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| 1 | PTEN-L is a novel protein phosphatase for ubiquitin dephosphorylation to inhibit PINK1-Parkin-mediated mitophagy显示文摘Mitophagy 是为损坏线粒体的特定的消除的选择 autophagy 的一种重要类型。(PINK1 )导致 PTEN 的通常认为的 kinase 蛋白质 1 催化 ubiquitin (Ub ) 的 phosphorylation 在 PINK1-Parkin-mediated mitophagy 的发作起一个关键作用。(PTEN-L ) 磷酸酶和 tensin 相当或相同的事物(PTEN ) 长是 PTEN 的最新识别的 isoform,与到它的 N 终点的 173 氨基酸的增加。这里,我们报导 PTEN-L 是经由它对 phosphorylated ubiquitin 的蛋白质磷酸酶活动的 mitophagy 的一个新奇否定管理者。我们发现 PTEN-L 在外部 mitochondrial 膜(OMM ) 本地化,而 PTEN-L 的删除支持, PTEN-L 的 overexpression 禁止, mitophagy 由各种各样的损坏线粒体的代理人导致了。机械学地, PTEN-L 能够有效地阻止 Parkin mitochondrial translocation,减少 Parkin phosphorylation,维持它的关上的不活跃的符合构造,并且禁止它的 E3 ligase 活动。更重要地, PTEN-L 在 vivo 减少 phosphorylated ubiquitin (pSer65-Ub ) 的水平,并且在 vitro,磷酸酶试金经由它的蛋白质磷酸酶活动证实那 PTEN-L dephosphorylates pSer65-Ub,独立于它的类脂化合物磷酸酶功能。一起拿,我们的调查结果为 ubiquitin 作为蛋白质磷酸酶表明 PTEN-L 的新奇功能,它抵抗在 mitophagy 正式就职和 mitophagy 的最终的抑制导致前馈控制机制的阻塞的调停 PINK1 的 ubiquitin phosphorylation。因此,理解 PTEN-L 的这新奇功能在控制 mitophagy 的分子的难题提供一关键错过片,在包括象 Parkinsons 那样的 neurodegenerative 混乱的许多重要人的疾病的一个批评过程疾病。 | Liming Wang Yik-Lam Cho Yancheng Tang Jigang Wang Jung-Eun Park Yajun Wu Chunxin Wang Yan Tong Ritu Chawla Jianbin Zhang Yin Shi Shuo Deng Guang Lu Yihua Wu Hayden Weng-Siong Tan Pornteera Pawijit Grace Gui-Yin Lim Hui-Ying Chan Jingzi Zhang Lei Fang Hanry Yu Yih-Cherng Liou Mallilankaraman Karthik Boon-Huat Bay Kah-Leong Lim Siu-Kwan Sze Celestial T. Yap Han-Ming Shen | 2018 | Cell Research2018，28，8： | 25 |
| 2 | A long-term Global LAnd Surface Satellite(GLASS)data-set for environmental studies显示文摘Recently,five Global LAnd Surface Satellite(GLASS)products have been released:leaf area index(LAI),shortwave broadband albedo,longwave broadband emissivity,incident short radiation,and photosynthetically active radiation(PAR).The first three products cover the years 19822012(LAI)and 19812010(albedo and emissivity)at 15 km and 8-day resolutions,and the last two radiation products span the period 20082010 at 5 km and 3-h resolutions.These products have been evaluated and validated,and the preliminary results indicate that they are of higher quality and accuracy than the existing products.In particular,the first three products have much longer time series,and are therefore highly suitable for various environmental studies.This paper outlines the algorithms,product characteristics,preliminary validation results,potential applications and some examples of initial analysis of these products. | Shunlin Liang Xiang Zhao Suhong Liu Wenping Yuan Xiao Cheng Zhiqiang Xiao Xiaotong Zhang Qiang Liu Jie Cheng Hairong Tang Yonghua Qu Yancheng Bo Ying Qu Huazhong Ren Kai Yu John Townshend | 2013 | International Journal of Digital Earth2013，6，S01： | 16 |
| 3 | Pulse radiolysis study on gatifloxacin——A fluoroquinolone antibiotic显示文摘The reactions between gatifloxacin(GFX) and various one-electron oxidants,such as ˙OH,N3˙,Br2˙ˉ,and SO4˙ˉ,have been studied by pulse radiolysis techniques.The GFX radical anion formed in the reaction of GFX with eaqˉ could either be protonated or deprotonated,and the absorption of GFX radical anion was located at 390 nm.The transient species produced by the reaction of GFX with ˙OH radical shows a broad band in the 380?600 nm region with a shoulder,while the oxidation by N3˙,SO4˙ˉ,and Br2˙ˉ results in an absorption band with λmax = 370 nm.At neutral condition(pH 7),the rate constants of GFX reacting with ˙OH,N3˙,Br2˙ˉ,SO4˙ˉ and eaqˉ are estimated to be 1.0 × 1010,3.1 × 109,2.8 × 109,3.0 × 109,and 1.8 × 1010 dm3 mol?1 s?1,respectively.From the pH dependence on the formation of electron adducts and on the rate constant of GFX with eaqˉ,the pKa of GFX radical anion is estimated to be 5.5 and 9.3. | LI HaiXia LIU YanCheng TANG RuiZhi ZHANG Peng FU HaiYing YAO SiDe WANG WenFeng | 2012 | Science China Chemistry2012，55，7： | 3 |
| 4 | Translation of fear reflex into impaired cognitive function mediated by worry显示文摘Published online:25 October 2016óScience China Press and Springer-Verlag Berlin Heidelberg 2016Anxiety is generally characterized by cognitive impairment.In particular,the worry dimension of anxiety | Qian Zhuang Lijun Wang Yancheng Tang Antao Chen | 2016 | Science Bulletin2016，61，24： | 2 |
| 5 | Synergistic effects of autophagy/mitophagy inhibitors and magnolol promote apoptosis and antitumor efficacy显示文摘Mitochondria as a signaling platform play crucial roles in deciding cell fate.Many classic anticancer agents are known to trigger cell death through induction of mitochondrial damage.Mitophagy,one selective autophagy,is the key mitochondrial quality control that effectively removes damaged mitochondria.However,the precise roles of mitophagy in tumorigenesis and anticancer agent treatment remain largely unclear.Here,we examined the functional implication of mitophagy in the anticancer properties of magnolol,a natural product isolated from herbal Magnolia officinalis.First,we found that magnolol induces mitochondrial depolarization,causes excessive mitochondrial fragmentation,and increases mitochondrial reactive oxygen species(mtROS).Second,magnolol induces PTEN-induced putative kinase protein 1(PINK1)-Parkin-mediated mitophagy through regulating two positive feedforward amplification loops.Third,magnolol triggers cancer cell death and inhibits neuroblastoma tumor growth via the intrinsic apoptosis pathway.Moreover,magnolol prolongs the survival time of tumor-bearing mice.Finally,inhibition of mitophagy by PINK1/Parkin knockdown or using inhibitors targeting different autophagy/mitophagy stages significantly promotes magnolol-induced cell death and enhances magnolol's anticancer efficacy,both in vitro and in vivo.Altogether,our study demonstrates that magnolol can induce autophagy/mitophagy and apoptosis,whereas blockage of autophagy/mitophagy remarkably enhances the anticancer efficacy of magnolol,suggesting that targeting mitophagy may be a promising strategy to overcome chemoresistance and improve anticancer therapy. | Yancheng Tang Liming Wang Tao Yi Jun Xu Jigang Wang Jiang-Jiang Qin Qilei Chen Ka-Man Yip Yihang Pan Peng Hong Yingying Lu Han-Ming Shen Hu-Biao Chen | 2021 | Acta Pharmaceutica Sinica B2021，11，12： | 2 |
| 6 | Pulse radiolysis of sparfloxacin in neutral aqueous solution显示文摘 | LIU Yancheng LI Haixia CUI Rongrong TANG Ruizhi XU Yulie WANG Wenfeng | 2013 | Nuclear Science and Techniques2013，24，B12： | 2 |
| 7 | Pulse radiolysis and laser flash photolysis study of balofloxacin显示文摘 | XU Yulie LIU Yancheng LI Haixia ZHANG Peng TANG Ruizhi CAO Xiyan WANG Wenfeng | 2013 | Nuclear Science and Techniques2013，24，B12： | 2 |
| 8 | Detection and Analysis of Pesticide Residues in Chinese Chives and Risk Assessment of Dietary Intake显示文摘[Objectives]This study was conducted to understand the status of pesticide residues and dietary intake risk of Chinese chives in Tangshan area. [Methods] Sixty eight kinds of pesticide residues in 415 Chinese chive samples collected from Tangshan area were qualitatively and quantitatively determined by high-performance liquid chromatography-tandem mass spectrometry(HPLC-MS/MS) and gas chromatography(GC) in 2020. [Results] The results showed that 41 kinds of pesticide residues were detected in the 415 Chinese chive samples, and the detection rate was 69.4%(288/415), and there was a combination of pesticides in many samples. According to the National Food Safety Standard―Maximum Residue Limits of Pesticides in Food(GB 2763-2019), the residues of 12 pesticides exceeded the maximum residue limits(MRLs), and the unqualified rate was 38.07%(158/415). The highest detection rate of clothianidin was 41.20%(171/415), but there was no MRL in GB 2763-2019. The next was procymidone, the detection rate of which was 35.42%(147/415), and the over-standard rate was 30.12%(125/415). Forbidden and restricted pesticides were detected in some samples. According to the dietary exposure risk assessment, the NEDI/ADI values were all less than 1 and the intake risk was within acceptable range. In Tangshan area, the types of pesticides used in Chinese chive production are complex, and there are risks of multi-residue pollution and use of banned and restricted pesticides and unregistered pesticides. It is suggested that routine monitoring of pesticide residues and management of pesticide use should be strengthened to ensure the quality and safety of agricultural products. [Conclusions] This study provides a theoretical basis for the safe production of Chinese chive and the standardized and rational use of pesticides. | Lei WANG Huihui LIU Shuo YANG Ying WANG Shuai WANG Haitao ZHAO Huifang YAO Yajing WANG Liang ZHANG Yancheng ZHOU Sining TANG Yanhua YAN | 2023 | Agricultural Biotechnology2023，12，1： | 1 |
| 9 | Cycling degradation of an automotive LiFePO4 lithium-ion battery 显示文摘 | Zhang Yancheng Wang Chaoyang Tang Xidong | 2011 | Journal of Power Sources2011，196，3： | 1 |
| 10 | Study on Soil Nutrient Fertility of Cultivated Land in Laos显示文摘[Objectives] This study was conducted to explore the differences in soil nutrient contents of cultivated land in different regions of Laos,and to provide a basis for soil nutrient management and scientific fertilization in Laos. [Methods] By collecting 166 samples of the 0-20 cm cultivated soil layer from farmland in the farming areas of Luang Namtha Province in the northern part of Laos and Vientiane Province in the middle of the country,the contents of soil organic matter,total nitrogen,available phosphorus,available potassium,available calcium and available magnesium were analyzed,so as to evaluate the current status of soil nutrient fertility and explore the differences in soil nutrient contents of regional cultivated land. [Results] The soil organic matter was relatively abundant,the total nitrogen and available potassium contents were at the lower-middle level,and the available phosphorus,available calcium and available magnesium were insufficient or extremely insufficient. The soil nutrient contents of cultivated land were different in different regions. [Conclusions] It is suggested that lime or other alkaline fertilizers should be applied on the farmland with acid soil,and nitrogen,phosphorus,and potassium fertilizers should be added at the same time to improve soil nutrient fertility. | Yuyi HUANG Guifen CHEN Yanfei HUANG Shuyi LIU Yancheng MENG Bin LIU Liping XIE Pheng SENGXUA Moryang CHUAYENG Qizhan TANG | 2020 | Agricultural Biotechnology2020，9，3： | 1 |
| 11 | Cycling degradation of an automotive LiFePO 4 lithium-ion battery显示文摘 | Yancheng Zhang Chao-Yang Wang Xidong Tang | 2010 | Journal of Power Sources2010，，3： | 1 |
| 12 | Synthesis of jet fuel additive with cyclopentanone显示文摘A new route was developed for the synthesis of renewable decalin with cyclopentanone which can be derived from lignocellulose.It was found that 1,2,3,4,5,6,7,8-octahydronaphthalene could be selectively produced by the hydrogenation/dehydration/rearrangement of [1,1-bi(cyclopentylidene)]-2-one(i.e.the selfaldol condensation product of cyclopentanone) over a dual-bed catalyst system.Among the investigated catalysts,the Ru/C and Amberlyst-15 resin exhibited the highest activities for the hydrogenation of [1,1-bi(cyclopentylidene)]-2-one to [1,1-bi(cyclopentan)]-2-ol and the dehydration/rearrangement of [1,1-bi(cyclopentan)]-2-ol to 1,2,3,4,5,6,7,8-octahydronaphthalene,respectively.Using Ru/C and Amberlyst-15 resin as the first bed and the second bed catalysts,1,2,3,4,5,6,7,8-octahydronaphthalene was directly produced in high carbon yield(83.7%) under mild conditions(393 K,1 MPa).After being hydrogenated,the1,2,3,4,5,6,7,8-octahydronaphthalene was converted to decalin which can be used as additive to improve the thermal stability and volumetric heat value of jet fuel. | Hao Tang Fang Chen Guangyi Li Xiaofeng Yang Yancheng Hu Aiqin Wang Yu Cong Xiaodong Wang Tao Zhang Ning Li | 2019 | Journal of Energy Chemistry2019，28，2： | 1 |
| 13 | Preparation and Characterization of Impurely Irrigated Soil Adsorbent from Beaches显示文摘[Objective]We aimed to study the preparation methods of impurely irrigated soil adsorbent from beaches,as well as its ability to absorb phenol.[Method]Using hydrochloric acid as activator,we compared the influences of various soil adsorbents on the adsorption of phenol through the desired orthogonal tests where the usage of saw dust,concentration of hydrochloric acid,liquid-solid ratio and carbonization temperature varied.Afterwards,we characterized this soil adsorbent.[Result]The optimal conditions for preparing the soil adsorbent were as follows,that is,the usage of saw dust was 20%,concentration of HCl was 1 mol /L,the ratio of liquid to solid was 2:1,carbonization temperature was 500 ℃,and activation time was one hour,the absorption efficiency of phenol in water by the soil adsorbent reached above 90%.Characterization showed that the prepared soil adsorbent changed obviously in the structure,that is,soil pores and carbon content increased greatly,as well as its absorption efficiency.[Conclusion]The prepared soil adsorbent by this method greatly improved the absorption efficiency of phenol in water,which provided a novel method for the reasonable utilization of saw dust,with good prospects. | DONG Mao-mao 1,2,TANG Fan 3,FEI Zheng-hao 2,QIAN Xiao-rong 3 1.Yancheng Environmental Monitoring Center,Yancheng 224000,China 2.Jiangsu Provincial Key Laboratory of Coastal Wetland Bioresources and Environmental Protection,Yancheng Teachers University,Yancheng 224002,China 3.Chemical and Biological Engineering College,Yancheng Institute of Technology,Yancheng 224003,China | 2011 | Meteorological and Environmental Research2011，2，11： | 1 |
| 14 | Cycling degrada- tion of an automotive LiFePO4 lithium-ion battery 显示文摘 | Zhang Yancheng Wang Chaoyang Tang Xidong | 2011 | Journal of Power Sources2011，196，3： | 1 |
| 15 | A long-term Global LAnd Surface Satellite (GLASS) data-set for environmental studies显示文摘 | Shunlin Liang Xiang Zhao Suhong Liu Wenping Yuan Xiao Cheng Zhiqiang Xiao Xiaotong Zhang Qiang Liu Jie Cheng Hairong Tang Yonghua Qu Yancheng Bo Ying Qu Huazhong Ren Kai Yu John Townshend | 2013 | 2013 (sup1)2013，，1： | 1 |
| 16 | Evaluation of Soil Nutrient Content and Fertility in Main Dry Farming Regions of Laos显示文摘[Objectives]To evaluate the status of soil nutrient and fertility in main dry farming regions of Laos,and to explore differences in soil nutrient content between regions and crop types.[Methods]By collecting 57 soil samples in the 0-20 cm layer of the main dryland in southern and northern provinces of Laos.Soil pH,organic matter,total nitrogen,available nitrogen,available phosphorus,available potassium,exchangeable calcium,exchangeable magnesium and available zinc content were analyzed.[Results]The soil in the main dry farming regions of Laos was acidic,the overall fertility level was good,and the exchangeable calcium and magnesium contents were low.There were differences in soil nutrient content in the dry farming regions of southern and northern Laos.Drylands where cassava and maize were growed had higher fertility.[Conclusions]It is suggested to apply lime or alkaline fertilizer in the dry land with acid soil to increase soil pH and increase the supply of soil calcium and magnesium.Organic fertilizer should be applied to improve soil water retention capacity,and it is necessary to pay attention to the fertilization ratio of macroelements to balance fertilization. | Shuyi LIU Yuyi HUANG Guifen CHEN Yancheng MENG Bin LIU Zhong LIU Yanfei HUANG Liping XIE Qizhan TANG Moryang CHUAYENG | 2022 | Asian Agricultural Research2022，14，3： | 0 |
| 17 | Photosensitized oxidation of tryptophan and tyrosine by aromatic ketones:A laser flash photolysis study显示文摘Photochemical processes of benzophenone (BP) and xanthone (XT) with tryptophan (TrpH) and tyrosine (TyrOH) were studied using the laser flash photolysis technique.It has been observed that the triplet state of BP and XT reacted with TrpH and TyrOH by hydrogen transfer with the formation of BP and XT ketyl radicals and oxidized radicals of TrpY and TyrOY.The related rate constants of these reactions were determined in this paper.The free energy changes (G) of these reactions suggested that the proposed hydrogen transfer mechanism was thermodynamically feasible.These results provide theoretical foundation for further studying structural effects on the photochemical behaviors of proteins with triplet state BP and XT. | TANG RuiZhi ZHANG Peng LI HaiXia LIU YanCheng WANG WenFeng | 2012 | Science China Chemistry2012，55，3： | 0 |
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