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5篇 您的检索式：作者名="Vikas Sachdev"

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		题名	作者	年代	出处	被引量
	1	Plasma cathepsin L:A prognostic marker for pancreatic cancer显示文摘AIM:To assess the prognostic significance of cathepsin L,a cysteine protease that degrades the peri-tumoral tissue,in patients with pancreatic cancer.METHODS:Plasma samples from 127 pancreatic cancer patients were analyzed for cathepsin L levels by ELISA.Out of these patients,25 underwent surgeryand their paraffin-embedded tissue was analyzed for cathepsin L expression by immunohistochemistry.Survival of patients and clinicopathological parameters was correlated with cathepsin L expression in plasma and tissue using appropriate statistical analysis.RESULTS:The mean(±SD)cathepsin L in plasma samples of pancreatic cancer patients was 5.98±2.5ng/m L that was significantly higher compared to the levels in healthy controls(3.83±0.45)or chronic pancreatitis patients(3.97±1.06).Using ROC curve,a cut-off level of 5.0 ng/m L was decided for survival analysis.Elevated plasma levels of cathepsin L were found to be associated with poor prognosis(P=0.01)in multivariate analysis.The plasma levels of the protease decreased after surgery.Though no significant correlation was seen between plasma and tissue expression of this protease,a trend did emerge that high cathepsin L expression in tissue correlated with its high levels in plasma.CONCLUSION:Cathepsin L levels in plasma of pancreatic cancer patients may be used as a potential prognostic marker for the disease.	Nidhi Singh Prasenjit Das Surabhi Gupta Vikas Sachdev Siddhartha Srivasatava Siddhartha Datta Gupta Ravindra Mohan Pandey Peush Sahni Shyam S Chauhan Anoop Saraya	2014	World Journal of Gastroenterology2014，20，46：	2
	2	Effect of Oral Glutamine Supplementation on Gut Permeability and Endotoxemia in Patients With Severe Acute Pancreatitis: A Randomized Controlled Trial显示文摘	Namrata Singh Sushil Kumar Mishra Vikas Sachdev etal	2014	Pancreas2014，43，6：	1
	3	Role of Probiotics on Gut Permeability and Endotoxemia in Patients With Acute Pancreatitis: A Double-Blind Randomized Controlled Trial显示文摘	Brij Sharma Siddharth Srivastava Namrata Singh Vikas Sachdev Suman Kapur Anoop Saraya	2011	Journal of Clinical Gastroenterology2011，，5：	1
	4	Effect of oral glutamine supplementation on gut permeability and endotoxemia in patients with severe acute pancreatitis:a randomized controlled trial显示文摘	Namrata Singh Sushil Kumar Mishra Vikas Sachdev	2014	Pancreas2014，43，6：	1
	5	Anti- Saccharomyces cerevisiae Antibody Does Not Differentiate Between Crohn’s Disease and Intestinal Tuberculosis显示文摘	Govind K. Makharia Vikas Sachdev Rajiva Gupta Suman Lal R. M. Pandey	2007	Digestive Diseases and Sciences2007，，1：	1

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