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| 1 | Simultaneous intraductal papillary neoplasms of the bile duct and pancreas treated with chemoradiotherapy显示文摘Some authors have suggested that intraductal papillary mucinous neoplasms of the bile duct(IPMN-B) could be the the biliary counterpart of IPMN of the pancreas(IPMN-P) since they share several clinical-pathological features.These include prominent intraductal papil-lary proliferation pattern,a gastrointestinal phenotype,frequent mucin hyper-secretion and progression to mu-cinous carcinoma.To date there are just four reported cases of patients with synchronous IPMN-B and IPMN-P all of which were treated surgically.We hereby report the case of a 76-year-old woman who was incidentally diagnosed with both an asymptomatic 3 cm bulky uid lesion obstructing the bile duct lumen,diagnosed as a malignant IPMN-B,and synchronous multiple pancreatic cystic lesions(10-13 mm) communicating with an irreg-ular Wirsung,diagnosed as branch duct IPMN-P.Since surgery was ruled-out because of the patient's age and preferences,she underwent a conservative manage-ment regimen comprising both chemotherapy and radio-therapy.This was effective in decreasing the mass size and in resolving subsequent jaundice.This is also the f irst reported case of IPMN-B successfully treated with chemoradiotherapy.Clinicians should consider medical treatment as an option in this clinical scenario,in pa-tients who may be unf it for surgery. | Roberto Valente Gabriele Capurso Paola Pierantognetti Elsa Iannicelli Matteo Piciucchi Adriana Romiti Paolo Mercantini Alberto Larghi Giulia Francesca Federici Viola Barucca Maria Falchetto Osti Emilio Di Giulio Vincenzo Ziparo Gianfranco Delle Fave | 2012 | World Journal of Gastrointestinal Oncology2012，4，2： | 13 |
| 2 | Evidence based medicine and surgical approaches for colon cancer: Evidences, benefits and limitations of the laparoscopic vs open resection显示文摘AIM:To report a meta-analysis of the studies that compared the laparoscopic with the open approach for colon cancer resection.METHODS:Forty-seven manuscripts were reviewed,33 of which employed for meta-analysis according to the PRISMA guidelines.The results were differentiated according to the study design(prospective randomized trials vs case-control series)and according to the tu-mor’s location.Outcome measures included:(1)shortterm results(operating times,blood losses,bowel function recovery,post-operative pain,return to the oral intake,complications and hospital stay);(2)oncological adequateness(number of nodes harvested in the surgical specimens);and(3)long-term results(including the survivals’rates and incidence of incisional hernias)and(4)costs.RESULTS:Meta-analysis of trials provided evidences in support of the laparoscopic procedures for a several short-term outcomes including:a lower blood loss,an earlier recovery of the bowel function,an earlier return to the oral intake,a shorter hospital stay and a lower morbidity rate.Opposite the operating time has been confirmed shorter in open surgery.The same trend has been reported investigating case-control series and cancer by sites,even though there are some concerns regarding the power of the studies in this latter field due to the small number of trials and the small sample of patients enrolled.The two approaches were comparable regarding the mean number of nodes harvested and long-term results,even though these variables were documented reviewing the literature but were not computable for meta-analysis.The analysis of the costs documented lower costs for the open surgery,however just few studies investigated the incidence of postoperative hernias.CONCLUSION:Laparoscopy is superior for the majority of short-term results.Future studies should better differentiate these approaches on the basis of tumors’location and the post-operative hernias. | Laura Lorenzon Marco La Torre Vincenzo Ziparo Francesco Montebelli Paolo Mercantini Genoveffa Balducci Mario Ferri | 2014 | World Journal of Gastroenterology2014，20，13： | 8 |
| 3 | Human papillomavirus does not have a causal role in colorectal carcinogenesis显示文摘AIM: To investigate the presence of human papillomavirus(HPV) DNA along with the integration,the quantification and the expression of the HPV16 in colorectal cancers.METHODS: A prospective series of colorectal tumors were genotyped for HPV DNA.The clinical and pathological variables of the HPV-positive tumors were compared to those of HPV-negative samples.The integration status of HPV16 was evaluated by calculating E2/E6 ng ratios.HPV16-positive tumors were also evaluated for(1) E2,E4,E5,E6 and E7 viral gene ng quantification;(2) relative quantification compared to W12 cells; and(3) viral E2,E4,E5,E6 and E7 mR NA transcripts by real-time polymerase chain reaction.RESULTS: HPV infection was detected in 16.9% of all tumors examined,and HPV16 was the most frequent type detected(63.6% of positive tissues).Notably,the clinical and pathological features of HPV-positive colorectal cancers were not significantly different than those of HPV-negative cancers(χ2 and t-test for all clinical and pathological features of HPV-positive vs HPV-negative colorectal cancers: p ns).HPV16 DNA was present exclusively in episomal form,and the HPV16 E2,E4,E5,E6 and E7 genes were detected in tracenanogram quantities.Furthermore,the HPV16 genes ranged from 10-3 to 10-9 compared to W12 cells at an episomal stage.Although the extractions were validated by housekeeping gene expression,all the HPV16 positive tissues were transcriptionally inactive for the E2,E4,E5,E6 and E7 mR NAs.CONCLUSION: Based on our results,HPV is unlikely involved in colorectal carcinogenesis. | Laura Lorenzon Francesca Mazzetta Emanuela Pilozzi Giordana Uggeri Maria Rosaria Torrisi Mario Ferri Vincenzo Ziparo Deborah French | 2015 | World Journal of Gastroenterology2015，21，1： | 3 |
| 4 | Outcomes for early rectal cancer managed with transanal endoscopic microsurgery显示文摘 | F. Stipa A. Burza G. Lucandri M. Ferri A. Pigazzi V. Ziparo G. Casula S. Stipa | 2006 | Surgical Endoscopy2006，，4： | 2 |
| 5 | Acute abdomen: Rare and unusual presentation of right colic xanthogranulomatosis显示文摘Xanthogranulomatous inflammation(XGI)is a disease of unknown origin,most frequently described in the kidney and gallbladder;its localization in the colorectal tract is extremely rare.The extension of the typical inflammatory process to the surrounding tissues may lead to misdiagnosis as cancer.We report the case of a 56-year-old woman presenting to the Emergency Department with pain,increased levels ofα1 andα2proteins and C-reactive protein(17.5 mg/dL;normal value 0-0.5),and a palpable mass,localized in the right lower quadrant of the abdomen.A computed tomography scan showed a large right cecal mass with necrotic areas,local inflammation of retroperitoneal fat,and enlargement of local lymph nodes.Because of the high suspicion of colic abscess as well as malignancy and worsening of the clinical condition,the patient underwent right colectomy after 4 d of antibiotic treatment.Pathology revealed xanthogranulomatous inflammation involving the ileocecal valve.We review the reports of large bowel tract XGI in the international literature. | Paola Addario Chieco Laura Antolino Valentina Giaccaglia Francesca Centanini Gaetano Vincenzo Cunsolo Alessandra Sparagna Stefania Uccini Vincenzo Ziparo | 2014 | World Journal of Gastroenterology2014，20，26： | 2 |
| 6 | Enteroscopy in children and adults with inflammatory bowel disease显示文摘Inflammatory bowel disease(IBD)includes Crohn’s disease(CD),ulcerative colitis and unclassified entities.CD commonly involves the terminal ileum and colon but at the time of diagnosis it can be confined to the small bowel(SB)in about 30%of the patients,especially in the young ones.Management of isolated SB-CD can be challenging and objective evaluation of the SB mucosa is essential in differentiating CD from other enteropathies to achieve therapeutic decisions and to plan the follow-up.The introduction of cross-sectional imaging techniques and capsule endoscopy(CE)have significantly expanded the ability to diagnose SB diseases providing a non-invasive test for the visualization of the entire SB mucosa.The main CE limitations are the low specificity,the lack of therapeutic capabilities and the impossibility to take biopsies.Device assisted enteroscopy(DAE)enables histological confirmation when traditional endoscopy,capsule endoscopy and cross-sectional imaging are inconclusive and also allows therapeutic interventions such as balloon stricture dilation,intralesional steroid injection,capsule retrieval and more recently stent insertion.In the current review we will discuss technical aspect,indications and safety profile of DAE in children and adults with IBD. | Giovanni Di Nardo Gianluca Esposito Chiara Ziparo Federica Micheli Luigi Masoni Maria Pia Villa PasqualeParisi Maria Beatrice Manca Flavia Baccini Vito Domenico Corleto | 2020 | World Journal of Gastroenterology2020，26，39： | 2 |
| 7 | CDX1 expression is reduced in colorectal carcinoma and is associated with promoter hypermethylation显示文摘 | Pilozzi E Onelli MR Ziparo V | 2004 | J Pathol2004，204，3： | 1 |
| 8 | Toll‐like receptors in prostate infection and cancer between bench and bedside显示文摘 | Guido Gambara Paola Cesaris Cosimo Nunzio Elio Ziparo Andrea Tubaro Antonio Filippini Anna Riccioli | 2013 | J Cell Mol Med2013，，6： | 1 |
| 9 | Local excision of rectal tumors显示文摘 | Stipa F Ziparo V Casula G | 2002 | Chir Ital2002，54，： | 1 |
| 10 | CDXI expression is reduced in colorectal carcinoma and is associated with promoter hypermethyla- tion 显示文摘 | Pilozzi E Onelli MR Ziparo V | 2004 | JPathol2004，204，3： | 1 |
| 11 | Free peritoneal tumor cells detection in gastric and colorectal cancer patients显示文摘 | Simone Rossi Del Monte Danilo Ranieri Francesca Mazzetta Andrea Kazemi Nava Salvatore Raffa Maria Rosaria Torrisi Vincenzo Ziparo | 2012 | J Surg Oncol2012，，1： | 1 |
| 12 | Morphological characteristics of male germ cells of rats in contact with Sertoli cells in vitro显示文摘 | Palombi F Ziparo E Rommerts FF | 1979 | J Reprod Ferlil1979，57，2： | 1 |
| 13 | Malnutrition and pancreatic surgery: prevalence and outcomes显示文摘 | La Torre M Ziparo V Nigri G | 2013 | J Surg Oneol2013，107，7： | 1 |
| 14 | Malnutrition and pancreatic surgery: Prevalence and outcomes显示文摘 | Marco La Torre Vincenzo Ziparo Giuseppe Nigri Marco Cavallini Genoveffa Balducci Giovanni Ramacciato | 2012 | J Surg Oncol2012，，7： | 1 |
| 15 | Malnutrition and pancreatic surgery: Prevalence and outcomes显示文摘 | Marco La Torre Vincenzo Ziparo Giuseppe Nigri Marco Cavallini Genoveffa Balducci Giovanni Ramacciato | 2012 | J Surg Oncol2012，，7： | 1 |
| 16 | Free peritoneal tumor cells detection in gastric and colorectal cancer patients显示文摘 | Simone Rossi Del Monte Danilo Ranieri Francesca Mazzetta Andrea Kazemi Nava Salvatore Raffa Maria Rosaria Torrisi Vincenzo Ziparo | 2012 | J. Surg. Oncol2012，，1： | 1 |
| 17 | The Glasgow Prognostic Score as a Predictor of Survival in Patients with Potentially Resectable Pancreatic Adenocarcinoma显示文摘 | Marco La Torre Giuseppe Nigri Marco Cavallini Paolo Mercantini Vincenzo Ziparo Giovanni Ramacciato | 2012 | Annals of Surgical Oncology2012，，9： | 1 |
| 18 | Indications and results of resection for hepatocellular carcinoma显示文摘 | Ziparo V Balducci G Lucandri G | 2002 | Eur J Surg Oncol2002，28，7： | 1 |
| 19 | Local excision of rectal tumors显示文摘 | Stipa F Ziparo V Casula G | 2002 | Chir Ital2002，54，3： | 1 |
| 20 | Number of harvested lymph nodes is the main prognostic factor in Stage IIa colorectal cancer patients显示文摘 | Marco La Torre Laura Lorenzon Emanuela Pilozzi Viola Barucca Marco Cavallini Vincenzo Ziparo Mario Ferri | 2012 | J Surg Oncol2012，，4： | 1 |
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