg,并编入1996年版指南中。然而,随后的实践显示,达到此目标值并未带来显著的益处,而并发症的发生率却有所上升,因此将此目标值降低为60mmHg。近来,有证据表明,创伤性脑损伤后,脑的自身调节功能被破坏,这样就有学者提出,应对CPP进行个体化的调整。另外,随着先进的神经监测技术的出现,临床医生能够更加准确地观察血流动力学调节措施对脑代谢的影响。但现在仍然缺乏有力的证据支持调控CPP可改善预后这一观点。迄今为止,关于最佳脑灌注压的争论仍在继续。 | Hayden White Bala Venkatesh 郭英(译) 米卫东(校) | 2011 | 麻醉与镇痛2011，7，1： | 2 |
| 14 | Pilot trial of autologous dendritic cells loaded with tumor lysate(s)from allogeneic tumor cell lines in patients with metastatic medullary thyroidcarcinoma显示文摘 | Thomas Bachleitner-Hofmann Josef Friedl Michaela Hassler Hubert Hayden Peter Dubsky Monika Sachet Erwin Rieder Roswitha Pfragner Christine Brostjan Stefan Riss Bruno Niederle Michael Gnant Anton Stift | 2009 | Oncology Reports2009，，6： | 2 |
| 15 | Low-loss cascadable MEMS distributed X-band phase shifters 显示文摘 | J S Hayden G M Rebeiz | 2000 | IEEE Microwave and guided wave letters2000，10，4： | 2 |
| 16 | Hemorheological abnormalities in lipoprotein lipase deficient mice with severe hypertriglyceridemia显示文摘 | Tieqiang Zhao Jun Guo Hui Li Wei Huang Xunde Xian Colin J.D. Ross Michael R. Hayden Zongyao Wen George Liu | 2006 | Biochemical and Biophysical Research Communications2006，，4： | 2 |
| 17 | 显示文摘 | Huang J H Lin C H Chen Hayden | 1999 | Materials Chemistry and Physics1999，59，： | 2 |
| 18 | Sepsis terminology in pediatrics显示文摘 | Hayden WR | 1994 | J Pediatr1994，124，4： | 1 |
| 19 | NF-kB and the immune response显示文摘 | HAYDEN M | 2006 | Oncogene2006，51，12： | 1 |
| 20 | Signaling to NF-κB显示文摘 | Hayden M S Ghosh S | 2004 | Genes Dev2004，18，18： | 1 |
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