|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 世界胃肠病学组织(WGO-OMGE)临床指南——发展中国家幽门螺杆菌感染显示文摘我非常高兴向大家推荐这份发展中国家幽门螺杆菌(H.priori)临床指南。该指南的编译是由数位在该领域具有丰富临床经验的世界知名专家共同完成的。 | Hunt RH Xiao SD Megraud F Leon-Barua R Bazzoli F Van der Merwe S vaz Coelho LG Fock KM Fedail S Cohen H Malfertheiner P Vakil N Hamid S Goh KL Wong BC Krabshuis JH 杜颖 丛衍群 戴宁 | 2007 | 胃肠病学2007，12，1： | 85 |
| 2 | 产后出血的预防和处理指南显示文摘目的:为产后出血(PPH)的预防和临床处理作一综述,为临床医师提供预防和处理产后出血的指南。涉及方面:预防、适当干预、使其影响最小化的方法。结果:建立常规,便于临床医师鉴别可能的高危人群,一旦发生产后过多出血,可指导临床如何迅速处理。证据:遵循加拿大定期健康检查办公室制定的证据等级。评估:由产科专家完善。利弊和成本:评估子宫收缩药和其他积极处理措施的方便性、正确性、有效性和安全性。建议:根据证据的等级,本指南分等级列出了12条建议。确认:按照MeSH词表推荐的postpartum haemorrhage在medline上查询相关文献,在Cochrane图书馆查找相关研究文献,并参考the ALARMcourse Manual。发起人:由产科临床实践委员会制定和综述,并由SOGC(加拿大妇产科协会)委员会批准。 | Nan Schuurmans MD FRCSC, Edmonton AB Catherine MacKinnon MD FRCSC, Brantford ON Carolyn Lane MD CCFP Calgary AB Duncan Etches MD CCFP Vancouver BC 刘铭(译) 段涛(译) | 2007 | 现代妇产科进展2007，16，3： | 152 |
| 3 | Management of hilar cholangiocarcinoma in the North of England: Pathology, treatment, and outcome显示文摘AIM: To assess the management and outcome of hilar cholangiocarcinoma (Klatskin tumor) in a single tertiary referral center.METHODS: The notes of all patients with a diagnosis of hilar cholangiocarcinoma referred to our unit for over an 8-year period were identified and retrospectively reviewed. Presentation, management and outcome were assessed.RESULTS: Seventy-five patients were identified. The median age was 64 years (range 34-84 years). Male to female ratio was 1:1. Eighty-nine percent of patients presented with jaundice. Most patients referred were under Bismuth classification 3a, 3b or 4. Seventy patients required biliary drainage, 65 patients required 152percutaneous drainage procedures, and 25 had other complications. Forty-one patients had 51 endoscopic drainage procedures performed (15 failed). Of these,36 subsequently required percutaneous drainage. The median number of drainage procedures for all patients was three, 18 patients underwent resection (24%), nine had major complications and three died post-operatively.The 5-year survival rate was 4.2% for all patients, 21%for resected patients and 0% for those who did not undergo resection (P = 0.0021). The median number of admissions after diagnosis in resected patients was two and three in non-resected patients (P<0.05).Twelve patients had external-beam radiotherapy, seven brachytherapy, and eight chemotherapy. There was no significant benefit in terms of survival (P = 0.46) or hospital admissions.CONCLUSION: Resection increases survival but carries the risk of significant morbidity and mortality.Percutaneous biliary drainage is almost always necessary and endoscopic drainage should be avoided if possible. | SD Mansfield O Barakat RM Charnley BC Jaques CB O'Suilleabhain PJ Atherton D Manas | 2005 | World Journal of Gastroenterology2005，11，48： | 37 |
| 4 | Progress in Numerical Simulation of Solidification Process of Shaped Casting显示文摘Solidification simulation of manufacturing shaped casting which plays an important role in asSuring the soundness and quality of castings, in minimizing the trial production time and in reducing the manufacturing cost becomes one of the hottest topics of the new research frontiers of foundry technology at home and abroad. Practical three dimensional computer numerical simulation system for temperature distribution during solidification as well as shrinkage cavity and porosity prediction has already been put into application all over the world. Further fundamental researche5 on fluid flow, thermal stress and micro-modeling as well as practical approaches of numerical simulation of solidification process of shaped castings for routine analysis of foundry industry are still underway. | LIU, BC SHEN, HF LI, WZ | 1995 | Journal of Materials Science & Technology1995，11，5： | 18 |
| 5 | Factors determining delay in relaparotomy for anastomotic leakage after colorectal resection显示文摘AIM: To analyze the time interval ('delay') between the first occurrence of clinical parameters associated with anastomotic leakage after colorectal resection and subsequent relaparotomy. METHODS: In 36 out of 289 consecutive patients with colorectal anastomosis, leakage was confirmed at relaparotomy. The medical records of these patients were retrospectively analysed and type and time of appearance of clinical parameters suggestive of anastomotic leakage were recorded. These parameters included heart rate, body temperature, local or generalized peritoneal reaction, leucocytosis, ileus and delayed gastric emptying. Factors influencing delay of relaparotomy and consequences of delayed recognition and treatment were determined. RESULTS: First documentation of at least one of the predefined parameters for anastomotic leakage was after a median interval of 4 ± 1.7 d after the operation. The median number of days between first parameter(s) associated with leakage and relaparotomy was 3.5 ± 5.7 d. The time interval between the first signs of leakage and relaparotomy was significantly longer when a weekend was included (4.2 d vs 2.4 d, P = 0.021) or radiological evaluation proved to be false-negative (8.1 d vs 3.5 d, P = 0.007). No significant association between delay and number of additional relaparotomies, hospital stay or mortality could be demonstrated. CONCLUSION: An intervening weekend and negative diagnostic imaging reports may contribute to a delay in diagnosis and relaparotomy for anastomotic leakage. That delay was more than two days in two-thirds of the patients. | A Doeksen PJ Tanis BC Vrouenraets JJB Lanschot van WF Tets van | 2007 | World Journal of Gastroenterology2007，13，27： | 17 |
| 6 | High expression levels of IKK alpha and IKK beta are necessary for the malignant properties of liver cancer显示文摘IKK-NF-kappa B signaling is regarded as an important factor in hepatocarcinogenesis and a potential target for liver cancer therapy.Therefore,in this study,we analyzed the expression of mRNAs encoding components and targets of NF-kappa B signaling including IKK alpha,IKK beta,RANK,RANKL,OPG,CyclinD3,mammary serine protease inhibitor(Maspin),CyclinD1,c-FLIP,Bcl-x1,Stat3,Cip1 and Cip2 by real-time PCR in 40 patients with liver cancer.After statistical analysis,7 indices including IKK alpha,IKK beta,RANK,Maspin,c-FLIP,Cip2 and cyclinD1 were found to show significant differences between tumor tissue and its corresponding adjacent tissue.When IKK alpha and IKK beta were downregulated in the hepatocellular carcinoma(HCC) cell lines of MHCC-97L and MHCC-97H in vitro,the numbers of BrdU positive cells were decreased in both IKK alpha and IKK beta knockdown cells.Levels of apoptosis were also investigated in IKK alpha and IKK beta knockdown cells.The growth of HCC was inhibited in the subcutaneous implantation model,and lung metastatogenesis was also significantly inhibited in the kidney capsule transplantation model.Downregulation of IKK alpha and IKK beta in HCC cultured in vitro revealed that increased Maspin,OPG and RANKL expression was associated with metastasis of HCC.These findings were associated with downregulation of Bcl-XL and c-FLIP,which may be the reason for increased apoptosis.The therapeutic effect of IKK alpha and IKK beta downregulation depends on extent of NF-kappa B inhibition and the malignant nature of the HCC.We anticipate that IKK-targeted gene therapy can be used in the treatment of HCC,a cancer that is notoriously resistant to radiation and chemotherapy. | Jiang,RQ Xia,YX Li,J Deng,L Zhao,L Shi,J Wang,XH Sun,BC Nanjing Med Univ,Liver Transplantat Ctr,Affiliated Hosp 1,Nanjing,Jiangsu Prov,Peoples R China Nanjing Med Univ,Ctr Canc,Nanjing,Jiangsu Prov,Peoples R China | 2010 | 南京医科大学学报(自然科学版)2010，30，5： | 13 |
| 7 | Interactive effect of dissolved organic matter and phenanthrene on soil enzymatic activities显示文摘The investigation of dissolved organic matter(DOM) on urease,catalase and polyphenol oxidase activity in a phenanthrene(Phe)contaminated soil was conducted under laboratory incubation conditions.Values of soil enzymatic activity depended mainly on incubation time.In the initial 16 days,urease activity increased,and was followed by a decrease.In the initial 8 days,catalase activity decreased and then increased.Variation of polyphenol oxidase activity was just the reverse of catalase activity.After 30 days of incubation,no pronounced difference among treatments with Phe,Phe and DOM,and control were detected in urease,catalase and polyphenol oxidase activity.Phe might inhibit urease and catalase,and stimulate polyphenol oxidase.DOM could improve inhibition of Phe in soil urease and catalase activity during the initial period of applying DOM.Nevertheless,DOM had no significant effect on polyphenol oxidase activity in the Phe contaminated soil.There was a negative correlation between catalase and polyphenol oxidase(r =-0.761***),and catalase and urease(r =-0.554**).Additionally,a positive correlation between polyphenol oxidase and urease was also detected(r = 0.701***).It is implied that the formed DOM after application of organic wastes into soils may counteract the inhibition of polycyclic aromatic hydrocarbons in soil enzyme activities. | Xinhua Zhan,Wenzhu Wu,Lixiang Zhou,Jianru Liang,Tinghui Jiang College of Resources and Environmental Sciences,Nanjing Agricultural University,Nanjing 210095,China.Greenstar Plant Products Inc.,9430 198 St,Langley,BC,Canada V1M3C8. | 2010 | Journal of Environmental Sciences2010，22，4： | 10 |
| 8 | ^(99m)Tc-labeled HAb18 McAb Fab fragment for radioimmunoimaging in nude mice bearing human hepatocellular carcinoma显示文摘99mTclabeledHAb18McAbFabfragmentforradioimmunoimaginginnudemicebearinghumanhepatocelularcarcinomaQIUKai1,2,WANGBoChen1,CHE... | Qiu K Wang BC Chen ZN Fang P Liu CG Wan WX Liu YF | 1998 | World Journal of Gastroenterology1998，4，2： | 8 |
| 9 | Photochemical smog in China:scientific challenges and implications for air-quality policies显示文摘INTRODUCTION Severe air-pollution events in many parts of China pose a major threat to health and ecosystems[1].China’s air pollution is concentrated to economically developed areas,such as Beijing–Tianjin–Hebei(BTH)and Pearl–River–Delta(PRD)[2,3].The situation has received considerable attention in | Mattias Hallquist John Munthe Min Hu Tao Wang Chak K Chan Jian Gao Johan Boman Song Guo Asa M Hallquist Johan Mellqvist Jana Moldanova Ravi K Pathak Jan BC Pettersson Hakan Pleijel David Simpson Marie Thynell | 2016 | National Science Review2016，3，4： | 8 |
| 10 | Mixed-layer water oscillations in tropical Pacific for ENSO cycle显示文摘The main modes of interannal variabilities of thermocline and sea surface wind stress in the tropical Pacific and their interactions are investigated,which show the following results.(1) The thermocline anomalies in the tropical Pacific have a zonal dipole pattern with 160°W as its axis and a meridional seesaw pattern with 6-8°N as its transverse axis.The meridional oscillation has a phase lag of about 90° to the zonal oscillation,both oscillations get together to form the El Ni?o/La Ni?a cycle,which be-haves as a mixed layer water oscillates anticlockwise within the tropical Pacific basin between equator and 12°N.(2) There are two main patterns of wind stress anomalies in the tropical Pacific,of which the first component caused by trade wind anomaly is characterized by the zonal wind stress anomalies and its corresponding divergences field in the equatorial Pacific,and the abnormal cross-equatorial flow wind stress and its corresponding divergence field,which has a sign opposite to that of the equatorial region,in the off-equator of the tropical North Pacific,and the second component represents the wind stress anomalies and corresponding divergences caused by the ITCZ anomaly.(3) The trade winds anomaly plays a decisive role in the strength and phase transition of the ENSO cycle,which results in the sea level tilting,provides an initial potential energy to the mixed layer water oscillation,and causes the opposite thermocline displacement between the west side and east side of the equator and also between the equator and 12°N of the North Pacific basin,therefore determines the amplitude and route for ENSO cycle.The ITCZ anomaly has some effects on the phase transition.(4) The thermal anomaly of the tropical western Pacific causes the wind stress anomaly and extends eastward along the equator accompanied with the mixed layer water oscillation in the equatorial Pacific,which causes the trade winds anomaly and produces the anomalous wind stress and the corresponding divergence in favor to conduce the oscillation,which in turn intensifies the oscillation.The coupled system of ocean-atmo-sphere interactions and the inertia gravity of the mixed layer water oscillation provide together a phase-switching mechanism and interannual memory for the ENSO cycle.In conclusion,the ENSO cycle essentially is an inertial oscillation of the mixed layer water induced by both the trade winds anomaly and the coupled ocean-atmosphere interaction in the tropical Pacific basin between the equator and 12°N.When the force produced by the coupled ocean-atmosphere interaction is larger than or equal to the resistance caused by the mixed layer water oscillation,the oscillation will be stronger or maintain as it is,while when the force is less than the resistance,the oscillation will be weaker,even break. | ZHAO YongPing1,CHEN YongLi1,WANG Fan1 & WU AiMing2 1 Institute of Oceanology,Chinese Academy of Sciences,Qingdao 266071,China 2 Department of Earth & Ocean Sciences,University of British Columbia,Vancouver,BC,V6T 1Z4,Canada | 2007 | Science China Earth Sciences2007，50，12： | 7 |
| 11 | Numerical Simulation of Thermal Stress of Shaped Casting Based on Rheological Model显示文摘In order to study the thermal stresses at the mushy zone, a three dimensional rheological model [H]-[H|N]-[N|S]including elastic, visco-elastic and visco-plastic elements was established, its al gorithm and codes for finite element method were also developed. A FDM/FEM integrated analysis system of thermal stresses was built based on the integration of this procedure with thermal analysis by finite difference method. A steel sample casting with a hot spot was simu lated in order to validate this system, and the calculated and experimental results were in good | Kang, JW Liu, BC Xiong, SM | 1999 | Journal of Materials Science & Technology1999，15，3： | 6 |
| 12 | 肝癌、肝硬化组织的胰岛素样生长因子-Ⅱ(IGF-Ⅱ)mRNA表达显示文摘人原发肝癌、肝硬化组织的IGF-Ⅱ基因mRNA的异常表达状态,其与正常肝组织的表达状态有明显不同。结果表明肝硬化不可能是肝癌的前期病变,IGF-Ⅱ基因异常激活与表达在肝癌。 | 赵文川 Park,BC | 1998 | 中国肿瘤临床1998，25，7： | 6 |
| 13 | Construction of energy transfer model of C-phycocyanin and allophycocyanin from Spirulina platensis显示文摘PHYCOBILIPROTEINS. which include phycoerythrin, phycocyanin, phycoerythroeyanin and allophycocyanin, are intensively coloured, highly fluorescent, water soluble chromoproteins. They are composed of at least two dissimilar polypeptides, α and β subunits, in a molar ratio of 1:1. The subunits possess linear tetrapyrrole prosthetic groups covalently linked to the primary structure via cysteine thioether linkages. In blue-green and red algae, phycobiliproteins occur in a supramolecular structure, the phycobilisome, located on the surface of thylakoid to | Wang, GC Zhou, BC Zeng, CK | 1997 | Chinese Science Bulletin1997，42，1： | 6 |
| 14 | Seismic Response Reduction for Fixed Offshore Platform by Tuned Liquid Damper显示文摘An approach to seismic response reduction for offshore platforms by the use of the tuned liq-uid damper is presented in this paper.First of all,the effects of the tuned frequency ratio and excited fre-quency ratio on the seismic response reduction of the platform structure are investigated.Based on the re-sults,a mechanical model and equation of motion for the TLD-platform system are established.And theneffectiveness of the appraoch is verified by numerical calculation. | Li, HN Ma, BC | 1997 | China Ocean Engineering1997，12，2： | 5 |
| 15 | The four-and-a-half-LIM protein 2 (FHL2) is overexpressed in gliomas and associated with oncogenic activities显示文摘Glia. 2008 Jul 9.Four-and-a-half-LIM protein 2 (FHL2) is a member of FHL protein family, which plays a crucial role in regulating geneexpression, cell survival, and migration.Although its function in oncogenesis appears to be tumor type-specific, its roles | Ng SS Yew DT Wong BC Kung HF | 2008 | 中国神经肿瘤杂志2008，6，2： | 3 |
| 16 | 围手术期使用可乐定及其它肾上腺素能激动药显示文摘可乐定(又名可乐宁,Clonidine)和其他α_2肾上腺素能激动药通过激活突触前、后的受体,发挥各种作用。由于对α_2肾上腺素受体的选择作用不完全,也能激活α_2肾上腺素能受体,所以其药理作用比较费解。但血药浓度愈高,对α_1肾上腺素能受体的作用愈强。 | Bloor BC 包丰龄 | 1990 | 国外医学(麻醉学与复苏分册)1990，11，4： | 3 |
| 17 | 东庄滚卷构造─—尺度物理模拟探讨成因机制显示文摘河南南襄盆地南阳凹陷东庄构造,是一个在拉张作用下形成的滚卷背斜构造,其背斜一拱顶地堑构造,是新野一曲洼断裂之上盘沉积岩层沿断裂面下滑形变造成的。滚卷构造的活动,导致不对称扇形断裂地堑的发育及盆地第三纪沉积中心的迁移。本文用重力滑移及滚卷褶皱二组尺度模型,对东庄构造的成因作了初步探讨。实验用于石英砂模拟脆性沉积岩层;用一种具牛顿流变特性的聚合硅树脂模拟塑流层或滑脱层;实验结果强调了东庄构造的滚卷成因机制。 | 戈红星 Vend.,BC | 1994 | 石油学报1994，15，1： | 3 |
| 18 | Phytochemical analysis,hepatoprotective and antioxidant activity of Alchornea cordifolia methanol leaf extract on carbon tetrachloride-induced hepatic damage in rats显示文摘Objective:To investigate the hepatoprotective and antioxidant activities of Alchornea cordifolia (A.cordifolia) leaf extract.Methods:Various solvent fractions of the methanol extract of the leaf of the plant.4.cordifolia Mull.Arg(Fam:Euphorbiaceae) were evaluated for hepatoprotective activity by carbon tetrachloride-induced liver damage in rats.The degree of protection was measured by using biochemical parameters such as serum glutamate oxalate transaminase(SGOT/ AST),serum glutamate pyruvate transaminase(SCPT/ALT),alkaline phosphatase(ALP) and total bilirubin.The in vitro antioxidant activity of the extract was also evaluated by the I,I-diphenyl 2-picrylhydrazyl(DPPH) free radical scavenging assay.The extract was subjected to preliminary phytoehemical screening.Results:The ethyl acetate and chloroform fractions,at a dose of 300 mg/kg,produced significant(P<0.05) hepatoprolection by decreasing the activities of the serum enzymes and bilirubin while there were marked scavenging of the DPPH free radicals by the fractions.The effects were comparable to those of the standard drugs used for the respective experiments,silymarin and ascorbic acid.Alkaloids,flavonoids,saponins and tannins were delected in the phylochemical screening.Conclusion:From this study,it was concluded that the plant of A.cordifolia possesses hepatoprotective as well as antioxidant activities and these activities reside mainly in the ethyl acetate and acetone fractions of methanol leaf extract. | Patience O Osadebe Festus BC Okoye Philip F Uzor Nneka R Nnamani Ijeoma E Adiele Nkemakonam C Obiano | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，4： | 2 |
| 19 | 兰江流域降雨量与气候指数的相关性研究显示文摘为探索兰江流域降雨量与气候指数的关系,利用1963—2000年间兰江流域28个气象站的日降雨量与同期经样条插值的太平洋年代际振荡(PDO)、南方涛动指数(SOI)和东亚夏季风指数(EASMI)日值时间序列,分别采用线性回归和多元回归方法分析兰江流域两大支流的降雨量与PDO和SOI的长期相关性及其与SOI和EASMI的短期相关性.结果表明,PDO与降雨量存在显著的长期正相关关系,其中金华江支流比衢江支流更为显著.在长期尺度上,SOI与降雨量存在负相关,且相关性均大于0.2.在短期尺度上,SOI、EASMI与降雨量均存在显著负相关;作为一种区域指数,EASMI与兰江流域降雨的相关性比其他指数显著,尤其在衢江流域,当PDO位于暖相位时,其相关性系数达到0.5.按照PDO相位划分的子时期评估结果显示,当PDO位于暖相位时,SOI、EASMI与降雨量的相关性都更为显著.多元回归分析证实PDO、SOI及EASMI的相互组合可显著提高其与降雨量的相关关系,特别是PDO-SOI组合,其与降雨量的相关性在金华江和衢江流域分别达到0.39和0.28. | 刘莉 Krewinkel BC Booij MJ 许月萍 | 2018 | 浙江大学学报(工学版)2018，52，12： | 2 |
| 20 | ELIMIMATION OF RANDOM DEFACTS IN AEROSPACE MATERIALS显示文摘In the pastfew years,severalnew melting processeshavebeenindustrialised forthe produc tion ofsuperalloys,titanium alloysand high qualitysteelsfor useintheaero engineindustry.Theseincludeelectron beam , plasma,inductionskull,andthe”triple melt”process( VIM + ESR+ VAR) . These developments have allbeen instituted in responsetothe major per ceived problem oftheindustry ;that oftheincidence of random defectsin the alloys whichcause problemsinregardto predictablelifing ofthefinished partinservice. Thedirectconse quenceofthe uncertaintyislossof revenue due to premature retirement of parts which mayhavecompleted on a fraction oftheir actualservicelife; a conservatism on the partof design parameters whichleadsto uneccesary weightin thepart;and ariskofeitherservicefailuresor partrecalls whichinterruptengine performance. Thebenefitsoftheprocesschangesinrespectoftheproducts’absolute propertiesand alsoonthereproducibility and inspectability ofthose properties have been substantial. Itisclearthattheprocesses offer the industry a solution to the present dilem ma of how to treatthe ”rare”defectsfrom the pointof view of fracture mechanicslifing methodology. The use ofprocesscontrols which guarantee”zero defect”productisdevelopingintoacriticaltoolfortheextension oftherangeof a given alloy’s use. Itislikelyto permit very substantial gainsinboth componentlife and intheallowablestressin rotating parts withoutthe needtointroduce new materials carrying new problems of user confidence, production reliability and data base. Weconcludethatthenew processesareatastageof development wherethey arereadyforwideindustry usein production. They will not add significantly tothecomponentcost andthey willgive a renwed lifespan to the more familiar materials and methodsof aero engineconstruction. | A. Mitchell Advanced Materials Research Laboratory, University of British Columbia, Vancouver BC,Canada | 1999 | Acta Metallurgica Sinica(English Letters)1999，12，4： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员