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| 1 | Role of liver biopsy in nonalcoholic fatty liver disease显示文摘Nonalcoholic fatty liver disease(NAFLD), defined as abnormal accumulation(> 5%) of hepatic triglyceride without excess alcohol intake, is the most common form of chronic liver disease in adults and children in the United States. NAFLD encompasses a spectrum of histologic findings including uncomplicated steatosis, steatosis with inflammation and steatohepatitis [nonalcoholic steatohepatitis(NASH)]; the latter can advance to cirrhosis and hepatocellular carcinoma. NASH is currently accepted as the hepatic manifestation of the set of cardiovascular risk factors collectively known as metabolic syndrome. In 1999 a system for histologic grading and staging for NASH was proposed; this was revised by the NASH Clinical Research Network in 2005 for the entire spectrum of lesions in NAFLD, including the lesions and patterns of pediatric NAFLD, and for application in clinical research trials. Diagnosis remains distinct from grade and stage. A recent European proposal separates steatosis from activity to derive a numeric diagnosis of NASH. Even though there have been promising advancements in non-invasive testing, these tests are not yet detailed enough to replace the full range of findings provided by liver biopsy evaluation. Limitations of biopsy are acknowledged, but liver biopsy remains the 'gold standard' for diagnosis and determination of amounts of necroinflammatory activity, and location of fibrosis, as well as remodeling of the parenchyma in NASH. This review focuses on the specific histologic lesions of NAFLD and NASH, grading and staging, differential diagnoses to be considered, and the continuing role of the liver biopsy in this important liver disease. | ILKe Nalbantoglu Elizabeth M Brunt | 2014 | World Journal of Gastroenterology2014，20，27： | 16 |
| 2 | 非酒精性脂肪性肝病流行现状调查显示文摘非酒精性脂肪性肝病(NAFLD)是除外酒精和其他明确的肝损害因素所致,以肝细胞内脂肪过度沉积为特征的临床病理综合征。伴随民众生活方式的改变和社会人口的老龄化,NAFLD全球发病率逐渐攀升,亚洲尤甚,其中我国是NAFLD负担较重的国家之一。相关统计数据显示,NAFLD全球患病率为25.24%。目前,NAFLD已成为全球第一大慢性肝病、肝移植第二大原因,由其导致的死亡病例逐年增加,成为严重危害人类健康的疾病。该文基于PubMed和中国知网(CNKI)数据库发表的全球较大规模流行病学调查数据,汇总分析NAFLD在全球和我国的流行现状,为全面、系统地了解NAFLD在人群中的危害性提供流行病学依据,以期持续推进相关研究并制定防治策略,降低NAFLD发病风险,促进人类健康。 | 金玉 武晓旭 李秋娟 关怀 | 2021 | 人民军医2021，64，5： | 14 |
| 3 | 非酒精性脂肪性肝病的流行病学及防治显示文摘非酒精性脂肪性肝病(NAFLD)是目前最常见的慢性肝病,与多种代谢性疾病有密切关系。NAFLD的全球总患病率随着生活水平的提高逐年增高,引起人们的关注。该文旨在对NAFLD的流行病学特点、危险因素及预防进行综述。 | 丁雪娇 赵双清 李雅丽 | 2021 | 中国临床保健杂志2021，24，6： | 14 |
| 4 | 非酒精性脂肪性肝病的研究进展及认识显示文摘非酒精性脂肪性肝病是引起肝酶升高及慢性肝病的常见病因,其发病趋势呈低龄化且增长迅速,已成为一个不可忽视的全球健康卫生问题。本文综述非酒精性脂肪性肝病的最新研究进展及相关临床认识。 | 柴尚玉 曲伸 | 2013 | 世界临床药物2013，34，8： | 3 |
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