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| 1 | Effect of nutritional counselling on hepatic,muscle and adipose tissue fat content and distribution in non-alcoholic fatty liver disease显示文摘AIM: To assess the effectiveness of the current UK clinical practice in reducing hepatic fat (IHCL). METHODS: Whole body MRI and 1H MRS were obtained, before and after 6 mo nutritional counselling, from liver, soleus and tibialis muscles in 10 subjects with non-alcoholic fatty liver disease (NAFLD). RESULTS: A 500 Kcal-restricted diet resulted in an average weight loss of 4% (-3.4 kg,) accompanied by significant reductions in most adipose tissue (AT) depots, including subcutaneous (-9.9%), abdominal subcutaneous (-10.2%) and intra-abdominal-AT (-11.4%). Intramyocellular lipids (IMCL) were significantly reduced in the tibialis muscle (-28.2%). Decreases in both IHCL (-39.9%) and soleus IMCL (-12.2%) content were also observed, although these were not significant. Several individuals showed dramatic decreases in IHCL, while others paradoxically showed increases in IHCL content. Changes in body composition were accompanied by improvements in certain liver function tests: serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT). Significant correlations were found between decreases in IHCL and reductions in both intra-abdominal and abdominal subcutaneous AT. Improvements in liver function tests were associated with reductions in intra-abdominal AT, but not with changes in IHCL. CONCLUSION: This study shows that even a very modest reduction in body weight achieved through lifestyle modification can result in changes in body fat depots and improvements in LFTs. | E Louise Thomas Audrey E Brynes Gavin Hamilton Nayna Patel Adam Spong Robert D Goldin Gary Frost Jimmy D Bell Simon D Taylor-Robinson | 2006 | World Journal of Gastroenterology2006，12，36： | 13 |
| 2 | Oral immune regulation using colitis extracted proteins for treatment of Crohn's disease: Results of a phase Ⅰ clinical trial显示文摘AIM: To evaluate safety and possible efficacy of induction of oral immune regulation using colitis extracted proteins(CEP) in Crohn's disease (CD) subjects.METHODS: Ten CDs were treated orally with autologous CEP thrice weekly for 16 wk. Subjects were monitored for CDAI and IBDQ. Immune modulatory effect was assessed by T-lymphocyte FACS analysis, CEP-specific IFNγ ELISPOT assay and cytokine levels.RESULTS: Induction of oral immune regulation significantly ameliorated disease activity. All (10/10) subjects had clinical response (CDAI≤70) and 7/10 achieved clinical remission (CDAI≤150). Significant increase in mean IBDQ score was noted (134±9vs 164±12). No treatment-related adverse events were noted. High levels of CEP-specific IFNγ spot forming colonies were detected in five subjects prior to treatment and in all five, a marked decrease was observed. The CD4+/CDS+ lymphocyte ratio and peripheral NKT cell numbers increased significantly, in 7/10 and in 5/10 subjects, respectively. Significant increase in serum IL-10 and IL-4 levels was observed in 7/10 subjects during treatment period.CONCLUSION: Immune regulation via oral administration of CEP is a safe and possibly effective treatment for subjects with moderate CD and may provide means of antigen-specific immune modulation. | Eran Israeli Eran Goldin Oren Shibolet Athalia Klein Nilla Hemed Dean Engelhardt Elazar Rabbani Yaron Ilan | 2005 | World Journal of Gastroenterology2005，11，20： | 8 |
| 3 | Hepatic steatosis and fibrosis: Non-invasive assessment显示文摘Chronic liver disease is a major cause of morbidity and mortality worldwide and usually develops over many years, as a result of chronic inflammation and scarring, resulting in end-stage liver disease and its complications. The progression of disease is characterised by ongoing inflammation and consequent fibrosis, although hepatic steatosis is increasingly being recognised as an important pathological feature of disease, rather than being simply an innocent bystander. However, the current gold standard method of quantifying and staging liver disease, histological analysis by liver biopsy, has several limitations and can have associated morbidity and even mortality. Therefore, there is a clear need for safe and noninvasive assessment modalities to determine hepatic steatosis, inflammation and fibrosis. This review covers key mechanisms and the importance of fibrosis and steatosis in the progression of liver disease. We address non-invasive imaging and blood biomarker assessments that can be used as an alternative to information gained on liver biopsy. | Rustam N Karanjia Mary ME Crossey I Jane Cox Haddy KS Fye Ramou Njie Robert D Goldin Simon D Taylor-Robinson | 2016 | World Journal of Gastroenterology2016，22，45： | 6 |
| 4 | Advanced Glycation End Products: Sparking the Development of Diabetic Vascular Injury显示文摘 | Alison Goldin Joshua A. Beckman Ann Marie Schmidt Mark A. Creager | 2006 | Circulation2006，，6： | 5 |
| 5 | Oral mixture of autologous colon-extracted proteins for the Crohn's disease: A double-blind trial显示文摘AIM: To evaluate the safety and efficacy of oral administration of AlequelTM, an autologous proteincontaining colon extract.a randomized,placebo-controlled,double-blind trial.Patients were orally administered with autologous protein-containing colon extract three doses of autologous study drug per week for 15 wk,for a total of45 doses.Patients were followed for safety parameters.Remission was defined as a Crohn’s disease activity index(CDAI)score of less than or equal to 150.All patients were followed for changes in subsets of T cells by fluorescence-activated cell sorting analysis.RESULTS:Analysis was performed on a total number of evaluable patients of 14 in the study drug group and15 in the placebo group.Treatment was well tolerated by all patients.No major treatment-related adverse events were reported or observed in any of the treated patients during the feeding or follow-up periods.Between weeks 6 and 9 of the study,six of the 14(43%)evaluable subjects who received the study drug achieved a CDAI of 150 or lower.In contrast,five of the 15(33%)evaluable subjects in the placebo group achieved remission.Between weeks 9 and 12,the remission rates were 50%and 33%for the drug group and placebo group,respectively.Among the drug-treated subjects who achieved remission,the effect of the drug was judged as stable in eight of the 14 subjects as measured by at least two CDAI scores indicating remission in the 15-wk treatment period.A decreased percentage of peripheral natural killer T regulatory cells(a decrease of 28%vs an increase of 16%)and an increased ratio of CD4+/CD8+T lymphocytes(an increase of 11%vs a decrease of9%)were noted in subjects with a significant clinical response.CONCLUSION:Oral administration of the autologous colonic extract could be a safe and effective for the treatment of patients with moderate to severe Crohn’s disease. | Eran Israeli Ehud Zigmond Gadi Lalazar Athalia Klein Nilla Hemed Eran Goldin Yaron Ilan | 2015 | World Journal of Gastroenterology2015，21，18： | 3 |
| 6 | The tumour biology of synchronous and metachronous colorectal liver metastases: a systematic review显示文摘 | A. A. P. Slesser P. Georgiou G. Brown S. Mudan R. Goldin P. Tekkis | 2013 | Clinical & Experimental Metastasis2013，，4： | 2 |
| 7 | A prospective study assessing the efficacy of abdominal computed tomography scan without bowel preparation in diagnosing intestinal wall and luminal lesions in patients presenting to the emergency room with abdominal complaints显示文摘AIM: To evaluate the positive predictive value of abdominal non-prepared computed tomography (CT) for diagnosing intestinal lumen or wall lesions in patients presenting to the emergency room (ER) with abdominal complaints.METHODS: For 1-year we prospectively evaluated all ER patients hospitalized after abdominal CT scan detected either intraluminal or intestinal wall lesions. These patients underwent colonoscopy serving as gold standard. Patients with prior abdominal pathology or CT findings of appendicitis or diverticulitis were excluded.RESULTS: Five hundred and sixty-eight abdominopelvic CT scans were performed in the ER, 96 had positive colonic findings. Sixty-two patients were excluded, 46 because of diverticulitis or appendicitis, 16 because of prior abdominal pathology. Of the remaining 34 patients, 14 did not undergo colonoscopy during hospitalization.Twenty eligible patients were included in the study. The positive predictive value of the CT scans performed in the ER was calculated to be 45% (95% CI 25-67).CONCLUSION: CT findings correlated with colonoscopic findings only in approximately half of the cases. Relying on non-prepared CT scan findings in planning patient management and colonoscopy may lead to unnecessary diagnostic work-ups. | Michal Mizrahi Yoav Mintz Avraham Rivkind David Kisselgoff Eugene Libson Mayer Brezis Eran Goldin Oren Shibolet | 2005 | World Journal of Gastroenterology2005，11，13： | 2 |
| 8 | The relationship of in vivo 31 P MR spectroscopy to histology in chronic hepatitis C显示文摘 | Adrian K.P. Lim Nayna Patel Gavin Hamilton Joseph V. Hajnal Robert D. Goldin Simon D. Taylor-Robinson | 2003 | Hepatology2003，，4： | 2 |
| 9 | The role of epithelial mesenchymal transition and resistance to neoadjuvant therapy in locally advanced rectal cancer显示文摘 | A. Bhangu G. Wood G. Brown A. Darzi P. Tekkis R. Goldin | 2014 | Colorectal Dis2014，，4： | 2 |
| 10 | Those Who Don’t Know Speak: translations of the Daode jing by people who do not know Chinese显示文摘 | Paul R. Goldin | 2002 | Asian Philosophy2002，，3： | 2 |
| 11 | Histological outcome during long-term lamivudine therapy显示文摘 | Jules L. Dienstag Robert D. Goldin E.Jenny Heathcote H.W.L. Hann Mary Woessner Sally L. Stephenson Stephen Gardner D.Fraser Gray Eugene R. Schiff | 2003 | Gastroenterology2003，，： | 2 |
| 12 | The epidemiology, pathogenesis and histopathology of fatty liver disease显示文摘 | Adam P Levene Robert D Goldin | 2012 | Histopathology2012，，2： | 2 |
| 13 | Histological outcome during long-term lamivudine therapy显示文摘 | Dienstag JL Goldin RD Heathcote EJ | | 0，，： | 2 |
| 14 | Representations, Learning, and Problem Solving in Mathematics 显示文摘 | Goldin G A | 1998 | Journal of Mathematical Behavior1998，17，2： | 1 |
| 15 | Evaluating Software Reuse hltematives: A Model and Its Application to an Industrial Case Study显示文摘 | Tomer h Goldin L Kuflik | 2004 | IEEE Transactions on Software Engineering2004，，9： | 1 |
| 16 | Soybean phytoestrogen intake and cancer risk显示文摘 | Adlercreutz CHT Goldin BR Gorbach SL | 1995 | J Nutr1995，125，： | 1 |
| 17 | Optimal ascertainment strategies to detect linkage to common disease alleles显示文摘 | Badner J A Gershon E S Goldin L R | 1998 | Am J Hum Genet1998，63，3： | 1 |
| 18 | Accuracy of PET/CT in characterization of solitary pulmonary lesions 显示文摘 | Kim SK Allen-Auerbach M Goldin J | 2007 | J NuclMed2007，48，： | 1 |
| 19 | Affective Pathways and Representations in Mathematical Problem Solving 显示文摘 | Goldin G A | 2000 | Mathematical Thinking and Learning2000，17，： | 1 |
| 20 | The use of whole exome sequencing to identify rare susceptibility variants in cancer prone families显示文摘 | Goldin LR Yang XR McMaster ML | 2010 | Genetic epidemiology2010，34，8： | 1 |
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