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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Urodynamic studies in the surgical treatment of benign prostatic hyperplasial显示文摘 | De Lima ML Netto NR Jr | 2003 | Int Braz J Urol2003，29，5： | 1 |
| 3 | Eosinophilie inflammation and airway hyper-responsiv-eness are profoundly inhibited by a helminth (Ascaris suum) extract in a murine model of asthma显示文摘 | Lima C Perini A Gareia ML | 2002 | Clin Exp Allergy2002，32，11： | 1 |
| 4 | Hepatic histopathology of pa- tients with morbid obesity submitted to gaslrie bypass 显示文摘 | Lima ML Mourao SC Diniz MT | 2005 | Obes Surg2005，15，： | 1 |
| 5 | Comparative analysis of the performance of various crystalloid cardioplegic solutions on myocardial protection after prolonged cold ischemia 显示文摘 | Lima ML Fiorelli AI Gomes OM | 2011 | Trans- plant Proc2011，43，1： | 1 |
| 6 | Molecular characterization of Mycobacterium massiliense and Mycobacterium bolletii in isolates collected from outbreaks of infections after laparoscopic surgeries and cosmetic procedures显示文摘 | Viana-Niero C Lima KV Lopes ML | 2008 | J Clin Microbiol2008，46，： | 1 |
| 7 | Antigenotoxic effects of quercetin, rutin and ursolic acid on HepG2 cells:evaluation by the comet assay 显示文摘 | Ramos AA Lima CF Pereira ML | 2008 | Toxicol Lett2008，177，1： | 1 |
| 8 | Quality of life of indi- viduals with stroke and their caregivers in a city of Triangulo Mi- neiro 显示文摘 | de Lima ML Santos JL Sawada NO | 2014 | Rev Bras Epidemiol2014，17，2： | 1 |
| 9 | Eosinophilic inflammation and airway hyper-responsiveness are profoundly inhibited by a helminth (Ascaris suum) extract in a murine model of asthma显示文摘 | Perini A Garcia ML | 2002 | Clin Exp Allergy2002，32，11： | 1 |
| 10 | Eosinophilic inflammation and airway hyper-responsiveness are profoundly inhibited by a helminth (Ascaris suum) extract in a murine model of asthma 显示文摘 | Lima C Perini A Garcia ML | 2002 | Clin Exp Allergy2002，32，11： | 1 |
| 11 | Blockage of dopaminergic D(2)receptors produces decrease of REM but not of slow wave sleep in rats after REM sleep deprivation 显示文摘 | Lima MM Andersen ML Reksidler AB | 2008 | Behav Brain Res2008，188，2： | 1 |
| 12 | Viral hemorrhagic fever-induced actlte kidney injury显示文摘 | Lima EQ Nogueira ML | 2008 | Semin Nephrol2008，28，4： | 1 |
| 13 | Baseline blood pressure and other variables influencing survival on haemodialysis of patients without overt cardiovascular disease 显示文摘 | De- Lima J J Vieira ML Abensur H | 2001 | Nephrol Dial Transplant2001，16，4： | 1 |
| 14 | Viral hemorrhagic fever - induced acute kidney injury显示文摘 | Lima EQ Nogueira ML | 2008 | Semin Nephrol2008，28，4： | 1 |
| 15 | Anaemia in patients with cancer: role of inflammatory activity on iron metabolism and severity of anaemia 显示文摘 | Jacober ML Mamoni RL Lima CS | 2007 | Med Oncol2007，24，3： | 1 |
| 16 | Blood pressure and the risk of complex arrhythmia in renal insuffeiency, hemodialysis, and renal transplant patients 显示文摘 | de Lima JJ Vieira ML Lopes HF | 1999 | Am J Hypertens1999，12，21： | 1 |
| 17 | Is transurethral vaporization a remarke of transurethral resection of the prostate显示文摘 | Netto NR Jr De Lima ML Lucena R | 1999 | Endoural1999，13，： | 1 |
| 18 | Predisposing factors for infiltration in children submitted to peripheral venous catheterization显示文摘 | Lima Jacinto AK Avelar AF Pedreira ML | | 0，，06： | 1 |
| 19 | Antigenotoxic effects of quercetin, rutin and ursolic acid on HepG2 cells: evaluation by the comet assay 显示文摘 | Ramos AA Lima CF Pereira ML | 2008 | Toxicol Lett2008，177，1： | 1 |
| 20 | Comparative analysis of the performance of various crystalloid cardioplegic solutions on myocardial protection after prolonged cold ischemia显示文摘 | Lima ML Fiorelli AI Gomes OM | | 0，，： | 1 |
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