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| 1 | Massive individual orbital angular momentum channels for multiplexing enabled by Dammann gratings显示文摘Data transmission rates in optical communication systems are approaching the limits of conventional multiplexing methods.Orbital angular momentum(OAM)in optical vortex beams offers a new degree of freedom and the potential to increase the capacity of free-space optical communication systems,with OAM beams acting as information carriers for OAM division multiplexing(OAM-DM).We demonstrate independent collinear OAM channel generation,transmission and simultaneous detection using Dammann optical vortex gratings(DOVGs).We achieve 80/160 Tbit s^(-1) capacity with uniform power distributions along all channels,with 1600 individually modulated quadrature phase-shift keying(QPSK)/16-QAM data channels multiplexed by 10 OAM states,80 wavelengths and two polarizations.DOVG-enabled OAM multiplexing technology removes the bottleneck of massive OAM state parallel detection and offers an opportunity to raise optical communication systems capacity to Pbit s^(-1) level. | Ting Lei Meng Zhang Yuru Li Ping Jia Gordon Ning Liu Xiaogeng Xu Zhaohui Li Changjun Min Jiao Lin Changyuan Yu Hanben Niu Xiaocong Yuan | 2015 | Light(Science & Applications)2015，4，1： | 47 |
| 2 | 钠-葡萄糖共转运蛋白-2抑制剂或胰高血糖素样肽-1受体激动剂治疗成人2型糖尿病:临床实践指南显示文摘临床问题对于存在不同心血管风险及肾脏结局的2型糖尿病患者,在原有生活方式干预和/或其他降糖药物的基础上加用钠-葡萄糖共转运蛋白2(SGLT-2)抑制剂和胰高血糖素样肽1(GLP-1)受体激动剂的获益及风险是什么?现行做法几十年来,2型糖尿病的治疗决策都以控制血糖为主导。SGLT-2抑制剂和GLP-1受体激动剂在传统观念中常被用于二甲双胍治疗后血糖仍控制不佳的患者。目前这一现状已经发生了改变,这得益于多项临床研究结果。研究显示SGLT-2抑制剂和GLP-1受体激动剂拥有独立于药物降糖作用之外的对于动脉粥样硬化性心血管病(CVD)和慢性肾脏病(CKD)的获益。建议本指南阐述了针对不同风险分层的成人2型糖尿病患者使用SGLT-2抑制剂或GLP-1受体激动剂的建议。•伴有3种或更少的心血管风险因素且不存在CVD或CKD:不建议启动SGLT-2抑制剂或GLP-1受体激动剂治疗。(推荐等级:弱)•伴有3种以上心血管风险因素且不存在CVD或CKD:建议启动SGLT-2抑制剂治疗,不建议启动GLP-1受体激动剂治疗。(推荐等级:弱)•已经存在CVD或CKD:建议启动SGLT-2抑制剂治疗和GLP-1受体激动剂治疗。(推荐等级:弱)•已经存在CVD和CKD:建议启动SGLT-2抑制剂治疗(推荐等级:强)和GLP-1受体激动剂治疗。(推荐等级:弱)•对于那些想要进一步降低CVD和CKD结局风险的患者:推荐优先启用SGLT-2抑制剂治疗而非GLP-1受体激动剂治疗。(推荐等级:弱)这项指南是如何制订的一个由患者、临床医生和方法学家共同组成的国际小组提出了这些推荐意见。这些推荐意见基于可信度较高的指南的标准,并使用GRADE分级方法进行评估。该小组采用了息者个体化的观点。证据一项关于获益与风险的系统综述和网络meta分析(764项随机对照研究,包括421346例参与者)发现SGLT-2抑制剂和GLP-1受体激动剂可以降低总体死亡率、心肌梗死发生率、终末期肾病或肾衰竭的发生率(中等至高等质量的证据)。在不同的亚组中这些药物对卒中、因心力衰竭所致住院和其他主要不良事件有不同的影响。药物绝对获益的程度因患者个体风险的不同有很大的差异。(例如,对于接受了超过5年药物治疗的1000例患者,在最低风险人群中死亡人数减少了5人,在最高风险人群中死亡人数减少了48人)。一项关于预后的综述确认了14种风险预测模型,其中一种(RECODe)在证据总结中报告了大部分基线风险评估数据,小组利用该模型以支持风险分层的建议。考虑到患者的价值观及个体差异,指南推荐的支撑证据包括一项对已发表论文的系统综述、一项患者焦点小组研究、一项临床问题总结,以及一项指南调查。指南解读我们依据不同的CVD和CKD风险水平,综合考虑获益、风险和其他因素的平衡,以及每一个风险组别的实际问题,来对推荐意见进行分层。本指南强烈建议CVD和CKD患者使用SGLT-2抑制剂治疗,这说明专家组认为其具有显著的获益。而对于其他成人2型糖尿病患者,推荐等级较弱,这说明专家组想要在获益、风险及治疗花费上取得一个更好的平衡。临床医生通过该指南可以使用可靠的风险计算模型,如RECODe,来明确其患者的个体心血管和肾脏疾病风险。医患交互式总结临床证据和制订决策有助于患者知晓治疗选择,包括进行共同决策。2型糖尿病人群(全球患病率不断增长1-2)正面临着不断增加的心血管疾病、肾脏病和其他并发症的风险3。数十年来,2型糖尿病的管理始终以控制血糖及糖化血红蛋白(HbA1c)为治疗目标4-5,但是,最近的高质量随机对照研究已经对这种以血糖为中心的治疗模式发起了挑战。研究结果显示,强化血糖控制未必会降低大血管不良事件,它还可能带来不利影响监管机构现在要求新型糖尿病药物必须证明其具有心血管和肾脏获益才能获得批准。对两类新药--钠-葡萄糖共转运蛋白2(SGLT-2)抑制剂和胰高血糖素样肽1(GLP-1)受体激动剂(见框图1)的临床试验结果显示,在现有治疗方案(常规治疗)之上加用这些药物,对死亡、心肌梗死、卒中、心力衰竭和肾脏的结局(如进展为终末期肾病)都有获益8-12。 | Sheyu Li Per Olav Vandvik Lyubov Lytvyn Gordon H Guyatt Suetonia C Palmer Rene Rodriguez-Gutierrez Farid Foroutan Thomas Agoritsas Reed A C Siemieniuk Michael Walsh Lawrie Frere David J Tunnicliffe Evi V Nagler Veena Manja Bjφrn Olav Asvold Vivekanand Jha Mieke Vermandere Karim Gariani Qian Zhao Yan Ren Emma Jane Cartwright Patrick Gee Alan Wickes Linda Fems Robin Wright Ling Li Qiukui Hao Reem A Mustafa 无 郭鹤鸣(译) | 2021 | 英国医学杂志中文版2021，24，9： | 7 |
| 3 | Simulations and software development for the Hard X-ray Imager onboard ASO-S显示文摘China’s first solar mission,the Advanced Space-based Solar Observatory(ASO-S),is now changing from Phase B to Phase C.Its main scientific objectives are summarized as’1M2B’,namely magnetic field and two types of bursts(solar flares and coronal mass ejections).Among the three scientific payloads,Hard X-ray Imager(HXI)observes images and spectra of X-ray bursts in solar flares.In this paper,we briefly report on the progresses made by the HXI science team(data and software team)during the design phase(till May 2019).These include simulations of HXI imaging,optimization of HXI grids,development of imaging algorithms,estimation of orbital background,as well as in-orbit calibration plan.These efforts provided guidance for the engineering,improved HXI’s imaging capability and reduced the cost of the instrument. | Yang Su Wei Liu You-Ping Li Zhe Zhang Gordon JHurford Wei Chen Yu Huang Zhen-Tong Li Xian-Kai Jiang Hao-Xiang Wang Fan-Xiao-Yu Xia Chang-Xue Chen Wen-Hui Yu Fu Yu Jian Wu Wei-Qun Gan | 2019 | Research in Astronomy and Astrophysics2019，19，11： | 7 |
| 4 | Cytotoxic effect of interleukin-8 in retinal ganglion cells and its possible mechanisms显示文摘AIM: To investigate the effect of interleukin-8(IL-8) on neural retinal ganglion cells(RGCs) and whether it can be alleviated by G31P. METHODS: RGC-5 cells were exposed to IL-8 with or without its specific receptor antagonist G31P for 24h, and the cell viability was assessed by Cell Counting Kit 8(CCK-8). Apoptosis was measured by examining nuclear morphology and quantifying with flow cytometry. Reverse transcription quantitative real-time polymerase chain reaction(RT-qP CR) and Western blot were used to investigate the expression of apoptosis-related genes. RESULTS: CCK-8 assay showed that IL-8 significantly inhibits the viability of RGC-5 cells in a dose-dependent manner. Cell apoptosis assays exhibited higher apoptotic rate in IL-8 treatment group compared to control group. We further found that IL-8 could promote Bax and caspase-3 expressions, but decrease the level of Bcl-2 in the aspect of m RNA and protein. However, pre-treatment with G31P partly attenuated these effects in RGC-5 cells(P<0.05).CONCLUSION: These results indicate that anti-proliferation effects of IL-8 through induction of cell apoptosis regulated by Bcl-2, Bax and caspase-3 expressions, can be ameliorated by G31P. | Jing-Jing Wang Walana Williams Bing Wang Jing Wei Xia Lu Jya-Wei Cheng John R Gordon Jing-Min Li Fang Li | 2018 | International Journal of Ophthalmology(English edition)2018，11，8： | 3 |
| 5 | 雨养农业:中国半干旱地区雨水灌溉土地上的水资源综合管理系统显示文摘雨养农业(RHA)最早是由甘肃省科学家在十几年前开发的,它是适用于半干旱地区靠雨水灌溉土地的一种水资源综合管理系统。这个系统由三个主要部分组成:雨水收集系统、节水灌溉系统和高效农作物生产系统。它的主要功能是为农民们提供一种能够在用水受限制的环境下获得满足家庭生活和农业所需要的水的途径。在甘肃省和中国西北地区的其他省份,RHA的最初设置表明RHA有能力改进靠雨水灌溉的农业系统的表现,并且能够致力于解决土壤侵蚀等一些环境问题。RHA系统规模小、成本低,很客易在农民家庭推广应用。但是,为了能够取得成功,需要把RHA系统纳入到一个综合农业管理系统之中:即RHA管理必须与其他农业技术与管理实践结合在一起运用。此外,在大范围内推广使用RHA需要考虑一系列技术、农业水文、生态、社会、文化、经济和政治因素。特别是需要向农民提供培训和技术指导,以开发和传播更为有效和廉价的RHA技术方式来更新换代并设计开发出替代性的政策工具和社会规则以便于RHA在实践中的应用。 | Li Fengrui Seth Cook Gordon T. Geballe William R. Burch | 2000 | AMBIO-人类环境杂志2000，29，8： | 3 |
| 6 | Three-dimensional bioprinting speeds up smart regenerative medicine显示文摘Biological materials can actively participate in the formation of bioactive organs and can even control cell fate to form functional tissues that we name as the smart regenerative medicine(SRM). The SRM requires interdisciplinary efforts to finalize the pre-designed organs. Three-dimensional(3D) printing, as an additive manufacturing technology, has been widely used in various fields due to its high resolution and individuation. In SRM, with the assistance of 3D printing, cells and biomaterials could be precisely positioned to construct complicated tissues. This review summarizes the state of the SRM advances and focuses in particular on the 3D printing application in biofabrication. We further discuss the issues of SRM development and finally propose some approaches for future 3D printing, which involves SRM. | Qi Gu He Zhu Jing Li Xia Li Jie Hao Gordon G.Wallace Qi Zhou | 2016 | National Science Review2016，3，3： | 2 |
| 7 | 鞘内注射吗啡预处理激活大鼠δ、κ、μ受体致心肌保护显示文摘背景鞘内注射小剂量吗啡可产生与静脉注射吗啡相似的心肌保护作用,但鞘内注射吗啡预处理(IT—MPC)与缺血预处理(IPC)作用强度的差别还未知,IT-MPC是否由阿片类受体所介导也未阐明。因此,本实验比较IT—MPC与IPC作用强度差别并探讨阿片类受体的作用。方法80只SD大鼠麻醉后开胸,成功置入鞘内导管后随机分为13组(n=6—7)。IPC组接受3次5分钟缺血-5分钟再灌注的心肌IPC(阻闭左冠状动脉),随之给予30分钟缺血-2小时再灌注诱导心肌缺血再灌注(IR)损伤。IT-MPC组按剂量不同分为4个亚组(分别是0.03、0.3、3及30μg/kg),以3次5分钟注射-5分钟间停的模式平均注入鞘内,随之诱导IR损伤。静脉注射吗啡预处理组(IV-MPC)组经静脉给予吗啡300μg/kg,对照组鞘内给予10μl生理盐水。受体阻滞剂组选择在IT—MPC(3μg/kg)前分别给予选择性δ、κ、μ受体阻滞剂NTD、nor-BNI及CTOP,以评价阿片类受体亚型的作用。通过2,3,5-tripheny ltetrazolium染色,计算心肌梗死面积(IS),即梗死心肌占缺血危险区(AAR)的百分比。结果与对照组相比,鞘内注射0.3~30μg/kg吗啡降低心肌IS,3组IS/AAR分别为33%±10%(0.3μg/kg)、29%±10%(3μg/kg)、29%±16%(30μg/kg),对照组为53%±8%(P〈0.01)。IT-MPC降低心肌IS/AAR程度与IV-MPC(33%±6%,P=0.84)及IPC(22%±4%,P=0.41)相近。注射选择性受体阻滞剂后,由IT-MPC(3μg/kg)产生的心肌预处理效果降低(NTD+IT-MPC,50%±9%:nor-BNI+IT-MPc,43%±6%;CTOP+IT—MPC,53%±9%;与对照组相比,P=0.14)。结论IT—MPC产生与IPC及IV—MPC相近的心肌保护作用,其机制涉及到δ、κ、μ受体。 | Rui Li Gordon T. C. Wong Tak Ming Wong Ye Zhang, MD Zhengyuan Xia Michael G. Irwin 潘鹏(译) 李文志(校) | 2009 | 麻醉与镇痛2009，，6： | 2 |
| 8 | An integrated fuzzy-stochastic modeling approach for risk assessment of groundwater contamination显示文摘 | Jianbing Li Gordon H. Huang Guangming Zeng Imran Maqsood Yuefei Huang | 2006 | Journal of Environmental Management2006，，2： | 2 |
| 9 | In vivo evaluation of additively manufacturedmulti-layered scaffold for the repair of large osteochondral defects显示文摘The repair of osteochondral defects is one of the major clinical challenges in orthopaedics.Well-established osteochondral tissue engineering methods have shown promising results for the early treatment of small defects.However,less success has been achieved for the regeneration of large defects,which is mainly due to the mechanical environment of the joint and the heterogeneous nature of the tissue.In this study,we developed a multi-layered osteochondral scaffold to match the heterogeneous nature of osteochondral tissue by harnessing additive manufacturing technologies and combining the established art laser sintering and material extrusion techniques.The developed scaffold is based on a titanium and polylactic acid matrix-reinforced collagen“sandwich”composite system.The microstructure and mechanical properties of the scaffold were examined,and its safety and efficacy in the repair of large osteochondral defects were tested in an ovine condyle model.The 12-week in vivo evaluation period revealed extensive and significantly higher bone in-growth in the multi-layered scaffold compared with the collagen–HAp scaffold,and the achieved stable mechanical fixation provided strong support to the healing of the overlying cartilage,as demonstrated by hyaline-like cartilage formation.The histological examination showed that the regenerated cartilage in the multi-layer scaffold group was superior to that formed in the control group.Chondrogenic genes such as aggrecan and collagen-II were upregulated in the scaffold and were higher than those in the control group.The findings showed the safety and efficacy of the cell-free“translation-ready”osteochondral scaffold,which has the potential to be used in a one-step surgical procedure for the treatment of large osteochondral defects. | Maryam Tamaddon Gordon Blunn Rongwei Tan Pan Yang Xiaodan Sun Shen-Mao Chen Jiajun Luo Ziyu Liu Ling Wang Dichen Li Ricardo Donate Mario Monzón Chaozong Liu | 2022 | Bio-Design and Manufacturing2022，5，3： | 2 |
| 10 | Antiviral Therapy for Chronic Hepatitis B Virus Infection and Development of Hepatocellular Carcinoma in a US Population显示文摘 | Stuart C. Gordon Lois E. Lamerato Loralee B. Rupp Jia Li Scott D. Holmberg Anne C. Moorman Philip R. Spradling Eyasu H. Teshale Vinutha Vijayadeva Joseph A. Boscarino Emily M. Henkle Nancy Oja–Tebbe Mei Lu | 2014 | Clinical Gastroenterology and Hepatology2014，，： | 2 |
| 11 | 查看详情显示文摘 | Li D Muller M.B Gilje S Richard B.K. Gordon G.W | | 0，，： | 1 |
| 12 | Safety of yttrium-90 ibritumomab tiuxetan radioimmunotherapy for relapsed low-grade,follicular,or transformed non-Hodgkin's lymphoma显示文摘 | Witzig TE White CA Gordon LI | 2003 | J Clin Oncol2003，21，7： | 1 |
| 13 | Tax structures in developing countries: Many puzzles and a possible explanation显示文摘 | Gordon R Li W | 2009 | Journal of Public Economics2009，93，78： | 1 |
| 14 | Ideal rather than actual body weight should be used to calculate cell dose in allogeneic hematopoietic stem cell transplantation 显示文摘 | Singhal S Gordon LI Tallman MS | 2006 | Bone Marrow Transplant2006，37，11： | 1 |
| 15 | Treatment with ibritumomab tiuxetan radioimmunotherapy in patients with rituximab-refractory follicular non-Hodgkin's lymphoma显示文摘 | Witzig TE Flinn IW Gordon LI | 2002 | J Clin Oncol2002，20，15： | 1 |
| 16 | Synergistic enhancement of antitumor immunity with adoptively transferred tumor-specific CD4^+ and CD8^+ T cells and intratumoral lymphotacin transgene expression显示文摘 | Huang H Li F Gordon JR | 2002 | Cancer Res2002，62，7： | 1 |
| 17 | Phase Ⅱ study of rituximab plus cyclophosphamide,doxorubicin,vincristine,and prednisone immunochemotherapy followed by yttrium-90-ibritumomab tiuxetan in untreated mantle-cell lymphoma:Eastern Cooperative Oncology Group Study E1499显示文摘 | Smith MR Li H Gordon L | 2012 | J Clin Oncol2012，30，25： | 1 |
| 18 | Inflammation and cancer: role of phagocyte-generated oxidants in carcinogenesis 显示文摘 | WeitzmanSA Gordon LI | 1990 | Blood1990，76，： | 1 |
| 19 | CXCL8((3-73显示文摘 | Li F Zhang X Gordon JR | | 0，，03： | 1 |
| 20 | Sequential Inactivation of Cryptosporidium Parvum Using Ozone and Chlorine显示文摘 | Hanbin Li Gordon R F Daniel W | 2001 | Water Research2001，35，18： | 1 |
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