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| 1 | Magnetic resonance imaging:A new tool for diagnosis of acute ischemic colitis?显示文摘AIM:To define the evolution of ischemic lesions with 7T magnetic resonance imaging(7T-MRI)in an animal model of acute colonic ischemia.METHODS:Adult Sprague-Dawley rats were divided into two groups.GroupⅠ underwent inferior mesenteric artery(IMA)ligation followed by macroscopic observations and histological analysis.In groupⅡ,7T-MRI was performed before and after IMA ligation and followed by histological analysis.RESULTS:Morphological alterations started to develop 1 h after IMA ligation,when pale areas became evident in the splenic flexure mesentery and progressively worsened up to 8 h thereafter,when the mesentery was less pale,and the splenic flexure loop appeared very dark.The 7T-MRI results reflected these alterations,showing a hyperintense signal in both the intraperitoneal space and the colonic loop wall 1 h after IMA ligation;the latter progressively increased to demonstrate a reduction in the colonic loop lumen at 6 h.Eight hours after IMA ligation,MRI showed a persistent colonic mural hyperintensity associated with a reduction in peritoneal free fluid.The 7T-MRI findings were correlated with histological alterations,varying from an attenuated epithelium with glandular apex lesions at 1 h to coagulative necrosis and loss of the surface epithelium detected 8 h after IMA ligation.CONCLUSION:MRI may be used as a substitute for invasive procedures in diagnosing and grading acute ischemic colitis,allowing for the early identification of pathological findings. | Francesca Iacobellis Daniela Berritto Francesco Somma Carlo Cavaliere Marco Corona Santolo Cozzolino Franco Fulciniti Salvatore Cappabianca Antonio Rotondo Roberto Grassi | 2012 | World Journal of Gastroenterology2012，18，13： | 7 |
| 2 | Hepatic steatosis in overweight/obese females: New screening method for those at risk显示文摘AIM: To identify which parameters could help to distinguish the 'metabolically benign obesity', which is not accompanied by insulin resistance (IR) and early atherosclerosis.METHODS: Eighty two of 124 overweight/obese females formed the study population, which was divided into two groups (52 and 30 subjects, respectively) with and without IR according to a HO meostatic Metabolic Assessment (HOMA) cut-off of 2, and were studied in a cross-sectional manner. The main outcome measures were waist circumference, serum uric acid, high-density lipoprotein-cholesterol and triglycerides, alanine amino-transferase, blood pressure and the two imaging para-meters, hepatic steatosis and longitudinal diameter of the spleen, which were measured in relation to the presence/absence of IR. RESULTS: A variable grade of visceral obesity was observed in all subjects with the exception of three.Obesity of a severe grade was represented more in the group of IR individuals (P = 0.01). Hepatic steatosis, revealed at ultrasound, was more pronounced in IR than in non-IR subjects (P = 0.005). The two groups also demonstrated a clear difference in longitudinal spleen diameter and blood pressure, with raised and signif icant values in the IR group. Metabolic syndrome was frequent in the IR group, and was not modified when adjusted for menopause (P = 0.001). At linear regression, the β values of waist circumference and body mass index predicting HOMA were 0.295, P = 0.007 and 0.41, P = 0.0001, respectively. Measures of spleen longitudinal diameter were well predicted by body mass index (BMI) values, β = 0.35, P = 0.01, and by HOMA, β = 0.41, P = 0.0001. Blood pressure was predicted by HOMA values, β = 0.39, P = 0.0001). HOMA and hepatic steatosis were highly associated (rho = 0.34, P = 0.002). Interestingly, IR patients were almost twice as likely to have hepatic steatosis as non-IR patients. Among the MS criteria, blood pressure was very accurate in identifying the presence of IR (AUROC for systolic blood pressure 0.66, cut-off 125 mm of Hg, sensibility 64%, specif icity 75%; AUROC for diastolic blood pressure 0.70, cut-off 85 mm of Hg, sensibility 54.5%, specif icity 75%). CONCLUSION: As health care costs are skyrocketing, reliable and mainly inexpensive tools are advisable to better defi ne subjects who really need to lose weight. | Giovanni Tarantino Genoveffa Pizza Annamaria Colao Fabrizio Pasanisi Paolo Conca Patrizia Colicchio Carmine Finelli Franco Contaldo Carolina Di Somma Silvia Savastano | 2009 | World Journal of Gastroenterology2009，15，45： | 4 |
| 3 | TCR engagement regulates differential reponsiveness of human memory T cells to FasL (CD95)-mediated apoptosis 显示文摘 | Di Somma M M Somma F Montani M S G | 1999 | J Immunology1999，162，1： | 1 |
| 4 | Does a gender-related effect of growth hormone(GH)replacement exist on cardiovascular risk factors,cardiac morphology,and performance and atherosclerosis?Results of a two-year open,prospective study in young adult men and women with se-vere GH deficiency显示文摘 | Colao A Di Somma C Cuocolo A | 2005 | J Clin Endocrinol Metab2005，90，： | 1 |
| 5 | Kinetic and chemical characterization of thermal decomposition of dicumyl-peroxide in cumene 显示文摘 | Ilaria Di Somma | 2011 | Journal of Hazardous Materials2011，187，13： | 1 |
| 6 | Considerations for earlyacute myocardial infarction rule - out for emergency departmentchest pain patients : the case of copeptin 显示文摘 | Lippi G Plebani M Di Somma S | 2012 | Clin Chem LabMed2012，50，2： | 1 |
| 7 | In-hospital percentage BNP reduction is highly predictive for adveme events in patients admitted for acute heart failure: the Italian RED study显示文摘 | Di Somma S Magrini L Pittoni V | 2010 | Cfit Care2010，14，3： | 1 |
| 8 | PCR identification of durum wheat BAC clones containing genes coding for carotenoid biosynthesis enzymes and their chromosome localization 显示文摘 | Cenci S Somma S Chantret N | 2004 | Genome2004，47，： | 1 |
| 9 | Oxidation of 2,4-dichlorophenol and 3,4-dichlorophenol by means of Fe(Ⅲ)-homogeneous photocatalysis and algal toxicity assessment of the treated solutions显示文摘 | Andreozzi R Somma L D Marotta R | | 0，，05： | 1 |
| 10 | Auditory P3 in antidepres- sant pharmacotherapy treatment responders, non-responders and con- t*ls 显示文摘 | Jaworska De Somma E Blondeau C | 2013 | Eur Neuropsychophatnaeol2013，23，11： | 1 |
| 11 | Additive value to clinical judgement of blood neutrophil gelatinase-associated lipocalin in diagnosis of acute kidney injury and prediction of mortality in patients hospitalized from the emergency department显示文摘 | Di Somma S Magrini L De Berardinis B | 2012 | Critical Care2012，16，1： | 1 |
| 12 | Conservative ap- proach to dental extractions in patients on anticoagulant therapy: A clinical study 显示文摘 | Somma F Grande NM Plotino G | 2010 | Gen Dent2010，58，1： | 1 |
| 13 | Shear strength analysis and prediction for reinforced concrete beams without stirrups显示文摘 | RUSSO G SOMMA G MITRI D | 2005 | Journal of Structural Engineering2005，131，1： | 1 |
| 14 | Short-term effects of growth hormone (GH) treatment or deprivation on cardiovascular risk parametersand intima-media thickness at carotid arteries in patients with severe GHD efficiency显示文摘 | Colao A di Somma C Rot F | 2005 | J Clin Endocrinol Metab2005，90，5： | 1 |
| 15 | Shear strength analysis and prediction for reinforced concrete beams with-out stirrups 显示文摘 | RUSSO G SOMMA G MITRI D | 2005 | Journal of Structural Engineering2005，131，1： | 1 |
| 16 | Randomized phase Ⅱ noncomparative trial of oral and intravenous doxifluridine plus levo-leucovorin in untreated patients with advanced colorectal carcinoma显示文摘 | Bajetta E Di Bartolomeo M Somma L | 1996 | Cancer1996，78，10： | 1 |
| 17 | Growth hormone and the heart显示文摘 | Colao A Marzullo P Di Somma C | 2001 | Clin Endocrinol (Oxf)2001，54，2： | 1 |
| 18 | Ultrasound-guided laser thermal ablation in the treatment of autonomous hyperfunctioning thyroid nodules and compressive nontoxic nodular goiter显示文摘 | Spiezia S Vitale G Di Somma C | | 0，，10： | 1 |
| 19 | Traumatic brain injury and subaraehnoid haemorrhage areeonditions at high risk tbr hypopituitarism: screening study at 3 months after the brain injmy 显示文摘 | Aimaretti G1 Ambrosio MR Di Somma C | 2004 | Clin Endocrinol(Oxf)2004，61，3： | 1 |
| 20 | In-hospital brain natriuretic peptide and N-terminal prohormone brain natriuretic peptide variations are predictors of short-term and long-term outcome in acute decompensated heart failure显示文摘 | Di Somma S Magrini L Ferri E | 2011 | Crit Care2011，15，1： | 1 |
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