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| 1 | Interferon-α response in chronic hepatitis B-transfected HepG2.2.15 cells is partially restored by lamivudine treatment显示文摘AIM: To characterize the IFN-response and its modul- ation by the antiviral compound lamivudine in HBV- transfected HepG2.2.15 cells. METHODS: HepG2.2.15 and HepG2 cells were stimulated with various concentrations of IFN-a2a in the presence or absence of lamivudine. Then, total RNA was extracted and analysed by customised cDNA arrays and northern blot for interferon-inducible genes (ISGs). In addition, cellular proteins were extracted for EMSA and western blot. HBV replication was assessed by southern blot or ELISAs for HBsAg and HBeAg. RESULTS: Two genes (MxA, Cig5) with completely abolished and 4 genes (IFITM1, -2, -3, and 6-16) with partially reduced IFN-responses were identified in HepG2.2.15 cells. In 2 genes (IFITM1, 6-16), the response to IFN-a could be restored by treatment with lamivudine. This effect could not be explained by a direct modulation of the Jak/Stat signalling pathway since EMSA and western blot experiments revealed no suppression of Stat1 activation and ISGF3 formation after stimulation with IFN-a in HepG2.2.15 compared to HepG2 cells. CONCLUSION: These results are consistent with the assumption that chronic hepatitis B may specifically modulate the cellular response to IFN by a selective blockage of some ISGs. Antiviral treatment with lamivudine may partially restore ISG expression by reducing HBV gene expression and replication. | Shi-He Guan Mengji Lu Petra Grünewald Michael Roggendorf Guido Gerken Joerg F Schlaak | 2007 | World Journal of Gastroenterology2007，13，2： | 22 |
| 2 | Gastroenteropancreatic neuroendocrine tumours显示文摘 | Irvin M Modlin Kjell Oberg Daniel C Chung Robert T Jensen Wouter W de Herder Rajesh V Thakker Martyn Caplin Gianfranco Delle Fave Greg A Kaltsas Eric P Krenning Steven F Moss Ola Nilsson Guido Rindi Ramon Salazar Philippe Ruszniewski Anders Sundin | 2008 | Lancet Oncology2008，，1： | 8 |
| 3 | Standardized measurement of the future liver remnant prior to extended liver resection: Methodology and clinical associations显示文摘 | Jean-Nicolas Vauthey Amin Chaoui Kim-Anh Do Malcolm M Bilimoria Marc J Fenstermacher Chuslip Charnsangavej Marshall Hicks Guido Alsfasser Gregory Lauwers Irvin F Hawkins James Caridi | 2000 | Surgery2000，，5： | 2 |
| 4 | Differential diagnosis in patients with suspected bile acid synthesis defects显示文摘AIM: To investigate the clinical presentations associated with bile acid synthesis defects and to describe identification of individual disorders and diagnostic pitfalls. METHODS: We describe semiquantitative determination of 16 urinary bile acid metabolites by electrospray ionization-tandem mass spectrometry. Sample preparation was performed by solid-phase extraction. The total analysis time was 2 min per sample. We determined bile acid metabolites in 363 patients with suspected defects in bile acid metabolism. RESULTS: Abnormal bile acid metabolites were found in 36 patients. Two patients had bile acid synthesis defects but presented with atypical presentations. In 2 other patients who were later shown to be affected by biliary atresia and cystic fibrosis the profile of bile acid metabolites was initially suggestive of a bile acid synthesis defect. Three adult patients suffered from cerebrotendinous xanthomatosis. Nineteen patients had peroxisomal disorders, and 10 patients had cholestatic hepatopathy of other cause. CONCLUSION: Screening for urinary cholanoids should be done in every infant with cholestatic hepatopathy as well as in children with progressive neurological disease to provide specific therapy. | Dorothea Haas Hongying Gan-Schreier Claus-Dieter Langhans Tilman Rohrer Guido Engelmann Maura Heverin David W Russell Peter T Clayton Georg F Hoffmann Jürgen G Okun | 2012 | World Journal of Gastroenterology2012，18，10： | 2 |
| 5 | Clinical,virologic and histologic outcome following seroconversion from HBeAg to anti-HBe in chronic hepatitis type B显示文摘 | Fattovich G Rugge M Brollo L Pontisso P Noventa F Guido M Alberti A Realdi G | 1986 | Hepatology1986，6，2： | 1 |
| 6 | Reciprocal reflection interferometer for a fiber-optic Faraday current sensor显示文摘 | GUIDO F | 1994 | Applied Optics1994，33，25： | 1 |
| 7 | Operational research in the manage- ment of the operating theatre: a survey 显示文摘 | Guerriero F Guido R | 2011 | Health Care Management Science2011，14，1： | 1 |
| 8 | Determination of E-2-nonenal by high-performance liquid chromatography with UV detection assay for the evaluation of beer ageing显示文摘 | Santos J R Carneiro J R Guido L F Almeida P J Rodrigues J A Barros A A | 2003 | J Chromatog A2003，985，12： | 1 |
| 9 | Damage Detection of a Prestressed Concrete Beam Using Modal Strains 显示文摘 | Jtirg F U Anne T Guido D R | 2005 | Journal of Structural Engineering2005，131，9： | 1 |
| 10 | Hypothalamic-pituitary- adrenal axis sensitivity to opioids in women with polycystic ovary syndrome显示文摘 | Ciampelli M Guido M Cucinelli F | 2000 | Fertil Steril2000，73，4： | 1 |
| 11 | Systemic hemodynamic effect of sequential pneumatic compression of the lower limps: a prospective study in health volunteers 显示文摘 | Guido F Michele Z Marco B | 2008 | Journal of Clinical Anesthesia2008，20，5： | 1 |
| 12 | Determination of galacturonic acid content in pectin from fruit juices by liquid chromatographydiode array detection-electrospray ionization tandem mass spectrometry显示文摘 | Moreira M M Guido L F Cruz J M | 2012 | Central European Journal of Chemistry2012，8，6： | 1 |
| 13 | Trace protein,cystain C,2microglobulin,and creatinine compared for detecting impaired glomemlar filtration rates in children显示文摘 | Guido F Friedrich P Nathalie L | 2002 | Clin Chem2002，48，： | 1 |
| 14 | Synthesis of 2-Amino-5- Sulfanyl-1,3,4-Thiadiazole Derivatives and Evaluation of Their Antidepressant and Anxiolytic Activity 显示文摘 | Clerici F Pocar D Guido M | 2001 | J Med Chem2001，44，6： | 1 |
| 15 | Chronic hepatitis B in children after e antigen seroclearance:final report of a 29-year longitudinal study显示文摘 | Bortolotti F Guido M Bartolacci S | | Hepatology0，，： | 1 |
| 16 | Lack of clinical AIDS in SIV-infected sooty mangabeys with significant CD4^sup +^ T cell loss is associated with double-negative T cells显示文摘 | Milush Jeffrey M Mir Kiran D Sundaravaradan Vasudha Gordon Shari N Engram Jessica Cano Christopher A Reeves Jacqueline F Anton Elizabeth O’Neill Eduardo Butler Eboneé Hancock Kathy Cole Kelly S Brenchley Jason M Else James G Silvestri Guido | 2011 | Journal of Clinical Investigation2011，，3： | 1 |
| 17 | Apoptotic, non-apoptotic, and anti-apoptotic pathways of tumor necrosis factor signalling 显示文摘 | Natoli G Costanzo A Guido F | 1998 | Biochem Pharmacol1998，56，8： | 1 |
| 18 | Flexible piezoelectric cantilevers fabricated on polyimide substrate显示文摘 | PETRONI S MARUCCIO G GUIDO F | 2012 | Microelectronic Engineering2012，，： | 1 |
| 19 | β2-Trace protein, cystatin C, β2-Microglobulin, and creatinine compared for detecting impaired glomerular filtration rates in children显示文摘 | Guido F Friedrich P Nathalie L | 2002 | Clin Chem2002，48，5： | 1 |
| 20 | Effects of Matrix Viscoelasticity on Drop Deformation in Dilute Blends Under Slow Shear Flow显示文摘 | S Guido M Simeone F Greco | 2003 | Polymer2003，44，3： | 1 |
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