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| 1 | Portopulmonary hypertension and serum endothelin levels in hospitalized patients with cirrhosis显示文摘BACKGROUND:Cirrhosis is associated with several extrahepatic manifestations including portopulmonary hypertension (PPHT).Recent data suggest that endothelins (ETs) are related to the pathophysiology of PPHT.The study aimed to measure serum ET levels in hospitalized cirrhotic patients and to determine their association with PPHT and patient outcome.METHODS:Fifty-seven cirrhotic patients [43 males;median age 58 (28-87) years] underwent Doppler echocardiography.Patients with systolic pulmonary arterial pressure ≥40 mmHg and pulmonary acceleration time <100 ms were deemed to have PPHT.ET-1,2,and 3 serum levels were measured with an ELISA assay.All-cause mortality was recorded over a median period of 24 months.RESULTS:Nine out of 57 patients (15.8%) had PPHT.Among various clinical variables,only autoimmune hepatitis was associated with PPHT (OR=11.5;95% CI,1.58-83.4;P=0.01).ET-1 levels [9.1 (1.6-20.7) vs 2.5 (1.4-9.2) pg/mL,P=0.02] and the ET-1/ET-3 ratio [4.73 (0.9-22.4) vs 1.6 (0.3-10.7),P=0.02] were significantly higher in patients with PPHT than in those without.ET-2 and ET-3 levels did not differ between the two groups.There was no difference in survival between the two groups,although ET-1 levels were associated with an adverse outcome in Cox regression analysis (HR=1.11;95% CI,1.02-1.22;P=0.02 per unit increase in ET-1).CONCLUSION:Our data suggest that ET-1 and the ET-1/ET-3 ratio are elevated in patients with PPHT and that ET-1 is associated with a poor outcome irrespective of PPHT. | Aristotelis Tsiakalos Gregorios Hatzis Ioannis Moyssakis Aggelos Karatzaferis Panayiotis D Ziakas George E Tzelepis | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，4： | 7 |
| 2 | Melatonin attenuates high fat diet-induced fatty liver disease in rats显示文摘AIM:To investigate melatonin's preventive action in oxidative stress in a rat model with high fat diet-induced non-alcoholic fatty liver disease(NAFLD).METHODS:NAFLD was induced by high fat diet(HFD)in adult,male,Wistar rats,weighing 180-230 g.After acclimatization for one week,they were randomly assigned to 6 experimental groups that comprised animals on regular diet plus 5 or 10 mg/kg melatonin,for 4 or 8 wk;animals on HFD,with or without 5 or 10 mg/kg melatonin,for 4 or 8 wk;and animals on HFD for 8 or 12 wk,with melatonin 10 mg/kg for the last 4 wk.Liver damage was assessed biochemically by the serum levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST),and histologically.Lipid peroxidation and oxidative stress were assessed by malondialdehyde and glutathione levels in liver tissue.Lipidemic indices and portal vein pressure were also measured.RESULTS:Compared to rats not receiving melatonin,rats on 5 or 10 mg/kg of melatonin had lower mean liver weight(-5.0 g and-4.9 g)(P < 0.001)and lower liver weight to body weight ratio(-1.0%)(P < 0.001),for the two doses,respectively.All rats fed HFD without melatonin developed severe,grade Ⅲ,steatosis.Rats on HFD with concurrent use of melatonin showed significantly less steatosis,with grade Ⅲ steatosis observed in 1 of 29(3.4%)rats on 10 mg/kg melatonin and in 3 of 27(11.1%)rats on 5 mg/kg melatonin.Melatonin was ineffective in reversing established steatosis.Melatonin also had no effect on any of the common lipidemic serum markers,the levels of which did not differ significantly among the rats on HFD,irrespective of the use or not of melatonin.Liver cell necrosis was significantly less in rats on HFD receiving melatonin than in those not on melatonin,with the AST levels declining by a mean of 170 U/L(P = 0.01)and 224 U/L(P = 0.001),and the ALT levels declining by a mean of 62.9 U/L(P = 0.01)and 93.4 U/L(P < 0.001),for the 5 and 10 mg/kg melatonin dose,respectively.Melatonin mitigated liver damage due to peroxidation and oxidative stress in liver tissue as indicated by a significant decline in MDA production by 12.7(P < 0.001)and 12.2(P < 0.001)μmol/L/mg protein/mg tissue,and a significant increase in glutathione by 20.1(P = 0.004)and 29.2(P < 0.001)μmol/L/mg protein/mg tissue,for the 5 and 10 mg/kg melatonin dose,respectively.CONCLUSION:Melatonin can attenuate oxidative stress,lessen liver damage,and improve liver histology in rats with high fat diet-induced NAFLD,when given concurrently with the diet. | Gregorios Hatzis Panayiotis Ziakas Nikolaos Kavantzas Aggeliki Triantafyllou Panagiotis Sigalas Ioanna Andreadou Konstantinos Ioannidis Stamatios Chatzis Konstantinos Filis Alexandros Papalampros Fragiska Sigala | 2013 | World Journal of Hepatology2013，5，4： | 4 |
| 3 | Circulating autoantibodies to endogenous erythropoietin are associated with chronic hepatitis C virus infection-related anemia显示文摘BACKGROUND: Chronic hepatitis C virus(HCV) infection is associated with autoimmune phenomena and is often complicated by anemia. Circulating autoantibodies to endogenous erythropoietin(anti-EPO) have been detected in patients with chronic viral infections and were correlated to anemia. The present study aimed to determine anti-EPO prevalence in patients with chronic HCV infection and investigate its possible association with anemia.METHODS: Ninety-three consecutive patients(62 males and 31 females) with chronic HCV infection, who had never received antiviral therapy or recombinant EPO, were enrolled in the study. Circulating anti-EPO were detected in the serum by using an ELISA assay. Quantitative determination of serum EPO levels was done by radioimmunoassay. HCV RNA viral load measurement and genotype sequencing were also performed.RESULTS: Circulating anti-EPO were detected in 10.8% of HCV-infected patients and the prevalence of anti-EPO was significantly higher in patients with anemia(19.4% vs 5.3%, P=0.040) compared to that in those without anemia. Compared to anti-EPO negative cases, anti-EPO positive patients had higher frequency of anemia(70.0% vs 34.9%, P=0.030), lower EPO concentrations(median 16.35 vs 30.65 m U/m L, P=0.005), and higher HCV RNA viral load(median 891.5×103 vs 367.5×103 IU/m L, P=0.016). In multivariate regression analysis the presence of anti-EPO remained an independent predictor of anemia(adjusted OR: 14.303, 95% CI: 1.417-36.580, P=0.024). EPO response to anemia was less prominent among anti-EPO positive patients(P=0.001).CONCLUSIONS: Circulating anti-EPO are detected in a significant proportion of treatment-na?ve HCV-infected patients and are independently associated with anemia, suggesting a further implication of autoimmunity in the pathophysiology of HCV-related anemia. | Aristotelis Tsiakalos Theoharis Voumvas Alexandros Psarris Christina K Oikonomou Dimitrios C Ziogas Ioannis Ketikoglou Grigorios Hatzis Nikolaos V Sipsas | 2017 | Hepatobiliary & Pancreatic Diseases International2017，16，3： | 4 |
| 4 | The association of aromatase (CYP19) gene variants wil sperm concentration and motility显示文摘 | Leandros Lazaros Nectaria Xita Apostolos Kaponis Elissavet Hatzi Nicolaos Plachouras Nicolaos Sofikitis Konstantinos Zikopoulos Ioannis Georgiou | 2011 | Asian Journal of Andrology2011，13，2： | 2 |
| 5 | BCL6 repression of EP300 in human diffuse large B cell lymphoma cells provides a basis for rational combinatorial therapy显示文摘 | Cerchietti Leandro C Hatzi Katerina Caldas-Lopes Eloisi Yang Shao Ning Figueroa Maria E Morin Ryan D Hirst Martin Mendez Lourdes Shaknovich Rita Cole Philip A Bhalla Kapil Gascoyne Randy D Marra Marco Chiosis Gabriela Melnick Ari | 2010 | Journal of Clinical Investigation2010，，12： | 1 |
| 6 | Endothelial dysfunction in conduit arteries and in microcirculation. Novel therapeutic approaches显示文摘 | Dimitris Tousoulis Chryssa Simopoulou Nikos Papageorgiou Evangelos Oikonomou George Hatzis Gerasimos Siasos Eleftherios Tsiamis Christodoulos Stefanadis | 2014 | Pharmacology and Therapeutics2014，，3： | 1 |
| 7 | Biochemical engineering analysis of critical process factors in the biomass-to-etha- nol technology 显示文摘 | PHILIPPIDIS G P HATZIS C | 1997 | Biotechnology Progress1997，13，3： | 1 |
| 8 | Hypercapnia due to a heat and moisture exchanger显示文摘 | Briassoulis G Paraschou D Hatzis T | 2000 | Intensive Care Med2000，26，1： | 1 |
| 9 | Hepatotoxicity due to Atractylis gummifera-L显示文摘 | Creorgiou M Sianidou L Hatzis T | 1988 | Toxicol Clin Toxicol1988，26，： | 1 |
| 10 | Measurement of Re- sidual Breast Cancer Burden to Predict Survival After Neoadju- vant Chemotherapy显示文摘 | Symmans WF Peintinger F Hatzis C | 2007 | J Clin Oncol2007，25，28： | 1 |
| 11 | Phosphatidylethanolamine N-methyltransferase and choline dehydrogenase gene polymorphisms are associated with human sperm concentration显示文摘胆碱是在精子膜结构和流动性的规定的一个关键因素,并且这营养素在成熟和精子的使肥沃的能力起一个重要作用。phosphatidylethanolamine N-methyltransferase (PEMT ) 和胆碱脱氢酶(CHDH ) 的抄本,胆碱新陈代谢的二基本的酶,在人的睾丸被观察了,在这纸巾表明他们的基因表示。在现在的学习,我们探索了 PEMT 和 CHDH 基因变体的贡献到精子参数。200 oligospermic 和 250 个 normozoospermic 人被招募。DNA 从精子,和 PEMT − 被提取; 774G > C 和 CHDH + 432G > T 多型性是 genotyped。PEMT − 的遗传型分发; 774G > C 多型性没在 oligospermic 和 normozoospermic 人之间不同。相反,在 CHDH + 的情况中; 432G > T 多型性, oligospermic 人比 normozoospermic 人更经常介绍了 CHDH 432G/G 遗传型(62 %对 42 %, P< 0.001 ) 。 PEMT 774G/G 遗传型在 oligospermic 人与 PEMT 774G/C 和 774C/C 遗传型相比与更高的精子集中被联系( 12.5 ± ; 5.6 × ; 10 6精子 ml −1对 8.3 ± ; 5.2 × ; 10 6精子 ml −1, P< ; 0.002 )并且 normozoospermic 人( 81.5 ± ; 55.6 × ; 10 6对 68.1 ± ; 44.5 × ; 10 6精子 ml −1, P< ; 0.006 )。另外, CHDH 432G/G 遗传型在 oligospermic 与 CHDH 432G/T 和 432T/T 遗传型相比与更高的精子集中被联系( 11.8 ± ; 5.1 × ; 10 6对 7.8 ± ; 5.3 × ; 10 6精子 ml −1, P< ; 0.003 )并且 normozoospermic 人( 98.6 ± ; 62.2 × ; 10 6对 58.8 ± ; 33.6 × ; 10 6精子 ml −1, P< ; 0.001 )。在我们的系列, PEMT − 774G > C 和 CHDH + 432G > T 多型性与精子集中被联系。这发现在精子质量上建议这些基因的可能的影响。 | Leandros Lazaros Nectaria Xita Elissavet Hatzi Apostolos Kaponis Georgios Makrydimas Atsushi Takenaka Nikolaos Sofikitis Theodoros Stefos Konstantinos Zikopoulos Ioannis Georgiou | 2012 | Asian Journal of Andrology2012，14，5： | 1 |
| 12 | The wrinkle and its measurement A skin surface Profilometric marhod显示文摘 | HATZIS J | 2004 | Micron2004，35，： | 1 |
| 13 | The role of colongscopyin the differential hemorrhagic colitis显示文摘 | Mantzaris GJ Hatzis A Archavfis E | 1995 | Endoscopy1995，27，6： | 1 |
| 14 | Commercialized multigene predictors of clinical outcome for breast cancer显示文摘 | Ross JS Hatzis C Symmans WF | 2008 | Oncologist2008，13，5： | 1 |
| 15 | The ovarian response to standard gonadotrophin stimulationdepends on FSHR, SHBG and CYP19 gene synergism显示文摘 | Lazaros LA Hatzi EG Pamporaki CE | 2012 | Journal of assisted reproduction and genetics2012，29，11： | 1 |
| 16 | BCL6-mediated re- pression of p53 is critical for leukemia stem cell survival in chronic myeloid leukemia显示文摘 | Hurtz C Hatzi K Cerchietti L | 2011 | J Exp Med2011，208，11： | 1 |
| 17 | Plasticity and expanding complexity of the hepatic transcription factor network during liver development显示文摘 | Kyrmizi I Hatzis P Katrakili N | 2006 | Genes Dev2006，20，16： | 1 |
| 18 | Genome-wide pattern of TCF7L2/TCF4 chromatin occupancy in colorectal cancer cells显示文摘 | Hatzis P van der Flier LG van Driel MA | 2008 | Mol Cell Biol2008，28，8： | 1 |
| 19 | Intrathecal injection of cAMP response element bingding protein(CREB)antisense oligonucleotide attenuates tactile aUodynia caused by partial sciatic nerve ligation显示文摘 | Ma W Hatzis C Eisenach J C | 2003 | Brain Res2003，988，12： | 1 |
| 20 | The widespread expression of angiogenin in different human eeUs suggests a bio log ical funetio n not only related to angiogenesis显示文摘 | Gusse M Hatzi E | | Eur J Biochem0，226，： | 1 |
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