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| 1 | Correlation of N-myc downstream-regulated gene 1 expression with clinical outcomes of colorectal cancer patients of different race/ethnicity显示文摘AIM: To evaluate the role of N-myc downstream-regulated gene 1 (NDRG1) expression in prognosis and survival of colorectal cancer patients with different ethnic backgrounds. METHODS: Because NDRG1 is a downstream target of p53 and hypoxia inducible factor-1α (HIF-1α),we examined NDRG1 expression together with p53 and HIF-1α by immunohistochemistry. A total of 157 colorectal cancer specimens including 80 from Japanese patients and 77 from US patients were examined. The correlation between protein expression with clinicopathological features and survival after surgery was analyzed.in colorectal tumor compared with normal epithelium in both Japanese and US patient groups. Expression of NDRG1 protein was significantly correlated with lymphatic invasion,venous invasion,depth of invasion,histopathological type,and Dukes' stage in Japanese colorectal cancer patients. NDRG1 expression was correlated to histopathological type,Dukes' stage and HIF-1α expression in US-Caucasian patients but not in US-African American patients. Interestingly,Kaplan-Meier survival analysis demonstrated that NDRG1 expression correlated significantly with poorer survival in US-African American patients but not in other patient groups. However,in p53-positive US cases,NDRG1 positivity correlated significantly with better survival. In addition,NDRG1 expression also correlated significantly with improved survival in US patients with stages Ⅲ and Ⅳ tumors without chemotherapy. In Japanese patients with stages Ⅱ and Ⅲ tumors,strong NDRG1 staining in p53-positive tumors correlated significantly with improved survival but negatively in patients without chemotherapy. CONCLUSION: NDRG1 expression was correlated with various clinicopathological features and clinical outcomes in colorectal cancer depending on the race/ethnicity of the patients. NDRG1 may serve as a biological basis for the disparity of clinical outcomes of colorectal cancer patients with different ethnic backgrounds. | Minori Koshiji Kensuke Kumamoto Keiichirou Morimura Yasufumi Utsumi Michiko Aizawa Masami Hoshino Shinji Ohki Seiichi Takenoshita Max Costa Thérèse Commes David Piquemal Curtis C Harris Kam-Meng Tchou-Wong | 2007 | World Journal of Gastroenterology2007，13，20： | 25 |
| 2 | Review of the genotoxicity of formaldehyde exposure显示文摘 | Ma TH Harris MM | 1990 | Pro Am Assoc Cancer Res1990，31，： | 2 |
| 3 | Color Doppler ultrasound imaging of the eye and orbit显示文摘 | Williamson TH Frcophth F Harris A | | 0，，： | 1 |
| 4 | Preventing nosocomial pneumonia:Evidence based practice显示文摘 | Harris JR Miller TH | 2000 | Crit Care Nurse2000，20，1： | 1 |
| 5 | Dynamic imaging of CD8+T cells and dendritic cells during infection with Toxo-plasma gondii显示文摘 | John B Harris TH Tait ED | 2009 | PLoS Pathog2009，5，7： | 1 |
| 6 | An Abnormal Mitochondrial–Hypoxia Inducible Factor-1α–Kv Channel Pathway Disrupts Oxygen Sensing and Triggers Pulmonary Arterial Hypertension in Fawn Hooded Rats: Similarities to Human Pulmonary Arterial Hypertension显示文摘 | Sébastien Bonnet Evangelos D. Michelakis Christopher J. Porter Miguel A. Andrade-Navarro Bernard Thébaud Sandra Bonnet Alois Haromy Gwyneth Harry Rohit Moudgil M Sean McMurtry E Kenneth Weir Stephen L. Archer | 2006 | Circulation2006，，22： | 1 |
| 7 | Toll-like receptor 4 contributes to poor outcome after intracerebral hemorrhage显示文摘 | Sansing LH Harris TH Welsh FA | | 0，，04： | 1 |
| 8 | Preferential Expression and Function of Voltage-Gated, O2-Sensitive K+ Channels in Resistance Pulmonary Arteries Explains Regional Heterogeneity in Hypoxic Pulmonary Vasoconstriction: Ionic Diversity in Smooth Muscle Cells显示文摘 | Stephen L. Archer Xi-Chen Wu Bernard Thébaud Ali Nsair Sebastien Bonnet Ben Tyrrell M Sean McMurtry Kyoko Hashimoto Gwyneth Harry Evangelos D. Michelakis | 2004 | Circulation Research2004，，3： | 1 |
| 9 | Toll-like receptor 4 contributes to poor outcome after intracerebral hemorrhage显示文摘 | ANSING LH HARRIS TH WELSH FA | 2011 | Ann Neurol2011，70，4： | 1 |
| 10 | Color Doppler ultransound imaging of the eye and orbit 显示文摘 | Williamson TH Harris A | 1996 | Surv Ophthalmology1996，40，4： | 1 |
| 11 | Neutrophil depletion diminishes monocyte infiltration and improves functional outcome after experimental intracercbral hcmorrhagc显示文摘 | Sansing LH Harris TH Kasner SE | 2011 | Acta Neurochir Suppl2011，111，： | 1 |
| 12 | Occlusion of the right posterior inferiorcerebellar artery and right vertebral artery显示文摘 | Harris TH Hauser A | 1931 | Arch NeurolPsychiatry1931，26，： | 1 |
| 13 | Review of the genotoxicity of formaldehyde explsure显示文摘 | Ma TH Harris MM | 1990 | Proc Am Assoc Cancer Res1990，31，： | 1 |
| 14 | Nuclear Factor-kappa B and apoptosis inducing factor activation by doxorubicin analog WP744 in SH-SY5Y neuroblastoma cells显示文摘 | Wu J Harris N L Inge TH | 2004 | J Surg Res2004，122，2： | 1 |
| 15 | A mouse model of vitiligo with focused epidermal depigmentation requires IFN-γfor autoreactive CD8+ T-cell accumulation in the skin显示文摘 | Harris JE Harris TH Weninger W | | 0，，07： | 1 |
| 16 | Toll-like receptor 4 contributes to poor outcome after intracerebral hemorrhage显示文摘 | Sansing LH Harris TH Welsh FA | 2011 | Ann Neurol2011，70，4： | 1 |
| 17 | A mouse model of vitiligo with focused epidermal depigmentation requires IFN-/for autoreactive CD8+ T-cell accumulation in the skin 显示文摘 | Harris JE Harris TH Weninger W | 2012 | J Invest Dermatol2012，132，7： | 1 |
| 18 | Incidence of sudden sensori- neural hearing loss 显示文摘 | Alexander TH Harris JP | 2013 | Otology Neurotol2013，34，9： | 1 |
| 19 | Toll-like receptor 4 contributes to poor outcome after intracerebral hemorrhage显示文摘 | Sansing LH Harris TH Welsh FA | 2011 | Ann Neurol2011，70，： | 1 |
| 20 | Incidence of sudden sensorineuralhearing loss显示文摘 | Alexander TH Harris JP | 2013 | Otol Neurotol2013，34，9： | 1 |
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