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| 1 | Spinal cord injury in the setting of traumatic thoracolumbar fracture is not reliably associated with increased risk of associated intra-abdominal injury following blunt trauma:An analysis of a National Trauma Registry database显示文摘Purpose:There is a common opinion that spinal fractures usually reflect the substantial impact of injuries and therefore may be used as a marker of significant associated injuries,specifically for intra-abdominal injury(IAI).The impact of concomitant spinal cord injury(SCI)with the risk of associated IAI has not been well clarified.The aim of this study was to evaluate the incidence and severity of IAIs in patients suffering from spinal fractures with or without SCI.Methods:A retrospective cohort study using the Israeli National Trauma Registry was conducted.Patients with thoracic,lumbar and thoracolumbar fractures resulting from blunt mechanisms of injury from January 1,1997 to December 31,2018 were examined,comparing the incidence,severity and mortality of IAIs in patients with or without SCI.The collected variables included age,gender,mechanism of injury,incidence and severity of the concomitant IAIs and pelvic fractures,abbreviated injury scale,injury severity score,and mortality.Statistical analysis was performed using GraphPad InStat?Version 3.10,with Chi-square test for independence and two sided Fisher’s exact probability test.Results:Review of the Israeli National Trauma Database revealed a total of 16,878 patients with spinal fractures.Combined thoracic and lumbar fractures were observed in 1272 patients(7.5%),isolated thoracic fractures in 4967 patients(29.4%)and isolated lumbar fractures in 10,639 patients(63.0%).The incidence of concomitant SCI was found in 4.95%(63/1272),7.65%(380/4967)and 2.50%(266/10639)of these patients,respectively.The overall mortality was 2.5%,proving higher among isolated thoracic fracture patient than among isolated lumbar fracture counterparts(11.3%vs.4.6%,p<0.001).Isolated thoracic fractures with SCI were significantly more likely to die than non-SCI counterparts(8.2%vs.3.1%,p<0.001).There were no differences in the incidence of IAIs between patients with or without SCI following thoracolumbar fractures overall or in isolated thoracic fractures;although isolated lumbar fractures patients with SCI were more likely to have renal(3.4%vs.1.6%,p=0.02)or bowel injuries(2.3%vs.1.0%,p=0.04)than the non-SCI counterparts.Conclusion:SCI in the setting of thoracolumbar fracture does not appear to be a marker for associated IAI.However,in a subset of isolated lumbar fractures,SCI patient is associated with increased risks for renal and bowel injury. | Veacheslav Zilbermints Yehuda Hershkovitz Kobi Peleg Joseph J.Dubose Adi Givon David Aranovich Mickey Dudkiewicz Israeli Trauma Group Boris Kessel | 2021 | Chinese Journal of Traumatology2021，24，3： | 9 |
| 2 | Oral immune regulation using colitis extracted proteins for treatment of Crohn's disease: Results of a phase Ⅰ clinical trial显示文摘AIM: To evaluate safety and possible efficacy of induction of oral immune regulation using colitis extracted proteins(CEP) in Crohn's disease (CD) subjects.METHODS: Ten CDs were treated orally with autologous CEP thrice weekly for 16 wk. Subjects were monitored for CDAI and IBDQ. Immune modulatory effect was assessed by T-lymphocyte FACS analysis, CEP-specific IFNγ ELISPOT assay and cytokine levels.RESULTS: Induction of oral immune regulation significantly ameliorated disease activity. All (10/10) subjects had clinical response (CDAI≤70) and 7/10 achieved clinical remission (CDAI≤150). Significant increase in mean IBDQ score was noted (134±9vs 164±12). No treatment-related adverse events were noted. High levels of CEP-specific IFNγ spot forming colonies were detected in five subjects prior to treatment and in all five, a marked decrease was observed. The CD4+/CDS+ lymphocyte ratio and peripheral NKT cell numbers increased significantly, in 7/10 and in 5/10 subjects, respectively. Significant increase in serum IL-10 and IL-4 levels was observed in 7/10 subjects during treatment period.CONCLUSION: Immune regulation via oral administration of CEP is a safe and possibly effective treatment for subjects with moderate CD and may provide means of antigen-specific immune modulation. | Eran Israeli Eran Goldin Oren Shibolet Athalia Klein Nilla Hemed Dean Engelhardt Elazar Rabbani Yaron Ilan | 2005 | World Journal of Gastroenterology2005，11，20： | 8 |
| 3 | Analysis of incidence of traumatic brain injury in blunt trauma patients with Glasgow Coma Scale of 12 or less显示文摘 | Alexander Becket Kobi Peleg Oded Olsha Adi Givon Boris Kessel Israeli Trauma Group | 2018 | Chinese Journal of Traumatology2018，21，3： | 7 |
| 4 | Oral mixture of autologous colon-extracted proteins for the Crohn's disease: A double-blind trial显示文摘AIM: To evaluate the safety and efficacy of oral administration of AlequelTM, an autologous proteincontaining colon extract.a randomized,placebo-controlled,double-blind trial.Patients were orally administered with autologous protein-containing colon extract three doses of autologous study drug per week for 15 wk,for a total of45 doses.Patients were followed for safety parameters.Remission was defined as a Crohn’s disease activity index(CDAI)score of less than or equal to 150.All patients were followed for changes in subsets of T cells by fluorescence-activated cell sorting analysis.RESULTS:Analysis was performed on a total number of evaluable patients of 14 in the study drug group and15 in the placebo group.Treatment was well tolerated by all patients.No major treatment-related adverse events were reported or observed in any of the treated patients during the feeding or follow-up periods.Between weeks 6 and 9 of the study,six of the 14(43%)evaluable subjects who received the study drug achieved a CDAI of 150 or lower.In contrast,five of the 15(33%)evaluable subjects in the placebo group achieved remission.Between weeks 9 and 12,the remission rates were 50%and 33%for the drug group and placebo group,respectively.Among the drug-treated subjects who achieved remission,the effect of the drug was judged as stable in eight of the 14 subjects as measured by at least two CDAI scores indicating remission in the 15-wk treatment period.A decreased percentage of peripheral natural killer T regulatory cells(a decrease of 28%vs an increase of 16%)and an increased ratio of CD4+/CD8+T lymphocytes(an increase of 11%vs a decrease of9%)were noted in subjects with a significant clinical response.CONCLUSION:Oral administration of the autologous colonic extract could be a safe and effective for the treatment of patients with moderate to severe Crohn’s disease. | Eran Israeli Ehud Zigmond Gadi Lalazar Athalia Klein Nilla Hemed Eran Goldin Yaron Ilan | 2015 | World Journal of Gastroenterology2015，21，18： | 3 |
| 5 | Inflammatory bowel disease patient profiles are related to specific information needs: A nationwide survey显示文摘BACKGROUND Inflammatory bowel diseases(IBD) is a heterogenous, lifelong disease, with an unpredictable and potentially progressive course, that may impose negative psychosocial impact on patients.While informed patients with chronic illness have improved adherence and outcomes, previous research showed that the majority of IBD patients receive insufficient information regarding their disease.The large heterogeneity of IBD and the wide range of information topics makes a one-size fits all knowledge resource overwhelming and cumbersome.We hypothesized that different patient profiles may have different and specific information needs, the identification of which will allow building personalized computer-based information resources in the future.AIM To evaluate the scope of disease-related knowledge among IBD patients and determine whether different patient profiles drive unique information needs.METHODS We conducted a nationwide survey addressing hospital-based IBD clinics.A Total of 571 patients completed a 28-item questionnaire, rating the amount of information received at time of diagnosis and the importance of information, as perceived by participants, for a newly diagnosed patient, and for the participants themselves, at current time.We performed an exploratory factor analysis of the crude responses aiming to create a number of representative knowledge domains(factors), and analyzed the responses of a set of 15 real-life patient profiles generated by the study team.RESULTS Participants gave low ratings for the amount of information received at disease onset(averaging 0.9/5) and high ratings for importance, both for the newly diagnosed patients(mean 4.2/5) and for the participants themselves at current time(mean 3.5/5).Factor analysis grouped responses into six informationdomains.The responses of selected profiles, compared with the rest of the participants, yielded significant associations(defined as a difference in rating of >0.5 points with a P < 0.05).Patients with active disease showed a higher interest in work-disability, stress-coping, and therapy-complications.Patients newly diagnosed at age > 50, and patients with long-standing disease(> 10 years)showed less interest in work-disability.Patients in remission with mesalamine or no therapy showed less interest in all domains except for nutrition and long-term complications.CONCLUSION We demonstrate unmet patient information needs.Analysis of various patient profiles revealed associations with specific information topics, paving the way for building patient-tailored information resources. | Saleh Daher Tawfik Khoury Ariel Benson John R Walker Oded Hammerman Ron Kedem Timna Naftali Rami Eliakim Ofer Ben-Bassat Charles N Bernstein Eran Israeli | 2019 | World Journal of Gastroenterology2019，25，30： | 3 |
| 6 | Expression of the prostate-specific membrane antigen显示文摘 | | 1994 | Cancer Res1994，54，： | 1 |
| 7 | Individualized immune monitoring of cardiac transplant recipients by noninvasive longitudinal cellular immunity tests 显示文摘 | Israeli M Ben-Gal T Yaari V | 2010 | Transplantation2010，89，8： | 1 |
| 8 | Chromosome 20p11 gains are associated with liver-specific metastasis in patients with coloreetal cancer显示文摘 | Mekenkamp L J Haan J C Koopman M Vink B6rger M E Israeli D Teerenstra S | 2013 | Gut2013，62，： | 1 |
| 9 | Control of NF-kappa activity by the I kappa Bβinhibitor显示文摘 | WEIL R WHITESIDE S T ISRAL A | 1997 | Immunobiology1997，198，123： | 1 |
| 10 | Association of the C677T polymorphism in the MTHFR gene with breast and/or ovarian cancer risk in Jewish women 显示文摘 | Dagan E Israeli D | 2000 | Eur J Cancer2000，36，： | 1 |
| 11 | Behavioral response of carp (Cyprinus carpio) to ammonia stress 显示文摘 | Israeli D Kimmel E | 1998 | Aquaculture1998，165，1： | 1 |
| 12 | Complex proximal humeral fractures in adults systematic review of management显示文摘 | Isra A Mamlli KN | 2001 | Injury2001，32，5： | 1 |
| 13 | Sensitive nested reverse transcription polymerase chain reaction detection of prostatic hematogenous tumor cells: comparison of prostate specific antigen and prostate-specific antigenbased assays 显示文摘 | Israeli R S Miller W H Jr Su L | 1994 | Cancer Res1994，54，24： | 1 |
| 14 | Reducing ischaemic Damage in rodent ovarian xenogafts transplanted into granulation tissue显示文摘 | Israely T Nevo N Harmelin A | 2006 | Hum Reprod2006，21，6： | 1 |
| 15 | In silico chromosomal clustering of genes displaying altered expression patterns in ovarian cancer显示文摘 | Israeli O Goldring-Aviram A Rienstein S | 2005 | Cancer Genet Cytogenet2005，160，1： | 1 |
| 16 | Trehalose and sucrose protect both membranes and proteins in intact Bacteria during drying显示文摘 | LESLIE S B ISRAELI E LIGHTHART B | 1995 | Applied and Environmental Microbiology1995，61，10： | 1 |
| 17 | High-order time-accurate splitting methods for incompressible Navier-Stokes equations显示文摘 | KARNIADAKIS G E ISRAELI M ORSZAG S A | 1991 | J Comput Phys1991，97，： | 1 |
| 18 | Acellular dermal matrix in breast recon- struction in the setting of radiotherapy 显示文摘 | Israeli R Feingold RS | 2011 | Aesthet Surg J2011，31，7： | 1 |
| 19 | Trehalose and sucrose protect both membrance and proteins in intact bacteria during drying显示文摘 | SB Leslie E Israeli B Lighthart | 1995 | Applied Environment and Microbiology1995，61，3： | 1 |
| 20 | FGF6 mediated expansion of a resident subset of ceils with SP phenotype in the C2C12 myogenic line显示文摘 | ISRAELI D BENCHAOUIR R ZIAEI S | 2004 | J Cell Physiol2004，201，3： | 1 |
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