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| 1 | Appendiceal mucocoeles and pseudomyxoma peritonei显示文摘Mucocoele of the appendix occurs when obstruction of the appendiceal lumen results in mucus accumulation and consequent abnormal dilatation. The most impor- tant aetiology, from a surgical perspective, is either mucinous cystadenoma or cystadenocarcinoma. In the latter, a spontaneous or iatrogenic rupture of the mucocoele can lead to mucinous intraperitoneal ascites, a syndrome known as pseudomyxoma peritonei. Optimal management of mucoceles is achieved through accurate preoperative identification and subsequent careful resection. We report two cases and subsequently discuss the clinical presentation of mucocoeles, their association with pseudomyxoma peritonei and an optimal management of both conditions. | Anupam Dixit John HP Robertson Satvinder S Mudan Charles Akle | 2007 | World Journal of Gastroenterology2007，13，16： | 14 |
| 2 | Surrogate production of genome-edited sperm from a different subfamily by spermatogonial stem cell transplantation显示文摘The surrogate reproduction technique,such as inter-specific spermatogonial stem cells(SSCs)transplantation(SSCT),provides a powerful tool for production of gametes derived from endangered species or those with desirable traits.However,generation of genome-edited gametes from a different species or production of gametes from a phylogenetically distant species such as from a different subfamily,by SSCT,has not succeeded.Here,using two small cyprinid fishes from different subfamilies,Chinese rare minnow(gobiocypris rarus,for brief:Gr)and zebrafish(danio rerio),we successfully obtained Gr-derived genome-edited sperm in zebrafish by an optimized SSCT procedure.The transplanted Gr SSCs supported the host gonadal development and underwent normal spermatogenesis,resulting in a reconstructed fertile testis containing Gr spermatids and zebrafish testicular somatic cells.Interestingly,the surrogate spermatozoa resembled those of host zebrafish but not donor Gr in morphology and swimming behavior.When pou5f3 and chd knockout Gr SSCs were transplanted,Gr-derived genome-edited sperm was successfully produced in zebrafish.This is the first report demonstrating surrogate production of gametes from a different subfamily by SSCT,and surrogate production of genome-edited gametes from another species as well.This method is feasible to be applied to future breeding of commercial fish and livestock. | Fenghua Zhang Yongkang Hao Xianmei Li Yi Li Ding Ye Ru Zhang Xiaosi Wang Mudan He Houpeng Wang Zuoyan Zhu Yonghua Sun | 2022 | Science China(Life Sciences)2022，65，5： | 7 |
| 3 | Immune signature profiling identified prognostic factors for gastric cancer显示文摘Objective: Tumor microenvironment, especially the host immune system, plays a pivotal role in tumor initiation and progression. Profiling of immune signature within tumor might uncover biomarkers for targeted therapies and clinical outcomes. However, systematic analysis of immune-related genes in gastric cancer(GC) has not been reported.Methods: Expressions of a total of 718 immune-related genes were generated in 372 stomach adenocarcinoma(STAD) patients from The Cancer Genome Atlas(TCGA) database using RNA-sequencing data. Integrated bioinformatics analyses were performed to identify prognostic factors as well.Results: Survival analyses revealed 73 genes, which were significantly associated with patient’s overall survival(OS). Taken together with clinicopathological parameters, we established a predictive model, containing 10 immune-related genes, which were NRP1, C6, CXCR4, LBP, PNMA1, TLR5, ITGA6, MICB, PBK and TNFRSF18,with powerful efficiency in distinguishing satisfactory or poor survival of STAD patients. Moreover, the top 3 ranked prognostic genes, NRP1, TGFβ2 and MFGE8, were also significantly associated with patient’s OS by an independent validation achieved from Kaplan-Meier plotter database.Conclusions: We profiled prognostic immune signature and established prognostic predictive model for GC,which could reflect immune disorders within tumor microenvironment, and also may provide novel predictive and therapeutic targets for GC patients in the near future. | Wenhui Yang Zhiyong Lai Yuan Li Jianbing Mu Mudan Yang Jun Xie Jun Xu | 2019 | Chinese Journal of Cancer Research2019，31，3： | 5 |
| 4 | Two Hundred Gastrointestinal Stromal Tumors: Recurrence Patterns and Prognostic Factors for Survival显示文摘 | Ronald P. DeMatteo Jonathan J. Lewis Denis Leung Satvinder S. Mudan James M. Woodruff Murray F. Brennan | 2000 | Annals of Surgery2000，，1： | 4 |
| 5 | The tumour biology of synchronous and metachronous colorectal liver metastases: a systematic review显示文摘 | A. A. P. Slesser P. Georgiou G. Brown S. Mudan R. Goldin P. Tekkis | 2013 | Clinical & Experimental Metastasis2013，，4： | 2 |
| 6 | Two Hundred Gastrointestinal Stromal Tumors: Recurrence Patterns and Prognostic Factors for Survival显示文摘 | Ronald P. DeMatteo Jonathan J. Lewis Denis Leung Satvinder S. Mudan James M. Woodruff Murray F. Brennan | 2000 | Annals of Surgery2000，，1： | 2 |
| 7 | Liver regeneration: mechanisms, mysteriesandmore 显示文摘 | Khan AZ Mudan SS | 2007 | ANZJ Surg2007，77，12： | 1 |
| 8 | Preparation of AZO/acrylic resin transparent insulation coating 显示文摘 | Chen Yong Wang Mudan Xu Hui | 2012 | Adv Mater Res2012，，： | 1 |
| 9 | Unusual presentation of metastatic adenocarcinoma显示文摘 | Cook G Mudan S | 2007 | World J Surg 0ncol2007，18，5： | 1 |
| 10 | Salvage surgery for patients with recurrent gastrointestinal sarcoma:pronostic factors to guide patient selection显示文摘 | Mudan S S Conlon K C Woodruff J M | 2000 | Cancer2000，88，1： | 1 |
| 11 | Salvage surgery for patients with recurrent gastrointestinal sarcoma: Pronostic factors to guide patient selection显示文摘 | Mudan SS Conlon KC Woodruff JM | 2000 | Cancer2000，88，1： | 1 |
| 12 | Dissecting the stress activating signaling pathways in acute pancreatitis 显示文摘 | GIAKOUSTIDIS A MUDAN S S GIAKOUSTIDIS D | 2010 | Hepa- togastroenterology2010，57，99100： | 1 |
| 13 | Dissecting the stress ac-tivating signaling pathways in acute pancreatitis显示文摘 | Giakoustidis A Mudan SS Giakoustidis D | 2010 | Hepatogastro-enterology2010，57，99100： | 1 |
| 14 | Geometric view factors for thermal radiation hazard assessment显示文摘 | MUDAN K S | 1987 | Fire Safety Journal1987，12，2： | 1 |
| 15 | Unusual presentation of me tastatic adenocarcinoma显示文摘 | Bagwan IN Cook G Mudan S | 2007 | World J Surg Oncol2007，18，5： | 1 |
| 16 | Thermal radiation hazards from hydrocarbon pool fires显示文摘 | MUDAN K S | 1984 | Progress in Energy and Combustion Science1984，10，1： | 1 |
| 17 | Calculating impacts for large open hydrocarbon fires显示文摘 | CROCE P A MUDAN K S | 1986 | Fire Safety Journal1986，11，12： | 1 |
| 18 | Pancreaticoduodenectomy for advanced gastric cancer显示文摘 | Saka M Mudan SS Katai H | 2005 | Gastric Cancer2005，8，1： | 1 |
| 19 | Liquid and gas discharge rates through holes in process vessels显示文摘 | Woodward J L Mudan K S | 1991 | Journal of Loss Prevention in the Process Industries1991，4，3： | 1 |
| 20 | Salvage surgery for patients with recurrent gastrointestinal sarcoma: prognostic factors to guide patient selection显示文摘 | Mudan SS Conlon KC Woodruff JM | 2000 | Cancer2000，88，1： | 1 |
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