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| 1 | Evidence based medicine and surgical approaches for colon cancer: Evidences, benefits and limitations of the laparoscopic vs open resection显示文摘AIM:To report a meta-analysis of the studies that compared the laparoscopic with the open approach for colon cancer resection.METHODS:Forty-seven manuscripts were reviewed,33 of which employed for meta-analysis according to the PRISMA guidelines.The results were differentiated according to the study design(prospective randomized trials vs case-control series)and according to the tu-mor’s location.Outcome measures included:(1)shortterm results(operating times,blood losses,bowel function recovery,post-operative pain,return to the oral intake,complications and hospital stay);(2)oncological adequateness(number of nodes harvested in the surgical specimens);and(3)long-term results(including the survivals’rates and incidence of incisional hernias)and(4)costs.RESULTS:Meta-analysis of trials provided evidences in support of the laparoscopic procedures for a several short-term outcomes including:a lower blood loss,an earlier recovery of the bowel function,an earlier return to the oral intake,a shorter hospital stay and a lower morbidity rate.Opposite the operating time has been confirmed shorter in open surgery.The same trend has been reported investigating case-control series and cancer by sites,even though there are some concerns regarding the power of the studies in this latter field due to the small number of trials and the small sample of patients enrolled.The two approaches were comparable regarding the mean number of nodes harvested and long-term results,even though these variables were documented reviewing the literature but were not computable for meta-analysis.The analysis of the costs documented lower costs for the open surgery,however just few studies investigated the incidence of postoperative hernias.CONCLUSION:Laparoscopy is superior for the majority of short-term results.Future studies should better differentiate these approaches on the basis of tumors’location and the post-operative hernias. | Laura Lorenzon Marco La Torre Vincenzo Ziparo Francesco Montebelli Paolo Mercantini Genoveffa Balducci Mario Ferri | 2014 | World Journal of Gastroenterology2014，20，13： | 8 |
| 2 | Hepatic steatosis in overweight/obese females: New screening method for those at risk显示文摘AIM: To identify which parameters could help to distinguish the 'metabolically benign obesity', which is not accompanied by insulin resistance (IR) and early atherosclerosis.METHODS: Eighty two of 124 overweight/obese females formed the study population, which was divided into two groups (52 and 30 subjects, respectively) with and without IR according to a HO meostatic Metabolic Assessment (HOMA) cut-off of 2, and were studied in a cross-sectional manner. The main outcome measures were waist circumference, serum uric acid, high-density lipoprotein-cholesterol and triglycerides, alanine amino-transferase, blood pressure and the two imaging para-meters, hepatic steatosis and longitudinal diameter of the spleen, which were measured in relation to the presence/absence of IR. RESULTS: A variable grade of visceral obesity was observed in all subjects with the exception of three.Obesity of a severe grade was represented more in the group of IR individuals (P = 0.01). Hepatic steatosis, revealed at ultrasound, was more pronounced in IR than in non-IR subjects (P = 0.005). The two groups also demonstrated a clear difference in longitudinal spleen diameter and blood pressure, with raised and signif icant values in the IR group. Metabolic syndrome was frequent in the IR group, and was not modified when adjusted for menopause (P = 0.001). At linear regression, the β values of waist circumference and body mass index predicting HOMA were 0.295, P = 0.007 and 0.41, P = 0.0001, respectively. Measures of spleen longitudinal diameter were well predicted by body mass index (BMI) values, β = 0.35, P = 0.01, and by HOMA, β = 0.41, P = 0.0001. Blood pressure was predicted by HOMA values, β = 0.39, P = 0.0001). HOMA and hepatic steatosis were highly associated (rho = 0.34, P = 0.002). Interestingly, IR patients were almost twice as likely to have hepatic steatosis as non-IR patients. Among the MS criteria, blood pressure was very accurate in identifying the presence of IR (AUROC for systolic blood pressure 0.66, cut-off 125 mm of Hg, sensibility 64%, specif icity 75%; AUROC for diastolic blood pressure 0.70, cut-off 85 mm of Hg, sensibility 54.5%, specif icity 75%). CONCLUSION: As health care costs are skyrocketing, reliable and mainly inexpensive tools are advisable to better defi ne subjects who really need to lose weight. | Giovanni Tarantino Genoveffa Pizza Annamaria Colao Fabrizio Pasanisi Paolo Conca Patrizia Colicchio Carmine Finelli Franco Contaldo Carolina Di Somma Silvia Savastano | 2009 | World Journal of Gastroenterology2009，15，45： | 4 |
| 3 | Development and evaluation of a virtual campus on Second Life: The case of SecondDMI显示文摘 | Andrea De Lucia Rita Francese Ignazio Passero Genoveffa Tortora | 2008 | Computers & Education2008，，1： | 2 |
| 4 | Multiple giant diverticula of the foregut causing upper gastrointestinal obstruction显示文摘Small bowel diverticulosis represents an uncommon disorder (except for Meckel diverticulum) often misdiagnosed since it causes non-specific gastroin- testinal symptoms. Most of times the diagnosis is carried out in case of related complications, such as diverticulitis, hemorrhage, perforation or obstruction. Intestinal obstruction can be caused by inflammatory stenosis due to repeated episodes of diverticulitis, volvulus, intussusception or jejunal stones. Herein we report a case of multiple jejunal diverticula causing chronic gastrointestinal obstruction. | Genoveffa Balducci Mario Dente Giulia Cosenza Paolo Mercantini Pier Federico Salvi | 2008 | World Journal of Gastroenterology2008，14，20： | 1 |
| 5 | Bisphenol A in polycystic ovary syndrome and its association with liver–spleen axis显示文摘 | Giovanni Tarantino Rossella Valentino Carolina Di Somma Vittoria D’Esposito Federica Passaretti Genoveffa Pizza Valentina Brancato Francesco Orio Pietro Formisano Annamaria Colao Silvia Savastano | 2013 | Clin Endocrinol2013，，3： | 1 |
| 6 | Malnutrition and pancreatic surgery: Prevalence and outcomes显示文摘 | Marco La Torre Vincenzo Ziparo Giuseppe Nigri Marco Cavallini Genoveffa Balducci Giovanni Ramacciato | 2012 | J Surg Oncol2012，，7： | 1 |
| 7 | Malnutrition and pancreatic surgery: Prevalence and outcomes显示文摘 | Marco La Torre Vincenzo Ziparo Giuseppe Nigri Marco Cavallini Genoveffa Balducci Giovanni Ramacciato | 2012 | J Surg Oncol2012，，7： | 1 |
| 8 | Pseudoachalasia: A peculiar case report and review of the literature显示文摘Pseudoachalasia is a rare secondary achalasia, which accounts for only a small subgroup of patients. We describe a 77-year-old woman with recent onset of dysphagia and typical esophageal manometric findings of achalasia. Moreover, esophageal manometric findings of vascular compression at 36 cm from the nose were associated with dysphagia. An upper endoscopy showed the absence of lesions both in the esophagus and gastro-esophageal junction, whilst a 15-mm ulcer on the gastric angulus was detected. The gastric ulcer resulted in being a diffuse signet ring cell carcinoma at histology, suggesting pseudoachalasia. An abdominal computed tomography scan showed an irregular concentric thickening of the gastro-esophageal junction wall extending for 7 cm and a dilated ascending thoracic aorta with no presence of the inferior vena cava, with an enlarged azygos as the source of vascular compression of esophagus. Moreover, cardia involvement from diffuse signet ring cell carcinoma of the gastric angulus was also recognized as the cause of dysphagia. The cancer was not suitable for a surgical approach in an old patient with cardiovascular comorbidities and support therapy was started. In our ambulatory series, pseudoachalasia was eventually diagnosed in 4.7% of 234 consecutive patients with esophageal manometric finding suggestive of achalasia. We also reviewed cases in the literature and aimed to evaluate the reported causes of pseudoachalasia. | Salvatore Maria Antonio Campo Angelo Zullo Chiara Maria Scandavini Barbara Frezza Paola Cerro Genoveffa Balducci | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，9： | 1 |
| 9 | Hemoperitoneum from a Spontaneous Rupture of a Giant Hemangioma of the Liver: Report of a Case显示文摘 | Nicola Corigliano Paolo Mercantini Pietro Maria Amodio Genoveffa Balducci Salvatore Caterino Giovanni Ramacciato Vincenzo Ziparo | 2003 | Surgery Today2003，，6： | 1 |
| 10 | Superior T memory stem cell persistence supports long-lived T cell memory显示文摘 | Lugli Enrico Dominguez Maria H Gattinoni Luca Chattopadhyay Pratip K Bolton Diane L Song Kaimei Klatt Nichole R Brenchley Jason M Vaccari Monica Gostick Emma Price David A Waldmann Thomas A Restifo Nicholas P Franchini Genoveffa Roederer Ma | 2013 | Journal of Clinical Investigation2013，，2： | 1 |
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