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| 1 | Bile acid interactions with cholangiocytes显示文摘Cholangiocytes 在他们的顶端的膜暴露于胆汁酸的高集中。为胆汁酸的选择 transporter,顶端的钠胆汁酸 Cotransporter (ASBT )( 也叫作 Ibat;基因名字 Slc10a2 ) 在 cholangiocyte 上是局部性的顶端的膜。在 basolateral 膜上,四个运输系统被识别了(t-ASBT,多药抵抗(MDR ) 3,一个未辩别出的阴离子 exchanger 系统和器官的溶质 transporter (Ost ) 异侧 transporter, Ostalpha-Ostbeta。一起,这些单向性地搬运 ers 从管的胆汁的行动胆汁酸到发行量。cholangiocytes 吸收的胆汁酸为重新分泌物经由仙子胆管丛再循环回到 hepatocytes 进胆汁。这再循环在 hepatocytes 和 cholangiocytes 之间的胆汁酸被叫作 cholehepatic 分流小径。最近的研究建议 cholehepatic 分流小径可以由于额外的肝的阻塞在胆汁酸并且到改编的全面肝胆管运输作出贡献到长期的胆汁郁积。ASBT 被腺苷 3' 尖锐地调整, 5'-monophosphate (营地) 依赖者易位到顶端的膜并且由 phosphorylation 依赖的 ubiquitination 和 proteasome 降级。ASBT 被变化长期地响应胆汁的胆汁酸集中和煽动性的 cytokines 在基因表示调整。cholangiocyte ASBT 的另一潜在的功能是允许 cholangiocytes 取样胆汁的胆汁酸以便激活细胞内部的表明小径。在细胞内部的钙,蛋白质激酶 C (PKC ) , phosphoinositide 3-kinase (PI3K ) ,激活 mitogen 的蛋白质(地图) 激酶和细胞外的调整信号的蛋白质激酶(英皇家空军之阶级最低之兵) 的胆汁酸扳机变化细胞内部的信号。胆汁酸显著地改变 cholangiocyte 分泌物,增长和幸存。不同胆汁酸在 cholangiocyte 上有微分效果细胞内部发信号,并且在一些例子,扳机反对在 cholangiocyte 上完成分泌物,增长和幸存。在这些之上基于概念和观察, cholangiocyte 被建议了是为在肝的胆汁酸的原则目标房间。 | Xuefeng Xia Heather Francis Shannon Glaser Gianfranco Alpini Gene LeSage | 2006 | World Journal of Gastroenterology2006，12，22： | 16 |
| 2 | Involvement of cholangiocyte proliferation in biliary fibrosis显示文摘Cholangiocytes are the epithelial cells that line the biliary tree.In the adult liver,they are a mitotically dormant cell population,unless ductular reaction is triggered by injury.The ability of cholangiocytes to proliferate is important in many different human pathological liver conditions that target this cell type,which are termed cholangiopathies(i.e.primary biliary cirrhosis,primary sclerosing cholangitis and biliary atresia).In our article,we provide background information on the morphological and functional heterogeneity of cholangiocytes,summarize what is currently known about their proliferative processes,and briefly describe the diseases that target these cells.In addition,we address recent findings that suggest cholangiocyte involvement in epithelial-to-mesenchymal transformation and liver fibrosis,and propose directions for future studies. | Sally Priester Candace Wise Shannon S Glaser | 2010 | World Journal of Gastrointestinal Pathophysiology2010，1，2： | 10 |
| 3 | Long-term results of endoscopic balloon dilatation of lower gastrointestinal tract strictures in Crohn's disease:A prospective study显示文摘AIM:To examine the long-term results of endoscopic treatment in a prospective study conducted over a period of 10 years,1997 to January 2007.METHODS:A total of 25 patients(20 female and five male:aged 18-75 years),with at least one symptom of stricture not passable with the standard colonoscope and with a confirmed scarred Crohn's stricture of the lower gastrointestinal tract,were included in the study.The main symptom was abdominal pain.The endoscopic balloon dilatation was performed with an 18 mm balloon under endoscopic and radiological control.RESULTS:Eleven strictures were located in the colon,13 at the anastomosis after ileocecal resection,three at the Bauhin valve and four in the ileum.Four patients had two strictures and one patient had three strictures.Of the 31 strictures,in 30 was balloon dilatation successful in a single endoscopic session,so that eventually the strictures could be passed easily with the standard colonoscope.In one patient with a long stricture of the ileum involving the Bauhin valve and an additional stricture of the ileum which were 15 cm apart,sufficient dilatation was not possible.This patient therefore required surgery.Improvement of abdominal symptoms was achieved in all cases which had technically successful balloon dilatation,althoughin one case perforation occurred after dilatation of a recurrent stricture.Available follow-up was in the range of 54-118 mo(mean of 81 mo).The relapse rate over this period was 46%,but 64% of relapsing strictures could be successfully dilated again.Only in four patients was surgery required during this follow-up period.CONCLUSION:We conclude from these initial results that endoscopic balloon dilatation,especially for short strictures in Crohn's disease,can be performed with reliable success.Perforation is a rare complication.It is our opinion that in the long-term,the relapse rate is probably higher than after surgery,but usually a second endoscopic treatment can be performed successfully,leading to a considerable success rate of the endoscopic procedure. | Klaus Stienecker Daniel Gleichmann Ulrike Neumayer H Joachim Glaser Carolin Tonus | 2009 | World Journal of Gastroenterology2009，15，21： | 9 |
| 4 | Cholangiocytes and blood supply显示文摘胆汁的树的微脉管的供应,仙子胆管丛(PBP ) ,源自肝的动脉树枝和流动进肝窦状隙。PBP 的详细三维的研究被使用扫描电子执行了显微镜学脉管的腐蚀演员组(SEMvcc ) 技术。认为 PBP 在支持胆汁的上皮的能分泌、吸收性的功能起一个基本作用,他们在常态和病理的组织被探索。正常的肝证明 PBP 安排在 extra-附近 -- 并且肝内的胆汁的树。在小门道, PBP 被日益增多地继续了它显示出一个更复杂的脉管的网络的额外的肝的 PBP 的 capillaries 的单个层描绘。在普通的管结扎(BDL ) 以后,胆汁管和 PBP 增长的进步修正被观察。PBP 介绍在许多胆汁管附近安排的一个三维的网络并且作为容器的捆出现,由有典型圆网孔结构的同类的直径的 capillaries 镇静。PBP 网络从显得正常的正弦曲线网络是容易可区分的。在 BDL 期间考虑 PBP 的庞大的延期,脉管的内皮生长因素(VEGF ) 起的可能的作用被评估。VEGF -- A, VEGF-C 和他们的相关受体高度出现了在 BDL 老鼠的增殖的 cholangiocytes 积极的免疫。到象肝的动脉结扎一样的 BDL 老鼠的 anti-VEGF-A 或 anti-VEGF-C 抗体的管理导致了一个减少的胆汁管团。rVEGF 的管理 -- 到 BDL 肝的动脉的 A 绑扎老鼠阻止了 cholangiocyte 增长和 VEGF 的减少 -- 表情作为与 BDL 控制老鼠相比。这些数据处于 cholangiocyte 增长的条件建议胆汁的树的动脉的血供给的角色,例如它发生在长期的胆汁郁积期间。在另一方面, VEGF 作为在 cholangiocytes 和 PBP endothelial 之间的串音的一个工具起的作用建议 VEGF 版本和功能的那操作能为肝的动脉或胆汁的树的损坏描绘的人的病理学的条件代表治疗学的策略。 | Eugenio Gaudio Antonio Franchitto Luigi Pannarale Guido Carpino Gianfranco Alpini Heather Francis Shannon Glaser Domenico Alvaro Paolo Onori | 2006 | World Journal of Gastroenterology2006，12，22： | 9 |
| 5 | Nutrient availability and leaching in an archaeological Anthrosol and a Ferralsol of the Central Amazon basin: fertilizer, manure and charcoal amendments显示文摘 | Johannes Lehmann Jose Pereira da Silva Christoph Steiner Thomas Nehls Wolfgang Zech Bruno Glaser | 2003 | Plant and Soil2003，，2： | 8 |
| 6 | Dual Targeting to Mitochondria and Chloroplasts: Characterization of Thr-tRNA Synthetase Targeting Peptide显示文摘 | Anna-Karin Berglund Erika Spanning Henrik Biverstahl Gianluca Maddalo Christian Tellgren-Roth Lena Maler Elzbieta Glaser | 2009 | Molecular Plant2009，2，6： | 6 |
| 7 | Inactivation of Mitochondrial Complex Ⅰ Induces the Expression of a Twin Cysteine Protein that Targets and Affects Cytosolic, Chloroplastidic and Mitochondrial Function显示文摘At12Cys-1 (At5g64400 ) 和 At12Cys-2 (At5g09570 ) 是二密切相关的 isogenes 编码小、成双的半胱氨酸蛋白质,典型地在线粒体定位了。At12Cys-2 抄本与破坏 mitochondrial 蛋白质,而是 At12Cys 的增加在许多异种被导致蛋白质仅仅与减少的 mitochondrial 在异种被检测复杂我丰富。在缺乏 mitochondrial 建筑群的异种的 At12Cys 蛋白质感应我被位于线粒体,叶绿体,和 cytosol 的 At12Cys 蛋白质伴随。生物化学的分析揭示了那甚至单个的基因删除,即, At12cys-1 或 At12cys-2,在 mitochondrial 和叶绿体功能上有效果。然而,仅仅加倍异种,即, At12cys-1 : At12cys-2,影响许多蛋白质和 mRNA 抄本编码翻译延伸因素以及 rRNA 丰富。蓝本国的页证明 At12Cys 与 mitochondrial supercomplex 共同移居我 + III。同样, At12cys-1 和 At12cys-2 基因的删除,然而并非单个基因删除,导致提高的忍耐到干旱和轻应力和增加的抗氧化剂能力。正式就职和在在建筑群的减小之上的 At12Cys 的多重本地化我丰富提供机制明确地表明 mitochondrial 机能障碍到 cytosol 然后在以外到在房间的另外的细胞器。 | Yan Wang Wenhui Lyu Oliver Berkowitz Jordan D. Radomiljac Simon R. Law Monika W. Murcha Chris Carrie Pedro F. Teixeira Beata Kmiec Owen Duncan Olivier Van Aken Reena Narsai Elzbieta Glaser Shaobai Huang Ute Roessner A. Harvey Millar James Whelan | 2016 | Molecular Plant2016，9，5： | 5 |
| 8 | Mechanisms of biliary carcinogenesis and growth显示文摘Cholangiocarcinoma is a rare cancer originating from the neoplastic transformation of the epithelial cells (i.e. cholangiocytes) that line the biliary tract. The prognosis for patients with cholangiocarcinoma is grim due to lack of viable treatment options. The increase in world-wide incidence and mortality from cholangiocarcinoma highlights the importance of understanding the intracellular mechanisms that trigger the neoplastic transformation of cholangiocytes and the growth of biliary cancers. The purpose of the following review is to address what has been learned over the past decade concerning the molecular basis of cholangiocarcinogenesis. The material presented is divided into two sections:(1) mechanisms regulating neoplastic transformation of cholangiocytes; and (2) factors regulating cholangiocarcinoma growth. An understanding of the growth regulatory mechanisms of cholangiocarcinoma will lead to the identification of therapeutic targets for this devastating cancer. | Candace Wise Metaneeya Pilanthananond Benjamin F Perry Gianfranco Alpini Michael McNeal Shannon S Glaser | 2008 | World Journal of Gastroenterology2008，14，19： | 5 |
| 9 | Heterogeneity of the intrahepatic biliary epithelium显示文摘这评论的目的是在 apoptotic,增生的和分泌活动与变化构画出与胆汁的上皮的词法异质和对肝胃肠激素和肽和肝损伤的不同大小的胆汁管的异构的 pathophysiological 回答有关的最近的调查结果。因为胆汁的上皮细胞(cholangiocytes ) 是人的 cholangiopathies 的目标的识别,胆汁的功能的知识很快正在增加,它被胆汁管的增长 / 损坏在尺寸的一个小范围以内描绘。胆汁的上皮的唯一的解剖,形态学,神经分布和血管形成与在胆汁的树的不同区域以内的 cholangiocytes 的功能一致。在活体内模型[例如,胆汁管结扎( BDL ),部分肝切除术,胆汁酸,四氯化碳( CCl4 )或 alpha-naphthylisothiocyanate ( ANIT )喂]并且在活体内试验性的工具[例如,刚孤立小、大的 cholangiocytes 或肝内胆汁管单位( IBDU )和小、大的鼠科的 cholangiocytes 的主要文化]允许我们表明肝内的胆汁的上皮的词法、功能的异质。这些模型表明了微分分泌活动和异构的 apoptotic 和不同的大小的管的增生的回答。类似于限制为特定的大小的管的 cholangiocyte 增长 / 损害的动物模型,在人的肝疾病,胆汁管损坏支配特定的大小的胆汁管。与肝内的胆汁的上皮的功能的异质有关的未来研究可以与 cholangiopathies 为病人揭示新 pathophysiological 治疗。 | Shannon Glaser Heather Francis Sharon DeMorrow Gene LeSage Giammarco Fava Marco Marzioni Julie Venter Gianfranco Alpini | 2006 | World Journal of Gastroenterology2006，12，22： | 5 |
| 10 | Clinical Progression of Incidental, Asymptomatic Lesions Discovered During Culprit Vessel Coronary Intervention显示文摘 | Ruchira Glaser Faith Selzer David P. Faxon Warren K. Laskey Howard A. Cohen James Slater Katherine M. Detre Robert L. Wilensky | 2005 | Circulation2005，，2： | 4 |
| 11 | Purinergic Receptors in Basal Ganglia Diseases:Shared Molecular Mechanisms between Huntington’s and Parkinson’s Disease显示文摘Huntington’s(HD)and Parkinson’s diseases(PD)are neurodegenerative disorders caused by the death of GABAergic and dopaminergic neurons in the basal ganglia leading to hyperkinetic and hypokinetic symptoms,respectively.We review here the participation of purinergic receptors through intracellular Ca^2+signaling in these neurodegenerative diseases.The adenosine A2A receptor stimulates striatopallidal GABAergic neurons,resulting in inhibitory actions on GABAergic neurons of the globus pallidus.A2A and dopamine D2 receptors form functional heteromeric complexes inducing allosteric inhibition,and A2A receptor activation results in motor inhibition.Furthermore,the A2A receptor physically and functionally interacts with glutamate receptors,mainly with the mGlu5 receptor subtype.This interaction facilitates glutamate release,resulting in NMDA glutamate receptor activation and an increase of Ca2+influx.P2X7 receptor activation also promotes glutamate release and neuronal damage.Thus,modulation of purinergic receptor activity,such as A2A and P2X7 receptors,and subsequent aberrant Ca^2+signaling,might present interesting therapeutic potential for HD and PD. | Talita Glaser Roberta Andrejew Agatha Oliveira-Giacomelli Deidiane Elisa Ribeiro Lucas Bonfim Marques Qing Ye Wen-Jing Ren Alexey Semyanov Peter Illes Yong Tang Henning Ulrich | 2020 | Neuroscience Bulletin2020，36，11： | 3 |
| 12 | Role of sex hormones in the modulation of cholangiocyte function显示文摘Over the last years,cholangiocytes,the cells that line the biliary tree,have been considered an important object of study for their biological properties which involves bile formation,proliferation,injury repair,fibrosis and angiogenesis.Cholangiocyte proliferation occurs in all pathologic conditions of liver injury where it is associated with inflammation and regeneration.During these processes,biliary cells start to secrete different cytokines,growth factors,neuropeptides and hormones which represent potential mechanisms for cross talk with other liver cells.Several studies suggest that hormones,and in particular,sex hormones,play a fundamental role in the modulation of the growth of this compartment in the injured liver which functionally conditions the progression of liver disease.Understanding the mechanisms of action and the intracellular pathways of these compounds on cholangiocyte pathophysiology will provide new potential strategies for the management of chronic liver diseases.The purpose of this review is to summarize the recent findings on the role of sex hormones in cholangiocyte proliferation and biology. | Romina Mancinelli Paolo Onori Sharon DeMorrow Heather Francis Shannon Glaser Antonio Franchitto Guido Carpino Gianfranco Alpini Eugenio Gaudio | 2010 | World Journal of Gastrointestinal Pathophysiology2010，1，2： | 3 |
| 13 | Synergistic effect of cobalt and niobium in Co_(3)-Nb-O_(x)on performance of selective catalytic reduction of NO with NH_(3)显示文摘Combining the redox properties of Co and the acid properties of Nb in a Co_(3)-Nb-O_(x)catalyst is shown to provide superior performance in the selective catalytic reduction of NO with NH_(3)(NH_(3)-SCR).Co_(3)O_(4)shows average activity,however,it exhibits a poor N_(2)selectivity.Nb_(2)O_(5)is not active for NH_(3)-SCR.However,the mixed Co_(3)-Nb-O_(x) catalyst shows higher NO conversion and N_(2)selectivity than the single Co_(3)O_(4)and Nb_(2)O_(5)catalysts at 100–300℃.The results of temperature programmed reduction by H_(2)and X-ray photoelectron(XP)spectra indicate that the addition of Nb changes the chemical states of Co and decreases the concentration of Co^(3+) and Oa,adjusting the activity for catalytic oxidation to a moderate level.This suppresses the formation of undesired N_(2)O from the over-oxidation of NH_(3).Incorporation of Co and Nb into one solid synergistically couples their redox behavior and surface acidity,ensuring the high catalytic activity and N2 selectivity in NH3-SCR. | Bo-Lin Zhang Li-Feng Deng Bo Liu Chun-Yun Luo Michael Liebau Shen-Gen Zhang Roger Glaser | 2022 | Rare Metals2022，41，1： | 2 |
| 14 | Nitrogen immobilization in paddy soils as affected by redox conditions and rice straw incorporation显示文摘 | Daniel Said-Pullicino Maria Alexandra Cucu Marcella Sodano Jago Jonathan Birk Bruno Glaser Luisella Celi | 2014 | Geoderma2014，，： | 2 |
| 15 | The ’Terra Preta’ phenomenon: a model for sustainable agriculture in the humid tropics显示文摘 | Bruno Glaser Ludwig Haumaier Georg Guggenberger Wolfgang Zech | 2001 | Naturwissenschaften2001，，1： | 2 |
| 16 | Induction of long-term glycemic control in newly diagnosed type 2 diabetic patients by transient intensive insulin treatment显示文摘 | Ilkova H Glaser B Tunckale A | | Diabetes Care0，，： | 2 |
| 17 | Biochar and sugar cane filter cake interaction on physical and hydrological soil properties under tropical field conditions显示文摘Biochar is known for its effects on carbon sequestration and soil fertility.However,there is a lack of information about its effects on soil physical and hydraulic properties for tropical soils.We assessed the effects of biochar(BC)plus sugar cane filter cake(FC)rate,and time of interaction on soil physical and hydraulic properties under humid tropical conditions.For this purpose,a field experiment was installed at a loamy sandy soil with five treatments and four replicates:control(only soil),25 Mg ha^(−1) sugar cane filter cake,and 25 Mg ha^(−1) sugar cane filter cake plus 6.25,12.5,and 25 Mg ha^(−1) Miscanthus biochar,respectively,two soil depths(0-10 and 10-20 cm)and two times of interaction(9 and 18 months).Physical prop-erties(aggregate stability,bulk density,total porosity,pores size distribution)and hydraulic properties(soil water holding capacity,hydraulic conductivity,plant-available water holding capacity)were measured after nine and eighteen months.The bulk density decreased slightly,and the porosity increased after nine months,for the biochar plus sugar cane filter cake(both 25 Mg ha^(−1)).After 18 months,biochar plus filter cake interaction increase micropores,aggregate stability,and plant-available water content.Saturated hydraulic conductivity was not influenced by sugar cane filter cake.However,biochar significantly reduced saturated hydraulic conductivity when combined with sugar cane filter cake after 18 months.We concluded that sugar cane filter cake in combination with biochar modified the pore size distribution,slightly increased plant-available water holding capacity,and significantly decreased saturated hydraulic conductivity. | Sara de Jesus Duarte Bruno Glaser Blanca Lucia Prado Pano Carlos Eduardo Pellegrino Cerri | 2020 | Biochar2020，2，2： | 2 |
| 18 | Severe Hand, Foot, and Mouth Disease Associated with Coxsackievirus A6 - Alabama, Connecticut, California, and Nevada, November 201 1 - February 2012显示文摘 | McIntyre Mary G Stevens Kelly M Davidson Sherri Pippin Tina Magill Dagny Kulhanjian Julie A Kelly Daniel Greenhow Tara L Salas Maria L Yagi Shigeo Padilla Tasha Berumen Ricardo Glaser Carol Landry Marie Louise Lott Jason Chen Lei Paulson | 2012 | EN2012，，12： | 2 |
| 19 | Overconfidence and trading volume显示文摘 | Markus Glaser Martin Weber | 2007 | THE GENEVA RISK AND INSURANCE REVIEW2007，，1： | 2 |
| 20 | Treatment and prognostic factors for long-term outcome in patients with anti-NMDA receptor encephalitis: an observational cohort study显示文摘 | Maarten J Titulaer Lindsey McCracken I?igo Gabilondo Thaís Armangué Carol Glaser Takahiro Iizuka Lawrence S Honig Susanne M Benseler Izumi Kawachi Eugenia Martinez-Hernandez Esther Aguilar Núria Gresa-Arribas Nicole Ryan-Florance Abiguei Torrents Albert S | 2013 | Lancet Neurology2013，，2： | 2 |
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