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| 1 | Hepatic steatosis in overweight/obese females: New screening method for those at risk显示文摘AIM: To identify which parameters could help to distinguish the 'metabolically benign obesity', which is not accompanied by insulin resistance (IR) and early atherosclerosis.METHODS: Eighty two of 124 overweight/obese females formed the study population, which was divided into two groups (52 and 30 subjects, respectively) with and without IR according to a HO meostatic Metabolic Assessment (HOMA) cut-off of 2, and were studied in a cross-sectional manner. The main outcome measures were waist circumference, serum uric acid, high-density lipoprotein-cholesterol and triglycerides, alanine amino-transferase, blood pressure and the two imaging para-meters, hepatic steatosis and longitudinal diameter of the spleen, which were measured in relation to the presence/absence of IR. RESULTS: A variable grade of visceral obesity was observed in all subjects with the exception of three.Obesity of a severe grade was represented more in the group of IR individuals (P = 0.01). Hepatic steatosis, revealed at ultrasound, was more pronounced in IR than in non-IR subjects (P = 0.005). The two groups also demonstrated a clear difference in longitudinal spleen diameter and blood pressure, with raised and signif icant values in the IR group. Metabolic syndrome was frequent in the IR group, and was not modified when adjusted for menopause (P = 0.001). At linear regression, the β values of waist circumference and body mass index predicting HOMA were 0.295, P = 0.007 and 0.41, P = 0.0001, respectively. Measures of spleen longitudinal diameter were well predicted by body mass index (BMI) values, β = 0.35, P = 0.01, and by HOMA, β = 0.41, P = 0.0001. Blood pressure was predicted by HOMA values, β = 0.39, P = 0.0001). HOMA and hepatic steatosis were highly associated (rho = 0.34, P = 0.002). Interestingly, IR patients were almost twice as likely to have hepatic steatosis as non-IR patients. Among the MS criteria, blood pressure was very accurate in identifying the presence of IR (AUROC for systolic blood pressure 0.66, cut-off 125 mm of Hg, sensibility 64%, specif icity 75%; AUROC for diastolic blood pressure 0.70, cut-off 85 mm of Hg, sensibility 54.5%, specif icity 75%). CONCLUSION: As health care costs are skyrocketing, reliable and mainly inexpensive tools are advisable to better defi ne subjects who really need to lose weight. | Giovanni Tarantino Genoveffa Pizza Annamaria Colao Fabrizio Pasanisi Paolo Conca Patrizia Colicchio Carmine Finelli Franco Contaldo Carolina Di Somma Silvia Savastano | 2009 | World Journal of Gastroenterology2009，15，45： | 4 |
| 2 | Investigation of compensatory postures with videofluoromanometry in dysphagia patients显示文摘AIM: To investigate the effectiveness of head compensatory postures to ensure safe oropharyngeal transit. METHODS: A total of 321 dysphagia patients were enrolled and assessed with videofluoromanometry (VFM). The dysphagia patients were classified as follows: safe transit; penetration without aspiration; aspiration before, during or after swallowing; multiple aspirations and no transit. The patients with aspiration or no transit were tested with VFM to determine whether compensatory postures could correct their swallowing disorder. RESULTS: VFM revealed penetration without aspiration in 71 patients (22.1%); aspiration before swallowing in 17 patients (5.3%); aspiration during swallowing in 32 patients (10%); aspiration after swallowing in 21 patients (6.5%); multiple aspirations in six patients (1.9%); no transit in five patients (1.6%); and safe transit in 169 patients (52.6%). Compensatory postures guaranteed a safe transit in 66/75 (88%) patients with aspiration or no transit. A chin-down posture achieved a safe swallow in 42/75 (56%) patients, a head-turned posture in 19/75 (25.3%) and a hyperextended head posture in 5/75 (6.7%). The compensatory postures were not effective in 9/75 (12%) cases. CONCLUSION: VFM allows the speech-language therapist to choose the most effective compensatory posture without a trial-and-error process and check the effectiveness of the posture. | Antonio Solazzo Luigi Monaco Lucia Del Vecchio Stefania Tamburrini Francesca Iacobellis Daniela Berritto Nunzia Luisa Pizza Alfonso Reginelli Natale Di Martino Roberto Grassi | 2012 | World Journal of Gastroenterology2012，18，23： | 3 |
| 3 | Immunotherapy of metas tatic kidney cancer显示文摘 | De Vinci C Lo Conte G | 2001 | Int J Cancer2001，94，1： | 1 |
| 4 | Group I nonreciprocal inhibition in restless legs syndrome secondary to chronic renal failure显示文摘 | Marconi S Seaglione C Pizza F | 2012 | Parkinsonism Relat Disord2012，18，： | 1 |
| 5 | Identification of vaccine candidates against serogroup B meningococcus by whole-genome sequencing显示文摘 | PIZZA M SCARLATO V MASIGNANI V | 2000 | Science2000，287，5459： | 1 |
| 6 | Restless legssyndrome enhances cardiovascular risk and mortality inpatients with end-stage kidney disease undergoing long-termhaemodialysis treatment显示文摘 | LA MANNA G PIZZA F PERSICI E | 2011 | Nephrol Dial Transplant2011，26，6： | 1 |
| 7 | Arbutin-2'-sulphonyl from the infusion of llex theezans leaves 显示文摘 | ANDRADE F D P PIACENTE S PIZZA C | 2004 | Fitoterapia2004，，78： | 1 |
| 8 | High prevalence of precocious puberty and obesity in childhood narcolepsy with cataplexy 显示文摘 | Poli F Pizza F Mignot E | 2013 | Sleep2013，36，2： | 1 |
| 9 | The adjuvants aluminum hydroxide and MF59 induce monocyte and granulocyte chemoattractants and enhance monocyte differentiation toward dendritic cells显示文摘 | SEUBERT A MONACI E PIZZA M | 2008 | J Immunol2008，180，8： | 1 |
| 10 | Inter-hemispheric scissure, a rare location for a traumatic subdural hematoma, case report and review of the literature 显示文摘 | Lamaida E Pizza V | 1997 | Clin Neurol Neurosurg1997，99，2： | 1 |
| 11 | Genetically detoxified mutantsof heat-labile toxin from Escherichia coli are able to act as oral adjuvants 显示文摘 | Douce G Giarmelli V Pizza M | 1999 | Infect Immun1999，67，9： | 1 |
| 12 | High prevalence of precocious puberty and obesity in childhood narcolepsy with cataplexy 显示文摘 | Poli F Pizza F Mignot E | 2013 | Sleep2013，36，2： | 1 |
| 13 | Saponins in alfalfa root and their structural elucidation显示文摘 | Bialy Z Jurzysta M Oleszek W Piacente S Pizza C | 1999 | Agricultural Food Chemistry1999，47，8： | 1 |
| 14 | Arbutin-2-sulphony from the infusion of Ilex theezans leaves显示文摘 | Andrade F D Piacents S Pizza C | 2004 | Fitoterapia2004，75，78： | 1 |
| 15 | Reverse viecinology: a genome- based approach for vaccine development 显示文摘 | Masignani V Rappuoli R Pizza M | 2002 | Expert Opinion on Biological Therapy2002，12，2： | 1 |
| 16 | Dynamics of Premixed Hydrogen/Air Flames in Microchannels 显示文摘 | Pizza G Frouzakis C E Mantzaras J | 2008 | Combust Flame2008，152，： | 1 |
| 17 | Sleep quality and motorvehi-cle crashes in adolescents 显示文摘 | Pizza F Contardi S Antognini AB | 2010 | J Clin Sleep Med2010，6，1： | 1 |
| 18 | High prevalence of preco- cious puberty and obesity in childhood narcolepsy with cata- plexy显示文摘 | Poll F Pizza F Mignot E | 2013 | Sleep2013，36，17： | 1 |
| 19 | Identification of vaccine candidates against serogroup B meningococcus by whole genome sequencing 显示文摘 | Pizza M Scarlato V Masignani V | 2000 | Science2000，287，5459： | 1 |
| 20 | Reverse vaccinology:a genome-based approach for vaccine development显示文摘 | Masignani V Rappuoli R Pizza M | 2002 | Expert Opin Biol Ther2002，2，8： | 1 |
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