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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Neutralizing anti- bodies to enterovirus 71 in Belem, Brazil 显示文摘 | Gomes ML de Castro CM OliVeira MJ | 2002 | Mem lnst Oswaldo Cruz2002，97，1： | 1 |
| 3 | An investiga- tion of the presence of specific anaerobic species in necrotic pri- mary teeth显示文摘 | Gomes GB Sarkis-Onofre R Bonow ML | 2013 | Braz Oral Res2013，27，2： | 1 |
| 4 | Heat stress impairs performance and induces intestinal inflammation in broiler chickens infected with salmonella enteritidis显示文摘 | Quinteiro-Filho WM Gomes AVS Pinheiro ML | 2012 | Avian Pathology2012，41，5： | 1 |
| 5 | Comparative analysis of the performance of various crystalloid cardioplegic solutions on myocardial protection after prolonged cold ischemia 显示文摘 | Lima ML Fiorelli AI Gomes OM | 2011 | Trans- plant Proc2011，43，1： | 1 |
| 6 | Vasoplegic syndrome after off-pump coronary artery bypass surgery 显示文摘 | Gomes WJ Erlichman MR Batista-Filho ML | 2003 | Eur J Cardiothorac Surg2003，23，2： | 1 |
| 7 | Genetic relationships between Trypanosoma cruzi strains isolated from chronic chagasic patients in southern Braizl as revealed by RAPD and SSR-PCR analysis显示文摘 | Gomes ML Macedo AM Pena SD | 1998 | Acta Tropica1998，69，2： | 1 |
| 8 | Vasoplegic syndrome after off-pump coronary artery bypass surgery显示文摘 | Gomes WJ Erlichman MR Batista-Filho ML | 2003 | Eur J Cardiothorac Surg2003，23，： | 1 |
| 9 | Muscle strength, muscle balance, physical function and plasma inter- leukin-6 (IL-6) levels in elderly women with knee osteoar- thritis (OA)显示文摘 | Santos ML Gomes WF Pereira DS | 2011 | Arch Gerontol Geriatr2011，52，3： | 1 |
| 10 | Neutralizing anti- bodies to entero virus 71 in Belem,Brazil显示文摘 | Gomes ML de Castro CM Oli Veira MJ | 2002 | Mem Inst Oswaldo Cruz2002，97，1： | 1 |
| 11 | Genome sequencing in microfabricated high-density picolitre reactors显示文摘 | Margulies M Egholm M Altman WE Attiya S Bader JS Bemben LA Berka J Braverman MS Chen YJ Chen Z Dewell SB Du L Fierro JM Gomes XV Godwin BC He W Helgesen S Ho CH Irzyk GP Jando SC Alenquer ML Jarvie TP Jirage KB Kim JB Knight JR Lanza JR Leamon JH Lefkowit | | 0，，7057： | 1 |
| 12 | Transmission of Oropouche virus from man to hamster by the midge Culicoides paraensis 显示文摘 | Pinheiro FP Travassosda RAP Gomes ML | 1982 | Science1982，215，4537： | 1 |
| 13 | Odontogenic cyst:a conservative approach显示文摘 | Massara ML Gomes CO | 2000 | J Dent Child2000，67，5： | 1 |
| 14 | The effect of mitomycin-C on the biodistribution of 99 Tcm-MDP in Balb/c mice显示文摘 | Gomes ML | 1998 | Nucl Med Commun1998，19，12： | 1 |
| 15 | Vasoplegic syndrome after off-pump coronary artery by pass surgery显示文摘 | Gomes WJ Erlichman MR Batista-Filho ML | 2003 | Eur J Cardio Thorac Surg2003，23，： | 1 |
| 16 | VasopIegic syndrome after off-pump coronary artery bypass surgery显示文摘 | Gomes WJ ErIichman MR Batista-FiIho ML et aI | 2003 | Eur J Cardiothorac Surg2003，23，2： | 1 |
| 17 | Comparative analysis of the performance of various crystalloid cardioplegic solutions on myocardial protection after prolonged cold ischemia显示文摘 | Lima ML Fiorelli AI Gomes OM | | 0，，： | 1 |
| 18 | Muscle strength,muscle balance,physical function and plasma interleukin-6(IL-6) levels in elderly women with knee osteoarthritis (OA)显示文摘 | Santos ML Gomes WF Pereira DS | | 0，，03： | 1 |
| 19 | Odontogenic cyst:a conservative approach显示文摘 | Massara ML Gomes CO | | 0，，05： | 1 |
| 20 | Vasoplegic syndrome after off-pump coronary artery bypass surgery显示文摘 | Gomes WJ Erlichman MR Batista-Filho ML | 2003 | Eur J Cardiothorac Surg2003，23，2： | 1 |
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