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| 1 | Genetic, metabolic and environmental factors involved in the development of liver cirrhosis in Mexico显示文摘Liver cirrhosis(LC) is a chronic illness caused by inflammatory responses and progressive fibrosis. Globally, the most common causes of chronic liver disease include persistent alcohol abuse, followed by viral hepatitis infections and nonalcoholic fatty liver disease. However, regardless of the etiological factors, the susceptibility and degree of liver damage may be influenced by genetic polymorphisms that are associated with distinct ethnic and cultural backgrounds. Consequently, metabolic genes are influenced by variable environmental lifestyle factors, such as diet, physical inactivity, and emotional stress, which are associated with regional differences among populations. This Topic Highlight will focus on the genetic and environmental factors that may influence the metabolism of alcohol and nutrients in the setting of distinct etiologies of liver disease. The interaction between genes and environment in the current-day admixed population, Mestizo and Native Mexican, will be described. Additionally, genes involved in immune regulation, insulin sensitivity, oxidative stress and extracellular matrix deposition may modulate the degree of severity. In conclusion, LC is a complex disease. The onset, progression, and clinical outcome of LC among the Mexican population are influenced by specific genetic and environmental factors. Among these are an admixed genome with a heterogenic distribution of European, Amerindian and African ancestry; a high score of alcohol consumption; viral infections; a hepatopathogenic diet; and a high prevalence of obesity. The variance in risk factors among populations suggests that intervention strategies directed towards the prevention and management of LC should be tailored according to such population-based features. | Omar Ramos-Lopez Erika Martinez-Lopez Sonia Roman Nora A Fierro Arturo Panduro | 2015 | World Journal of Gastroenterology2015，21，41： | 11 |
| 2 | Photoreceptor-Mediated Bending towards UV-B in Arabidopsis显示文摘植物使适应他们向光的生长是知道优化光合的轻 capturea 过程向光性。Phototropinsare 为向蓝色的 phototropic 生长必要、紫外的光敏电阻器 -- 一(紫外 A ) 光。这里,我们在变白的 Arabidopsis 幼苗向 UV-B 详细说明 phototropicresponse。我们报导早微分的生长被 phototropins 调停,但是清除在 phot1 phot2 向 UV-B ismaintained 弯曲的 phototropic 两倍异种。我们进一步证明对 UV-B 的这 phototropin 独立的 phototropic 回答要求 UV-B photoreceptorUVR8。植物生长素应答的基因的宽广 UV-B-mediated 压抑建议 UVR8 调整由 affectingauxin 发信号的方向性的弯曲。UVR8 依赖的方向性的弯曲比 phototropin response.We 晚发生的运动分析表演断定植物可以使用日光的完整的短波长的光谱到高效地使适应光合的 tissuewith 到来的 light.Key 词: | Filip Vandenbussche Kimberley Tilbrook Ana Carolina Fierro Kathleen Marchal Dirk Poelman Dominique Van Der Straeten Roman UIm | 2014 | Molecular Plant2014，7，6： | 7 |
| 3 | Hepatitis B virus infection in Latin America:A genomic medicine approach显示文摘Hepatitis B virus(HBV)infection is the leading cause of severe chronic liver disease.This article provides a critical view of the importance of genomic medicine for the study of HBV infection and its clinical outcomes in Latin America.Three levels of evolutionary adaptation may correlate with the clinical outcomes of HBV infection.Infections in Latin America are predominantly of genotype H in Mexico and genotype F in Central and South America;these strains have historically circulated among the indigenous population.Both genotypes appear to be linked to a benign course of disease among the native and mestizo Mexicans and native South Americans.In contrast,genotypes F,A and D are common in acute and chronic infections among mestizos with Caucasian ancestry.Hepatocellular carcinoma is rare in Mexicans,but it has been associated with genotype F1b among Argentineans.This observation illustrates the significance of ascertaining the genetic and environmental factors involved in the development of HBV-related liver disease in Latin America,which contrast with those reported in other regions of the world. | Sonia Roman Alexis Jose-Abrego Nora Alma Fierro Griselda Escobedo-Melendez Claudia Ojeda-Granados Erika Martinez-Lopez Arturo Puro | 2014 | World Journal of Gastroenterology2014，20，23： | 4 |
| 4 | 负载型钌催化剂催化山梨醇氢解制乙二醇(英)显示文摘Supported Ru catalysts were prepared by wet impregnation to evaluate the role of different oxide supports(Al_2O_3,SiO_2,TiO_2,ZrO_2) in sorbitol hydrogenolysis to glycols.X-ray diffraction,transmission electron microscopy,hydrogen chemisorption,X-ray photoelectron spectroscopy,and NH3temperature-programmed desorption were used to characterize the catalysts,which were active in the hydrogenolysis of sorbitol.The support affected both the physicochemical properties and catalytic behavior of the supported Ru particles.The characterization results revealed that the Ru/Al_2O_3catalyst has a high surface acidity,partially oxidized Ru species on the surface,and a higher surface Ru/Al atomic ratio,which gave it the highest selectivity and yield to glycols. | Inmaculada Murillo Leo Manuel Lopez Granados Jose Luis Garcia Fierro Rafael Mariscal | 2014 | 催化学报2014，35，5： | 4 |
| 5 | Continuous Action Reinforcement Learning for Control-Affine Systems with Unknown Dynamics显示文摘Control of nonlinear systems is challenging in realtime.Decision making,performed many times per second,must ensure system safety.Designing input to perform a task often involves solving a nonlinear system of differential equations,which is a computationally intensive,if not intractable problem.This article proposes sampling-based task learning for controlaffine nonlinear systems through the combined learning of both state and action-value functions in a model-free approximate value iteration setting with continuous inputs.A quadratic negative definite state-value function implies the existence of a unique maximum of the action-value function at any state.This allows the replacement of the standard greedy policy with a computationally efficient policy approximation that guarantees progression to a goal state without knowledge of the system dynamics.The policy approximation is consistent,i.e.,it does not depend on the action samples used to calculate it.This method is appropriate for mechanical systems with high-dimensional input spaces and unknown dynamics performing Constraint-Balancing Tasks.We verify it both in simulation and experimentally for an Unmanned Aerial Vehicles(UAVs) carrying a suspended load,and in simulation,for the rendezvous of heterogeneous robots. | Aleksandra Faust Peter Ruymgaart Molly Salman Rafael Fierro Lydia Tapia | 2014 | IEEE/CAA Journal of Automatica Sinica2014，1，3： | 3 |
| 6 | 印制电路板制造的等离子体工艺显示文摘由于高密度高速化(信号传输)的多层板发展,对多层板的性能提高了要求,为了层压这些多层板和从导通孔中除去残留物,采用常规的制造方法已不再有效了. | Lou fierro James D.Getty 孔祥麟 | 2003 | 印制电路信息2003，，9： | 2 |
| 7 | 显示文摘 | Fierro G Morpurgo S Jacono M L | 1998 | Applied Catalysis A:General1998，166，： | 1 |
| 8 | F- wave study at different stimulation rates in upper motoneurone lesions 显示文摘 | Fierro B Raimondo D Modica A | 1993 | Electromyogr Clin Neurophysiol1993，33，1： | 1 |
| 9 | Partial oxidation of methanol over supported palladium catalysts 显示文摘 | Cubeiro M L Fierro J L G | 1998 | Appl Catal A1998，168，： | 1 |
| 10 | High-dose immunoglobulines and extracorporeal photoehemotherapy in the treatment of febrile ulcerone- erotic Mucha-Ilabermaml disease 显示文摘 | Marenco F Fava P Fierro MT | 2010 | Dermatol Ther2010，23，4： | 1 |
| 11 | Enhancement of pyrolysisgasoline hydrogenation over Pd-promoted Ni/SiO2-Al2O3 catalysts显示文摘 | Castano P Pawelec B Fierro J L G | 2007 | Fuel2007，86，15： | 1 |
| 12 | Unusually high selectivity to C2+ alcohols on bimetallic CoFe catalysts during CO hydrogenation显示文摘 | De la PENA OSHEA V A MENENDEZ N N TORNERO J D FIERRO J L G | 2003 | Catal Lett2003，88，34： | 1 |
| 13 | Arsenic re- moval by iron-doped activated carbons prepared by ferric chloride forced hydrolysis 显示文摘 | Fierro V Mufiiz G Gonzalez-S6nchez G | 2009 | Journal of Hazardous Mate- rials2009，168，： | 1 |
| 14 | Highly effective conversion of CO2 to methanol over supported and promoted copper-based catalysts : Influence of support and promoter 显示文摘 | Toyir J Piscina P R de la Fierro JLG | 2001 | Applied Catalysis B : Environmental2001，29，： | 1 |
| 15 | Tungsten and tungsten carbide supported on activated carbon: Surface structure and performance for ethylene hydrogenation显示文摘 | MORENO C C ALVAREZ M A CARRASCO M F FIERRO J L | 2001 | Langmuir2001，17，5： | 1 |
| 16 | Partial oxidation of methanol over supported palladium catalysts显示文摘 | Cubeiro M L Fierro J L G | 1998 | Appl Catal A1998，168，： | 1 |
| 17 | Anatomic study of the lymph nodes of the mesorectum显示文摘 | César E. Canessa M.D. Federica Badía M.D. Socorro Fierro M.D. Verónica Fiol M.D. Gastón Háyek M.D | 2001 | Diseases of the Colon & Rectum2001，，9： | 1 |
| 18 | Decomposition of paper de- inking sludge in a sandpit minesoil during its revegetation 显示文摘 | Fierro A Angers D A Beauchamp C J | 2000 | Soil Biology & Biochemistry2000，32，2： | 1 |
| 19 | Robust practical point stabilization of a nonholonomic mobile robot using neural networks 显示文摘 | Lewis F L | 1997 | Journal of Intelligent and Robotic Systems1997，20，： | 1 |
| 20 | Mechanisms in anti-inflammation and resolution:the role of lipoxins and aspirin-triggered lipoxins显示文摘 | Fierro IM Serhan CN | 2001 | Braz J Med Biol Res2001，34，5： | 1 |
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