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| 1 | 循证实践中的医患选择——医疗决策不能迷信证据而要靠人显示文摘 | R Brain Haynes PJ Devereaux Gordon H Guyatt 陈霖 | 2003 | 中国循证医学杂志2003，3，4： | 7 |
| 2 | Randomized trial in malignant biliary obstruction:Plastic vs partially covered metal stents显示文摘AIM:To compare efficacy and complications of par-tially covered self-expandable metal stent(pcSEMS)to plastic stent(PS)in patients treated for malignant,infrahilar biliary obstruction.METHODS:Multicenter prospective randomized clinical trial with treatment allocation to a pcWallstent(SEMS)or a 10 French PS.Palliative patients aged≥18,for infrahilar malignant biliary obstruction and a Karnofsky performance scale index>60%from 6 participating North American university centers.Primary endpoint was time to stent failure,with secondary outcomes of death,adverse events,Karnofsky performance score and short-form-36 scale administered on a three-monthly basis for up to 2 years.Survival analyses were performed for stent failure and death,with Cox proportional hazards regression models to determine significant predictive characteristics.RESULTS:Eighty-five patients were accrued over 37mo,42 were randomized to the SEMS group and 83patients were available for analyses.Time to stent failure was 385.3±52.5 d in the SEMS and 153.3±19.8 d in the PS group,P=0.006.Time to death did not differ between groups(192.3±23.4 d for SEMS vs211.5±28.0 d for PS,P=0.70).The only significant predictor was treatment allocation,relating to the time to stent failure(P=0.01).Amongst other measured outcomes,only cholangitis differed,being more common in the PS group(4.9%vs 24.5%,P=0.029).The small number of patients in follow-up limits longitudinal assessments of performance and quality of life.From an initially planned 120 patients,only 85 patients were recruited.CONCLUSION:Partially covered SEMS result in a longer duration till stent failure without increased complication rates,yet without accompanying measurable benefits in survival,performance,or quality of life. | Peter L Moses Khalid M AlNaamani Alan N Barkun Stuart R Gordon Roger D Mitty M Stanley Branch Thomas E Kowalski Myriam Martel Viviane Adam | 2013 | World Journal of Gastroenterology2013，19，46： | 6 |
| 3 | Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial显示文摘 | Paul Y Kwo Eric J Lawitz Jonathan McCone Eugene R Schiff John M Vierling David Pound Mitchell N Davis Joseph S Galati Stuart C Gordon Natarajan Ravendhran Lorenzo Rossaro Frank H Anderson Ira M Jacobson Raymond Rubin Kenneth Koury Lisa D Pedicone Clifford | 2010 | The Lancet2010，，9742： | 3 |
| 4 | Cytotoxic effect of interleukin-8 in retinal ganglion cells and its possible mechanisms显示文摘AIM: To investigate the effect of interleukin-8(IL-8) on neural retinal ganglion cells(RGCs) and whether it can be alleviated by G31P. METHODS: RGC-5 cells were exposed to IL-8 with or without its specific receptor antagonist G31P for 24h, and the cell viability was assessed by Cell Counting Kit 8(CCK-8). Apoptosis was measured by examining nuclear morphology and quantifying with flow cytometry. Reverse transcription quantitative real-time polymerase chain reaction(RT-qP CR) and Western blot were used to investigate the expression of apoptosis-related genes. RESULTS: CCK-8 assay showed that IL-8 significantly inhibits the viability of RGC-5 cells in a dose-dependent manner. Cell apoptosis assays exhibited higher apoptotic rate in IL-8 treatment group compared to control group. We further found that IL-8 could promote Bax and caspase-3 expressions, but decrease the level of Bcl-2 in the aspect of m RNA and protein. However, pre-treatment with G31P partly attenuated these effects in RGC-5 cells(P<0.05).CONCLUSION: These results indicate that anti-proliferation effects of IL-8 through induction of cell apoptosis regulated by Bcl-2, Bax and caspase-3 expressions, can be ameliorated by G31P. | Jing-Jing Wang Walana Williams Bing Wang Jing Wei Xia Lu Jya-Wei Cheng John R Gordon Jing-Min Li Fang Li | 2018 | International Journal of Ophthalmology(English edition)2018，11，8： | 3 |
| 5 | The DA VINCI Study: Phase 2 Primary Results of VEGF Trap-Eye in Patients with Diabetic Macular Edema显示文摘 | Diana V. Do Ursula Schmidt-Erfurth Victor H. Gonzalez Carmelina M. Gordon Michael Tolentino Alyson J. Berliner Robert Vitti Rene Rückert Rupert Sandbrink David Stein Ke Yang Karola Beckmann Jeff S. Heier | 2011 | Ophthalmology2011，，9： | 3 |
| 6 | Acute lung injury and the acute respiratory distress syndrome: a clinical review显示文摘 | Arthur P Wheeler Gordon R Bernard | 2007 | 2007 (9572)2007，，9572： | 2 |
| 7 | The cognitive neuroscience of remote episodic, semantic and spatial memory显示文摘 | Morris Moscovitch Lynn Nadel Gordon Winocur Asaf Gilboa R Shayna Rosenbaum | 2006 | Current Opinion in Neurobiology2006，，2： | 2 |
| 8 | 彩色多型木材虎蛾的频率相关飞行活动显示文摘捕食者有效地学习,以避免一种类型的警告信号,而不是几个,使颜色多态性联合国-预期。警戒虎木蛾雄性车前草灯蛾有白色或黄色后翅色在欧盟绳。以前的研究表明,黄色的男性更好地防御天敌,而白色的男性有一个正频率相关的交配优势。然而,潜在的频率依赖性的行为差异的变种之间的航班,以及男男性的相互作用诱导的飞行活动的作用,没有考虑。我们跑到室外笼实验,男性型比例操纵测试是否飞行活动的频率依赖性,不同的变种。白色的变形比黄色的所有处理明显活跃,和更长的持续活动。在黄偏环境的两个变种整体的活动是相当低的,这表明人口中男性比例高于黄可能导致降低整体飞行活动。黄色变形的活动也跟着陡,窄的曲线比白色的变形峰女调用活动期间。我们建议最大的白人男性,他们大概是不太昂贵的防御工事,有更多的资源投资在捕食逃逸飞行和寻找配偶。黄色的男性,这是更好的保护,但不可能替代性选择,弥补其较低的飞行交流活动由“飞行智能高峰时段中的女性。因此,这两个变种可以行为平衡预警信号的选择和性选择之间的权衡。我们的研究结果强调需要更大的研究动物行为和在自然或半自然环境[当前生态61颜色多态性(4):765-772,2015 ]。 | Bibiana ROJAS Swanne R GORDON Johanna MAPPES | 2015 | Current Zoology2015，61，4： | 2 |
| 9 | 2004英国高血压学会高血压治疗指南(BHS-IV):概要显示文摘在高血压领域,不断出现的新证据已日益受到关注。例如:血压可作为心血管疾病的一个危险因素;改进生活方式对于预防和治疗高血压的重要意义;不同类型药物的有效性和安全性;高危高血压患者包括糖尿病患者的治疗;心血管疾病总体危险性评估的重要性以及使用他汀类药物所获得的额外益处。 | Bryan Williams Neil R Poulter Peter S Sever Morris J Brown Mark Davis Gordon T McInnes John F Potter 邱洪 | 2004 | 英国医学杂志中文版2004，7，5： | 2 |
| 10 | Algebraic reconstruction techniques (ART) for three dimensional electron microscopy and X-ray photography显示文摘 | Gordon R Bender R Herman GT | 1970 | Theor Biol1970，29，： | 1 |
| 11 | Disproportionation of chlorous acid, Part 1, Stoichiometry 显示文摘 | Kieffer R G Gordon G | 1968 | Inorganic Chemistry1968，7，3： | 1 |
| 12 | Analysis of wax hydrocarbons in petroleum source rocks from the Damintun depression, eastern China,using high temperature gas chromatography 显示文摘 | Huang H P Steve R L Gordon D L | 2003 | Organic Geochemistry2003，34，： | 1 |
| 13 | Largescale isolation of CD133+progenitor cells from G-CSF mobilized peripheral blood stem cells显示文摘 | GORDON P R LEIMI T BABARIN-DORNER A | 2003 | Bone Marrow Transplant2003，31，： | 1 |
| 14 | Deciphering the biology of My cobacterium tuberculosis from the complete genome sequence 显示文摘 | Cole S T Brosch R Parkhill J Gamier T Churcher C Harris D Gordon S V Eiglmeier K Gas S Barry C E Tekaia F Badcock K Basham D Brown D Chillingworth T Cormor R Davies R Devlin K FeltweU T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Kroghs A McLean J Moule S Murphy L Oliver K Osborne J Quail M A Rafandream M A Rogers J Rutter S Seeger K Skelton J Squaraes R Squares S Sulston J E Taylo K Whitehead S Barrell B G | 1998 | Nature1998，393，： | 1 |
| 15 | Optical detection of crack patterns in the opening-mode fracture of marble显示文摘 | NOLEN-HOEKSEMA R C GORDON R B | 1987 | International Journal of Rock Mechanics and Mining Sciences and Geomechanics Abstracts1987，24，4： | 1 |
| 16 | Can Capital Income Taxes Survive in Open Economies? 显示文摘 | Gordon R H | 1992 | Journal of Finance1992，，47： | 1 |
| 17 | Julia set of the complex Carotid-Kundalin function 显示文摘 | Gordon R J Cooper | 2001 | Computer & Graphics2001，，25： | 1 |
| 18 | The case for iron显示文摘 | John H Martin R Michael Gordon | 1991 | Limnol Oceanogr1991，36，8： | 1 |
| 19 | Application of CFD analysis for rotating machinery-Part I : hydrodynamic, hydrostatic beatings and squeeze film damper显示文摘 | Guo Zenglin Hirano Toshio Gordon Kirk R | 2005 | Journal of Engineering for Gas Turbines and Power2005，127，2： | 1 |
| 20 | Literature-based discovery by lexical statistics 显示文摘 | LINDSAY R K GORDON M D | 1999 | Journal of American Society for Informa- tion Science1999，49，8： | 1 |
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