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| 1 | Early palliative care for patients with metastatic non-small-cell lung cancer显示文摘Comments This landmark article demonstrates that integration of early palliative care with standard oncologic practice shortly after diagnosis may improve quality of life,mood,and overall survival for adults with advanced non-small-cell lung cancer(NSCLC).If validated,these findings could support a paradigm shift in the care of adults with metastatic NSCLC and possibly patients with other tumor types characterized by short survival and high symptom burden. | Temel JS Greer JA Muzikansky A Gallagher ER Admane S Jackson VA Dahlin CM Blinderman CD Jacobsen J Pirl WF Billings JA Lynch TJ | 2010 | 中国肺癌杂志2010，13，9： | 165 |
| 2 | Factors determining delay in relaparotomy for anastomotic leakage after colorectal resection显示文摘AIM: To analyze the time interval ('delay') between the first occurrence of clinical parameters associated with anastomotic leakage after colorectal resection and subsequent relaparotomy. METHODS: In 36 out of 289 consecutive patients with colorectal anastomosis, leakage was confirmed at relaparotomy. The medical records of these patients were retrospectively analysed and type and time of appearance of clinical parameters suggestive of anastomotic leakage were recorded. These parameters included heart rate, body temperature, local or generalized peritoneal reaction, leucocytosis, ileus and delayed gastric emptying. Factors influencing delay of relaparotomy and consequences of delayed recognition and treatment were determined. RESULTS: First documentation of at least one of the predefined parameters for anastomotic leakage was after a median interval of 4 ± 1.7 d after the operation. The median number of days between first parameter(s) associated with leakage and relaparotomy was 3.5 ± 5.7 d. The time interval between the first signs of leakage and relaparotomy was significantly longer when a weekend was included (4.2 d vs 2.4 d, P = 0.021) or radiological evaluation proved to be false-negative (8.1 d vs 3.5 d, P = 0.007). No significant association between delay and number of additional relaparotomies, hospital stay or mortality could be demonstrated. CONCLUSION: An intervening weekend and negative diagnostic imaging reports may contribute to a delay in diagnosis and relaparotomy for anastomotic leakage. That delay was more than two days in two-thirds of the patients. | A Doeksen PJ Tanis BC Vrouenraets JJB Lanschot van WF Tets van | 2007 | World Journal of Gastroenterology2007，13，27： | 17 |
| 3 | Awakening concentration of desflurane is decreased in patients with obstructive jaundice显示文摘 | Song JG Cao YF Yang LQ Yu WF Li Q Song JC Fu XY Fu Q | 2005 | 第二军医大学学报2005，26，8： | 15 |
| 4 | Future prospectives for the management of chronic hepatitis B显示文摘Chronic hepatitis B virus infection affects about 400 million people around the globe and causes approximately one million deaths a year. Since the discovery of interferon-α as a therapeutic option the treatment of hepatitis B has evolved fast and management has become increasingly complicated. The amount of viral replication reflected in the viral load (HBV-DNA) plays an important role in the development of cirrhosis and hepatocellular carcinoma. The current treatment modalities for chronic hepatitis B are immunomodulatory (interferons) and antiviral suppressants (nucleoside and nucleotide analogues) all with their own advantages and limitations. An overview of the treatment efficacy for both immunomodulatory as antiviral compounds is provided in order to provide the clinician insight into the factors influencing treatment outcome. With nucleoside or nucleotide analogues suppression of viral replication by 5-7 log10 is feasible, but not all patients respond to therapy. Known factors influencing treatment outcome are viral load, ALT levels and compliance. Many other factors which might influence treatment are scarcely investigated. Identifying the factors associated with response might result in stopping rules, so treatment could be adapted in an early stage to provide adequate treatment and avoid the development of resistance. The efficacy of compounds for the treatment of mutant virus and the cross- resistance is largely unknown. However, genotypic and phenotypic testing as well as small clinical trials provided some data on efficacy in this population. Discontinuation of nucleoside or nucleotide analogues frequently results in viral relapse; however, some patients have a sustained response. Data on the risk factors for relapse are necessary in order to determine when treatment can be discontinued safely. In conclusion: chronic hepatitis B has become a treatable disease; however, much research is needed to tailor therapy to an individual patient, to predict the sustainability of response and determine thebest treatment for those failing treatment. | WF Leemans HLA Janssen RA de Man | 2007 | World Journal of Gastroenterology2007，13，18： | 14 |
| 5 | Sedation and safety of propofol for therapeutic endoscopic retrograde cholangiopancreatography显示文摘Endoscopic retrograde cholangiopancrea tography(ERCP) is the most complex gastrointestinal procedure,which needs patients’ cooperation. The aim of this study was to observe the quality and safey of sedation with propofol in patients undergoing therapeutic ERCP. METHODS:Seventy patients who had undergone therapeutic ERCP were randomly divided into two groups.One group, given intravenously propofol, and the other sedated with routine method, served as the control. Blood pressure, heart rate,oxygen saturation were monitored and cardiorespiratory event was observed. Patient cooperation,performance, recovery time and amnesia served as variables postoperation. RESULTS:Blood pressure elevated in four patients in the propofol group, less than in the control group(P<0.01). Seven patients showed decreased blood pressure after administration of propofol,but none in the control group (P<0.01). Twelve patients in the control group showed mild or significant resistance, but none in the propofol group (P<0.01). The time for performance in the propofol group(P<0.05) was shorter than in the control group. Patient recovery was quicker in the propofol group than in the control group (P<0.01). The degree of amnesia better in the propofol group than in the control group ( P<0.01). The degree of amnesia was also better in the propofol group than in the control group (P<0.01). CONCLUSIONS:Propofol proves to be an excellent sedative for therapeutic ERCP. Being effective and safe, it shows a shorter ERCP duration but quick recovery and better amnesia. It is better than other routine sedatives. | Digestive Department (Chen WX, Lin HJ, Gu Q, Zhong XQ, Yu CH, Li YM and Gu ZY) and Department of Intensive Care Unit (Zhang WF), First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003 , China | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，3： | 10 |
| 6 | Protective effect of electroacupuncture and moxibustion on gastric mucosal damage and its relation with nitric oxide in rats显示文摘INTRODUCTION Gastric mucosal injury is one of the common disorders,there are many reports subjicted to its pathogenesis treatment and prevention.We investigated the protective effect | Pei WF Xu GS Sun Y Zhu SL Zhang DQ | 2000 | World Journal of Gastroenterology2000，6，3： | 8 |
| 7 | Transfusion transmitted virus infection in general populations and patients with various liver diseases in south China显示文摘INTRODUCTIONAlthough several specific detecting methods hadbeen applied to determine the hepatitis virus,therewas a lot of cryptogenic hepatitis without anyknown hepatitis infectious marker.Theprevalence of hepatitis G virus (HGV) (also knownas GB-C virus) infection has been reported to be 5%-13% in patients with non-A-E hepatitis andcirrhosis,however,there is little evidencesuggesting that HGV causes hepatitis in human. | Chen YP Liang WF Zhang L He HT Luo KX | 2000 | World Journal of Gastroenterology2000，6，5： | 7 |
| 8 | m TOR signaling in liver regeneration: Rapamycin combined with growth factor treatment显示文摘AIM: To investigate the effects of mammalian target of rapamycin(mT OR) inhibition on liver regeneration and autophagy in a surgical resection model.METHODS: C57BL/6 mice were subjected to a 70% partial hepatectomy(PH) and treated intraperitoneally every 24 h with a combination of the m TOR inhibitor rapamycin(2.5 mg/kg per day) and the steroid dexamethasone(2.0 mg/kg per day) in phosphate bufferedsaline(PBS) or with PBS alone as vehicle control. In the immunosuppressant group, part of the group was treated subcutaneously 4 h prior to and 24 h after PH with a combination of human recombinant interleukin 6(IL-6; 500 μg/kg per day) and hepatocyte growth factor(HGF; 100 μg/kg per day) in PBS. Animals were sacrificed 2, 3 or 5 d after PH and liver tissue and blood were collected for further analysis. Immunohistochemical staining for 5-Bromo-2'-deoxyuridine(Brd U) was used to quantify hepatocyte proliferation. Western blotting was used to detect hepatic microtubule-associated protein 1 light chain 3(LC3)-Ⅱ protein expression as a marker for autophagy. Hepatic gene expression levels of proliferation-, inflammation- and angiogenesisrelated genes were examined by real-time reverse transcription-polymerase chain reaction and serum bilirubin and transaminase levels were analyzed at the clinical chemical core facility of the Erasmus MC-University Medical Center.RESULTS: m TOR inhibition significantly suppressed regeneration, shown by decreased hepatocyte proliferation(2% vs 12% Brd U positive hepatocyte nuclei at day 2, P < 0.01; 0.8% vs 1.4% at day 5, P = 0.02) and liver weight reconstitution(63% vs 76% of initial total liver weight at day 3, P = 0.04), and furthermore increased serum transaminase levels(aspartate aminotransferase 641 U/L vs 185 U/L at day 2, P = 0.02). Expression of the autophagy marker LC3-Ⅱ, which was reduced during normal liver regeneration, increased after mT OR inhibition(46% increase at day 2, P = 0.04). Hepatic gene expression showed an increased inflammation-related response [tumor necrosis factor(TNF)-α 3.2-fold upregulation at day 2, P = 0.03; IL-1Ra 6.0-fold upregulation at day 2 and 42.3-fold upregulation at day 5, P < 0.01] and a reduced expression of cell cycle progression and angiogenesis-related factors(HGF 40% reduction at day 2; vascular endothelial growth factor receptor 2 50% reduction at days 2 and 5; angiopoietin 1 60% reduction at day 2, all P ≤ 0.01). Treatmentwith the regeneration stimulating cytokine IL-6 and growth factor HGF could overcome the inhibitory effect on liver weight(75% of initial total liver weight at day 3, P = 0.02 vs immunosuppression alone and P = 0.90 vs controls) and partially reversed gene expression changes caused by rapamycin(TNF-α and IL-1Ra levels at day 2 were restored to control levels). However, no significant changes in hepatocyte proliferation, serum injury markers or autophagy were found.CONCLUSION: mT OR inhibition severely impairs liver regeneration and increases autophagy after PH. These effects are partly reversed by stimulation of the IL-6 and HGF pathways. | Suomi MG Fouraschen Petra E de Ruiter Jaap Kwekkeboom Ron WF de Bruin Geert Kazemier Herold J Metselaar Hugo W Tilanus Luc JW van der Laan Jeroen de Jonge | 2013 | World Journal of Transplantation2013，3，3： | 6 |
| 9 | A meta-analysis of case-control studies on the combined effect of hepatitis B and C virus infections in causing hepatocellular carcinoma in China显示文摘 | Shi J Zhu L Liu S Xie WF | 2006 | 第二军医大学学报2006，27，5： | 5 |
| 10 | The first internal-tide deposits found in China显示文摘NOT until Gao Zhenzhong and Eriksson studied the Ordovician of Fincastle area, Appalachi-ans, the USA in 1990, did sedimentologist recognize internal-tide deposits in the ancientrecord and begin to use the term of 'internal-tide deposit'. In the Ordovician of Fincastlearea, two facies are recognized: (i) bidirectional cross-laminated very fine grained | Gao, ZZ He, YB Li, JM Li, WF Luo, SS Wang, ZZ | 1997 | Chinese Science Bulletin1997，42，13： | 5 |
| 11 | 衡量适当产前保健的成本和效益显示文摘许多研究显示接受适当产前保健,能改善妊娠后果,特别是减少低出生体重儿发生的风险。因为低体重儿的医疗费用是正常体重儿的几倍,人们不难预料,获得适当产前保健产妇的新生儿,其医疗费用将较那些不适当产前保健的新生儿为低。这项报告研究了新生儿和产妇产后保健的医疗补助费用的降低,是不是超过医疗困难补助制度整体保健费用的增加。适当产前保健的产前保健费用比不适当的产前保健高233美元。适当产前保健妊娠在产后60天内,新生儿和产后保健费用要低347美元。使得产前保健多用1美元就能节省1.49美元。 | Schramm WF 封禹 | 1993 | 国外医学(卫生经济分册)1993，10，4： | 3 |
| 12 | A system for the functional evaluation of reconstructive procedures after surgical treatment of tumors of the musculoskeletal system显示文摘 | Enneking WF Dunham W Gebhardt MC | | 0，，286： | 2 |
| 13 | Trabecular cells express the TGF-beta 2gene and secrete the cytokine显示文摘 | Tripathi RC Chan WF Li J | 1994 | Exp Eye Res1994，58，5： | 2 |
| 14 | 广泛经皮针刀筋膜切断术联合脂肪移植术:一种治疗掌腱膜挛缩的新疗法显示文摘背景手术切除治疗掌腱膜挛缩症复发率高且康复时间延长。本文将介绍一种新型微创手术替代治疗掌腱膜挛缩症的方法及其成果。方法过程包括采用广泛经皮针刀筋膜切断术将束带完全松解,并与真皮分离。随后,由此产生的松弛组织用以自体脂肪填充。术后伸直位制动1周,然后,建议术后3~6个月患者白天可以正常用手,夜间伸直位固定。本组患者共91例(99只手),手术在迈阿密和鹿特丹进行;对50例患者的手部伸展角度进行测量(平均随访44周)。结果近端指间关节挛缩的治疗效果显著,伸展角度由61°改善至27°,掌指关节挛缩的伸展角度由37°改善至-5°。94%患者在2~4周内手部恢复正常功能,95%患者对结果非常满意。无新的瘢痕生成,大部分恢复了柔软的手掌脂肪垫。发生了1例神经损伤的并发症,1例术后切口感染,4例复杂区域疼痛综合征。结论这一新的微创技术缩短了康复时间,增加了缺损的皮下脂肪组织,产生了柔软无痕的皮肤。并且有能力处理多个掌指纹,可解决整只手的异常情况。治疗过程安全有效,尤其对首次治疗者。目前,前瞻性随机对照研究过程充分确定了其治疗掌腱膜挛缩症的作用。(循证医学证据等级:Ⅳ级,疗法) | Steven E. R. Hovius Hester J. Kan Xander Smit Ruud Wf Selles Eufimiano Cardoso Roger K. Khouri 李可竹(译) 郭澍(译) 孙强(译) 魏峰(译) 高景恒(译) | 2013 | 中国美容整形外科杂志2013，24，1： | 2 |
| 15 | 大陆镁铁质岩墙群的构造环境:夭折支和早期被动边缘显示文摘 | 法.,WF 许碧燕 | 1989 | 国外地质科技1989，，8： | 2 |
| 16 | Glomerular mesangium; its function and relationship to angiotensin Ⅱ 显示文摘 | Raij L Keane WF | 1985 | Am J med1985，79，3： | 2 |
| 17 | Longevi of fixed partial dentures 显示文摘 | Libby G Arcuri MR Lavelle WF | 1997 | J Prosthet Dent1997，78，： | 2 |
| 18 | Home advantage:does it exist in individual sports显示文摘 | Gavten WF Langevin G | 1992 | Percept Mot Skills 19921992，706，： | 2 |
| 19 | A randomized controlled trial of methylprednisolone or naloxone in the treat ment of acute spinal-cord injury: result of the Second National A cute Spinal Cord Injury Study显示文摘 | Bracken MB Shepard MJ Collins WF | 1990 | N Engl J Med1990，322，20： | 1 |
| 20 | Human CD4^+ CD25^+ cells:a naturally occufing population of regulatory T cells显示文摘 | Ng WF Duggan PJ Ponchel F | 2001 | Blood2001，98，9： | 1 |
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