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| 1 | From diagnosis to treatment of hepatocellular carcinoma: An epidemic problem for both developed and developing world显示文摘Hepatocellular carcinoma(HCC) is the most frequent primary liver malignancy and the third cause of cancer-related death in the Western Countries. The well-established causes of HCC are chronic liver infections such as hepatitis B virus or chronic hepatitis C virus, nonalcoholic fatty liver disease, consumption of aflatoxins and tobacco smocking. Clinical presentation varies widely; patients can be asymptomatic while symptomatology extends from right upper abdominal quadrant paint and weight loss to obstructive jaundice and lethargy. Imaging is the first key and one of the most important aspects at all stages of diagnosis, therapy and follow-up of patients with HCC. The Barcelona Clinic Liver Cancer Staging System remains the most widely classification system used for HCC management guidelines. Up until now, HCC remains a challenge to early diagnose, and treat effectively; treating management is focused on hepatic resection, orthotopic liver transplantation, ablative therapies, chemoembolization and systemic therapies with cytotocix drugs, and targeted agents. This review article describes the current evidence on epidemiology, symptomatology, diagnosis and treatment of hepatocellular carcinoma. | Dimitrios Dimitroulis Christos Damaskos Serena Valsami Spyridon Davakis Nikolaos Garmpis Eleftherios Spartalis Antonios Athanasiou Demetrios Moris Stratigoula Sakellariou Stylianos Kykalos Gerasimos Tsourouflis Anna Garmpi Ioanna Delladetsima Konstantinos Kontzoglou Gregory Kouraklis | 2017 | World Journal of Gastroenterology2017，23，29： | 44 |
| 2 | Role of surgery in colorectal liver metastases:Too early or too late?显示文摘As colorectal cancer and colorectal liver metastases become a serious public health problem,new treatment modalities are needed in order to achieve better results. In the last decade there has been very important progress in oncology,with new and more effective chemotherapeutic agents administered alone or in combination improving the resectability rate in up to 40%of patients with colorectal liver metastases.Advances in interventional radiology,in particular,with the use of portal vein embolization and radiofrequency thermal ablation are new strategies allowing major liver resections and treatment of small liver metastases or early recurrences.Surgery,however,remains the gold standard strategy with intention to treat.In this review article we will describe the advanced role of surgery in the multidisciplinary approach to colorectal liver metastases,and the clinical problems the liver surgeon has to deal with,such as theresectability of the metastases,the presence of bilobar liver lesions and extrahepatic disease,the impact of chemotherapy in already resectable liver metastases,the problem of vanishing metastases after chemotherapy and the dilemma of staged or combined liver and colon operations and which organ first in the clinical scenario of synchronous colorectal liver metastases. | Dimitrios Dimitroulis Nikolaos Nikiteas Theodore Troupis Dimitrios Patsouras Panayiotis Skandalakis Gregory Kouraklis | 2010 | World Journal of Gastroenterology2010，16，28： | 5 |
| 3 | Hepatocellular carcinoma in patients co-infected with hepatitis C virus and human immunodeficiency virus显示文摘Hepatitis C virus (HCV) and human immunodeficiency virus (HIV) share a common route of transmission so that about one third of HIV infected individuals show HCV coinfection. Highly active antiretroviral therapy has offered a longer and better life to infected patients. While has removed AIDS-related diseases from the list of most common causes of death their place has been taken by complications of HCV infection, such as cirrhosis, end stage liver disease and hepatocellular carcinoma (HCC). HIV/HCV co-infection requires complex management, especially when HCC is present. Co-infected patients with HCC undergo the same therapeutic protocol as their mono-infected counterparts, but special issues such as interaction between regimens, withdrawal of therapy and choice of immunosuppressive agents, demand a careful approach by specialists. All these issues are analyzed in this minireview. | Dimitrios Dimitroulis Serena Valsami Eleftherios Spartalis Emmanuel Pikoulis Gregory Kouraklis | 2013 | World Journal of Hepatology2013，5，6： | 4 |
| 4 | Indications,limitations and maneuvers to enable extended hepatectomy:Current trends显示文摘The liver is a solid organ with a wide variety of primary benign or malignant tumors as well as metastatic lesions.Surgical resection of these tumors remains the only curative modality.Several limitations,however,do not allow the performance of these operations.This review evaluates the indications and limitations regarding these extended hepatic resections,as well as describing all the manipulations that increase the candidates for such operations.A thorough review of the literature was performed in order to define indications for extended hepatectomy,as well as to present all methods that contribute to increasing the volume of the future remnant liver.The role of portal vein ligation,portal vein embolization,two-stage hepatectomy,and in situ liver transection are evaluated in the setting of indications and results.Extended hepatectomies are a necessity due to oncological reasons.All methods developed in order to increase the volume of the remnant liver are safe and efficient.in situ liver transection is a novel and revolutionary two-step procedure for extended hepatic resections.Further clinical studies are required to estimate long-term results and the oncological basis of this technique. | Dimitrios Dimitroulis Petros Tsaparas Serena Valsami Dimitrios Mantas Eleftherios Spartalis Charalampos Markakis Gregory Kouraklis | 2014 | World Journal of Gastroenterology2014，20，24： | 4 |
| 5 | Barrett's esophagus with high-grade dysplasia:Focus on current treatment options显示文摘High-grade dysplasia(HGD) in Barrett's esophagus(BE) is the critical step before invasive esophageal adenocarcinoma.Although its natural history remains unclear,an aggressive therapeutic approach is usually indicated.Esophagectomy represents the only treatment able to reliably eradicate the neoplastic epithelium.In healthy patients with reasonable life expectancy,vagal-sparing esophagectomy,with associated low mortality and low early and late postoperative morbidity,is considered the treatment of choice for BE with HGD.Patients unfit for surgery should be managed in a less aggressive manner,using endoscopic ablation or endoscopic mucosal resection of the entire BE segment,followed by lifelong surveillance.Patients eligible for surgery who present with a long BE segment,multifocal dysplastic lesions,severe reflux symptoms,a large fixed hiatal hernia or dysphagia comprise a challenging group with regard to the appropriate treatment,either surgical or endoscopic. | Leonidas Lekakos Nikolaos P Karidis Dimitrios Dimitroulis Christos Tsigris Gregory Kouraklis Nikolaos Nikiteas | 2011 | World Journal of Gastroenterology2011，17，37： | 2 |
| 6 | Mechanistic insights of rapid liver regeneration after associating liver partition and portal vein ligation for stage hepatectomy显示文摘AIM To highlight the potential mechanisms of regeneration in the Associating Liver Partition and Portal vein ligation for Stage hepatectomy models(clinical and experimental) that could unlock the myth behind the extraordinary capability of the liver for regeneration,which would help in designing new therapeutic options for the regenerative drive in difficult setup,such as chronic liver diseases. Associating Liver Partition and Portal vein ligation for Stage hepatectomy has been recently advocated to induce rapid future liver remnant hypertrophy that significantly shortens the time for the second stage hepatectomy. The introduction of Associating Liver Partition and Portal vein ligation for Stage hepatectomy in the surgical armamentarium of therapeutic tools for liver surgeons represented a real breakthrough in the history of liver surgery. METHODS A comprehensive literature review of Associating Liver Partition and Portal vein ligation for Stage hepatectomy and its utility in liver regeneration is performed. RESULTS Liver regeneration after Associating Liver Partition and Portal vein ligation for Stage hepatectomy is a combination of portal flow changes and parenchymal transection that generate a systematic response inducing hepatocyte proliferation and remodeling. CONCLUSION Associating Liver Partition and Portal vein ligation for Stage hepatectomy represents a real breakthrough in the history of liver surgery because it offers rapid liver regeneration potential that facilitate resection of liver tumors that were previously though unresectable. The jury is still out though in terms of safety,efficacy and oncological outcomes. As far as Associating Liver Partition and Portal vein ligation for Stage hepatectomy-induced liver regeneration is concerned,further research on the field should focus on the role of nonparenchymal cells in liver regeneration as well as on the effect of Associating Liver Partition and Portal vein ligation for Stage hepatectomy in liver regeneration in the setup of parenchymal liver disease. | Demetrios Moris Spyridon Vernadakis Alexandros Papalampros Michail Vailas Nikolaos Dimitrokallis Athanasios Petrou Dimitrios Dimitroulis | 2016 | World Journal of Gastroenterology2016，22，33： | 2 |
| 7 | Role of platelet-rich plasma in ischemic heart disease: An update on the latest evidence显示文摘Myocardial infarction is the most common cause of congestive heart failure. Novel strategies such as directly reprogramming cardiac fibroblasts into cardiomyocytes are an exciting area of investigation for repair of injured myocardial tissue. The ultimate goal is to rebuild functional myocardium by transplanting exogenous stem cells or by activating native stem cells to induce endogenous repair. Cell-based myocardial restoration, however, has not penetrated broad clinical practice yet. Plateletrich plasma, an autologous fractionation of whole blood containing high concentrations of growth factors, has been shown to safely and effectively enhance healing and angiogenesis primarily by reparative cell signaling. In this review, we collected all recent advances in novel therapies as well as experimental evidence demonstrating the role of platelet-rich plasma in ischemic heart disease, focusing on aspects that might be important for future successful clinical application. | Eleftherios Spartalis Periklis Tomos Demetrios Moris Antonios Athanasiou Charalampos Markakis Michael D Spartalis Theodore Troupis Dimitrios Dimitroulis Despina Perrea | 2015 | World Journal of Cardiology2015，7，10： | 1 |
| 8 | Emergency Liver Resection for Combined Biliary and Vascular Injury Following Laparoscopic Cholecystectomy: Case Report and Review of the Literature显示文摘 | Evangelos Felekouras Thomas Megas Othon P. Michail Ioannis Papaconstantinou Nikolaos Nikiteas Dimitrios Dimitroulis John Griniatsos Anastasios Tsechpenakis Gregorios Kouraklis | 2007 | Southern Medical Journal2007，，3： | 1 |
| 9 | Associations between osteoprotegerin and femoral neck BMD in hemodialysis patients显示文摘 | Konstantinos K. Doumouchtsis Alkis I. Kostakis Stergios K. Doumouchtsis Marios P. Tziamalis Charalambos P. Stathakis Evanthia Diamanti-Kandarakis Dimitrios Dimitroulis Despoina N. Perrea | 2008 | Journal of Bone and Mineral Metabolism2008，，1： | 1 |
| 10 | Surgical dilemmas in the management of colorectal liver metastases: the role of timing显示文摘Colorectal cancer(CRC) is an emerging health problem in the Western World both for its raising tendency as well as for its metastatic potential. Almost half of the patients with CRC will develop liver metastases during the course of their disease. The liver surgeon dealing with colorectal liver metastases faces several surgical dilemmas especially in the setting of the timing of operation. Synchronous resectable metastases should be treated prior or after induction chemotherapy? Furthermore in the case of synchronous colorectal liver metastases which organ should we first deal with, the liver or the colon? All these questions are set in the editorial and impulse for further investigation is put focusing on multidisciplinary approach and individualization of treatment modalities. | Dimitrios Dimitroulis Gregory Kouraklis | 2016 | World Journal of Gastroenterology2016，22，21： | 1 |
| 11 | Comparison of cosmetic outcomes between remote-access and conventional thyroidectomy:A review of the current literature显示文摘Objective:The pursuit of an esthetically pleasing scar following open thyroid surgery has led to the development of endoscopic thyroidectomy through remote incisions placed in several locations outside the neck.The objective of this study is to review the recent literature and compare the incision site appearance and patient satisfaction with the cosmetic outcome after extracervical and conventional thyroidectomy.Methods:The English literature published since 2010 was searched through the PubMed/Medline database for studies comparing the cosmetic outcomes between remote-access endoscopic and conventional thyroidectomy using a form of scar assessment scale.Results:A total of 9 relevant papers fulfilled the eligibility criteria including 1486 patients.Among them,595 patients underwent endoscopic thyroidectomy through several remote-access approaches and 891 patients were assigned to the conventional group.Only one randomized-controlled trial was identified,whereas among the rest,four were prospective and four were retrospective nonrandomized cohorts.Regarding the extracervical modifications performed in the endoscopic groups,the axillary approach was performed in three studies and the breast approach in four studies,while the retroauricular facelift technique and the transoral vestibular method were applied in one study,respectively.Conclusions:Evaluation of the wound appearance and patient satisfaction with the cosmetic outcome at various time points during the follow-up highlighted the superiority of the extracervical approaches over the conventional cervicotomy.Considering these findings,remote-access techniques could possibly be the ideal surgical method for patients with high esthetic requirements,providing an excellent appearance of the thoroughly exposed neck. | Anna Kasouli Eleftherios Spartalis Alexios Giannakodimos Gerasimos Tsourouflis Dimitrios Dimitroulis Nikolaos I.Nikiteas | 2023 | World Journal of Otorhinolaryngology-Head and Neck Surgery2023，9，1： | 0 |
| 12 | Amyand's hernia: A case report显示文摘在腹股沟疝的蚓状的附录的存在是稀罕的并且作为 Amyand 的脱肠被知道。我们报导 Amyand 的脱肠,在附录 90 二年在一具男死尸在正确腹股沟疝被发现的地方。 | Sofia Anagnostopoulou Dimitrios Dimitroulis Theodore G Troupis Maria Allamani Alexandras Paraschos Antonios Mazarakis Nikolaos I Nikiteas Alkiviadis Kostakis | 2006 | World Journal of Gastroenterology2006，12，29： | 0 |
| 13 | 在年轻女性的 hepatocellular 腺瘤和焦点的榴状的增生的共存显示文摘 Focal nodular hyperplasia (FNH) and hepatocellular adenoma (HA) are both benign hepatocellular lesions, presenting mainly in women of childbearing age in non-cirrhotic, non-fibrotic livers. Simultaneous occur-rence of these two lesions is extremely rare. We herein report a case of a young female without any predis-posing risk factors who presented to our emergency department complaining of acute abdominal pain. Imaging studies revealed a 6 cm lesion in the right hepatic lobe and a 2.5 cm lesion in the left hepatic lobe, respectively. In view of the patient’s symptoms and lack of a confirmed diagnosis based on imaging, we performed a bisegmentectomy Ⅴ-Ⅵ and a wedge resection of the lesion in segment Ⅲ by laparotomy. Postoperative course was uneventful and the patient was discharged on the fourth postoperative day. The pathology report demonstrated an HA in segments Ⅴ-Ⅵ and FNH in segment Ⅲ, respectively. Six months later, the patient remains asymptomatic with normal liver function tests, ultrasound and magnetic reso-nance imaging follow-up. To our best knowledge, this is the first case to describe simultaneous occurrence of HA and FNH without the presence of any known risk factors for these entities. The uncertainty in diagnosis and acuteness of presenting symptoms were estab-lished criteria for prompt surgical intervention. | Dimitrios Dimitroulis Panagiotis Lainas Petros Chara-lampoudis Theodore Karatzas Nikolaos Karidis Gregory Kouraklis Ioanna Delladetsima Nikolaos Karidis Gregory Kouraklis Stratigoula Sakellariou | 2012 | World Journal of Hepatology2012，4，11： | 0 |
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