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| 1 | The human TTAGGG repeat factors I and 2 bind to a subsetof interstitial telomeric sequences and satellite repeats显示文摘 | Thomas Simonet Laure-Emmanuelle Zaragosi Claude Philippe Kevin Lebrigand Cldmentine Schouteden Adeline Augereau Serge Bauwens Jing Ye Marco Santagostino Elena Giulotto Frederique Magdinier Beatrice Horard Pascal Barbry Rainer Waldmann Eric Gilson | 2011 | Cell Research2011，21，7： | 7 |
| 2 | Modulating effects of acyl-CoA synthetase 5-derived mitochondrial Wnt2B palmitoylation on intestinal Wnt activity显示文摘AIM:To investigate the role of acyl-CoA synthetase 5(ACSL5)activity in Wnt signaling in intestinal surface epithelia.METHODS:Several cell lines were used to investigate the ACSL5-dependent expression and synthesis of Wnt2B,a mitochondrially expressed protein of the Wnt signaling family.Wnt activity was functionally assessed with a luciferase reporter assay.ACSL5-related biochemical Wnt2B modifications were investigatedwith a modified acyl-exchange assay.The findings from the cell culture models were verified using an Apcmin/+mouse model as well as normal and neoplastic diseased human intestinal tissues.RESULTS:In the presence of ACSL5,Wnt2B was unable to translocate into the nucleus and was enriched in mitochondria,which was paralleled by a significant decrease in Wnt activity.ACSL5-dependent S-palmitoylation of Wnt2B was identified as a molecular reason for mitochondrial Wnt2B accumulation.In cell culture systems,a strong relation of ACSL5 expression,Wnt2B palmitoylation,and degree of malignancy were found.Using normal mucosa,the association of ACSL5 and Wnt2B was seen,but in intestinal neoplasias the mechanism was only rudimentarily observed.CONCLUSION:ACSL5 mediates antiproliferative activities via Wnt2B palmitoylation with diminished Wnt activity.The molecular pathway is probably relevant for intestinal homeostasis,overwhelmed by other pathways in carcinogenesis. | Christina Klaus Ursula Schneider Christian Hedberg Anke K Schütz Jürgen Bernhagen Herbert Waldmann Nikolaus Gassler Elke Kaemmerer | 2014 | World Journal of Gastroenterology2014，20，40： | 4 |
| 3 | Feasibility and safety of cryoballoon ablation for atrial fibrillation inpatients with congenital heart disease显示文摘BACKGROUND The prevalence of atrial fibrillation (AF) is on the rise in the aging population with congenital heart disease (CHD). A few case series have described the feasibility and early outcomes associated with radiofrequency catheter ablation of AF centered on electrically isolating pulmonary veins (PV) in patients with CHD. In contrast, cryoballoon ablation has not previously been studied in this patient population despite its theoretical advantages, which include a favorable safety profile and shorter procedural time. AIM To assess the safety and feasibility of cryoballoon ablation for AF in an initial cohort of patients with CHD. METHODS The study population consisted of consecutive patients with CHD and cryoballoon ablation for AF at the Montreal Heart Institute between December 2012 and June 2017. Procedural complications, acute success, and 1-year freedom from recurrent AF after a single procedure with or without antiarrhythmic drugs were assessed. Procedures were performed under conscious sedation. Left atrial access was obtained via a single transseptal puncture or through an existing atrial septal defect (ASD). Cryoballoon occlusion was assessed by distal injection of 50% diluted contrast into the pulmonary vein. At least one 240-second cryothermal application was performed upon obtaining complete pulmonary vein occlusion. Following ablation, patients were routinely followed at outpatient visits at 1, 3, 6, and 12 mo, and then annually. RESULTS Ten patients, median age 57.9 (interquartile range 48.2-61.7) years, 60% female, met inclusion criteria and were followed for 2.8 (interquartile range 1.4-4.5) years.Two had moderately complex CHD (sinus venosus ASD with partial anomalous pulmonary venous return;aortic coarctation with a persistent left superior vena cava), with the remainder having simple defects. AF was paroxysmal in 8 (80.0%) and persistent in 2 (20.0%) patients. The pulmonary vein anatomy was normal in 6 (60.0%) patients. Four had left common PV (n = 3) and/or 3 right PV (n = 2). Electrical pulmonary vein isolation (PVI) was acutely successful in all. One patient had transient phrenic nerve palsy that recovered during the intervention. No major complication occurred. One year after a single ablation procedure, 6 (60%) patients remained free from AF. One patient with recurrent AF had recovered pulmonary vein conduction and underwent a second PVI procedure. A second patient had ablation of an extra-pulmonary vein trigger for AF. CONCLUSION Cryoballoon ablation for AF is feasible and safe in patients with simple and moderate forms of CHD, with an excellent acute success rate and modest 1-year freedom from recurrent AF. | Sylvia Abadir Victor Waldmann Katia Dyrda Mikael Laredo Blandine Mondésert Marc Dubuc Paul Khairy | 2019 | World Journal of Cardiology2019，11，5： | 3 |
| 4 | Enucleation and Limited Pancreatic Resection Provide Long-Term Cure for Insulinoma in Multiple Endocrine Neoplasia Type 1显示文摘 | Bartsch Detlef K Albers Max Knoop Richard Kann Peter H Fendrich Volker Waldmann Jens | 2014 | Neuroendocrinology2014，，4： | 2 |
| 5 | Line-of-sight rate estimation and linearizing control of an imaging seekers in a tactical missile guided by proportional navigation 显示文摘 | WALDMANN J | 2002 | IEEE Tran on Control Systems Technology2002，10，4： | 1 |
| 6 | Human T cell lymphotropic virus type Ⅰ Tax activates IL-15R alpha gene expression through an NF-kappa B site显示文摘 | Mariner JM Lantz V Waldmann TA | 2001 | J Immunol2001，166，4： | 1 |
| 7 | The role of interleu- kin- 15 in inflammation and immune responses to infection: im- plications for its therapeutic use显示文摘 | Perera PY Lichy JH Waldmann TA | 2012 | Microbes Infec2012，14，3： | 1 |
| 8 | Electronic identity cards for user authentication - promise and practice 显示文摘 | Poller A Waldmann U Vowe S | 2012 | IEEE Se- curity & Privacy2012，10，1： | 1 |
| 9 | Activated polyamidoamine dendrimers, a non-viral vector for gene transfer to the corneal endothelium显示文摘 | Hudde T Rayner SA Comer RM Weber M Isaacs JD Waldmann H | 1999 | Gene Ther1999，6，5： | 1 |
| 10 | Effective cancer therapy through immunomodulation 显示文摘 | Waldmann TA | 2006 | Annu Rev Med2006，57，： | 1 |
| 11 | Positive Feedback Investment Strategies and Destabilizing Rational Speculation显示文摘 | De Long Shleifer Summers Waldmann | 1990 | Journal of Finance1990，，45： | 1 |
| 12 | A protongated cation channel involved in acid-sensin显示文摘 | Waldmann R Champigny G Bassilana F | 1997 | Nature1997，386，6621： | 1 |
| 13 | Nuclear import of cJun is mediated by multiple transport receptors 显示文摘 | Waldmann I Walde S Kehlenbach RH | 2007 | J Biol Chem2007，，27： | 1 |
| 14 | The biology of interleukin-2 and interleu- kin-15: implications for cancer therapy and vaccine de- sign显示文摘 | Waldmann TA | 2006 | Nat Rev Immunol2006，，6： | 1 |
| 15 | The DEK protein -an a- bundant and ubiquitous constituent of mammalian chromatin 显示文摘 | Waldmann T Scholten I Kappes F | 2004 | Gene2004，343，1： | 1 |
| 16 | Shear stresses in honeycomb sandwich plates: analytical solution, finite element method and experimental verification 显示文摘 | Wahl L Maas S Waldmann D | 2012 | Journal of Sandwich Structmes & Materials2012，14，： | 1 |
| 17 | Molecular cloning of a non-inactivating proton-gated Na^+ channel specific for sensory neurons显示文摘 | Waldmann R Bassilana F de Weille J | 1997 | J Biol Chem1997，272，20： | 1 |
| 18 | Noise Trader Risk in Financial Market 显示文摘 | De Long J Bradford Andrei Shleifer Lawrence H Summers Robert J Waldmann | 1990 | Journal of Political Economy1990，98，4： | 1 |
| 19 | The IL-2/IL-2 receptor system: a target for rational immune intervention 显示文摘 | Waldmann T A | 1993 | Immunol Today1993，14，5： | 1 |
| 20 | A proton-gated cation channel involved in acid-sensing显示文摘 | Waldmann R Champigny G Bassilana F | 1997 | Nature1997，386，6621： | 1 |
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